Fæste CF, Rønning TF, Christians U, Granum PE. Liquid chromatography and mass spectrometry in food allergen detection. J Food Protect 2011; 74:316-45.
Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicol 2011; 32:50-57
Cohen MN, Christians U, Henthorn TK, Tran ZV, Moll V, Zuk J, Galinkin JL. Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesth Analgesia 2011; 112: 655-660.
Thethi T, Rajapurkar M, Walker P, McDuffie R, Goff D, Probstfield J, Yau C, Shah S, Christians U, Buse J, Fonseca V. Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria — a sub-study of the ACCORD trial. Clin Chem 2011; 57: 341-344.
Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi M, Cohen I, Shtivelman E, Christians U. Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer 2011; 129: 2945-2957.
Banerjee S, Gianino SM, Gao F, Christians U, Gutmann DH. Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically-engineered mouse model of Nf1-deficient astrocytes. Mol Cancer Ther. 2011 10:279-291
Clavijo CF, Hoffman KL, Thomas JJ, Carvalho B, Chu LF, Drover DR, Hammer GB, Christians U, Galinkin JL. A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011; 400: 715-728.
Strom T, Klawitter J, Klawitter J, Hoffman K, Schiebel H-M, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom 2011; 46: 615-624.
Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014;9(1):e86202. PubMed PMID: 24497939
Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2013 Dec 16. [Epub ahead of print] PubMed PMID: 24343898
Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol. 2014 Mar;25(3):547-63. PubMed PMID: 24262796
Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christians U, Thurman JM. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol. 2013 Nov;24(11):1849-62. PubMed PMID: 24092930
Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov;34(8):442-51. PubMed PMID: 24030928
Pian P, Labovitz E, Hoffman K, Clavijo CF, Rzasa Lynn R, Galinkin JL, Vinks AA, Malik P, Christians U. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 15;937:79-83. PubMed PMID: 24029553
Klawitter J, Zafar I, Klawitter J, Pennington AT, Klepacki J, Gitomer BY, Schrier RW, Christians U, Edelstein CL. Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD Rat model of polycystic kidney disease. BMC Nephrol. 2013 Jul 31;14(1):165. [Epub ahead of print] PubMed PMID: 23902712
Emoto C, Fukuda T, Cox S, Christians U, Vinks AA. Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content. CPT Pharmacometrics Syst Pharmacol. 2013 Jul 24;2:e59. PubMed PMID: 23884207
Lemos PA, Farooq V, Takimura CK, Gutierrez PS, Virmani R, Kolodgie F, Christians U, Kharlamov A, Doshi M, Sojitra P, van Beusekom HM, Serruys PW. Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter. EuroIntervention. 2013 May 20;9(1):148-56. PubMed PMID: 23685303
Taylor RR, Hoffman KL, Schniedewind B, Clavijo C, Galinkin JL, Christians U. Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2013 Sep;83:1-9. PubMed PMID: 23670126
Ogasawara K, Chitnis SD, Gohh RY, Christians U, Akhlaghi F. Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients. Clin Pharmacokinet. 2013 Sep;52(9):751-62. PubMed PMID: 23633119
Fernandez-Bustamante A, Klawitter J, Wilson P, Elkins ND, Agazio A, Shibata T, Uchida K, Christians U, Repine JE. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation. 2013 Oct;36(5):1030-40. PubMed PMID: 23616184
Razzaghi H, Tempczyk-Russell A, Haubold K, Santorico SA, Shokati T, Christians U, Churchill ME. Genetic and structure-function studies of missense mutations in human endothelial lipase. PLoS One. 2013;8(3):e55716. PubMed PMID: 23536757
Klepacki J, Brunner N, Schmitz V, Klawitter J, Christians U, Klawitter J. Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma. Clin Chim Acta. 2013 Jun 5;421:91-7. PubMed PMID: 23499573
Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis?. Transpl Int. 2013 Mar;26(3):225-41. PubMed PMID: 23350848
Chitnis SD, Ogasawara K, Schniedewind B, Gohh RY, Christians U, Akhlaghi F. Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. Xenobiotica. 2013 Jul;43(7):641-9. PubMed PMID: 23278282
Macy ME, Duncan T, Whitlock J, Hunger SP, Boklan J, Narendren A, Herzog C, Arceci RJ, Bagatell R, Trippett T, Christians U, Rolla K, Ivy SP, Gore L, Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC). A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors. Pediatr Blood Cancer. 2013 Feb;60(2):230-6. PubMed PMID: 23024067
Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc Res. 2013 Jan 1;97(1):66-76. PubMed PMID: 23015639
Pacheco-López G, Doenlen R, Krügel U, Arnold M, Wirth T, Riether C, Engler A, Niemi MB, Christians U, Engler H, Schedlowski M. Neurobehavioural activation during peripheral immunosuppression. Int J Neuropsychopharmacol. 2013 Feb;16(1):137-49. PubMed PMID: 22217400
Christians U, Klawitter J, Klawitter J. Multi-analyte LC-MS/MS assays for the quantification of endogenous compounds during the development of drugs and companion diagnostics – the Beauty and the Beast. Eur Pharm Rev 2013; 18: 13-16.
Bösche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology. 2014 Dec 19. [Epub ahead of print] PubMed PMID: 25529273
Klawitter J, Reed-Gitomer BY, McFann K, Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M, Christians U, Schrier RW. Endothelial dysfunction and oxidative stress in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1198-206. PubMed PMID: 25234311
Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA. Age dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Ther Drug Monit. 2014 Aug 26. [Epub ahead of print] PubMed PMID: 25162215
Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boernsen KO. Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct;406(25):6399-408. PubMed PMID: 25116600
Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC. Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1( ) leukemia. Am J Hematol. 2014 Sep;89(9):896-903. PubMed PMID: 24891015
Shihab F, Christians U, Smith L, Wellen JR, Kaplan B. Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. Transpl Immunol. 2014 Jun;31(1):22-32. PubMed PMID: 24861504
Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep;121(3):469-81. PubMed PMID: 24809976
Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014;9(1):e86202. PubMed PMID: 24497939
Cooper JE, Christians U, Wiseman AC. Everolimus in kidney transplantation. Transplant Res Risk Management 2011; 3: 1-16.
Clavijo CF, Thomas JJ, Cromie M, Schniedewind B, Hoffman KL, Christians U, Galinkin JL. A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children. J Sep Sci. 2011, e-publication Sep 13.
Klepacki J, Klawitter J, Bendrick-Peart J, Schniedewind B, Heischmann S, Shokati T, Christians U, Klawitter J. A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, e-publication Aug 2.
Aquilante CL, Kiser JJ, Anderson PL, Christians U, Kosmiski LA, Daily EB, Hoffman KL, Hopley CW, Predhomme JA, Schniedewind B, Sidhom MS. Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin. J Clin Pharmacol (in print)
Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E,1 McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi D-S, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK, Equilibrative nucleoside transporter ENT1 regulates post-ischemic blood-flow during acute kidney injury in mice. J Clin Invest 2012 Jan 24. pii: 60214
Christians U, Klepacki J, Shokati T, Klawitter J, Klawitter J. Mass spectrometry-based multiplexing for the analysis of biomarkers in drug development and clinical diagnostics- how much is too much? Microchem J (in print)
Pacheco-López G, Doenlen R, Krügel U, Arnold M, Wirth T, Riether C, Engler A, Niemi MB, Christians U, Engler H, Schedlowski M. Neurobehavioural activation during peripheral immunosuppression. Int J Neuropsychopharmacol. 2012; 5: 1-13.
Shokati T, Bodenberger N, Gadpaille H, Schniedewind B, Vinks AA, Jiang W, Alloway RR, Christians U. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. J Vis Exp. 2015 Nov 8;(105). PubMed PMID: 26575262
Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E. ANALYTICAL ASPECTS OF THE IMPLEMENTATION OF BIOMARKERS IN CLINICAL TRANSPLANTATION. Ther Drug Monit. 2015 Jul 30. [Epub ahead of print] PubMed PMID: 26418704
U C, Klawitter J, Klawitter J. Biomarkers in Transplantation- Proteomics and Metabolomics. Ther Drug Monit. 2015 Aug 28. [Epub ahead of print] PubMed PMID: 26418702
Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M. Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun. 2015 Sep 18. [Epub ahead of print] PubMed PMID: 26386321
Christians U, Vinks AA, Langman LJ, Clarke W, Wallemacq P, van Gelder T, Renjen V, Marquet P, Meyer EJ. Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs. Ther Drug Monit. 2015 Dec;37(6):718-24. PubMed PMID: 26291980
Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1534-41. PubMed PMID: 26224879
Schniedewind B, Niederlechner S, Galinkin JL, Johnson-Davis KL, Christians U, Meyer EJ. Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study. Ther Drug Monit. 2015 Jun;37(3):296-303. PubMed PMID: 25970506
Klawitter J, Nashan B, Christians U. Everolimus and sirolimus in transplantation-related but different. Expert Opin Drug Saf. 2015 Jul;14(7):1055-70. PubMed PMID: 25912929
Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15;446:43-53. PubMed PMID: 25871999
Bösche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology. 2015 Sep;96(Pt A):83-93. PubMed PMID: 25529273
Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Ther Drug Monit. 2015 Jun;37(3):395-9. PubMed PMID: 25162215
Strand T-E, Khiabani HZ, Boico A, Radiloff D, Irwin D, Hamilton K, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Schroeder T. Safety study of combined bambuterol and theophylline as a potential treatment of high altitude-induced fatigue in humans. J Cardiovasc Pharmacol
Seger C, Shipkova M, Christians U, Billaud E, Wang P, Holt D, Brunet M, Kunicki P, Langman L, Marquet P, Oellerich M, Wieland E, Wallemacq P. Assuring the proper analytical performance of measurement procedures for immunosuppressive drug concentrations in clinical practice: Recommendations of the IATDMCT Immunosuppressive Drugs Scientific Committee. Ther Drug Monit
Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, López-Hoyos M, Barten MJ, Bergan S, Picard N, Millán O, Marquest P, Hesselink DA, Noceti O Pawinski T, Wallemacq P, Oellerich M. Barcelona Consensus on biomarker-based therapeutic drug monitoring in solid organ transplantation. Ther Drug Monit
Fernandez-Bustamante A, Seres T, Agazio A, Pennington AT, Christians U, Klawitter J, Repine JE. Body mass index is inversely associated with exhaled breath condensate nitrate levels in patients without respiratory disease. J Pulmon Resp Med 2015, 5 : 243. doi:10.4172/2161-105X.1000243
Christians U, Schmitz V, Klawitter J, Klawitter J. Proteo-metabolomic strategies in the future of drug development. In: The Applicability of Analytical Techniques to Clinical Studies. Caroli S, Záray G (eds.) John Wiley and Sons, Inc. New York (2012)
Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman J, Christians U. Proteomics and metabolomics in renal transplantation- quo vadis? Transplant Int 2012 (in print)
Pacheco-López G, Doenlen R, Krügel U, Arnold M, Wirth T, Riether C, Engler A, Niemi MB, Christians U, Engler H, Schedlowski M. Neurobehavioural activation during peripheral immunosuppression. Int J Neuropsychopharmacol. 2013; 16: 137-149.
Leitman DC, Christians U. MF101 : a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms. Expert Opin Investig Drugs. 2012 ; 21 :1031-1042
Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res 2012; 11: 5135-5144
Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians U, Adams DM, Vinks AA. Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. CPT Pharmacometrics Syst Pharmacol. 2016 Aug;5(8):411-7. PubMed PMID: 27501453
Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U. Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?. Clin Biochem. 2016 Sep;49(13-14):955-61. PubMed PMID: 27288551
Clavijo CF, Rzasa Lynn R, Christians U, Galinkin J. Intranasal Fentanyl for breakthrough pain control. Clinical Medicine Insights: Therapeutics 2012: 4; 241–250
O'Connor S, Zhang YL, Christians U, Morrison JE Jr, Friesen RH. Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia. Paediatr Anaesth. 2016 Jul;26(7):703-9. PubMed PMID: 27146802
Macy ME, Duncan T, Whitlock J, Hunger SP, Boklan J, Narendaren A, Herzog C, Arceci RJ, Bagatell R, Trippett T, Christians U, Rolla K, Ivy PS, Gore L. A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors. Pediatr Blood Cancer 2013; 60: 230-236
209. Bohra R, Schöning W, Klawitter J, Brunner N, Schmitz V, Shokati T, Lawrence R, Abelaez MF, Schneidewind B, Christians U, Klawitter J. Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PLoS One 2012 ; 7:e48063
Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki PK, Pawinski T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P. Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee. Ther Drug Monit. 2016 Apr;38(2):170-89. PubMed PMID: 26982493
Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman J, Christians U.
Proteomics and metabolomics in renal transplantation-quo vadis? Transpl Int. 2012
Nov 21. doi: 10.1111/tri.12003. [Epub ahead of print] PubMed PMID: 23350848
Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowe BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT and ASK1/p38 mediated cell signaling with ischemic cardiomyopathy. Cardiovasc Res 2013; 97: 66-76.
Niederlechner S, Baird C, Klawitter J, Christians U, Wischmeyer P. Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. PLoS One 2012 ; 7: e48063
213. Chitnis SD, Ogasawara K, Schniedewind B, Gohh RY, Christians U, Akhlaghi F. Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. Xenobiotica. 2013 Jan 2. [Epub ahead of print]
Rhazzaghi H, Tempczyk-Russell A,Santorico SA, Shokati T, Christians U, Churchill MEA. Genetic and structure-function studies of missense mutations in human endothelial lipase. PLoS One 2013, in print.
Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, López-Hoyos M, Barten MJ, Bergan S, Picard N, Millán López O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M. Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation. Ther Drug Monit. 2016 Apr;38 Suppl 1:S1-20. PubMed PMID: 26977997
Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 2016;51(6):366-73. PubMed PMID: 26950528
Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish. J Chromatogr A. 2016 Feb 5;1432:58-72. PubMed PMID: 26787163
Shokati T, Bodenberger N, Gadpaille H, Schniedewind B, Vinks AA, Jiang W, Alloway RR, Christians U. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. J Vis Exp. 2015 Nov 8;(105):e52424. PubMed PMID: 26575262
Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E. Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation. Ther Drug Monit. 2016 Apr;38 Suppl 1:S80-92. PubMed PMID: 26418704
Christians U, Klawitter J, Klawitter J. Biomarkers in Transplantation--Proteomics and Metabolomics. Ther Drug Monit. 2016 Apr;38 Suppl 1:S70-4. PubMed PMID: 26418702
Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M. Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun. 2016 Feb;52:40-8. PubMed PMID: 26386321
Klawitter J, Hildreth KL, Christians U, Kohrt WM, Moreau KL. A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition. Physiol Rep. 2017 Sep;5(17). PubMed PMID: 28904082
Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 Sep 5;7(1):10540. PubMed PMID: 28874678
Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2017 Aug 31. [Epub ahead of print] PubMed PMID: 28857147
Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R. Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation. Neuropsychopharmacology. 2017 Aug 21. [Epub ahead of print] PubMed PMID: 28825423
Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U. A High-throughput HPLC-MS/MS Assay for the Detection, Quantification and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine. Ther Drug Monit. 2017 Oct;39(5):565-574. PubMed PMID: 28650900
Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct;39(5):556-564. PubMed PMID: 28640062
Heischmann S, Christians U. Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid. Xenobiotica. 2017 May 30;:1-9. [Epub ahead of print] PubMed PMID: 28489504
Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 Sep;95(9):1009-1018. PubMed PMID: 28467859
Atigh MK, Turner E, Christians U, Yazdani SK. The use of an occlusion perfusion catheter to deliver paclitaxel to the arterial wall. Cardiovasc Ther. 2017 Aug;35(4). PubMed PMID: 28445625
Diwan TS, Lichvar AB, Leino AD, Vinks AA, Christians U, Shields AR, Cardi MA, Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR. Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy. Clin Transplant. 2017 Jun;31(6). PubMed PMID: 28342282
Heischmann S, Dzieciatkowska M, Hansen K, Leibfritz D, Christians U. The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model. Sci Rep. 2017 Mar 22;7:45088. PubMed PMID: 28327659
Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB. Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data. J Proteome Res. 2017 Apr 7;16(4):1515-1525. PubMed PMID: 28314371
Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017 Sep;118(9):2933-2940. PubMed PMID: 28230282
Mishra N, Wang P, Goldsmith D, Zhao X, Xue Y, Christians U, Minassian BA. Everolimus does not prevent Lafora body formation in murine Lafora disease. Neurol Genet. 2017 Feb;3(1):e127. PubMed PMID: 28097224
Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M, Vinks AA. Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. Br J Clin Pharmacol. 2017 May;83(5):1097-1107. PubMed PMID: 28000286
Schoening W, Schmitz V, Klawitter J, Christians U, Klawitter J. Metabolic markers for differentiation between renal allograft rejection and immunosuppressant toxicity in rat urine. Metabolomics 2017; 13(9): 102.
Alloway RR, Vinks, AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle SE, Tremblay S, Klawitter J, Klawitter J, Christians U. Bioequivalence between brand and generic tacrolimus in liver and kidney transplant recipients: a randomized clinical trial. PLOS Medicine
Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB. A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction. Eur J Nutr. 2018 Nov 7. [Epub ahead of print] PubMed PMID: 30406389
Turner E, Erwin M, Atigh M, Christians U, Saul JM, Yazdani SK. In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons. Front Pharmacol. 2018;9:808. PubMed PMID: 30104972
Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jul 13;7(14). PubMed PMID: 30006493
Heischmann S, Gano LB, Quinn K, Liang LP, Klepacki J, Christians U, Reisdorph N, Patel M. Regulation of kynurenine metabolism by a ketogenic diet. J Lipid Res. 2018 Jun;59(6):958-966. PubMed PMID: 29605816
Goot BH, Kaufman J, Pan Z, Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, Zuk J, da Cruz EM. Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery. Pediatr Crit Care Med. 2018 May;19(5):459-467. PubMed PMID: 29547456
Bittersohl H, Schniedewind B, Christians U, Luppa PB. A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples. J Chromatogr A. 2018 Apr 27;1547:45-52. PubMed PMID: 29544893
Schniedewind B, Meyer EJ, Christians U. Long-term Performance of Laboratory-developed LC-MS/MS Tests and an FDA-approved Immunoassay for the Therapeutic Drug Monitoring of Everolimus. Ther Drug Monit. 2019 Oct 7. [Epub ahead of print] PubMed PMID: 31596754
Turner EA, Atigh MK, Erwin MM, Christians U, Yazdani SK. Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons. Cardiovasc Eng Technol. 2018 Jun;9(2):240-250. PubMed PMID: 29497966
Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 May;48(5):791-802. PubMed PMID: 29389016
Shokati T, Hartmann M, Davari B, Klawitter J, Klawitter J, Christians U. Temsirolimus Metabolic Pathways Revisited. Xenobiotica. 2019 Oct 9;:1-30. [Epub ahead of print] PubMed PMID: 31596164
McLay JS, Engelhardt T, Mohammed BS, Cameron G, Cohen MN, Galinkin JL, Christians U, Avram MJ, Henthorn TK, Dsida RM, Anderson BJ. The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis. Paediatr Anaesth. 2018 Feb;28(2):80-86. PubMed PMID: 29266539
Weinberg A, Huo Y, Kacanek D, Patel K, Watts DH, Wara D, Hoffman RM, Klawitter J, Christians U. Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D. J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):181-187. PubMed PMID: 31513074
Alloway RR, Vinks AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J, Klawitter J, Christians U. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS Med. 2017 Nov;14(11):e1002428. PubMed PMID: 29135993
Davari B, Kotecha N, Clavijo CF, Thomas JJ, Rzasa-Lynn R, Galinkin JL, Christians U, Sempio C. A SENSITIVE LC-MS/MS ASSAY FOR THE QUANTIFICATION OF METHADONE AND ITS METABOLITES IN DRIED BLOOD SPOTS: COMPARISON WITH PLASMA. Ther Drug Monit. 2019 Jul 15. [Epub ahead of print] PubMed PMID: 31318842
Klawitter J, Klawitter J, Pennington A, Kirkpatrick B, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683-F694. PubMed PMID: 31188033
Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2019 May 21;:1-5. [Epub ahead of print] PubMed PMID: 31111749
Brunet M, van Gelder T, Åsberg A, Haufroid V, Hesselink DA, Langman L, Lemaitre F, Marquet P, Seger C, Shipkova M, Vinks A, Wallemacq P, Wieland E, Woillard JB, Barten MJ, Budde K, Colom H, Dieterlen MT, Elens L, Johnson-Davis KL, Kunicki PK, MacPhee I, Masuda S, Mathew BS, Millán O, Mizuno T, Moes DAR, Monchaud C, Noceti O, Pawinski T, Picard N, van Schaik R, Sommerer C, Vethe NT, de Winter B, Christians U, Bergan S. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Ther Drug Monit. 2019 Jun;41(3):261-307. PubMed PMID: 31045868
Golomb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawitter J, Klawitter J, Smith D, Repine JE. Depressed prostaglandins and leukotrienes in veterans with Gulf War illness. J Environ Sci Health B. 2019;54(8):623-639. PubMed PMID: 31033394
Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 Jun 1;126(6):1533-1540. PubMed PMID: 30896357
Lichvar A, Tremblay S, Naik D, Lipscomb J, King E, Vinks AA, Christians U, Alloway RR. Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients. Pharmacotherapy. 2019 May;39(5):564-575. PubMed PMID: 30892704
Shipkova M, Christians U. Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring. Ther Drug Monit. 2019 Apr;41(2):111-114. PubMed PMID: 30883504
Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019 May;208:198-206.e2. PubMed PMID: 30879727
Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. PubMed PMID: 30873612
Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. PubMed PMID: 30873612
Emoto C, Johnson TN, Hahn D, Christians U, Alloway RR, Vinks AA, Fukuda T. A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition. CPT Pharmacometrics Syst Pharmacol. 2019 May;8(5):273-284. PubMed PMID: 30843669
Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J Am Heart Assoc. 2018 Dec 18;7(24):e010711. PubMed PMID: 30561257
Leino AD, King EC, Jiang W, Vinks AA, Klawitter J, Christians U, Woodle ES, Alloway RR, Rohan JM. Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. Am J Transplant. 2019 May;19(5):1410-1420. PubMed PMID: 30506623
Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB. A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction. Eur J Nutr. 2018 Nov 7. [Epub ahead of print] PubMed PMID: 30406389
Cawthon CV, Cooper K, Huett C, Lloret A, Villar-Matamoros E, Stokes L, Christians U, Schuler M, Yazdani SK. Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study. Pharmaceuticals (Basel). 2020 Nov 28;13(12). PubMed PMID: 33260517
Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2020 Nov 13. [Epub ahead of print] PubMed PMID: 33184653
Clavijo CF, Oliva AM, Dingmann C, Kaizer A, Christians U, Burger E, Patel V, Kleck CJ, Vogel SA, Scott BK, Janik DJ, Jameson LC, Ginde AA. Toxicology Screening Testing in Patients Undergoing Spine Surgery: A Prospective Observational Pilot Study. Ther Drug Monit. 2020 Nov 9. [Epub ahead of print] PubMed PMID: 33181620
Freedman R, Hunter SK, Noonan K, Wyrwa A, Christians U, Law AJ, Hoffman MC. Maternal Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With C-reactive Protein and Cortisol. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Aug 13. [Epub ahead of print] PubMed PMID: 33060035
Ye H, Minhajuddin M, Krug A, Pei S, Chou CH, Culp-Hill R, Ponder J, De Bloois E, Schniedewind B, Amaya ML, Inguva A, Stevens BM, Pollyea DA, Christians U, Grimes HL, D'Alessandro A, Jordan CT. The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG. Cancer Discov. 2020 Oct 7. [Epub ahead of print] PubMed PMID: 33028621
Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2020 Oct 2. [Epub ahead of print] PubMed PMID: 33002141
Mizuno T, McPhail BT, Kamatkar S, Wexelblatt S, Ward L, Christians U, Akinbi HT, Vinks AA. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clin Pharmacokinet. 2020 Sep 17. [Epub ahead of print] PubMed PMID: 32939690
Frymoyer A, Van Meurs KP, Drover DR, Klawitter J, Christians U, Chock VY. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2020 Dec;88(6):871-877. PubMed PMID: 32919393
Christians U. Roger Jelliffe MD, FCP, FAAPS Obituary. Ther Drug Monit. 2020 Aug 10. [Epub ahead of print] PubMed PMID: 32796388
Schniedewind B, Meyer EJ, Christians U. Long-Term Performance of Laboratory-Developed Liquid Chromatography-Tandem Mass Spectrometry Tests and a Food and Drug Administration-Approved Immunoassay for the Therapeutic Drug Monitoring of Everolimus. Ther Drug Monit. 2020 Jun;42(3):421-426. PubMed PMID: 32427781
Jelliffe R, Christians U. The New Direct-Acting Oral Anticoagulants Need to be Monitored!. Ther Drug Monit. 2020 Jun;42(3):357-359. PubMed PMID: 32427780
Christians U, Henthorn TK, Walson PD, Oellerich M, Eliasson E. In Memoriam: Professor Folke Sjöqvist. Ther Drug Monit. 2020 Apr 15. [Epub ahead of print] PubMed PMID: 32304489
Goel E, Erwin M, Cawthon CV, Schaff C, Fedor N, Rayl T, Wilson O, Christians U, Register TC, Geary RL, Saul J, Yazdani SK. Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons. Molecules. 2020 Mar 31;25(7). PubMed PMID: 32244375
Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. PubMed PMID: 32048179
Sempio C, Lindley E, Klawitter J, Christians U, Bowler RP, Adgate JL, Allshouse W, Awdziejczyk L, Fischer S, Bainbridge J, Vandyke M, Netsanet R, Crume T, Kinney GL. Surface Detection of THC Attributable to Vaporizer Use in the Indoor Environment. Sci Rep. 2019 Dec 9;9(1):18587. PubMed PMID: 31819131
Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
Weinberg A, Huo Y, Kacanek D, Patel K, Watts DH, Wara D, Hoffman RM, Klawitter J, Christians U. Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D. J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):181-187. PubMed PMID: 31513074
Davari B, Kotecha N, Clavijo CF, Thomas JJ, Rzasa-Lynn R, Galinkin JL, Christians U, Sempio C. A Sensitive LC-MS/MS Assay for the Quantification of Methadone and its Metabolites in Dried Blood Spots: Comparison With Plasma. Ther Drug Monit. 2020 Feb;42(1):118-128. PubMed PMID: 31318842
Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 Feb;58(2):124-128. PubMed PMID: 31111749
An approach to biomarker discovery of cannabis use utilizing proteomic, metabolomic, and lipidomic analyses. Cann Cannab Res 2020
Albeiroti S, Buggs V, Schniedewind B, Sobhani K, Christians U, Kelly KA. Therapeutic drug monitoring of immunosuppressants. In: Toxicology Cases for the Clinical and Forensic Laboratory. Ketha H, Garg U (eds) Elsevier Academic Press, San Diego (2020), pp. 317-332.
Davidson JA, Pfeifer Z, Frank B, Suhong T, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic fingerprinting of infants undergoing cardiopulmonary bypass: changes in metabolic pathways and association with mortality and cardiac intensive care unit length of stay. J Am Heart Assoc. 2018 [in print]
Lesche D, Sigurdardottir V, Leichtle AB, Nakas CT, Christians U, Engelberger L, Fiedler M, Largiadèr CR, Mohacsi P, Sistonen J. Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement. Metabolomics 2018; 14(1): 3.
Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2018 May;103(5):888-898. PubMed PMID: 28857147
Hunter SK, Freedman R, Law AJ, Christians U, Holzman JBW, Johnson Z, Hoffman MC. Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability. Neuroreport. 2021 Oct 6;32(14):1170-1174. PubMed PMID: 34284445
Mayne G, De Bloois E, Dabelea D, Christians U. Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy. Anal Bioanal Chem. 2021 Sep;413(21):5427-5438. PubMed PMID: 34279681
Hinckley JD, Saba L, Raymond K, Bartels K, Klawitter J, Christians U, Hopfer C. An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses. Cannabis Cannabinoid Res. 2020 Jun 19. [Epub ahead of print] PubMed PMID: 33998853
Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Targeting Treatments to Health Disparities. Schizophr Bull. 2021 Jul 8;47(4):886-887. PubMed PMID: 33940629
Chavant A, Jourdil JF, Jouve T, Christians U, Fonrose X, Stanke-Labesque F. A simple and easy-to-perform liquid chromatography-mass spectrometry method for the quantification of tacrolimus and its metabolites in human whole blood. Application to the determination of metabolic ratios in kidney transplant patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Apr 8;1173:122698. [Epub ahead of print] PubMed PMID: 33878532
Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R. Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation. Neuropsychopharmacology. 2018 Feb;43(3):583-589. PubMed PMID: 28825423
Heischmann S, Christians U. Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid. Xenobiotica. 2018 May;48(5):433-441. PubMed PMID: 28489504
Sempio C, Klawitter J, Jackson M, Freni F, Shillingburg R, Hutchison K, Bidwell LC, Christians U, Klawitter J. Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. Anal Bioanal Chem. 2021 May;413(12):3381-3392. PubMed PMID: 33817753
Baliga MM, Klawitter J, Christians U, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Klawitter J. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease. Sci Rep. 2021 Mar 23;11(1):6629. PubMed PMID: 33758231
Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids bY LC-MS-MS in Human Plasma. J Anal Toxicol. 2021 Mar 23. [Epub ahead of print] PubMed PMID: 33754154
Sempio C, Bidwell LC, Hutchison K, Huestis MA, Klawitter J, Christians U, Henthorn TK. Using Population Pharmacokinetic Modeling to Estimate Exposure to ?9-Tetrahydrocannabinol in an Observational Study of Cannabis Smokers in Colorado. Ther Drug Monit. 2021 Aug 1;43(4):536-545. PubMed PMID: 33656464
Cawthon CV, Cooper K, Huett C, Lloret A, Villar-Matamoros E, Stokes L, Christians U, Schuler M, Yazdani SK. Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study. Pharmaceuticals (Basel). 2020 Nov 28;13(12). PubMed PMID: 33260517
Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2021 Jul 8;47(4):896-905. PubMed PMID: 33184653
Clavijo CF, Oliva AM, Dingmann C, Kaizer A, Christians U, Burger E, Patel V, Kleck CJ, Vogel SA, Scott BK, Janik DJ, Jameson LC, Ginde AA. Toxicology Screening Testing in Patients Undergoing Spine Surgery: A Prospective Observational Pilot Study. Ther Drug Monit. 2021 Feb 1;43(1):136-138. PubMed PMID: 33181620
Freedman R, Hunter SK, Noonan K, Wyrwa A, Christians U, Law AJ, Hoffman MC. Maternal Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With C-reactive Protein and Cortisol. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Mar;6(3):310-320. PubMed PMID: 33060035
Ye H, Minhajuddin M, Krug A, Pei S, Chou CH, Culp-Hill R, Ponder J, De Bloois E, Schniedewind B, Amaya ML, Inguva A, Stevens BM, Pollyea DA, Christians U, Grimes HL, D'Alessandro A, Jordan CT. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discov. 2021 Feb;11(2):500-519. PubMed PMID: 33028621
Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2021 Aug 14;45(7):686-692. PubMed PMID: 33002141
Mizuno T, McPhail BT, Kamatkar S, Wexelblatt S, Ward L, Christians U, Akinbi HT, Vinks AA. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clin Pharmacokinet. 2021 Feb;60(2):249-259. PubMed PMID: 32939690
Frymoyer A, Van Meurs KP, Drover DR, Klawitter J, Christians U, Chock VY. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2020 Dec;88(6):871-877. PubMed PMID: 32919393
Van Hoogdalem MW, Johnson TN, McPhail BT, Kamatkar S, Wexelblatt SL, Ward LP, Christians U, Akinbi HT, Vinks AA, Mizuno T. Physiologically-based pharmacokinetic modeling to investigate the effect of maturation on buprenorphine pharmacokinetics in newborns with neonatal opioid withdrawal syndrome. Clin Pharmacol Ther.
Peters E, MacNair L, Mosesova I, Christians U, Sempio C, Klawitter J, Land MH, Ware MA, Turcotte C, Bonn-Miller MO. Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and ?9-tetrahydrocannabinol: a pilot study. Eur J Clin Pharmacol
Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. ?(9)-Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats. Cannabis Cannabinoid Res. 2022 Sep 30. [Epub ahead of print] PubMed PMID: 36179013
Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol. 2022 Jul 22. [Epub ahead of print] PubMed PMID: 35867237
Sempio C, Huestis MA, Kaplan B, Klawitter J, Christians U, Henthorn TK. Urinary clearance of 11-nor-9-carboxy-?(9) -tetrahydrocannabinol: A detailed pharmacokinetic analysis. Drug Test Anal. 2022 Aug;14(8):1368-1376. PubMed PMID: 35332698
Klawitter J, Sempio C, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Christians U, Klawitter J. Endocannabinoid System in Polycystic Kidney Disease. Am J Nephrol. 2022;53(4):264-272. PubMed PMID: 35263737
Cooper K, Cawthon CV, Goel E, Atigh M, Christians U, Yazdani SK. The Development of an ex vivo Flow System to Assess Acute Arterial Drug Retention of Cardiovascular Intravascular Devices. Front Med Technol. 2021;3:675188. PubMed PMID: 35047927
Hopp K, Kleczko EK, Gitomer BY, Chonchol M, Klawitter J, Christians U, Klawitter J. Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F258-F267. PubMed PMID: 35037466
van Hoogdalem MW, Johnson TN, McPhail BT, Kamatkar S, Wexelblatt SL, Ward LP, Christians U, Akinbi HT, Vinks AA, Mizuno T. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clin Pharmacol Ther. 2022 Feb;111(2):496-508. PubMed PMID: 34679189
Peters EN, MacNair L, Mosesova I, Christians U, Sempio C, Klawitter J, Land MH, Ware MA, Turcotte C, Bonn-Miller MO. Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and ?(9)-tetrahydrocannabinol: a pilot study. Eur J Clin Pharmacol. 2022 Feb;78(2):259-265. PubMed PMID: 34664109
Hunter SK, Freedman R, Law AJ, Christians U, Holzman JBW, Johnson Z, Hoffman MC. Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability. Neuroreport. 2021 Oct 6;32(14):1170-1174. PubMed PMID: 34284445
Hinckley JD, Saba L, Raymond K, Bartels K, Klawitter J, Christians U, Hopfer C. An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses. Cannabis Cannabinoid Res. 2022 Feb;7(1):65-77. PubMed PMID: 33998853
Shokati T, Drake SH, Zhao W, Klawitter J, Klawitter J, Christians U. Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns. Metabolites. 2023 Oct 19;13(10). PubMed PMID: 37887418
Martin EL, Baker NL, Sempio C, Christians U, Klawitter J, McRae-Clark AL. Sex differences in endocannabinoid tone in a pilot study of cannabis use disorder and acute cannabis abstinence. Addict Biol. 2023 Oct;28(10):e13337. PubMed PMID: 37753564
Moore BF, Salmons KA, Hoyt AT, Swenson KS, Bates EA, Sauder KA, Shapiro ALB, Wilkening G, Kinney GL, Neophytou AM, Sempio C, Klawitter J, Christians U, Dabelea D. Associations between Prenatal and Postnatal Exposure to Cannabis with Cognition and Behavior at Age 5 Years: The Healthy Start Study. Int J Environ Res Public Health. 2023 Mar 10;20(6). PubMed PMID: 36981794
Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids by LC-MS-MS in Human Plasma. J Anal Toxicol. 2022 Apr 21;46(4):383-392. PubMed PMID: 33754154
Frank BS, Khailova L, Dekermanjian J, Mitchell MB, Morgan GJ, Twite M, Christians U, DiMaria MV, Klawitter J, Davidson JA. Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. 2023 Jan;2(1). PubMed PMID: 36875009
Crouch CE, Wilkey BJ, Hendrickse A, Kaizer A, Schniedewind B, Christians U, Henthorn TK, Fernandez-Bustamante A. Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology 2022: in print.
Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. Effects of oral ?9-tetrahydrocannabinol and cannabidiol combinations on a sustained attention task in rats. Exp Clin Psychopharmacol. 2023 Oct;31(5):881-887. PubMed PMID: 36634015
Mayne GB, DeWITT PE, Ringham B, Warrener AG, Christians U, Dabelea D, Hurt KJ. A Nested Case-Control Study of Allopregnanolone and Preterm Birth in the Healthy Start Cohort. J Endocr Soc. 2022 Dec 15;7(2):bvac179. PubMed PMID: 36632210
Christians U. In Memoriam: Professor Charles E. Pippenger. Ther Drug Monit. 2023 Feb 1;45(1):1-2. PubMed PMID: 36624572
Hoffman MC, Hunter SJ, D'Alessandro A, Christians U, Law AJ, Freedman R. Maternal Plasma Choline during Gestation and Small for Gestational Age Infants. Am J Perinatol. 2022 Dec 30. [Epub ahead of print] PubMed PMID: 36584689
Crouch CE, Wilkey BJ, Hendrickse A, Kaizer AM, Schniedewind B, Christians U, Henthorn TK, Fernandez-Bustamante A. Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology. 2023 Jan 1;138(1):71-81. PubMed PMID: 36512707
Soós B, Hamar A, Pusztai A, Czókolyová M, Végh E, Szamosi S, Petho Z, Gulyás K, Kerekes G, Szántó S, Szucs G, Christians U, Klawitter J, Seres T, Szekanecz Z. Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach. Front Med (Lausanne). 2022;9:1011734. PubMed PMID: 36438060
Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. ?(9)-Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats. Cannabis Cannabinoid Res. 2022 Sep 30. [Epub ahead of print] PubMed PMID: 36179013
Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol. 2023 Jan;36(1):83-91. PubMed PMID: 35867237
Chen D, Krinsky C, Phillips M, Allred C, Khan A, Liu L, Christians U, Yazdani SK. Design and use of an ex vivo peripheral simulating bioreactor system for pharmacokinetic analysis of a drug coated stent. Bioeng. Transl. Med. 2023
Zhao W, Christians U. Challenges in the Therapeutic Drug Monitoring of Immunosuppressants. In: Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determinations. Pattanaik S, Sharma A (ed.) Elsevier, San Diego (2023), in print.
Christians U. Pharmacokinetics Laboratory Assays. In: Clinical Pharmacokinetics and Pharmacodynamics, A Precision Medicine Approach. Ramos K, Rogers S (eds.) Cognella, Solana Beach (2024), in print
Helmke SM, McRae MP, Christians U, Shokati T, Everson GT. A Validated LC-MS/MS Assay for the Quantification of Cholate Isotopes in Human Serum. J Appl Lab Med. 2024 Aug 16. [Epub ahead of print] PubMed PMID: 39150903
Younoszai N, Hollander C, Kinney GL, Hamlington KL, Klawitter J, Sempio C, Christians U, Dabelea D, Moore BF. Childhood exposure to cannabidiol and lung function: A pilot study. Pediatr Pulmonol. 2024 Jul 26. [Epub ahead of print] PubMed PMID: 39056509
Mayne G, DeWitt PE, Wen J, Schniedewind B, Dabelea D, Christians U, Hurt KJ. Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study. J Clin Endocrinol Metab. 2024 Jul 9. [Epub ahead of print] PubMed PMID: 38980936
Odell EP, Jabassini N, Schniedewind B, Pease-Raissi SE, Frymoyer A, Christians U, Green AJ, Chan JR, Ostrem BEL. Minimum effective dose of clemastine in a mouse model of preterm white matter injury. Pediatr Res. 2024 Jun 28. [Epub ahead of print] PubMed PMID: 38942888
Ward AM, Shokati T, Klawitter J, Klawitter J, Nguyen V, Kozell L, Abbas AI, Jones D, Christians U. Identification and Characterization of Cannabichromene's Major Metabolite Following Incubation with Human Liver Microsomes. Metabolites. 2024 Jun 13;14(6). PubMed PMID: 38921465
Sempio C, Campos-Palomino J, Klawitter J, Harrison A, Peters EN, MacNair L, Haghdoost M, Bonn-Miller M, Babalonis S, Huestis MA, Christians U, Klawitter J. LC-MS-MS quantification of ?8-THC, ?9-THC, THCV isomers and their main metabolites in human plasma. J Anal Toxicol. 2024 Aug 21;48(7):499-506. PubMed PMID: 38836589
Van Hove JLK, Friederich MW, Hock DH, Stroud DA, Caruana NJ, Christians U, Schniedewind B, Michel CR, Reisdorph R, Lopez Gonzalez EDJ, Brenner C, Donovan TE, Lee JC, Chatfield KC, Larson AA, Baker PR 2nd, McCandless SE, Moore Burk MF. ACAD9 treatment with bezafibrate and nicotinamide riboside temporarily stabilizes cardiomyopathy and lactic acidosis. Mitochondrion. 2024 Sep;78:101905. PubMed PMID: 38797357
Jakobs M, Hörbelt-Grünheidt T, Hadamitzky M, Bihorac J, Salem Y, Leisengang S, Christians U, Schniedewind B, Schedlowski M, Lückemann L. The Effects of Fingolimod (FTY720) on Leukocyte Subset Circulation cannot be Behaviourally Conditioned in Rats. J Neuroimmune Pharmacol. 2024 May 11;19(1):18. PubMed PMID: 38733535
Spindle TR, Zamarripa CA, Russo E, Pollak L, Bigelow G, Ward AM, Tompson B, Sempio C, Shokati T, Klawitter J, Christians U, Vandrey R. Vaporized D-limonene selectively mitigates the acute anxiogenic effects of ?9-tetrahydrocannabinol in healthy adults who intermittently use cannabis. Drug Alcohol Depend. 2024 Apr 1;257:111267. PubMed PMID: 38498958
Odell E, Jabassini N, Schniedewind B, Pease-Raissi SE, Frymoyer A, Christians U, Green AJ, Chan JR, Ostrem BEL. Minimum Effective Dose of Clemastine in a Mouse Model of Preterm White Matter Injury. bioRxiv. 2024 Mar 1. PubMed PMID: 38464078
Chen D, Krinsky C, Phillips M, Allred C, Khan A, Liu LB, Christians U, Yazdani SK. Design and use of an ex vivo peripheral simulating bioreactor system for pharmacokinetic analysis of a drug coated stent. Bioeng Transl Med. 2024 Mar;9(2):e10618. PubMed PMID: 38435812
Klawitter J, Weissenborn W, Gvon I, Walz M, Klawitter J, Jackson M, Sempio C, Joksimovic SL, Shokati T, Just I, Christians U, Todorovic SM. ß-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?. Mol Pharmacol. 2024 Jan 10;105(2):75-83. PubMed PMID: 38195158
Shokati T, Drake SH, Zhao W, Klawitter J, Klawitter J, Christians U. Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns. Metabolites. 2023 Oct 19;13(10). PubMed PMID: 37887418
Martin EL, Baker NL, Sempio C, Christians U, Klawitter J, McRae-Clark AL. Sex differences in endocannabinoid tone in a pilot study of cannabis use disorder and acute cannabis abstinence. Addict Biol. 2023 Oct;28(10):e13337. PubMed PMID: 37753564
Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. Effects of oral ?9-tetrahydrocannabinol and cannabidiol combinations on a sustained attention task in rats. Exp Clin Psychopharmacol. 2023 Oct;31(5):881-887. PubMed PMID: 36634015
Hoffman MC, Hunter SJ, D'Alessandro A, Christians U, Law AJ, Freedman R. Maternal Plasma Choline during Gestation and Small for Gestational Age Infants. Am J Perinatol. 2024 May;41(S 01):e939-e948. PubMed PMID: 36584689
Moore CF, Davis CM, Sempio C, Klawitter J, Christians U, Weerts EM. ?(9)-Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats. Cannabis Cannabinoid Res. 2024 Feb;9(1):111-120. PubMed PMID: 36179013
Zhao W, Christians U. Challenges in the Therapeutic Drug Monitoring of Immunosuppressants. In: Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determinations. Pattanaik S, Sharma A (eds.) Elsevier, San Diego (2024), in print.
Christians U. Pharmacokinetics Laboratory Assays. In: Clinical Pharmacokinetics and Pharmacodynamics, A Precision Medicine Approach. Ramos K, Rogers S (eds.) Cognella, Solana Beach (2024), in print