Medical Director: Mechanical Circulatory Support Program
Director: Advanced Heart Failure and Transplant Fellowship
Professor of Clinical Practice
Recognition & Awards
Best Doctor: Advanced Heart Failure and Transplant, 5280 Magazine
(2023)
Best Doctor: Advanced Heart Failure and Transplant, 5280 Magazine
(2018)
Best Doctor: Advanced Heart Failure and Transplant, 5280 Magazine
(2017)
Faculty of the Year, Cardiology Fellows University of Colorado
(2008)
Publications
Kim G, Sayer G, Ransom J, Keebler M, Katz J, Kilic A, Lindenfeld J, Egnaczyk G, Shah P, Brieke A, Walenga J, Crandall D, Farrar DJ, Sundareswaran K, Uriel N. Association of Angiopoetin-2 and TNF-a With Bleeding During Left Ventricular Assist Device Support: Analysis From the PREVENT Biorepository. ASAIO J. 2023 Aug 1;69(8):742-748. PubMed PMID: 37134003
Stone GW, Abraham WT, Lindenfeld J, Kar S, Grayburn PA, Lim DS, Mishell JM, Whisenant B, Rinaldi M, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Marx SO, Cohen DJ, Asch FM, Mack MJ. Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation. N Engl J Med. 2023 Jun 1;388(22):2037-2048. PubMed PMID: 36876756
Jeske W, Ransom J, Katz JN, Kilic A, Lindenfeld J, Egnaczyk G, Shah P, Brieke A, Uriel N, Crandall D, Farrar DJ, Walenga JM. Enhanced Thrombin Formation in Patients With Ventricular Assist Devices Experiencing Bleeding: Insights From the Multicenter PREVENT Study. ASAIO J. 2023 Mar 1;69(3):278-283. PubMed PMID: 36731068
Cowger JA, Estep JD, Rinde-Hoffman DA, Givertz MM, Anderson AS, Jacoby D, Chen L, Brieke A, Mahr C, Hall S, Ewald GA, Dirckx N, Baker AT, Pinney SP. Variability in Blood Pressure Assessment in Patients Supported with the HeartMate 3TM. ASAIO J. 2022 Mar 1;68(3):374-383. PubMed PMID: 34172641
Cowger JA, Estep JD, Rinde-Hoffman DA, Givertz MM, Anderson AS, Jacoby D, Chen L, Brieke A, Mahr C, Hall S, Ewald GA, Dirckx N, Baker AT, Pinney SP. Variability in Blood Pressure Assessment in Patients Supported with the HeartMate 3TM. ASAIO J. 2022 Mar 1;68(3):374-383. PubMed PMID: 34172641
Mack MJ, Lindenfeld J, Abraham WT, Kar S, Lim DS, Mishell JM, Whisenant BK, Grayburn PA, Rinaldi MJ, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Rogers JH, Marx SO, Cohen DJ, Weissman NJ, Stone GW. 3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure. J Am Coll Cardiol. 2021 Mar 2;77(8):1029-1040. PubMed PMID: 33632476
Lerakis S, Kini AS, Asch FM, Kar S, Lim DS, Mishell JM, Whisenant B, Grayburn PA, Weissman NJ, Rinaldi MJ, Sharma SK, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Tang GHL, Li D, Crowley A, Lindenfeld J, Abraham WT, Mack MJ, Stone GW. Outcomes of Transcatheter Mitral Valve Repair for Secondary Mitral Regurgitation by Severity of Left Ventricular Dysfunction. EuroIntervention. 2021 Feb 16. [Epub ahead of print] PubMed PMID: 33589408
Kosmidou I, Lindenfeld J, Abraham WT, Rinaldi MJ, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Gaba P, Rogers JH, Shahim B, Redfors B, Zhang Z, Mack MJ, Stone GW. Sex-Specific Outcomes of Transcatheter Mitral-Valve Repair and Medical Therapy for Mitral Regurgitation in Heart Failure. JACC Heart Fail. 2021 Sep;9(9):674-683. PubMed PMID: 34391744
Mack MJ, Lindenfeld J, Abraham WT, Kar S, Lim DS, Mishell JM, Whisenant BK, Grayburn PA, Rinaldi MJ, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Rogers JH, Marx SO, Cohen DJ, Weissman NJ, Stone GW. 3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure. J Am Coll Cardiol. 2021 Mar 2;77(8):1029-1040. PubMed PMID: 33632476
Lerakis S, Kini AS, Asch FM, Kar S, Lim DS, Mishell JM, Whisenant B, Grayburn PA, Weissman NJ, Rinaldi MJ, Sharma SK, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Tang GHL, Li D, Crowley A, Lindenfeld J, Abraham WT, Mack MJ, Stone GW. Outcomes of transcatheter mitral valve repair for secondary mitral regurgitation by severity of left ventricular dysfunction. EuroIntervention. 2021 Jul 20;17(4):e335-e342. PubMed PMID: 33589408
Purohit SN, Lee PJ, Strobel AL, Desai AA, Marsala MT, Bull TM, Brieke A, Vargas D, Kay JD, Altman NL. Unusual Case of Acquired Hypoxemia Following Left Ventricular Assist Device Implantation. Circ Heart Fail. 2020 Jan;13(1):e006394. PubMed PMID: 31896269
Pal JD, Cleveland J, Reece BT, Byrd J, Pierce CN, Brieke A, Cornwell WK 3rd. Cardiac Emergencies in Patients with Left Ventricular Assist Devices. Heart Fail Clin. 2020 Jul;16(3):295-303. PubMed PMID: 32503753
Purohit SN, Lee PJ, Strobel AL, Desai AA, Marsala MT, Bull TM, Brieke A, Vargas D, Kay JD, Altman NL. Unusual Case of Acquired Hypoxemia Following Left Ventricular Assist Device Implantation. Circ Heart Fail. 2020 Jan;13(1):e006394. PubMed PMID: 31896269
Flint K, Brieke A, Wiktor D, Carroll J. Percutaneous edge-to-edge mitral valve repair may rescue select patients in cardiogenic shock: Findings from a single center case series. Catheter Cardiovasc Interv. 2019 Jan 24. [Epub ahead of print] PubMed PMID: 30677212
Baron SJ, Wang K, Arnold SV, Magnuson EA, Whisenant B, Brieke A, Rinaldi M, Asgar AW, Lindenfeld J, Abraham WT, Mack MJ, Stone GW, Cohen DJ. Cost-Effectiveness of Transcatheter Mitral Valve Repair Versus Medical Therapy in Patients With Heart Failure and Secondary Mitral Regurgitation: Results From the COAPT Trial. Circulation. 2019 Dec 3;140(23):1881-1891. PubMed PMID: 31564137
Flint KM, Brieke A, Cornwell WK 3rd, Pierce C, Cleveland JC, Pal JD. HeartMate II System Controller Failure Presenting as Driveline Fault With Repeated Pump Stoppages. Circ Heart Fail. 2019 Jul;12(7):e005738. PubMed PMID: 31213070
Flint K, Brieke A, Wiktor D, Carroll J. Percutaneous edge-to-edge mitral valve repair may rescue select patients in cardiogenic shock: Findings from a single center case series. Catheter Cardiovasc Interv. 2019 Aug 1;94(2):E82-E87. PubMed PMID: 30677212
Stone GW, Lindenfeld J, Abraham WT, Kar S, Lim DS, Mishell JM, Whisenant B, Grayburn PA, Rinaldi M, Kapadia SR, Rajagopal V, Sarembock IJ, Brieke A, Marx SO, Cohen DJ, Weissman NJ, Mack MJ. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med. 2018 Dec 13;379(24):2307-2318. PubMed PMID: 30280640
Mehra MR, Goldstein DJ, Uriel N, Cleveland JC Jr, Yuzefpolskaya M, Salerno C, Walsh MN, Milano CA, Patel CB, Ewald GA, Itoh A, Dean D, Krishnamoorthy A, Cotts WG, Tatooles AJ, Jorde UP, Bruckner BA, Estep JD, Jeevanandam V, Sayer G, Horstmanshof D, Long JW, Gulati S, Skipper ER, O'Connell JB, Heatley G, Sood P, Naka Y. Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. N Engl J Med. 2018 Apr 12;378(15):1386-1395. PubMed PMID: 29526139
Patel AC, Dodson RB, Cornwell WK 3rd, Hunter KS, Cleveland JC Jr, Brieke A, Lindenfeld J, Ambardekar AV. Dynamic Changes in Aortic Vascular Stiffness in Patients Bridged to Transplant With Continuous-Flow Left Ventricular Assist Devices. JACC Heart Fail. 2017 Mar 4. [Epub ahead of print] PubMed PMID: 28285118
Maltais S, Kilic A, Nathan S, Keebler M, Emani S, Ransom J, Katz JN, Sheridan B, Brieke A, Egnaczyk G, Entwistle JW 3rd, Adamson R, Stulak J, Uriel N, O'Connell JB, Farrar DJ, Sundareswaran KS, Gregoric I. PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management: The PREVENT multi-center study. J Heart Lung Transplant. 2017 Jan;36(1):1-12. PubMed PMID: 27865732
Patel AC, Dodson RB, Cornwell WK 3rd, Hunter KS, Cleveland JC Jr, Brieke A, Lindenfeld J, Ambardekar AV. Dynamic Changes in Aortic Vascular Stiffness in Patients Bridged to Transplant With Continuous-Flow Left Ventricular Assist Devices. JACC Heart Fail. 2017 Jun;5(6):449-459. PubMed PMID: 28285118
Maltais S, Kilic A, Nathan S, Keebler M, Emani S, Ransom J, Katz JN, Sheridan B, Brieke A, Egnaczyk G, Entwistle JW 3rd, Adamson R, Stulak J, Uriel N, O'Connell JB, Farrar DJ, Sundareswaran KS, Gregoric I. PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management: The PREVENT multi-center study. J Heart Lung Transplant. 2017 Jan;36(1):1-12. PubMed PMID: 27865732
McIlvennan CK, Babu AN, Brieke A, Ambardekar AV. Concomitant surgical cryoablation for refractory ventricular tachycardia and left ventricular assist device placement: a dual remedy but a recipe for thrombosis?. J Cardiothorac Surg. 2016 Apr 11;11(1):53. PubMed PMID: 27067868
Borne RT, Babu A, Levi M, Brieke A, Quaife RA. Tropheryma whipplei Endocarditis: A Two-patient Case Series. Am J Med. 2015 Dec;128(12):1364-6. PubMed PMID: 26239095
McIlvennan CK, Page RL 2nd, Ambardekar AV, Brieke A, Lindenfeld J. Activated partial thromboplastin time overestimates anti-coagulation in left ventricular assist device patients. J Heart Lung Transplant. 2014 Dec;33(12):1312-4. PubMed PMID: 25443872
McIlvennan CK, Allen LA, Nowels C, Brieke A, Cleveland JC, Matlock DD. Decision making for destination therapy left ventricular assist devices: "there was no choice" versus "I thought about it an awful lot". Circ Cardiovasc Qual Outcomes. 2014 May;7(3):374-80. PubMed PMID: 24823949
Clinical Interests
My clinical interests include patients with severe heart failure, their treatment, including the need for heart transplantation, or the need for an artificial heart (i.e. mechanical circulatory support).
General Information
Medical Schools:
MD, Ludwig Maximillian University of Munich - Munich, Germany
(1995)
Internships:
Cleveland Clinic Foundation Program
(2000)
Residency Programs:
Cleveland Clinic Foundation Program, Internal Medicine (2002)
Fellowships:
Tufts-New England Medical Center Program, General Cardiology
(2002)