Milene Saavedra, MD

Research Interests

My research focuses on Cellular and Molecular Biology, Cystic Fibrosis and Inflammation.

Publications

• Walker TS, Tomlin KL, Worthen GS, Poch KR, Lieber JG, Saavedra MT, Fessler MB, Malcolm KC, Vasil ML, Nick JA. Enhanced Pseudomonas aeruginosa Biofilm Development Mediated by Human Neutrophils. Infect Immun. 2005 Jun;73(6):3693-701.
• . Wick MJ, Blaine S, Van Putten V, Saavedra M, Nemenoff RA. Lung Kruppel-like factor (LKLF) is a transcriptional activator of the cytosolic phospholipase A2 alpha promoter. Biochem J. 2005 Apr 1: 387 (Pt 1):239-46.
• . Rodman DM, Polis JM, Heltshe SL, Sontag MK, Chacon C, Rodman RV, Brayshaw SJ, Huitt GA, Iseman MD, Saavedra MT, Taussig LM, Wagener JS, Accurso FJ, Nick JA. Late Diagnosis Defines a Unique Population of Long-term Survivors of Cystic Fibrosis. Am J Respir Crit Care Med. 2005 Mar 15;171(6):621-6. 2004 Dec 10.
• Ding W, Yan Z, Zak R, Saavedra M, Rodman DM, Engelhardt JF. Second-strand genome conversion of adeno-associated virus type 2 (AAV-2) and AAV-5 is not rate limiting following apical infection of polarized human airway epithelia. J Virol. 2003 Jul; 77(13):
• . Zabner J, Karp P, Seiler M, Phillips SL, Mitchell CJ, Saavedra M, Welsh M, Klingelhutz AJ. Development of cystic fibrosis and noncystic fibrosis airway cell lines. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5): L844-54.
• Saavedra M, Nick J. Chronic Bronchiectasis and Cystic Fibrosis, Current Diagnosis and Treatment in Pulmonary Medicine, Lange Medical Books/ Mc-Graw Hill, 2003.
• Saavedra M., Vasil M., Randell S., West J., Rodman D., Pseudomonas aeruginosa-human airway epithelial cell interaction: effects of iron on inflammation and apoptosis. Chest. 2002 Mar;121(3 Suppl):40S-41S
• Saavedra M., Hanley M. Pneumothorax in Critical Care Secrets, Lippincott, Williams and Wilkins, 2002.
• Saavedra M., Hanley M. Atypical mycobacterial diseases in Critical Care Secrets, Lippincott, Williams and Wilkins, 2002.
• Pediatric Pulmonology, Volume 41, Issue S29 (p 209-415)
• Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L154-64. Epub 2006 Sep 1
• Saavedra MT, Patterson AD, West J, Randell SA, Riches DW, Malcolm KC, Cool CD, Nick JA, Dinarello CA. Abstract Abrogation of Anti-inflammatory Transcription Factor LKLF in Neutrophil Dominated Airways. Am J Respir Cell Mol Biol. 2008 Jan 24; [Epub ahead of print] PMID: 18218994 [PubMed - as supplied by publisher]

Practice Locations

National Jewish Health
1400 Jackson St
Denver, CO 80206
1-877-225-5654

Hospital Affiliation

• University of Colorado Hospital
• National Jewish Health

Specialty Information

Specialties

• Internal Medicine, Board Certification
• Pulmonary Disease and Critical Care Medicine, Board Certification

Conditions & Treatments

• Lungs and Breathing - Pulmonary Disorders
• Lungs and Breathing - Cystic Fibrosis
• Critical Care
• Lungs and Breathing