Loss of an gimap/ian Gene leads to Activation of NF-kB Through a MAPK Dependent Pathway. Mol. Immunol. [Epub ahead of print] (First two authors contributed equally).Loss of an gimap/ian Gene leads to Activation of NF-ɻB Through a MAPK Dependent Pathway
A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. Immunity. 22(4):519-31.
Jubala, C.M., M. Borakove, J. Lang, A. R. Lamerato, D. Coffey, K. M. Helm, J. Schaak, M. Baier, G. C. Cutter, D. Bellgrau, and J. F. Modiano. 2006. MHC-Dependent Desensitization of Intrinsic Anti-Self Reactivity. J. Immunol. Submitted.
Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway.
Mol Immunol. 2007 Jan;44(4):479-87. Epub 2006 Apr 11.
Coleman CB, Lang J, Sweet LA, Smith NA, Freed BM, Pan Z, Haverkos B, Pelanda R, Rochford R. Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice. J Virol. 2018 Nov 1;92(21). PubMed PMID: 30089703
Tentler J, Kim DJ, Benaim E, Lee YB, Eisen A, Bagby SM, Lang J, Pitts TM, Capasso A, Dailey KL and Diamond JR. RX-5902, a Beta-catenin Modulator, Enhances Immunotherapy through Positive Alterations in the Tumor Immunologic Environment in Preclinical models of Triple Negative Brest Cancer. 2018. EORTC-NCI-AACR Symposium.
Anna Capasso, Julie Lang, Jena D. French, Stacey M. Bagby, Lia S. Head, Adwitiya Kar, Hilary Somerset, Toshimasa J. Clark, Todd M. Pitts, Kimberly Jordan, Margaret E. Wierman, Stephen Leong, Katja Kiseljak-Vassiliades. Efficacy of Immunotherapy in a Patient Derived Xenograft of Metastatic Adrenocortical Carcinoma in a Humanized Mouse Model Correlated with Patient Response. 2018 March 17-20. Endocrine Society Meeting.
Lang J, Capasso A*, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R and Eckhardt SG. Immune responses to tumor xenografts implanted in hematopoietic humanized mice correlate with tumor growth inhibition upon anti-PD-1 therapy. In: Keystone Symposium: Uncovering Mechanisms of Immune-Based Therapy in Cancer and Autoimmunity; 2019 Feb 18-22; Breckenridge, CO. Silverthorne (CO): Keystone; 2019.
Lang J, Capasso A, Jordan KR, French JD, Kar A, Bagby SM, Barbee J, Yacob BW, Head LS, Tompkins KD, Freed BM, Somerset H, Clark TJ, Pitts TM, Messersmith WA, Eckhardt SG, Wierman ME, Leong S, Kiseljak-Vassiliades K. Development of an Adrenocortical Cancer Humanized Mouse Model to Characterize Anti-PD1 Effects on Tumor Microenvironment. J Clin Endocrinol Metab. 2020 Jan 1;105(1). PubMed PMID: 31513709
Julie Lang, Alexis D. Leal, Sarah J. Hartmann, Juan Marin-Jimenez, Jeremy Shulman, Anna Capasso, Stacey M. Bagby, Bethlehem W. Yacob, Patrick J. Blatchford, Christopher H. Lieu, Wells A. Messersmith and Todd M. Pitts. Cabozantinib Sensitizes Microsatellite Stable Colorectal Cancer to Immune Checkpoint Inhibition by Immune Modulation in Humanized Mouse Models; AACR meeting of Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; 2019. Abstract nr 109A.
JA. Mari´n, A. Capasso, S. Bagby, S. Hartman3, J. Shulman, J. Barkow, B. Yacob, P. Blatchford, T. Pitts, J. Lang. 2019. Evaluation of immune responses among responders vs non-responders in a humanized mouse model with colorectal cancer xenografts treated with combination immunotherapy. In European Society of Medical Oncologists Congress; 2019 Sep 27-Oct 1; Barcelona, Spain. Lugano (SZ): ESMO; 2019. Abstract No.3430.
Capasso A, Lang J, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, Eckhardt SG. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunother Cancer. 2019 Feb 8;7(1):37. PubMed PMID: 30736857
Tentler JJ, Lang J, Capasso A, Kim DJ, Benaim E, Lee YB, Eisen A, Bagby SM, Hartman SJ, Yacob BW, Gittleman B, Pitts TM, Pelanda R, Eckhardt SG, Diamond JR. RX-5902, a novel ß-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer. BMC Cancer. 2020 Nov 4;20(1):1063. PubMed PMID: 33148223
Lang J, Capasso A, Jordan KR, French JD, Kar A, Bagby SM, Barbee J, Yacob BW, Head LS, Tompkins KD, Freed BM, Somerset H, Clark TJ, Pitts TM, Messersmith WA, Eckhardt SG, Wierman ME, Leong S, Kiseljak-Vassiliades K. Development of an Adrenocortical Cancer Humanized Mouse Model to Characterize Anti-PD1 Effects on Tumor Microenvironment. J Clin Endocrinol Metab. 2020 Jan 1;105(1). PubMed PMID: 31513709
Alves da Costa, T, J. Lang, R.M. Torres and R. Pelanda. 2019. The development of human immune system mice and their use to study tolerance and autoimmunity. Journal of Translational Autoimmunity Vol 2, Dec 2019, 100021.
Marín-Jiménez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021;12:607282. PubMed PMID: 33854497
Alves da Costa T, Peterson JN, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM, Pelanda R. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). PubMed PMID: 33850015
Lang J, Leal AD, Marín-Jiménez JA, Hartman SJ, Shulman J, Navarro NM, Lewis MS, Capasso A, Bagby SM, Yacob BW, MacBeth M, Freed BM, Eckhardt SG, Jordan K, Blatchford PJ, Pelanda R, Lieu CH, Messersmith WA, Pitts TM. Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models. Front Oncol. 2022;12:877635. PubMed PMID: 36419897
Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R. Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies. Front Immunol. 2022;13:795209. PubMed PMID: 35185888
Lanis, J. M., Lewis, M. S., Strassburger, H., Bagby, S. M., Dominguez, A. T. A., Marín-Jiménez, J. A., Pelanda, R., Pitts, T. M., Lang, J. Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors. < em>J. Vis. Exp.< /em> (190), e64606, doi:10.3791/64606 (2022).
Julie Lang, PhD; Adrian Dominquez; Matthew Lewis, MS; Sarah J. Hartmann, MS; Jordi M. Lanis, PhD; Hannah Strassburger; Wells A. Messersmith, MD, FACP, FASCO; S. Lindsey Davis, MD; Alexis D. Leal, MD; Sunnie Kim, MD; Kimberly R. Jordan, PhD; Tyler Friedrich, MD; Christopher Lieu, MD; Todd Pitts, PhD. Triple therapy (binimetinib, bevacizumab, pembrolizumab) modulates the tumor immune microenvironment in microsatellite stable colorectal cancer PDXs in a humanized mice model. SITC Annual conference. 2022, Boston, MA.
Lanis, J. M., Lewis, M. S., Strassburger, H., Larsen, K., Bagby, S. M., Dominguez, A. T. A., Marín-Jiménez, J. A., Pelanda, R., Pitts, T. M., Lang, J. Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors. < em>J. Vis. Exp.< /em> (190), e64606, doi:10.3791/64606 (2022).