Lauren Frey, MD

Professional Titles

• Director, Neurofeedback Clinic

Publications

• Hankin JA, Farias S, Barkley RM, Heidenreich K, Frey LC, Hamazaki K, Kim H, Murphy RC. MALDI Mass Spectrometric Imaging of Lipids in Rat Brain Injury Models. JASMS. In press.
• Strom LA, Koh S, Frey L. New antiepileptic drugs: Lacosamide, rufinamide and vigabatrin. Current Treatment Options in Neurology 2010;12:287-299.
• Schickedanz A, Hasebroock K, Lepkin A, Serkova N, Frey LC. Assessment of a novel, non-invasive measure of acute posttraumatic brain edema. Abstract. RaCAS Symposium. April 2010.
• Spitz, M., Moreland, S., Frey, L., O’Brien, C., Shrestha, A., Strom, L.: Ablative temporal lobe epilepsy surgery should be considered in patients with a pre-existing liver transplantation. Abstract 3.125. American Epilepsy Society Annual Meeting. December 2010.
• Frey LC, Lepkin A, Hasebroock K, Serkova N. Blood-brain barrier disruption on T1-weighted MRI is a biomarker for seizure susceptibility after experimental traumatic brain injury in the rat. Platform A-05. Annual Meeting of the American Epilepsy Society. December 2010.
• Strom LA, Frey LC, Spitz MC. Continuous EEG monitoring in a tertiary care facility. Abstract. American Clinical Neurophysiology Society Annual Meeting. February 2010.
• Hankin JA, Farias S, Barkley RM, Heidenreich K, Frey LC, Hamazaki K, Kim H, Murphy RC. MALDI Mass Spectrometric Imaging of Lipids in Rat Brain Injury Models. JASMS 2011;22:1014-1021.
• Rodgers KA, Deming YK, McCallum DL, Frey LC, Johnson KW, Watkins LR, Barth DS. Acute neuroimmune modulation prevents the development of anxiety-like behavior in and animal model of traumatic brain injury. Journal of Neurotrauma. In press.
• Frey L, Lepkin A, Schickedanz A, Hasebroock K, Brown MS, Serkova N. ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury. Neurological Research 2014;36:26-37.
• Frey LC, Spitz MC. Physiologic Basis of EEG Generation of Electrical Activity of the Cerebral Cortex. In: Arciniegas D, Anderson A, Filley C, Eds. Behavioral Neurology and Neuropsychiatry. 2013.
• Frey, LC. Clinical Diagnosis and Treatment of Posttraumatic Epilepsy. In: Arciniegas D, Jaffee M, Vanderploeg R, Zasler N, Eds. Clinical Manual for the Management of Adults with Traumatic Brain Injury. 2013.
• Raible D, Boychuk J, Butler C, Cruz del Angel, Y, Russek S, Smith BN, Frey L, Brooks-Kayal A. Jak/STAT inhibition to prevent post-traumatic epileptogenesis. Abstract 1.015. American Epilepsy Society Annual Meeting. December 2013.
• Drees C, Makic M, Hill A, Limon S, Mancuso M, Walczak P, Biesecker K, Wikler K, Bravo K, Frey L. Incidence and risk factors for electrode-related skin irritation during video-EEG monitoring. Abstract 2.002. American Epilepsy Society Annual Meeting. December 2013.
• Spitz M, Drees C, Frey L, Fleming J, Bainbridge J, Pearson S, Shrestha A, Strom L. Pharmaco-adherence in patients with epilepsy and neurologic tumors. Abstract 2.171. American Epilepsy Society Annual Meeting. December 2013.
• Bainbridge J, Spitz M, Frey L, McDermott D, Drees C, O’Brien C, Strom L, Shrestha A, Pearson S. Retrospective study of lacosamide in the elderly (>60). Abstract 2.172. American Epilepsy Society Annual Meeting. December 2013.
• McDermott D, Frey L, Faithe M, Bainbridge J, O’Brien C, Oh C, Pearson S, Shrestha A, Strom L, Spitz M, Drees C. Improving time to treatment and resolution of status epilepticus. Abstract 3.153. American Epilepsy Society Annual Meeting. December 2013.
• Frey L, Friedlander L, Strom L. Impact of Sensorimotor Rhythm (SMR) neurofeedback on quality of life in patients with epilepsy: A case series. Abstract 3.222. American Epilepsy Society Annual Meeting. December 2013.
• Frey, LC. Clinical Diagnosis and Treatment of Posttraumatic Epilepsy. In: Arciniegas D, Jaffee M, Vanderploeg R, Zasler N, Eds. Clinical Manual for the Management of Adults with Traumatic Brain Injury. In press.
• C. Livsey, L. Frey, M. Spitz: Is it Peri-ictal Cough or Cough-related Syncope? American Epilepsy Society Abstract December 2011.
• Raible DJ, Frey LC, Brooks-Kayal AR. Effects of JAK2-STAT3 signaling after cerebral insults. JAKSTAT. 2014;3:e29510. PubMed PMID: 25105066
• Lampe E, Forster J, Herbst E, Spitz M, Frey L. Pre-admission clinical factors affect length of stay in the epilepsy monitoring unit. Neurodiagn J. 2014 Jun;54(2):138-47. PubMed PMID: 25080773
• Corser-Jensen CE, Goodell DJ, Freund RK, Serbedzija P, Murphy RC, Farias SE, Dell'Acqua ML, Frey LC, Serkova N, Heidenreich KA. Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. Exp Neurol. 2014 Jun;256:7-16. PubMed PMID: 24681156
• Frey L, Lepkin A, Schickedanz A, Huber K, Brown MS, Serkova N. ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury. Neurol Res. 2014 Jan;36(1):26-37. PubMed PMID: 24107461
• 7. Rodgers KA, Deming YK, McCallum DL, Frey LC, Johnson KW, Watkins LR, Barth DS. Acute neuroimmune modulation prevents the development of anxiety-like behavior in and animal model of traumatic brain injury. Journal of Neurotrauma 2012;29:1886-1897.
• Frey, LC, Hamilton B. Seizures. In: Fillipi M, Simon J, Eds. Imaging Acute Neurological Disease: A Symptom-based Approach. Cambridge University Press. 2014.
• 8. Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, and Brooks-Kayal AR (2012) GABAA Receptor Regulation after Experimental Traumatic Brain Injury. Journal of Neurotrauma 2012;29:2548-2554.
• 7. Frey LC, Spitz MC. Physiologic Basis of EEG Generation of Electrical Activity of the Cerebral Cortex. In: Arciniegas D, Anderson A, Filley C, Eds. Behavioral Neurology and Neuropsychiatry. 2013.
• 14. Boychuk JA, Butler CR, Raible D, Frey L, Brooks-Kayal AR, Smith BN. Focal traumatic brain damage results in localized GABA neuron loss and JAK/STAT activation early following injury. Abstract 2.007. American Epilepsy Society Annual Meeting. December 2012.
• 15. Lampe E, Herbst E, Frey L. Clinical factors affecting length of stay in the Epilepsy Monitoring Unit. Abstract 2.341. American Epilepsy Society Annual Meeting. December 2012.
• Frey LC and Koberda JL. LORETA Z-score Neurofeedback in Patients with Medically Refractory Epilepsy. Neurol Neurobiol 2015, Volume1.1: http://dx.doi.org/10.16966/2379-7150.102
• Raible DJ, Frey LC, Cruz Del Angel Y, Carlsen J, Hund D, Russek SJ, Smith BN. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Experimental Neurology 2015;271:445-456.
• Miravalle A, Frey L, Simpson J, West M, Rich A. Leaders in Education, Administration and Research: Developing a Leadership Curriculum in a Neurology Residency Program. Poster and abstract presented at the Annual American Academy of Neurology annual meeting, Washington, D.C. April 21, 2015
• Miravalle A, Corboy J, Frey L, Jones W, Simpson J, Quan D, Rich A. Increasing Faculty Involvement in Educational Activities. Poster presentation at the Annual American Neurologic Association meeting, Chicago, IL September 28, 2015.
• Frey LC. Impact of sensorimotor rhythm (SMR) neurofeedback on quality of life in patients with medically-refractory seizures. Oral platform presentation. Annual Meeting of the International Society for Neurofeedback Research. October 2015.
• Bainbridge J, Wong P-S, Spitz M, Frey L, Shrestha A, Strom L, Benbadis S, Sriven J, Chung SS. Retrospective study of lacosamide in the elderly (>= 60 years of age). Abstract 3.073. American Epilepsy Society Annual Meeting. December 2015.
• 16. McDermott D, Strom L, Frey L. Presurgical evaluation of epilepsy surgery in adult patients with Tuberous Sclerosis Complex. Abstract 3.289. American Epilepsy Society Annual Meeting. December 2012.
• 17. A. Shrestha, T. Larabee, L. Frey, K. Polovitz, J. Campbell. Deterioration in the EEG Following Rewarming in Cardiac Arrest Patients After mild Therapeutic Hypothermia. Abstract 3.078. American Epilepsy Society Annual Meeting. December 2012.
• 18. M. C. Spitz, M. Friedman, L. Frey, C. Drees, S. Pearson. Forensic Implications of Ictal or Peri-Ictal Grabbing Behaviors. Abstract 3.093. American Epilepsy Society Annual Meeting. December 2012.
• Britton JW, Frey LC, Hopp JL, Korb P, Koubeissi MZ, Lievens WE, Pestana-Knight EM, St. Louis EK. . . 2016. PubMed PMID: 27748095
• Frey L. Impact of sensorimotor rhythm neurofeedback on quality of life in patients with medically-refractory seizures: A pilot study. NeuroRegulation 2016;3:3-6.
• Drees C, Makic MB, Case K, Mancuso MP, Hill A, Walczak P, Limon S, Biesecker K, Frey L. Electrode-related skin irritation during video-EEG monitoring. The Neurodiagnostic Journal 56 (3): 139-150, 2016.
• Miravalle A, Josefowitz R, Schreiner T, Ney D, Korb P, Anderson CA, Frey L, McNulty M, Aagaard E. Development of validated neurology-specific rotational EPAs for GME. Poster presentation American Association of Medical Colleges Annual Meeting. November 2016.
• Frey L. Does an abnormal baseline EEG predict the outcomes of neurofeedback training in patients with medically-refractory epilepsy? Abstract 2.234. American Epilepsy Society Annual Meeting. December 2017.
• Reese JW, Frey L, Janosy N, Brainard A, Morris C, Beacham A. Addressing effects of adverse clinical events in physicians: An opportunity to reduce burnout. Poster presentation. American Conference on Physician Health. October 2017.
• Frey LC, Turner R. Seizures and Epilepsy. In: Coben R, Ed. Neurofeedback and Neuromodulation Techniques and Applications
• Reese J, Brainard A, Morris C, Frey L, Janosy N, Beacham A. Addressing effects of adverse clinical events in pediatric providers: An opportunity to reduce burnout. Poster presentation. Pediatric Academic Societies Annual Meeting. May 2017.
• Frey LC. In: Evans JR, Delliger MB and Russell HL, Eds. Neurofeedback: The First 50 Years.
• Frey LC. Spinal muscular atrophy: clinical aspects. Neurology Times. Published May 14, 2019. https://www.neurologytimes.com/nervous-system-diseases/spinal-muscular-atrophy-clinical-aspects.

Professional Memberships

• American Epilepsy Society, Fellow
• International Society for Neurofeedback Research, Member

Specialty Information

• Neurology, Board Certification (2013)
• Epilepsy (2013)
• Biofeedback Certification International Alliance- Neurofeedback, Certificate (2013)

• Brain and Nervous System
• Brain and Nervous System - Epilepsy