Joshua Klopper, MD

Recognitions

• Loan Repayment Award, NIH (2010)
  2nd Renewal LRP award
• Loan Repayment Award, NIH (2008)
  1st Renewal LRP award
• Junior Faculty Poster Award, UCD Department of Medicine Research Day (2007)
  Research Poster Award
• Loan Repayment Award, NIH (2006)
  Initial Loan Repayment Award

Research Interests

Publications

• Joshua Klopper, Andrew Berenz and Bryan Haugen. Acquired Resistance to a Rexinoid and TZD in the Anaplastic Thyroid Cancer Cell Line DRO Occurs in Part through Decreased PPAR? Expression. American Thyroid Association, 2006.
• Joshua Klopper, Vibha Sharma and Bryan Haugen. PPAR? Expression Is Required For the Anti-Proliferative Effect of A Rexinoid and TZD In The Anaplastic Thyroid Cancer Cell Line DRO. Endocrine Society, 2007
• Klopper, J and McDermott, M. Pediatric Papillary Thyroid Cancer: An Aggressive Presentation of an Aggressive Disease. Journal of Medical Case Reports. Submitted.
• Klopper, JP, Berenz, A, Hays, WR et al. In Vivo and Microarray Analysis of the Treatment Effects of a Rexinoid on the Anaplastic Thyroid Carcinoma Cell Line DRO-90. Clinical Cancer Research. Submitted.
• Mehra S, Tuttle RM Md, Bergman DA, Bernet V, Brett EM, Cobin R, Doherty G, Klopper J, Lee SL, Machac J, Milas M, Mechanick JI, Orloff LA, Randolph G, Ross DS, Smallridge RC, Terris DJ, Tufano R, Alon E, Clain J, Dos Reis LL, Scherl S, Urken ML. Improving the Quality of Thyroid Cancer Care: How Does the Thyroid Cancer Care Collaborative Cross the Institute of Medicine's Quality Chasm?. Thyroid. 2014 Feb 10. [Epub ahead of print] PubMed PMID: 24512449
• Urken ML, Milas M, Randolph GW, Tufano R, Bergman D, Bernet V, Brett EM, Brierley JD, Cobin R, Doherty G, Klopper J, Lee S, Machac J, Mechanick JI, Orloff LA, Ross D, Smallridge RC, Terris DJ, Clain JB, Tuttle M. A review of the management of recurrent and persistent metastatic lymph nodes in well differentiated thyroid cancer: A multifactorial decision making guide created for the Thyroid Cancer Care Collaborative. Head Neck. 2014 Jan 17. [Epub ahead of print] PubMed PMID: 24436291
• Alexander EK, Schorr M, Klopper J, Kim C, Sipos J, Nabhan F, Parker C, Steward DL, Mandel SJ, Haugen BR. Multicenter clinical experience with the Afirma gene expression classifier. J Clin Endocrinol Metab. 2014 Jan;99(1):119-25. PubMed PMID: 24152684
• Klopper JP, McDermott MT. Palpable pediatric thyroid abnormalities - diagnostic pitfalls necessitate a high index of clinical suspicion: a case report. J Med Case Reports. 2007 Jun 22;1(1):29
• Smallridge RC, Copland JA, Brose MS, Wadsworth JT, Houvras Y, Menefee ME, Bible KC, Shah MH, Gramza AW, Klopper JP, Marlow LA, Heckman MG, Von Roemeling R. Efatutazone, an oral PPAR-? agonist, in combination with paclitaxel in anaplastic thyroid cancer: results of a multicenter phase 1 trial. J Clin Endocrinol Metab. 2013 Jun;98(6):2392-400. PubMed PMID: 23589525
• Klopper, JP and Haugen BR. (2013). Follicular Thyroid Cancer. In GW Randolph, Surgery for the Thyroid and Parathyroid Glands, 2nd Edition (pp. 197-202). Philadelphia: Elsevier.
• JP Klopper, MA Kane and BR Haugen. (2013). Anaplastic Thyroid Cancer and Miscellaneous Tumors of the Thyroid. In LE Braverman and DS Cooper, Werner & Ingbar’s The Thyroid A Fundamental and Clinical Text, 10th Edition (pp. 765-774). Philadelphia: Lippincott Williams & Wilkins.
• Joshua P. Klopper, Andrew Berenz, William R. Hays, Vibha Sharma, Umarani Pugazhenthi, Jennifer Janssen, Meenakshi Singh, Reid P. Bissonnette and Bryan R. Haugen. In Vivo and Microarray Analysis of Rexinoid Responsive Anaplastic Thyroid Carcinoma. Clin Cancer Res. 2008 Jan 15; 14(2):589-596.
• Joshua Klopper. (2013). Thyroid Cancer. In Michael T. McDermott, Endocrine Secrets, 6th Edition (pp. 301-308). Philadelphia: Elsevier.
• Joshua P. Klopper, Andrew J. Berenz, Vibha Sharma and Bryan R. Haugen. Leukemia Inhibitory Factor (LIF): A Potential Marker for Rexinoid Responsive Thyroid Cancer. American Thyroid Association, 2007.
• Rebecca E. Schweppe, Joshua P. Klopper, Christopher Korch, Jeffrey A. Knauf, James A. Fagin, Laura Marlow, John A. Copland III, Robert C. Smallridge, and Bryan R. Haugen. DNA Profiling Analysis of Human Thyroid Cancer Cell Lines Reveals Cross-Contamination Resulting in Cell Line Redundancy and Misidentification. Endocrine Society, 2008.
• Joshua Klopper, Vibha Sharma and Bryan Haugen. Vitamin D Receptor (VDR) and Retinoid X Receptor (RXR) as Therapeutic Targets in Advanced Thyroid Cancer. American Thyroid Association, 2008
• VITAMIN D RECEPTOR (VDR) ACTIVATION DECREASES THYROID CANCER CELL GROWTH AND IS ENHANCED BY INHIBITION OF THE MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) PATHWAY. Endocrine Society, 2009
• CONSUMPTIVE HYPOTHYROIDISM RESULTING FROM HEMANGIOMAS IN AN ATHYREOTIC ADULT. Endocrine Society, 2009
• Rebecca E. Schweppe, Joshua P. Klopper, Christopher Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James A. Fagin, Laura Marlow, John A. Copland, Robert C. Smallridge, and Bryan R. Haugen. DNA Profiling Analysis of 40 Human Thyroid Cancer Cell Lines Reveals Cross-Contamination Resulting In Cell Line Redundancy And Misidentification. J Clin Endocrinol Metab 2008 93: 4331–4341.
• Klopper J, Haugen B. Can calcitonin and carcinoembryonic antigen doubling times predict progression of medullary thyroid carcinoma? Nat Clin Pract Endocrinol Metab. 2008 Aug;4(8):428-9.
• Joshua P. Klopper, Vibha Sharma, Reid P. Bissonnette and Bryan R. Haugen. Combination PPAR? and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2. PPAR Research. 2010:729876. Epub 2009 Oct 18.
• Jena D. French, Zachary J. Weber, Deborah L. Fretwell, M. Sherif Said, Joshua P. Klopper and Bryan R. Haugen. Tumor-Associated Lymphocytes and Increased FoxP3+ Regulatory T Cell Frequency Correlate with More Aggressive Papillary Thyroid Cancer. J Clin Endocrinol Metab. 2010 In press.
• Vibha Sharma, Deborah Fretwell, Zachary Crees, Anna Kerege and Joshua Klopper. Thyroid Cancer Resistance to Vitamin D Receptor Activation is Associated with the FokI Polymorphism and 24-Hydroxylase Levels. Thyroid. In preparation.
• 11. Vibha Sharma, Deborah Fretwell, Zachary Crees, Anna Kerege and Joshua Klopper. Thyroid Cancer Resistance to Vitamin D Receptor Activation is Associated with 24-Hydroxylase Levels But Not the ff FokI Polymorphism. Thyroid. 2010 Oct;20(10):1103-11. PMID: 20860424
• 12. David Howard, Francisco G. La Rosa, Stephen Huang, Domenico Salvatore, Michelle Mulcahey, Jennifer Sang-Lee, Michael Wachs and Joshua P. Klopper. Consumptive Hypothyroidism Resulting From Hepatic Vascular Tumors in an Athyreotic Adult. J Clin Endocrinol Metab. 2011 In Press
• 12. David Howard, Francisco G. La Rosa, Stephen Huang, Domenico Salvatore, Michelle Mulcahey, Jennifer Sang-Lee, Michael Wachs and Joshua P. Klopper. Consumptive Hypothyroidism Resulting From Hepatic Vascular Tumors in an Athyreotic Adult. J Clin Endocrinol Metab. 2011 Jul;96(7):1966-70
• 13. Jena D. French, Gregory R. Kotnis, Sherif Said, Christopher D. Raeburn, Robert C. McIntyre, Joshua P. Klopper, Bryan R. Haugen. Programmed Death-1+ T Cells and Regulatory T Cells are Enriched in Tumor-Involved Lymph Nodes and Associated with Aggressive Metastatic Papillary Thyroid Cancer. J Clin Endocrinol Metab. In Revision
• The Impact of Benign Gene Expression Classifier Test Resuls on the Endocrinologist-Patient Decision to Operate on Patients with Thyroid Nodules with Indeterminate FNA Cytopathology. Thyroid. 2012 Jul 11. [Epub ahead of print].
• Follicular Thyroid Cancer. In GW Randolph, Surgery for the Thyroid and Parathyroid Glands, 2nd Edition (pp. 197-202). Philadelphia: Elsevier.
• Anaplastic Thyroid Cancer and Miscellaneous Tumors of the Thyroid. In LE Braverman and DS Cooper, Werner & Ingbar’s The Thyroid A Fundamental and Clinical Text, 10th Edition (pp. 765-774). Philadelphia: Lippincott Williams & Wilkins.

Professional Memberships

• American Thyroid Association (ATA) , Member
• The Endocrine Society , Member
• American Association of Clinical Endocrinologists (AACE), Member

Practice Locations

• University of Colorado Hospital
• Veterans Affairs Medical Center

• University of Colorado Cancer Center
• Colorado Clinical & Translational Sciences Institute (CCTSI)

Specialty Information

• Endocrinology, Diabetes and Metabolism, Board Certification (2006)
• Internal Medicine, Board Certification (2002)

• Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
• Endocrine System (Hormones) - Thyroid Cancer
• Endocrine System (Hormones) - Thyroid Disease
• Bones, Joints and Muscles - Osteoporosis
• Bones, Joints and Muscles
• Endocrine System (Hormones)