Stephen (Steve) Dreskin, MD, PhD

Professional Titles

• Clinical Professor of Medicine and Immunology
• Tenured Professor of Medicine, Allergy and Immunology, Retired
• Interim Division Head, Allergy and Clinical Immunology

Recognitions

• Top Doctor in Denver 2012-2021, 5280 Magazine (2021)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"

Research Interests

Publications

• Palmer GW, Dibbern DA, Jr., Burks AW, Bannon GA, Bock SA, Porterfield, HS McDermott RA, and Dreskin SC. Comparative Potency of Ara h 1 and Ara h 2 in Immunochemical and Functional Assays of Allergenicity. Clinical Immunology, 115:302-312, 2005.
• Guyer B, Shimamoto SR, Bradhurst A, Grossbard E, Dreskin S, and Nelson H. Safety and Efficacy of a Mast Cell Inhibitor (R926112) in Adults with Asymptomatic Allergic Rhinitis. In press, Allergy and Asthma Proceedings, 2006
• Yasnowsky KM, Dreskin SC, Schoen DJ, Vedantahan PK, Alam R and Harbeck R. Chronic Urticaria Sera Increase Basophil CD203c Surface Expression. In press, J Allergy and Clin Immunol, 2006.
• Dreskin, SC. Immunological Reactions to Drugs and Chemicals in Critical Care Toxicology,: Diagnosis and Management of the Critically Poisoned Patient. Brent et al., ed., Elsevier, Mosby. 2005.
• Dreskin, SC and Palmer, GW: Anaphylaxis in eMedicine, Textbook of Medicine; A. Burke et al., eds, http://www.emedicine.com/med/topic128.htm, Originally, 2002, Updated, 2005.
• Dreskin, SC and Andrews, KY: The Thyroid and Urticaria. Current Opinions in Allergy and Clinical Immunology, 5: 408-412, 2005.
• Dreskin, SC Genetics of Food Allergy, Current Allergy & Asthma Reports, 6: 58-64, 2006
• Dreskin, SC Urticaria and Angioedema in Cecil’s Textbook of Medicine, in press, 2006.
• Leung, DY and Dreskin, S.C. “Urticaria” in Nelson’s Textbook of Pediatrics, in press, 2006.
• Dreskin, SC “Do HLA genes play a role in the genetics of food allergy?” Invited editorial, Annals of Allergy, Asthma, and Immunology, in press, 2006.
• Dreskin SC “Henry N. Claman, a brief biography”, in press, J Allergy and Clin Immunol, 2006.
• Guyer B, Shimamoto SR, Bradhurst A, Grossbard E, Dreskin S, and Nelson H. Safety and Efficacy of a Mast Cell Inhibitor (R926112) in Adults with Asymptomatic Allergic Rhinitis. Allergy and Asthma Proceedings, 27: 208-213, 2006.
• Yasnowsky KM, Dreskin SC, Efaw B, Schoen D, Vedantahan PK, Alam R, and Harbeck R. Chronic Urticaria Sera Increase Basophil CD203c Surface Expression. J Allergy and Clin Immunol, 117: 1430-1434, 2006.
• El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, and Nomiyzma H. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation, Immunol Lett, In press, 2006.
• El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int. Immunopharmacol 6: 1135-42, 2006.
• El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Dreskin SC. Down regulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta 1760: 1088-1095, 2006.
• Robert A. McDermott, Harry Porterfield, Rabab El Mezayan, Darcy Schlichting, Kirk C. Hansen, Mark Duncan, Benjamin Solomon, Michael Simpson, Ronald Harbeck, Stephen C. Dreskin. Successful Removal of Ara h 2 from a Crude Peanut Extract Yields Minimal Change in Allergenicity, In Press, Clinical and Experimental Allergy, 2007.
• Dreskin, SC; “Urticaria and Angioedema” in Cecil’s Textbook of Medicine, in press, 2007
• Dreskin, SC: Genetics of Food Allergy, Current Allergy & Asthma Reports, 6: 58-64, 2006.
• Leung, DY and Dreskin, S.C. “Urticaria” in Nelson’s Textbook of Pediatrics, in press, 2007
• Dreskin, SC: Do HLA genes play a role in the genetics of food allergy? Invited editorial, Annals of Allergy, Asthma, and Immunology, 96:766-8, 2006.
• Dreskin SC: Henry N. Claman in profile. J Allergy and Clin Immunol, 117:959-960, 2006
• Dreskin SC and Claman HN. “Allergy and Immunology”, Internal Medicine Casebook, RW Schrier, ed. in press, 2007.
• HS Porterfield, Mark W. Duncan, Kirk C. Hansen, and SC Dreskin. The Majority of the Effector Activity of a Crude Peanut Extract Co-purifies with Ara h 2 but not Ara h 1 or Ara h 3. JACI 119:S193, 2007.
• R El Mezayen, L Pons, M West, S Stanley, AW Burks, M El Gazzar, Mark W. Duncan, Kirk C. Hansen, and SC Dreskin. Ara h 2.02 Is A More Potent Cross-linker of Anti- peanut IgE Than Is Ara h 2.01. JACI 119:S193, 2007.
• McDermott RA, Porterfield HS, El Mezayan R and Dreskin SC Contribution of Ara h 2 to peanut-specific IgE-mediated cell activation. Clinical and Experimental Allergy 37: 752-763, 2007
• Zheng W and Dreskin SC A systemic reaction to thimerosal in influenza vaccine. Annals of Allergy and Clinical Immunology, In press, 2008.
• McDermott RA, Porterfield HS, El Mezayan R, Burks AW, Schlichting D, Solomon B, Redzic JS, Harbeck RJ, Duncan MW, Hansen KC, SC Dreskin. Contribution of Ara h 2 to peanut-specific immunoglobulin E-mediated, cell activation, Clinical and Experimental Allergy, 37:752-763, 2007
• 45. Zheng W and Dreskin SC, A systemic reaction to thimerosal in influenza vaccine. Annals of Allergy and Clinical Immunology, 99:574-575, 2007
• 46. McDermott RA, Nelson HS, Dreskin SC, Mediator measurements following daily instillation of allergen: increased IL-5 and decreased IFN-?. Allergy & Asthma Proceedings, 29: 146-151, 2008
• 47. Wood RA, Berger M, Dreskin SC, Setse R, Engler RJ, Dekker CL, Halsey NA. Hypersensitivity Working Group of the Clinical Immunization Safety Assessment (CISA) Network. An algorithm for treatment of patients with hypersensitivity reactions after vaccines. Pediatrics. 122(3):e771-7, 2008 Sep.
• Porterfield HS, Murray KS, Schlichting DG , Chen X, Hansen KC, Duncan MW, and Dreskin SC. Effector Activity of Peanut Allergens: A critical role for Ara h 2, Ara h 6, and their variants. Clinical and Experimental Allergy, Clinical and Experimental Allergy 39:1099-1108, 2009
• Wood RA, Berger M, Dreskin SC, Setse R, Engler RJ, Dekker CL, Halsey NA & The Hypersensitivity Working Group of the Clinical Immunization Safety Assessment (CISA) Network. Management of Patients with Hypersensitivity Reactions Following Vaccines. Pediatrics. 122(3):e771-7, 2008
• Mustafa, SS and Dreskin SC. Urticaria and Angioedema. ePocrates, 2009
• 14. Dreskin SC, Tripputi MT, Aubrey, MT, Mustafa, SS, Atkins, D, Leo, HL, Song, Schlichting, D, Talwar, H, Wang, Q, and Freed, BM. Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II. Clinical Immunology Sept 15, 137: 366-373, 2010. PMID: 20850383. PMCID: 2976616.
• 15. Dreskin SC, Ayars A, Jin Y, Atkins D, Leo, HL, and Song B. Genetic variants of CD14 are associated with peanut allergy and elevated IgE levels in peanut allergic subjects. Ann Allergy Asthma and Immunol. 2011 Feb;106(2):170-2. PMID: 21277522.
• 52. Johann-Liang R, Josephs, S, and Dreskin SC. Analysis of Anaphylaxis Cases following Vaccination: Ten Years Review from the National Vaccine Injury Compensation Program. Ann of Allergy Asthma & Immunol. In press. 2011.
• 19. Fonacier LS, Dreskin SC, and Leung DYM, Allergic skin diseases. J Allergy and Clin Immunol, 125: S138-149, 2010.
• 50. Mathias SD, Dreskin S, Kaplan A, Saini S, Spector S, and Rosen KE. Development of an Urticaria Patient Daily Diary for Chronic Idiopathic Urticaria. Annals of Allergy, Asthma, and Immunology, 105:142-148, 2010. PMID: 20674825.
• Kulis M, Chen X, Lew J, Wang Q, Ojas Patel P, Zhuang Y, Murray KS, Duncan MW, Porterfield HS, Burks AW, Dreskin SC. The 2S albumin allergens of Arachis hypogaea, Ara h 2 and Ara h 6, are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice. Clin Exp Allergy. 2012 Feb;42(2):326-36. PMID:22288514
• Zhuang Y, Durrani S, Hodges BD, Dreskin SC, Chen X. Expression of recombinant Ara h 6 in Pichia pastoris but not in E. coli preserves allergic effector function and allows assessment of specific mutations Mol Nutr Food Res. 2012 Jun;56(6):986-95. PMID:22707273.[PubMed - in process].
• Zhuang Y and Dreskin SC. Redefining the major peanut allergens. Immunol Res. 2012 Sep 5. [Epub ahead of print]. PMID: 22948807.
• Chen X, Wang Q, Zhuang, Y, and Dreskin SC. The allergic effector activity of a crude peanut extract: Ara h 2 and Ara h 6 are equipotent and substantially redundant. International Archives of Allergy and Clinical Immunology, in press, 2012.
• Zhuang Y, Dreskin SC. Redefining the major peanut allergens. Immunol Res. 2013 Mar;55(1-3):125-34. PubMed PMID: 22948807
• Chen X, Wang Q, El-Mezayen R, Zhuang Y, Dreskin SC. Ara h 2 and Ara h 6 have similar allergenic activity and are substantially redundant. Int Arch Allergy Immunol. 2013;160(3):251-8. PubMed PMID: 23075924
• Pahud BA, Williams SE, Dekker CL, Halsey N, Larussa P, Baxter RP, Klein NP, Marchant CD, Sparks RC, Jakob K, Aukes L, Swope S, Barnett E, Lewis P, Berger M, Dreskin SC, Donofrio PD, Sejvar JJ, Slade BA, Gidudu J, Vellozzi C, Edwards KM. Clinical assessment of serious adverse events in children receiving 2009 H1N1 vaccination. Pediatr Infect Dis J. 2013 Feb;32(2):163-8. PubMed PMID: 23334340
• Go AC, Barber GR, Dreskin SC. Implementing standardized intravenous antibiotic desensitizations among hospital inpatients. Am J Health Syst Pharm. 2013 Mar 15;70(6):540-8. PubMed PMID: 23456408
• Stitt JM, Dreskin SC. Urticaria and autoimmunity: where are we now?. Curr Allergy Asthma Rep. 2013 Oct;13(5):555-62. PubMed PMID: 23821106
• Halsey NA, Griffioen M, Dreskin SC, Dekker CL, Wood R, Sharma D, Jones JF, LaRussa PS, Garner J, Berger M, Proveaux T, Vellozzi C, Hypersensitivity Working Group of the Clinical Immunization Safety Assessment Network, Broder K, Setse R, Pahud B, Hrncir D, Choi H, Sparks R, Williams SE, Engler RJ, Gidudu J, Baxter R, Klein N, Edwards K, Cano M, Kelso JM. Immediate hypersensitivity reactions following monovalent 2009 pandemic influenza A (H1N1) vaccines: reports to VAERS. Vaccine. 2013 Dec 9;31(51):6107-12. PubMed PMID: 24120547
• Koid AE, Chapman MD, Hamilton RG, Van Ree R, Versteeg SA, Dreskin SC, Koppelman SJ, Wuenschmann S. Ara h 6 Complements Ara h 2 as an Important Marker for IgE Reactivity to Peanut. J Agric Food Chem. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24328145
• Leiding JW, Beakes D, Dreskin SC, Grumach A, Hide M, Reshef A, Triggiani M, Kaliner MA. Case Title: 45 year-old male with recurrent angioedema: WAO international case-based discussions. World Allergy Organ J. 2014 Jan 22;7(1):2. PubMed PMID: 24450312
• Koid AE, Chapman MD, Hamilton RG, van Ree R, Versteeg SA, Dreskin SC, Koppelman SJ, Wünschmann S. Ara h 6 complements Ara h 2 as an important marker for IgE reactivity to peanut. J Agric Food Chem. 2014 Jan 8;62(1):206-13. PubMed PMID: 24328145
• Mills K, Lay J, Wu W, Robinette C, Kesic MJ, Dreskin SC, Peden DB, Hernandez M. Vitamin E, ?-tocopherol, diminishes ex vivo basophil response to dust mite allergen. Allergy. 2014 Apr;69(4):541-4. PubMed PMID: 24697338
• Bernard H, Guillon B, Drumare MF, Paty E, Dreskin SC, Wal JM, Adel-Patient K, Hazebrouck S. Allergenicity of peanut component Ara h 2: Contribution of conformational versus linear hydroxyproline-containing epitopes. J Allergy Clin Immunol. 2014 Dec 4. [Epub ahead of print] PubMed PMID: 25483599
• Leiding J, Beakes D, Dreskin SC, Frumach A, Hide M, Reshef A, Triggiani M, and Kalliner MA. Case Title: 45 year-old male with recurrent angioedema: WAO international case-based discussions. World Allergy Organization Journal. 7(1); 2, 2014.
• Stitt S and Dreskin SC. The potential role of omalizumab in the treatment of chronic urticaria. Immunotherapy 6(6) 691-697, 2014.
• Dreskin, S. C. and Patel, O.P. (2014). Urticaria and Angioedema. In P.K Vedanthan, H. Nelson, S. N. Agashe, P.A. Mahesh, R. Katial. Textbook of Allergy for the Clinician. Boca Raton, FL: CRC Press, 2014.
• Atkins D, Frank MM, Dreskin SC, and Leung, DY “Urticaria (Hives) and Angioedema” in Nelson’s Textbook of Pediatrics, Urticaria (Hives) and Angioedema, 2014.
• Chen X, Dreskin SC. Application of phage peptide display technology for the study of food allergen epitopes. Mol Nutr Food Res. 2016 Dec 20. [Epub ahead of print] PubMed PMID: 27995755
• Moutsoglou DM, Dreskin SC. Prolonged Treatment of Peanut-Allergic Mice with Bortezomib Significantly Reduces Serum Anti-Peanut IgE but Does Not Affect Allergic Symptoms. Int Arch Allergy Immunol. 2016;170(4):257-261. PubMed PMID: 27705966
• Dreskin SC, Halsey NA, Kelso JM, Wood RA, Hummell DS, Edwards KM, Caubet JC, Engler RJ, Gold MS, Ponvert C, Demoly P, Sanchez-Borges M, Muraro A, Li JT, Rottem M, Rosenwasser LJ. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organ J. 2016 Sep 16;9(1):32. PubMed PMID: 27679682
• Chen, X and Dreskin SC. Application of phage peptide display technology for the study of food allergen epitopes. Mol Nutr Food Res. 2017, 46:1120-1128. PMID: 27995755
• Chen X, Negi SS, Liao S, Gao V, Braun W, Dreskin SC. Conformational IgE epitopes of peanut allergens Ara h 2 and Ara h 6. Clin Exp Allergy. 2016 Aug;46(8):1120-8. PubMed PMID: 27238146
• Moutsoglou DM, Dreskin SC. B cells establish, but do not maintain, long-lived murine anti-peanut IgE(a). Clin Exp Allergy. 2016 Apr;46(4):640-53. PubMed PMID: 27021119
• van der Kleij HPM, Warmenhoven HJM, van Ree R, Versteeg SA, Pieters RHH, Dreskin SC, Knulst AC, Hoffen EV, Opstelten DJE, Koppelman SJ, Smit JJ. Chemically modified peanut extract shows increased safety while maintaining immunogenicity. Allergy. 2018 Dec 2. [Epub ahead of print] PubMed PMID: 30506686
• Dreskin SC. Dr. Henry N. Claman. Ann Allergy Asthma Immunol. 2018 Nov;121(5):519-522. PubMed PMID: 30170028
• Stitt JM, Dzieciatkowska M, Edwards MG, Hansen K, Hedlund G, Dreskin SC. The basophil proteome in chronic spontaneous urticaria distinguishes responders to omalizumab from non-responders. Clin Exp Allergy. 2018 Jul;48(7):898-901. PubMed PMID: 29671921
• Zimmermann N, Abonia JP, Dreskin SC, Akin C, Bolton S, Happel CS, Geller M, Larenas-Linnemann D, Nanda A, Peterson K, Wasan A, Wechsler J, Zhang S, Bernstein JA. Developing a standardized approach for assessing mast cells and eosinophils on tissue biopsies: A Work Group Report of the AAAAI Allergic Skin Diseases Committee. J Allergy Clin Immunol. 2021 Oct;148(4):964-983. PubMed PMID: 34384610
• Schein CH, Levine CB, McLellan SLF, Negi SS, Braun W, Dreskin SC, Anaya ES, Schmidt J. Synthetic proteins for COVID-19 diagnostics. Peptides. 2021 Sep;143:170583. PubMed PMID: 34087220
• Dreskin SC, Koppelman SJ, Andorf S, Nadeau KC, Kalra A, Braun W, Negi SS, Chen X, Schein CH. The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds. J Allergy Clin Immunol. 2021 Apr;147(4):1154-1163. PubMed PMID: 33217410
• Hazebrouck S, Patil SU, Guillon B, Lahood N, Dreskin SC, Adel-Patient K, Bernard H. Immunodominant conformational and linear IgE epitopes lie in a single segment of Ara h 2. J Allergy Clin Immunol. 2022. Epub 2022/02/13. doi: 10.1016/j.jaci.2021.12.796. PubMed PMID: 35150723.
• Hazebrouck S, Canon N, Dreskin SC. The Effector Function of Allergens. Front. Allergy. 2022;3:818732. Epub 2022/04/08. doi: 10.3389/falgy.2022.818732. PubMed PMID: 35386644; PMCID: PMC8974742
• Canon N, Schein CH, Braun W, Negi SS, Chen X, Kulis MD, Kim EH, Pathy V, Pozzoli M, Liu W, Dreskin SC. Alanine Scanning of the Unstructured Region of Ara h 2 and of a Related Mimotope Reveals Critical Amino Acids for IgE Binding. Mol Nutr Food Res. 2023 Nov;67(22):e2300134. PubMed PMID: 37706599
• Warmenhoven HJM, Hulsbos L, Dreskin SC, Akkerdaas JH, Versteeg SA, van Ree R. IgE cross-inhibition between Ara h 1 and Ara h 2 is explained by complex formation of both major peanut allergens. J Allergy Clin Immunol. 2023 Aug;152(2):436-444.e6. PubMed PMID: 37028524
• Castenmiller C, Stigler M, Kirpas ME, Versteeg S, Akkerdaas JH, Pena-Castellanos G, Blokhuis BR, Dreskin SC, Auger L, Desgagnés R, Martel C, Mirande L, Morel B, Roberge J, Stordeur V, Tropper G, Vézina LP, Gomord V, de Jong EC, Redegeld F, Shreffler WG, Aglas L, van Ree R. Plant-based enveloped Ara h 2 bioparticles display exceptional hypo-allergenicity. Clin Exp Allergy. 2023 May;53(5):577-581. PubMed PMID: 36779573
• Foo ACY, Nesbit JB, Gipson SAY, DeRose EF, Cheng H, Hurlburt BK, Kulis MD, Kim EH, Dreskin SC, Mustafa S, Maleki SJ, Mueller GA. Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides. J Agric Food Chem. 2023 Feb 15;71(6):2990-2998. PubMed PMID: 36728846

Professional Memberships

• American Academy of Allergy, Asthma and Immunology (AAAI), Fellow
• American College of Allergy and Immunology, Fellow

Practice Locations

• University of Colorado Hospital

Specialty Information

• Internal Medicine, Board Certification (1980)
• Allergy and Immunology, Board Certification (1983)
• Diagnostic Laboratory Immunology, Board Certification (1990)