Kucherov A, Polotsky, AJ, Menke, M, Isaac, B, McAvey, B, Buyuk, E, Bradford, AP, Hickmon, C Babbs, B, Berga, S, Loucks, T and Santoro, N. Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil. Steril 2011. In Press
Regulation of Protein Kinase C? Expression and Sensitivity to Chemotherapy in Endometrial Cancers. Alicia M Thorne and Andrew P. Bradford, Endocrine Society Annual Meeting 2010. Poster presentation.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, Jordan VC, Bradford AP.
Gynecol Oncol. 2012 Oct;127(1):241-8
Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways.
Iwanaga R, Wang CA, Micalizzi DS, Harrell JC, Jedlicka P, Sartorius CA, Kabos P, Farabaugh SM, Bradford AP, Ford HL.
Breast Cancer Res. 2012 Jul 5;14(4):R100
Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype.
Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ.
Syst Biol Reprod Med. 2013 Jan 2
Characterization of the uterine leiomyoma microRNAome by deep sequencing.
Georgieva B, Milev I, Minkov I, Dimitrova I, Bradford AP, Baev V.
Genomics. 2012 May;99(5):275-81
Dai D, Bradford AP, Prossnitz ER. Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches. Obstet Gynecol Int. 2014;2014:710405. PubMed PMID: 24550988
Ross LA, Polotsky AJ, Kucherov A, Bradford AP, Lesh J, Chosich J, Gee N, Santoro N. Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring). 2014 Jan 31. [Epub ahead of print] PubMed PMID: 24482405
Wooding KM, Barkley RM, Hankin JA, Johnson CA, Bradford AP, Santoro N, Murphy RC. Mechanism of formation of the major estradiol product ions following collisional activation of the molecular anion in a tandem quadrupole mass spectrometer. J Am Soc Mass Spectrom. 2013 Oct;24(10):1451-5. PubMed PMID: 23955001
Merhi Z, Polotsky AJ, Bradford AP, Buyuk E, Chosich J, Phang T, Jindal S, Santoro N. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015 Feb 11. [Epub ahead of print] PubMed PMID: 25676576
Wooding KM, Hankin JA, Johnson CA, Chosich JD, Baek SW, Bradford AP, Murphy RC, Santoro N. Measurement of estradiol, estrone, and testosterone in postmenopausal human serum by isotope dilution liquid chromatography tandem mass spectrometry without derivatization. Steroids. 2015 Apr;96:89-94. PubMed PMID: 25617740
Thorne AM, Jackson TA, Willis VC, Bradford AP. Protein Kinase C a Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells. Obstet Gynecol Int. 2013;2013:537479. PubMed PMID: 23843797
Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Komori H, Ohtani K. Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs. Biochem Biophys Res Commun. 2014 Jul 18;450(1):240-6. PubMed PMID: 24893334
Roth LW, Bradshaw-Pierce EL, Allshouse AA, Lesh J, Chosich J, Bradford AP, Polotsky AJ, Santoro N. Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab. 2014 May;99(5):E871-5. PubMed PMID: 24650013
Roth LW, Allshouse AA, Bradshaw-Pierce EL, Lesh J, Chosich J, Kohrt W, Bradford AP, Polotsky AJ, Santoro N. Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women. Clin Endocrinol (Oxf). 2014 Sep;81(3):418-25. PubMed PMID: 24576183
Kundu MC, May MC, Chosich J, Bradford AP, Lasley B, Gee N, Santoro N, Appt SE, Polotsky AJ. Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotype. Syst Biol Reprod Med. 2013 Apr;59(2):74-81. PubMed PMID: 23278149
Dai D, Bradford AP, Prossnitz ER. Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches. Obstet Gynecol Int. 2014;2014:710405. PubMed PMID: 24550988
Ross LA, Polotsky AJ, Kucherov A, Bradford AP, Lesh J, Chosich J, Gee N, Santoro N. Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring). 2014 Jun;22(6):1464-9. PubMed PMID: 24482405
Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan;101(1):324-33. PubMed PMID: 26523525
Chosich J, Bradford AP, Allshouse AA, Reusch JE, Santoro N, Schauer IE. Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring). 2017 Feb 3. [Epub ahead of print] PubMed PMID: 28158916
Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Ectopic expression of the CDK inhibitor p21(Cip1) enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter. Biochem Biophys Res Commun. 2017 Jan 29;483(1):107-114. PubMed PMID: 28042030
Kurayoshi K, Okuno J, Ozono E, Iwanaga R, Bradford AP, Kugawa K, Araki K, Ohtani K. The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity. Biochem Biophys Res Commun. 2017 Jan 22;482(4):784-790. PubMed PMID: 27888102
Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med. 2016 Aug;62(4):227-42. PubMed PMID: 27187064
Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan;101(1):324-33. PubMed PMID: 26523525
Al-Safi ZA, Liu H, Carlson NE, Chosich J, Lesh J, Robledo C, Bradford AP, Gee NA, Phang T, Santoro N, Kohrt W, Polotsky AJ. Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women. J Clin Endocrinol Metab. 2015 Nov;100(11):4372-81. PubMed PMID: 26425884
Ozono E, Bradford AP, Iwanaga R, Kurayoshi K, Araki K, Ohtani K. Deregulated E2F activity: Novel targets and therapeutic potential in cancer treatment. KEIjournals Medical Research Archives. 2016 Nov 1 (3), 286. doi:10.18103/ibr.v0i3.286
Noshchenko A, Hoffecker L, Lindley EM, Burger EL, Cain CM, Patel VV, Bradford AP. Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis. World J Orthop. 2015 Aug 18;6(7):537-58. PubMed PMID: 26301183
Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ. Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One. 2015;10(8):e0135163. PubMed PMID: 26258540
Kitamura H, Ozono E, Iwanaga R, Bradford AP, Okuno J, Shimizu E, Kurayoshi K, Kugawa K, Toh H, Ohtani K. Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts. Genes Cells. 2015 Sep;20(9):739-57. PubMed PMID: 26201719
Merhi Z, Polotsky AJ, Bradford AP, Buyuk E, Chosich J, Phang T, Jindal S, Santoro N. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015 Oct;22(10):1220-8. PubMed PMID: 25676576
Wooding KM, Hankin JA, Johnson CA, Chosich JD, Baek SW, Bradford AP, Murphy RC, Santoro N. Measurement of estradiol, estrone, and testosterone in postmenopausal human serum by isotope dilution liquid chromatography tandem mass spectrometry without derivatization. Steroids. 2015 Apr;96:89-94. PubMed PMID: 25617740
Al-Safi ZA, Polotsky A, Chosich J, Roth L, Allshouse AA, Bradford AP, Santoro N. Evidence for disruption of normal circadian cortisol rhythm in women with obesity. Gynecol Endocrinol. 2017 Oct 25;:1-5. [Epub ahead of print] PubMed PMID: 29068243
Chosich J, Bradford AP, Allshouse AA, Reusch JE, Santoro N, Schauer IE. Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring). 2017 Mar;25(3):553-560. PubMed PMID: 28158916
Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Ectopic expression of the CDK inhibitor p21(Cip1) enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter. Biochem Biophys Res Commun. 2017 Jan 29;483(1):107-114. PubMed PMID: 28042030
Kurayoshi K, Okuno J, Ozono E, Iwanaga R, Bradford AP, Kugawa K, Araki K, Ohtani K. The phosphatidyl inositol 3 kinase pathway does not suppress activation of the ARF and BIM genes by deregulated E2F1 activity. Biochem Biophys Res Commun. 2017 Jan 22;482(4):784-790. PubMed PMID: 27888102
Ozono E, Bradford AP, Iwanaga R, Kurayoshi K, Araki K, Ohtani K. Deregulated E2F activity: Novel targets and therapeutic potential in cancer treatment. KEIjournals Medical Research Archives. 2016 Nov 1 (3), 286. doi:10.18103/ibr.v0i3.286
Corral J, Post M & Bradford A (2017): Just-in-Time Faculty Development for Pathology Small Groups, Medical Science Educator, DOI: 10.1007/s40670-017-0516-z
Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018 May 31;8(1):8438. PubMed PMID: 29855511
Al-Safi ZA, Polotsky A, Chosich J, Roth L, Allshouse AA, Bradford AP, Santoro N. Evidence for disruption of normal circadian cortisol rhythm in women with obesity. Gynecol Endocrinol. 2018 Apr;34(4):336-340. PubMed PMID: 29068243
Adams CL, Dimitrova I, Post MD, Gibson L, Spillman MA, Behbakht K, Bradford AP. Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma. Exp Mol Pathol. 2019 Oct;110:104284. PubMed PMID: 31301306
Bauer JL, Kuhn K, Bradford AP, Al-Safi ZA, Harris MA, Eckel RH, Robledo CY, Malkhasyan A, Johnson J, Gee NR, Polotsky AJ. Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women. Reprod Sci. 2019 Aug;26(8):1025-1033. PubMed PMID: 30773100
Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018 May 31;8(1):8438. PubMed PMID: 29855511
Al-Safi ZA, Polotsky A, Chosich J, Roth L, Allshouse AA, Bradford AP, Santoro N. Evidence for disruption of normal circadian cortisol rhythm in women with obesity. Gynecol Endocrinol. 2018 Apr;34(4):336-340. PubMed PMID: 29068243
Jones K, Ryan S, Carlson NE, Chosich J, Bradford AP, Santoro N, Polotsky AJ. Aromatase Inhibition Ameliorates Decreased LH Output Found in Obese Women. Reprod Sci. 2020 Apr;27(4):1018-1023. PubMed PMID: 32046430
Adams CL, Dimitrova I, Post MD, Gibson L, Spillman MA, Behbakht K, Bradford AP. Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma. Exp Mol Pathol. 2019 Oct;110:104284. PubMed PMID: 31301306
Bauer JL, Kuhn K, Bradford AP, Al-Safi ZA, Harris MA, Eckel RH, Robledo CY, Malkhasyan A, Johnson J, Gee NR, Polotsky AJ. Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women. Reprod Sci. 2019 Aug;26(8):1025-1033. PubMed PMID: 30773100
Santoro N, Schauer IE, Kuhn K, Fought AJ, Babcock-Gilbert S, Bradford AP. Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial. Fertil Steril. 2021 Aug;116(2):566-574. PubMed PMID: 33838870
Tannous A, Bradford AP, Kuhn K, Fought A, Schauer I, Santoro N. A randomised trial examining inflammatory signaling in acutely induced hyperinsulinemia and hyperlipidemia in normal weight women-the reprometabolic syndrome. PLoS One. 2021;16(3):e0247638. PubMed PMID: 33764994
Jones K, Ryan S, Carlson NE, Chosich J, Bradford AP, Santoro N, Polotsky AJ. Aromatase Inhibition Ameliorates Decreased LH Output Found in Obese Women. Reprod Sci. 2020 Apr;27(4):1018-1023. PubMed PMID: 32046430
Santoro NF, Kohn SA, Fought AJ, Kuhn K, Jones K, Bradford AP, Schauer I (2021). Heparin effects on serum gonadotropins. Journal Endocrine Society, in press. https://doi.org/10.1210/jendso/bvab178
McDonald R, Kuhn K, Nguyen TB, Tannous A, Schauer I, Santoro N, Bradford AP. A randomized clinical trial demonstrating cell type specific effects of hyperlipidemia and hyperinsulinemia on pituitary function. PLoS One. 2022;17(5):e0268323. PubMed PMID: 35544473
Kohn SA, Fought AJ, Kuhn K, Jones Slogett K, Bradford AP, Santoro N, Schauer I. Heparin Effects on Serum Gonadotropins. J Endocr Soc. 2022 Jan 1;6(1):bvab178. PubMed PMID: 35024539
Santoro N, Schauer IE, Kuhn K, Fought AJ, Babcock-Gilbert S, Bradford AP. Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial. Fertil Steril. 2021 Aug;116(2):566-574. PubMed PMID: 33838870
Tannous A, Bradford AP, Kuhn K, Fought A, Schauer I, Santoro N. A randomised trial examining inflammatory signaling in acutely induced hyperinsulinemia and hyperlipidemia in normal weight women-the reprometabolic syndrome. PLoS One. 2021;16(3):e0247638. PubMed PMID: 33764994
Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, Carlson NE, Kumar TR, Polotsky AJ. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 Oct;120(4):890-898. PubMed PMID: 37276947
Nakajima R, Deguchi R, Komori H, Zhao L, Zhou Y, Shirasawa M, Angelina A, Goto Y, Tohjo F, Nakahashi K, Nakata K, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K. The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F. Biochem Biophys Res Commun. 2023 Jun 30;663:154-162. PubMed PMID: 37141667
Nakajima R, Zhao L, Zhou Y, Shirasawa M, Uchida A, Murakawa H, Fikriyanti M, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K. Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool. Genes (Basel). 2023 Feb 2;14(2). PubMed PMID: 36833320
Santoro N, Kuhn K, Pretzel S, Schauer I E, Fought A, D’Alessandro A, Stephenson D, Bradford AP, A High-Fat Eucaloric Diet Induces Reprometabolic Syndrome of Obesity in Normal Weight Women, 2023 PNAS Nexus, in press
Zhou, Y.; Nakajima, R.;
Shirasawa, M.; Fikriyanti, M.; Zhao,
L.; Iwanaga, R.; Bradford, A.P.;
Kurayoshi, K.; Araki, K.; Ohtani, K.
Expanding Roles of the E2F-RB-p53
Pathway in Tumor Suppression.
Biology 2023, 12, 1511. https://
doi.org/10.3390/biology12121511