Henry Caplan, MD

Professional Titles

• Assistant Professor

Research Interests

Pediatric Trauma, Pediatric Burns, Traumatic Brain Injury, Inflammation, Cell therapy, Hemorrhagic shock and coagulopathy

Publications

• Cox CS Jr, Notrica DM, Juranek J, Miller JH, Triolo F, Kosmach S, Savitz SI, Adelson PD, Pedroza C, Olson SD, Scott MC, Kumar A, Aertker BM, Caplan HW, Jackson ML, Gill BS, Hetz RA, Lavoie MS, Ewing-Cobbs L. Autologous bone marrow mononuclear cells to treat severe traumatic brain injury in children. Brain. 2024 May 3;147(5):1914-1925. PubMed PMID: 38181433
• Bedi SS, Scott MC, Skibber MA, Kumar A, Caplan HW, Xue H, Sequeira D, Speer AL, Cardenas F, Gudenkauf F, Uray K, Srivastava AK, Prossin AR, Cox CS Jr. PET imaging of microglia using PBR28suv determines therapeutic efficacy of autologous bone marrow mononuclear cells therapy in traumatic brain injury. Sci Rep. 2023 Sep 26;13(1):16142. PubMed PMID: 37752232
• Gottlieb A, Toledano-Furman N, Prabhakara KS, Kumar A, Caplan HW, Bedi S, Cox CS Jr, Olson SD. Time dependent analysis of rat microglial surface markers in traumatic brain injury reveals dynamics of distinct cell subpopulations. Sci Rep. 2022 Apr 15;12(1):6289. PubMed PMID: 35428862
• Cox CS Jr, Juranek J, Kosmach S, Pedroza C, Thakur N, Dempsey A, Rennie K, Scott MC, Jackson M, Kumar A, Aertker B, Caplan H, Triolo F, Savitz SI. Autologous cellular therapy for cerebral palsy: a randomized, crossover trial. Brain Commun. 2022;4(3):fcac131. PubMed PMID: 35702731
• Caplan HW, Prabhakara KS, Toledano Furman NE, Zorofchian S, Martin C, Xue H, Olson SD, Cox CS Jr. Human-derived Treg and MSC combination therapy may augment immunosuppressive potency in vitro, but did not improve blood brain barrier integrity in an experimental rat traumatic brain injury model. PLoS One. 2021;16(5):e0251601. PubMed PMID: 34038436
• Caplan HW, Prabhakara KS, Toledano Furman NE, Zorofchian S, Kumar A, Martin C, Xue H, Olson SD, Cox CS Jr. Combination therapy with Treg and mesenchymal stromal cells enhances potency and attenuation of inflammation after traumatic brain injury compared to monotherapy. Stem Cells. 2021 Mar;39(3):358-370. PubMed PMID: 33368792
• Caplan HW, Prabhakara KS, Kumar A, Toledano-Furman NE, Martin C, Carrillo L, Moreno NF, Bordt AS, Olson SD, Cox CS Jr. Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury. Stem Cells Transl Med. 2020 Aug;9(8):903-916. PubMed PMID: 32383348
• Caplan HW, Cardenas F, Gudenkauf F, Zelnick P, Xue H, Cox CS, Bedi SS. Spatiotemporal Distribution of Microglia After Traumatic Brain Injury in Male Mice. ASN Neuro. 2020 Jan-Dec;12:1759091420911770. PubMed PMID: 32146827
• Toledano Furman N, Gottlieb A, Prabhakara KS, Bedi S, Caplan HW, Ruppert KA, Srivastava AK, Olson SD, Cox CS Jr. High-resolution and differential analysis of rat microglial markers in traumatic brain injury: conventional flow cytometric and bioinformatics analysis. Sci Rep. 2020 Jul 20;10(1):11991. PubMed PMID: 32686718
• Caplan HW, Cox CS. Resuscitation Strategies for Traumatic Brain Injury. Curr Surg Rep. 2019 Jul;7(7). PubMed PMID: 31205819
• Caplan H, Olson SD, Kumar A, George M, Prabhakara KS, Wenzel P, Bedi S, Toledano-Furman NE, Triolo F, Kamhieh-Milz J, Moll G, Cox CS Jr. Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application. Front Immunol. 2019;10:1645. PubMed PMID: 31417542
• Bedi SS, Aertker BM, Liao GP, Caplan HW, Bhattarai D, Mandy F, Mandy F, Fernandez LG, Zelnick P, Mitchell MB, Schiffer W, Johnson M, Denson E, Prabhakara K, Xue H, Smith P, Uray K, Olson SD, Mays RW, Cox CS Jr. Therapeutic time window of multipotent adult progenitor therapy after traumatic brain injury. J Neuroinflammation. 2018 Mar 16;15(1):84. PubMed PMID: 29548333
• Liras IN, Caplan HW, Stensballe J, Wade CE, Cox CS, Cotton BA. Prevalence and Impact of Admission Acute Traumatic Coagulopathy on Treatment Intensity, Resource Use, and Mortality: An Evaluation of 956 Severely Injured Children and Adolescents. J Am Coll Surg. 2017 Apr;224(4):625-632. PubMed PMID: 28131925
• Caplan HW, Cox CS, Bedi SS. Do microglia play a role in sex differences in TBI?. J Neurosci Res. 2017 Jan 2;95(1-2):509-517. PubMed PMID: 27870453

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Hospital Colorado North Campus - Broomfield
469 State Highway 7
Broomfield, CO 80023
720-478-5000

Hospital Affiliation

• Children's Hospital Colorado
• University of Colorado Hospital

Specialty Information

Specialties

• Pediatric Surgery, Board Certification (2026)
• Surgery, Board Certification (2023)
• Surgical Critical Care, Board Certification (2026)