Tyler Brown, MD

Professional Titles

• Assistant Professor

Research Interests

My research focuses on the evolution, transmission, and geographic spread of infectious disease epidemics, with a focus on emerging and antimicrobial-resistant pathogens (including malaria, tuberculosis, and other drug-resistant bacteria). To do this, we use tools from microbial genomics, population genetics, and mathematical modeling, leveraging both conventional and newer data sources (including microbial genomic sequence data and human mobility data). Ultimately, this research seeks to advance new tools and strategies for the surveillance, prevention, and clinical care of high-priority infectious diseases that threaten human health and well-being.

Publications

• Sobol R, Omar SV, Brown TS, Joseph L, Lutchminarian K, Tang L, Lan Y, Willis F, Campbell A, Warren JL, Cohen T, Brust JCM, Naidoo K, Shah NS, Gandhi NR, Mathema B. Transmission of bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa. Am J Respir Crit Care Med. 2026 Jan 1;212(1):138-147. PubMed PMID: 41026808
• Brown TS, Nelson K, Kissler S, Martinez L, Horsburgh CR, White LF, Mathema B, Jacobson KR. Understanding and exploiting superspreading to disrupt Mycobacterium tuberculosis transmission. Lancet Infect Dis. 2026 May 14. [Epub ahead of print] PubMed PMID: 42134384
• Ravishankar K, Mace KE, Koiso S, Ridpath AD, Gulbas E, Thwing J, LaRocque RC, Williams S, Ryan ET, Brown TS, Hyle EP. Mapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply. Clin Infect Dis. 2026 Apr 7. [Epub ahead of print] PubMed PMID: 41955078
• Lan Y, Rancu I, Chitwood MH, Sobkowiak B, Nyhan K, Lin HH, Wu CY, Mathema B, Brown TS, Colijn C, Warren JL, Cohen T. Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review. Lancet Microbe. 2025 Aug;6(8):101094. PubMed PMID: 40228509
• Mohareb AM, Deukmejian M, Guerra Castillo C, Brown TS, LaRocque R, Taveras E, Sarin Gupta P. School-Based Mobile Clinics to Improve Vaccine Access: A Cross-sectional Study of COVID-19 Vaccination. J Pediatric Infect Dis Soc. 2024 May 30;13(5):274-275. PubMed PMID: 38587478
• Brown TS, Tang L, Omar SV, Joseph L, Meintjes G, Maartens G, Wasserman S, Shah NS, Farhat MR, Gandhi NR, Ismail N, Brust JCM, Mathema B. Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis. Clin Infect Dis. 2024 Feb 17;78(2):269-276. PubMed PMID: 37874928
• Mohareb AM, Brown TS. Medical Student Debt and the US Infectious Diseases Workforce. Clin Infect Dis. 2023 Apr 3;76(7):1322-1327. PubMed PMID: 36318609
• Brown T, de Salazar Munoz PM, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb A, Thierauf J, Yang W, Villalba J, Naranbai V, Garcia Beltran W, Miller TE, Kress D, Stelljes K, Johnson K, Larremore D, Lennerz J, Iafrate AJ, Balsari S, Buckee C, Grad Y. Geographically skewed recruitment and COVID-19 seroprevalence estimates: a cross-sectional serosurveillance study and mathematical modelling analysis. BMJ Open. 2023 Mar 7;13(3):e061840. PubMed PMID: 36882240
• Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 Nov;30(11):1036-1044. PubMed PMID: 35597716
• Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 Jun;35:100441. PubMed PMID: 33667878
• Dugdale CM, Rubins DM, Lee H, McCluskey SM, Ryan ET, Kotton CN, Hurtado RM, Ciaranello AL, Barshak MB, McEvoy DS, Nelson SB, Basgoz N, Lazarus JE, Ivers LC, Reedy JL, Hysell KM, Lemieux JE, Heller HM, Dutta S, Albin JS, Brown TS, Miller AL, Calderwood SB, Walensky RP, Zachary KC, Hooper DC, Hyle EP, Shenoy ES. Coronavirus Disease 2019 (COVID-19) Diagnostic Clinical Decision Support: A Pre-Post Implementation Study of CORAL (COvid Risk cALculator). Clin Infect Dis. 2021 Dec 16;73(12):2248-2256. PubMed PMID: 33564833
• Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 Aug;7(8). PubMed PMID: 34431762
• Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 Dec;17(12):e1009335. PubMed PMID: 34928954
• Salje H, Wesolowski A, Brown TS, Kiang MV, Berry IM, Lefrancq N, Fernandez S, Jarman RG, Ruchusatsawat K, Iamsirithaworn S, Vandepitte WP, Suntarattiwong P, Read JM, Klungthong C, Thaisomboonsuk B, Engø-Monsen K, Buckee C, Cauchemez S, Cummings DAT. Reconstructing unseen transmission events to infer dengue dynamics from viral sequences. Nat Commun. 2021 Mar 22;12(1):1810. PubMed PMID: 33753725
• Brown TS, Dubowski K, Plitt M, Falci L, Lee E, Huynh M, Furuya Y, Vora NM. Erroneous Reporting of Deaths Attributed to Pneumonia and Influenza at 2 New York City Teaching Hospitals, 2013-2014. Public Health Rep. 2020 Nov Dec;135(6):796-804. PubMed PMID: 33031711
• Nelson KN, Jenness SM, Mathema B, Lopman BA, Auld SC, Shah NS, Brust JCM, Ismail N, Omar SV, Brown TS, Allana S, Campbell A, Moodley P, Mlisana K, Gandhi NR. Social Mixing and Clinical Features Linked With Transmission in a Network of Extensively Drug-resistant Tuberculosis Cases in KwaZulu-Natal, South Africa. Clin Infect Dis. 2020 May 23;70(11):2396-2402. PubMed PMID: 31342067
• Hanff TC, Harhay MO, Brown TS, Cohen JB, Mohareb AM. Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations. Clin Infect Dis. 2020 Jul 28;71(15):870-874. PubMed PMID: 32215613
• Nelson KN, Gandhi NR, Mathema B, Lopman BA, Brust JCM, Auld SC, Ismail N, Omar SV, Brown TS, Allana S, Campbell A, Moodley P, Mlisana K, Shah NS, Jenness SM. Modeling Missing Cases and Transmission Links in Networks of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa. Am J Epidemiol. 2020 Jul 1;189(7):735-745. PubMed PMID: 32242216
• Brown TS, Walensky RP. Serosurveillance and the COVID-19 Epidemic in the US: Undetected, Uncertain, and Out of Control. JAMA. 2020 Aug 25;324(8):749-751. PubMed PMID: 32692350
• Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23284-23291. PubMed PMID: 31659018
• O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A. Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing. Antimicrob Agents Chemother. 2019 Apr;63(4). PubMed PMID: 30670422
• Brynildsrud OB, Pepperell CS, Suffys P, Grandjean L, Monteserin J, Debech N, Bohlin J, Alfsnes K, Pettersson JO, Kirkeleite I, Fandinho F, da Silva MA, Perdigao J, Portugal I, Viveiros M, Clark T, Caws M, Dunstan S, Thai PVK, Lopez B, Ritacco V, Kitchen A, Brown TS, van Soolingen D, O'Neill MB, Holt KE, Feil EJ, Mathema B, Balloux F, Eldholm V. Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Sci Adv. 2018 Oct;4(10):eaat5869. PubMed PMID: 30345355
• Yuengling KA, Padayatchi N, Wolf A, Mathema B, Brown T, Horsburgh CR, O'Donnell MR. Effect of Antiretroviral Therapy on Treatment Outcomes in a Prospective Study of Extensively Drug-Resistant Tuberculosis (XDR-TB) HIV Coinfection Treatment in KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr. 2018 Dec 1;79(4):474-480. PubMed PMID: 30212394
• Auld SC, Shah NS, Mathema B, Brown TS, Ismail N, Omar SV, Brust JCM, Nelson KN, Allana S, Campbell A, Mlisana K, Moodley P, Gandhi NR. Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities. Eur Respir J. 2018 Oct;52(4). PubMed PMID: 30115614
• Nelson KN, Shah NS, Mathema B, Ismail N, Brust JCM, Brown TS, Auld SC, Omar SV, Morris N, Campbell A, Allana S, Moodley P, Mlisana K, Gandhi NR. Spatial Patterns of Extensively Drug-Resistant Tuberculosis Transmission in KwaZulu-Natal, South Africa. J Infect Dis. 2018 Nov 5;218(12):1964-1973. PubMed PMID: 29961879
• Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 Jan 19;376(3):243-253. PubMed PMID: 28099825
• Brown TS, Jacob CG, Silva JC, Takala-Harrison S, Djimdé A, Dondorp AM, Fukuda M, Noedl H, Nyunt MM, Kyaw MP, Mayxay M, Hien TT, Plowe CV, Cummings MP. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype. Infect Genet Evol. 2015 Mar;30:318-322. PubMed PMID: 25514047
• Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. J Infect Dis. 2015 Mar 1;211(5):670-9. PubMed PMID: 25180241
• Brown T, Shah N, Brown L. Aiding and abetting: Aggregatibacter aphrophilus coinciding with Mycobacterium avium. Am J Med. 2014 Jun;127(6):494-7. PubMed PMID: 24632057
• Brown T, Smith LS, Oo EK, Shawng K, Lee TJ, Sullivan D, Beyrer C, Richards AK. Molecular surveillance for drug-resistant Plasmodium falciparum in clinical and subclinical populations from three border regions of Burma/Myanmar: cross-sectional data and a systematic review of resistance studies. Malar J. 2012 Sep 19;11:333. PubMed PMID: 22992214

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Infectious Disease, Board Certification (2019)
• Internal Medicine, Board Certification (2017)