Alice Soragni, PhD

Professional Titles

• Professor of Biomedical Informatics and Neurosurgery
• Marsico Chair in Excellence in Functional Precision Medicine
• Director, Functional Precision Medicine Initiative, Colorado Center for Personalized Medicine

Publications

• Dela Cruz FS, Stewart EA, Surdez D, Daley JD, Soragni A, Tomazou EM, Alvarez-Perez J, Feinberg TY, Amatruda JF, Ganapathi SS, Ohm JE, Heske CM, Cohen-Gogo S, Pesic D, Nash JO, Shlien A, Roundhill EA, Burchill SA, Crompton BD, Lawlor ER, Loeb DM, Delattre O, Mora J, Scotlandi K, Reed DR, Grohar PJ, Grünewald TGP, Kovar H, Bailey KM. Advancing Preclinical Biology for Ewing Sarcoma: An International Effort. Mol Cancer Ther. 2026 Jan 2;25(1):48-70. PubMed PMID: 40911901
• Dermawan JK, Vanoli F, de Traux de Wardin H, Levi JN, Sanchez GI, Siddiquee A, Brosius S, You D, Tirode F, Sung P, Karanian M, Pissaloux D, Wexler LH, Kung A, Soragni A, Dela Cruz FS, Pavisic J, Antonescu CR. Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in MYOD1-mutant rhabdomyosarcoma. Sci Adv. 2026 Feb 27;12(9):eaea6453. PubMed PMID: 41758938
• X. Wang*, M. Calucho*, C.M. Estrada-Zuniga*, M. Noureen*, H. Gonzalez-Cantu*, S. Mossuto*, J. Levi*, B. Landry, Q. Guo, K. Rutherford, Z.-M. Cheng, A. Sannajust, S. Raghusk3287.k!!83jNnathan, S. Balaji, V. Nascimento da Conceicao, S. Norris, S.Y. Munawar, H.T.-L. Nguyen, J. De Rosa, G. Tomlinson, J.X. Wu, M.W. Yeh, M.J. Livhits, A. Vaidya, J. Powers, R. Lechan, A. Tischler, M. Zhang, P. Graham, C. Jimenez, M. Peitzsch, N. Bechmann, G. Eisenhofer, Y. Ding, M. Kitano, A. Soragni# and P.L.M. Dahia# (2025). Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas. *Co-first authors, #Co-corresponding authors Preprint available on bioRxiv, doi: 10.1101/2025.08.22.671868
• H. Zhao, Y.M. Park, Y. Zheng, Q. Mao, C. Collet, B. Hu, T. Zhou, L. Lin, S. Wong, Y. Pan, A. Vistoro Monreal, U.K. Sinha, P. Sedghizadeh, A. Soragni#, and De-Chen Lin# (2025). Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities. #Co-senior authors Preprint available on bioRxiv, doi: 10.1101/2025.01.18.631624
• Iyer R, Deshpande A, Pedgaonkar A, Bala PA, Kim T, Brien GL, Finlay D, Vuori K, Soragni A, Wetterstein HI, Murad R, Deshpande AJ. Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18::SSX fusion oncoproteins and impairs sarcomagenesis. EMBO J. 2025 Sep;44(18):4984-5004. PubMed PMID: 40804185
• Ji YR, Lee J, Kim H, Kong H, Zhao C, Ju Y, Zhang R, Kim J, Qian A, Gonzalez DSB, Mathkour Y, Vo K, Keren-Gill H, Phung A, She JW, Yu HH, You S, Ulmert HD, Soragni A, Dry S, Crompton JG, Federman N, Jonas SJ, Lu S, Zhu Y, Tseng HR. Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry-Mediated Enrichment of Extracellular Vesicles. Adv Funct Mater. 2025 Oct 8;35(41). PubMed PMID: 41924566
• Daley JD, Whiteway SL, Heske CM, Dela Cruz FS, Whittle SB, Cohen-Gogo S, Collier AB, Gupta A, Ohm J, Clark A, Soragni A, Lawlor E, Setty B, Grohar PJ, Janeway K, Reed DR, Slotkin EK, Bailey KM. New Approaches to Investigate Novel Agents in Ewing Sarcoma: A Report From the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer. 2025 Oct;72(10):e31917. PubMed PMID: 40879325
• Crane JN, Douglass DP, Oberoi S, Collins NB, Gupta A, Metts JL, Avutu V, Dela Cruz FS, Davis JL, Federman NC, Hiniker SM, Laetsch TW, Linardic CM, Navid F, Saab R, Shulman DS, Shern JF, Soragni A, Stewart EA, Terezakis S, Weigel BJ, Weiss AR. Prioritization of novel agents for further investigation in pediatric non-rhabdomyosarcoma soft tissue sarcomas: A report from the Children's Oncology Group. Eur J Cancer. 2025 Aug 26;226:115600. PubMed PMID: 40651390
• Soragni A, Knudsen ES, O'Connor TN, Tognon CE, Tyner JW, Gini B, Kim D, Bivona TG, Zang X, Witkiewicz AK, Goodrich DW, Jiang D, Gammon ST, Willey CD, Boutros PC, Sandulache VC, Osman AA, Myers JN, Mehla K, Singh PK, Chan KS, Gao H, Marathe H. Acquired resistance in cancer: towards targeted therapeutic strategies. Nat Rev Cancer. 2025 Aug;25(8):613-633. PubMed PMID: 40461793
• Al Shihabi A, Tebon PJ, Nguyen HTL, Chantharasamee J, Sartini S, Davarifar A, Jensen AY, Diaz-Infante M, Cox H, Gonzalez AE, Norris S, Sperry J, Nakashima J, Tavanaie N, Winata H, Fitz-Gibbon ST, Yamaguchi TN, Jeong JH, Dry S, Singh AS, Chmielowski B, Crompton JG, Kalbasi AK, Eilber FC, Hornicek F, Bernthal NM, Nelson SD, Boutros PC, Federman NC, Yanagawa J, Soragni A. The landscape of drug sensitivity and resistance in sarcoma. Cell Stem Cell. 2024 Oct 3;31(10):1524-1542.e4. PubMed PMID: 39305899
• Metts JL, Aye JM, Crane JN, Oberoi S, Balis FM, Bhatia S, Bona K, Carleton B, Dasgupta R, Dela Cruz FS, Greenzang KA, Kaufman JL, Linardic CM, Parsons SK, Robertson-Tessi M, Rudzinski ER, Soragni A, Stewart E, Weigel BJ, Wolden SL, Weiss AR, Venkatramani R, Heske CM. Roadmap for the next generation of Children's Oncology Group rhabdomyosarcoma trials. Cancer. 2024 Nov 15;130(22):3785-3796. PubMed PMID: 38941509
• Nguyen HTL, Kohl E, Bade J, Eng SE, Tosevska A, Al Shihabi A, Tebon PJ, Hong JJ, Dry S, Boutros PC, Panossian A, Gosline SJC, Soragni A. A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening. Cell Rep Methods. 2024 May 20;4(5):100772. PubMed PMID: 38744290
• Gigon L, Müller P, Haenni B, Iacovache I, Barbo M, Gosheva G, Yousefi S, Soragni A, von Ballmoos C, Zuber B, Simon HU. Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA. Cell Rep. 2024 Apr 23;43(4):114084. PubMed PMID: 38583154
• S. Sartini, L. Omholt, N. Moatamed and A. Soragni (2024). Mutant p53 Misfolding and Aggregation Precedes Transformation into High-Grade Serous Ovarian Carcinoma. Preprint available on bioRxiv, doi: 10.1101/2024.09.17.612958
• Al Shihabi A, Davarifar A, Nguyen HTL, Tavanaie N, Nelson SD, Yanagawa J, Federman N, Bernthal N, Hornicek F, Soragni A. Personalized chordoma organoids for drug discovery studies. Sci Adv. 2022 Feb 18;8(7):eabl3674. PubMed PMID: 35171675
• Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong ELS, Balachander GM, Chen Z, Soragni A, Huch M, Zeng YA, Wang Q, Yu H. Organoids. Nat Rev Methods Primers. 2022;2. PubMed PMID: 37325195
• Sartini S, Soragni A. Cervical organoids go viral. Cell Stem Cell. 2021 Aug 5;28(8):1337-1338. PubMed PMID: 34358436
• Nguyen HTL, Soragni A. Patient-Derived Tumor Organoid Rings for Histologic Characterization and High-Throughput Screening. STAR Protoc. 2020 Sep 18;1(2). PubMed PMID: 33043307
• Soragni A, Maitra A. Of scientists and tweets. Nat Rev Cancer. 2019 Sep;19(9):479-480. PubMed PMID: 31253855
• Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11;29(1):90-103. PubMed PMID: 26748848
• Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19;57(6):1011-1021. PubMed PMID: 25728769
• Rabe M, Soragni A, Reynolds NP, Verdes D, Liverani E, Riek R, Seeger S. On-surface aggregation of a-synuclein at nanomolar concentrations results in two distinct growth mechanisms. ACS Chem Neurosci. 2013 Mar 20;4(3):408-17. PubMed PMID: 23509977
• Ries J, Udayar V, Soragni A, Hornemann S, Nilsson KP, Riek R, Hock C, Ewers H, Aguzzi AA, Rajendran L. Superresolution imaging of amyloid fibrils with binding-activated probes. ACS Chem Neurosci. 2013 Jul 17;4(7):1057-61. PubMed PMID: 23594172
• Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9. PubMed PMID: 21325059
• Schütz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Böckmann A, Meier BH. The amyloid-Congo red interface at atomic resolution. Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5956-60. PubMed PMID: 21591034
• Reynolds NP, Soragni A, Rabe M, Verdes D, Liverani E, Handschin S, Riek R, Seeger S. Mechanism of membrane interaction and disruption by a-synuclein. J Am Chem Soc. 2011 Dec 7;133(48):19366-75. PubMed PMID: 21978222
• Wasmer C, Zimmer A, Sabaté R, Soragni A, Saupe SJ, Ritter C, Meier BH. Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity. J Mol Biol. 2010 Sep 17;402(2):311-25. PubMed PMID: 20600104
• Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R. The mechanism of prion inhibition by HET-S. Mol Cell. 2010 Jun 25;38(6):889-99. PubMed PMID: 20620958
• Lange A, Gattin Z, Van Melckebeke H, Wasmer C, Soragni A, van Gunsteren WF, Meier BH. A combined solid-state NMR and MD characterization of the stability and dynamics of the HET-s(218-289) prion in its amyloid conformation. Chembiochem. 2009 Jul 6;10(10):1657-65. PubMed PMID: 19504509
• Soragni A, Zambelli B, Mukrasch MD, Biernat J, Jeganathan S, Griesinger C, Ciurli S, Mandelkow E, Zweckstetter M. Structural characterization of binding of Cu(II) to tau protein. Biochemistry. 2008 Oct 14;47(41):10841-51. PubMed PMID: 18803399
• Wasmer C, Soragni A, Sabaté R, Lange A, Riek R, Meier BH. Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra. Angew Chem Int Ed Engl. 2008;47(31):5839-41. PubMed PMID: 18548467
• Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21;282(51):37036-44. PubMed PMID: 17928294
• Delany I, Ieva R, Soragni A, Hilleringmann M, Rappuoli R, Scarlato V. In vitro analysis of protein-operator interactions of the NikR and fur metal-responsive regulators of coregulated genes in Helicobacter pylori. J Bacteriol. 2005 Nov;187(22):7703-15. PubMed PMID: 16267295

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000