Charles Simpkin, DO

Professional Titles

• Assistant Professor

Research Interests

My research interest are primarily focused on the echocardiographic evaluation of children and young adults with pulmonary hypertension

Publications

• Gonzalez T*, Simpkin CT*, Dias Maia P, Archambault JL, Taylor A, Ivy DD, Abman SH, Frank BS. Flow versus resistance: hemodynamic phenotyping of pulmonary hypertension in infants with shunts and concurrent lung disease. Front Pediatr. 2026;14:1880632. PubMed PMID: 42807509
• Simpkin CT, Taylor AC, MacLean J, Cookson M, Friesen R, Downs E, Ivy DD, Gonzalez de Alba C, Frank BS. Targeted Flow Cardiac Magnetic Resonance Imaging in Neonates with Intracardiac Shunts: A Novel Multimodality Imaging Approach to Hemodynamic Assessment. J Pediatr. 2026 Jul 23;298:115261. [Epub ahead of print] PubMed PMID: 42492659
• Palmert T, Hui W, Simpkin CT, Dragulescu A, Mertens L, Ivy D, Burkett D, Friedberg MK. Association between hepatic vein Doppler and echocardiographic diastolic indices with invasively measured right ventricular filling pressures in pediatric pulmonary arterial hypertension. Int J Cardiol. 2026 Oct 1;460:134619. PubMed PMID: 42276255
• Aldawsari KA, Simpkin CT, Frank BS, Ivy DD. Association of Pericardial Tamponade With Initiation of Sotatercept in a Patient With Eisenmenger Syndrome. Pulm Circ. 2026 Jun;16(2):e70300. PubMed PMID: 42005857
• Simpkin CT, DeLima M, MacBeth M, Burkett DA, Ivy DD, Frank BS. Eccentricity Index Is Associated With Pulmonary Arterial Hypertension in Children After Repair of Complete Atrioventricular Septal Defects. Echocardiography. 2026 Apr;43(4):e70451. PubMed PMID: 41949040
• Sakuma R, Morgan G, Yeung E, Frank BS, Simpkin CT, Ivy DD. Repair of Sinus Venosus Atrial Septal Defect in 2 Patients with Severe Pulmonary Arterial Hypertension. Pulmonary Circulation 16 (2026): e70285,
• Simpkin CT, Gau C, Scheeler K, Cookson M, Archambault J, Ivy DD, Frank BS. Identification of Diastolic Vortices by Blood Speckle Tracking in High-Risk Neonates with Pulmonary Hypertension
• Curry A, Patrick W, Burkett D, Tsen D, Jaggers J, Simpkin CT. Perioperative Uses of 3D Echocardiography in the Evaluation of a Left Main Coronary Artery from the Noncoronary Sinus.
• Snow B, Downs E, Gau C, Swaminathan N, Simpkin CT, Tsen D. Evaluation of Subvalvar Apparatus by 3D Echocardiography Improves Pre-Operative Planning and Outcomes in Mitral Valve Repair.
• Sakuma R, MacLean J, Grenolds A, Simpkin CT, Frank BS Pulmonary Hypertension with Interstitial Lung Disease in a Child with Trisomy 21: Beyond the Karyotype
• Aldawsari, KA, Simpkin CT, Frank BS, Ivy DD. Pericardial Tamponade Associated with Sotatercept Initiation in Eisenmenger Syndrome: A Case Report
• Simpkin CT, Frank BS, Liu Y, Pan Z, Ivy DD, Burkett DA. Echocardiographic Prediction of Hemodynamics During Acute Vasoreactivity Testing in Pediatric Pulmonary Arterial Hypertension. Echocardiography. 2025 Jun;42(6):e70232. PubMed PMID: 40548394
• Simpkin CT, Ivy DD, Friedberg MK, Burkett DA. Use of Right Ventricular Free-Wall Strain in a Multivariable Estimate of Right Ventricular-Arterial Coupling in Pediatric Pulmonary Arterial Hypertension. Circ Cardiovasc Imaging. 2024 Dec;17(12):e016882. PubMed PMID: 39689167
• Simpkin CT, McElroy BJ, Morgan GJ, Dunbar Ivy D, Burkett DA, Twite MD, Frank BS. Impact of general anesthesia on the echocardiographic assessment of right ventricular function in pediatric patients with pulmonary arterial hypertension. Pulm Circ. 2024 Jul;14(3):e12435. PubMed PMID: 39308941
• Simpkin CT, Frank BS. From Decompression to Desaturation: Restricting the Atrial Septum After Reverse Potts Shunt. JACC: Case Reports.
• Fujiwara T, Lu VI, Frank BS, Simpkin CT, Ivy DD, Fonseca B, Neves da Silva H, Sassoon D, Saucedo JG, Burkett DA, Browne LP, Barker AJ. Robust Approach to Measure Time-Resolved Septal Curvature in Pediatric Pulmonary Hypertension Patients Using Standard Short-Axis Ventricular Volume Contours: A Retrospective, Cross-Sectional Study. JCMR

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Pediatrics, Board Certification
• Pediatric Cardiology, Board Certification