Medical School
- MD, University of Washington School of Medicine (2020)
Graduate School
- PhD, University of Washington (2018)
Undergraduate School
- BSc, Duke University (NC) (2012)
Internship
- Memorial Sloan-Kettering Cancer Center Program (2021)
Residency
- University of Texas Southwestern Medical School Program, Dermatology (2024)
Fellowships
- Memorial Sloan-Kettering Cancer Center Program, Mohs Surgery (2025)
Department
DermatologyProfessional Titles
- Mohs Micrographic and Reconstructive Surgeon
Recognitions
-
Rising Derm Star, Foundation for Research and Education in Dermatology
(2025)
2023, 2024, 2025 - Resident of Distinction, dermMentors (2024)
- G3 Spotlight Collection of Research and Scholarship Excellence, G3 (2020)
- Editors Highlights in Genomes and Epigenomes, Nature Communications (2019)
- ARCS Foundation Scholar, ARCS Foundation (2017)
Research Interests
I am interested in the genetic determinants of skin cancer. We currently have ongoing projects on soft tissue sarcomas, squamous cell carcinoma, and improving biopsy site identificationPublications
- Thakker S, Arbesman J, Klein JC, Sunshine JC, Rebecca VW, Belzberg M. Three-Dimensional Nuclear Architecture and Genomic Structural Variations in Melanoma. J Invest Dermatol. 2025 Jun;145(6):1530-1534. PubMed PMID: 39725157
- Klein JC, Mahapatra R, Hon GC, Wang RC. Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank. JID Innov. 2025 Jan;5(1):100322. PubMed PMID: 39624183
- Klein JC, Wilky BA, Ford HL. Molecular Characterization of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma. Cancers (Basel). 2025 May 27;17(11). PubMed PMID: 40507266
- Klein JC, Wang L, Strand D, Lastufka C, Hosler GA, Hon GC. Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma. Mol Cancer. 2024 Nov 15;23(1):257. PubMed PMID: 39548577
- Klein JC, Nijhawan RI. Retroauricular hinge flaps for full-thickness conchal bowl defects. J Am Acad Dermatol. 2024 Feb;90(2):e71-e72. PubMed PMID: 36356706
- Klein JC, Nijhawan RI. Repair of a Large Lateral Brow Defect. Dermatol Surg. 2023 Nov 1;49(11):1027-1029. PubMed PMID: 37341532
- Klein JC, Dominguez AR. Cutaneous Angiosarcoma. JAMA Dermatol. 2023 Mar 1;159(3):332. PubMed PMID: 36652219
- Klein JC, Nijhawan RI. Commentary on "Publication Productivity Using H-Index to Evaluate Academic Success Among Fellowship-Trained Mohs Surgeons". Dermatol Surg. 2023 Jan 1;49(1):29-30. PubMed PMID: 36533792
- Klein JC, McKesey J, Srivastava D, Nijhawan RI. In transit metastases of cutaneous squamous cell carcinoma: A single institution case series. J Am Acad Dermatol. 2023 Apr;88(4):943-945. PubMed PMID: 36403751
- Klein JC, Nijhawan RI. Commentary on "Is There a Smoking Gun for Nicotine? A Review of the Role of Nicotine in Dermatologic Surgery". Dermatol Surg. 2022 Nov 1;48(11):1176-1177. PubMed PMID: 36342248
- Klein JC, Agarwal V, Inoue F, Keith A, Martin B, Kircher M, Ahituv N, Shendure J. A systematic evaluation of the design and context dependencies of massively parallel reporter assays. Nat Methods. 2020 Nov;17(11):1083-1091. PubMed PMID: 33046894
- Spana EP, Abrams AB, Ellis KT, Klein JC, Ruderman BT, Shi AH, Zhu D, Stewart A, May S. speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene. G3 (Bethesda). 2020 Sep 2;10(9):3387-3398. PubMed PMID: 32709620
- Klein JC, Keith A, Rice SJ, Shepherd C, Agarwal V, Loughlin J, Shendure J. Functional testing of thousands of osteoarthritis-associated variants for regulatory activity. Nat Commun. 2019 Jun 4;10(1):2434. PubMed PMID: 31164647
- Klein JC, Keith A, Agarwal V, Durham T, Shendure J. Functional characterization of enhancer evolution in the primate lineage. Genome Biol. 2018 Jul 25;19(1):99. PubMed PMID: 30045748
- Klein JC, Chen W, Gasperini M, Shendure J. Identifying Novel Enhancer Elements with CRISPR-Based Screens. ACS Chem Biol. 2018 Feb 16;13(2):326-332. PubMed PMID: 29300083
- Dougherty M, Lazar J, Klein JC, Diaz K, Gobillot T, Grunblatt E, Hasle N, Lawrence D, Maurano M, Nelson M, Olson G, Srivatsan S, Shendure J, Keene CD, Bird T, Horwitz MS, Marshall DA. Genome sequencing in a case of Niemann-Pick type C. Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001222. PubMed PMID: 27900365
- Klein JC, Lajoie MJ, Schwartz JJ, Strauch EM, Nelson J, Baker D, Shendure J. Multiplex pairwise assembly of array-derived DNA oligonucleotides. Nucleic Acids Res. 2016 Mar 18;44(5):e43. PubMed PMID: 26553805
- Findlay GM, Boyle EA, Hause RJ, Klein JC, Shendure J. Saturation editing of genomic regions by multiplex homology-directed repair. Nature. 2014 Sep 4;513(7516):120-3. PubMed PMID: 25141179
- Kumar A, Dougherty M, Findlay GM, Geisheker M, Klein J, Lazar J, Machkovech H, Resnick J, Resnick R, Salter AI, Talebi-Liasi F, Arakawa C, Baudin J, Bogaard A, Salesky R, Zhou Q, Smith K, Clark JI, Shendure J, Horwitz MS. Genome sequencing of idiopathic pulmonary fibrosis in conjunction with a medical school human anatomy course. PLoS One. 2014;9(9):e106744. PubMed PMID: 25192356
Professional Memberships
- American Board of Dermatology, Diplomat
- Society for Investigative Dermatology, Member
- American Society for Dermatolgic Surgery, Member
Practice Locations
UCHealth Dermatology Clinic - Anschutz Medical Campus1665 Aurora Ct
3rd Floor, Anschutz Cancer Pavilion
Aurora, CO 80045
720-848-0500
Specialty Information
Specialties- Dermatology, Board Certification
- Fellowship trained Mohs Surgeon, Specialized Training (2025)
- Cancers - Cancer Prevention
- Cancers
- Cancers - Cancer Pathology
- Cancers - Melanoma
- Cancers - Skin Cancer
Clinical Interests
My clinical interests involve surgical and nonsurgical management of melanoma and non melanoma skin cancers. I also run a laboratory studying the genetic drivers of skin cancer, with a particular focus on rare skin tumors.
Care Philosophy
As a physician-scientist and Mohs surgeon, I believe in providing the best care for each patient incorporating the latest advances in medicine and healthcare along with patient preferences. I will work together with you to develop the best treatment plan and ensure that you receive the highest quality of care.
My clinical interests involve surgical and nonsurgical management of melanoma and non melanoma skin cancers. I also run a laboratory studying the genetic drivers of skin cancer, with a particular focus on rare skin tumors.
Care Philosophy
As a physician-scientist and Mohs surgeon, I believe in providing the best care for each patient incorporating the latest advances in medicine and healthcare along with patient preferences. I will work together with you to develop the best treatment plan and ensure that you receive the highest quality of care.
Personal Interests
In my spare time, I enjoy running, biking, and triathlons. I also enjoy hiking and camping with my wife and dog.
Public Speaking
Yes
Have spoken at national and international meetings including: American College of Mohs Surgery, Society for Investigative Dermatology, Winter Clinical Hawaii, Maui Dermatology, and the National Institutes of Health
In my spare time, I enjoy running, biking, and triathlons. I also enjoy hiking and camping with my wife and dog.
Public Speaking
Yes
Have spoken at national and international meetings including: American College of Mohs Surgery, Society for Investigative Dermatology, Winter Clinical Hawaii, Maui Dermatology, and the National Institutes of Health