Kai Wang, PhD

Professional Titles

• Assistant Professor

Research Interests

My research interests focus on medical imaging, medical image analysis, and treatment outcome prediction for cancer radiotherapy, with an emphasis on integrating multi-modal data and developing reliable, interpretable AI models to support personalized treatment planning and clinical decision-making.

Publications

• Wang R, Chen J, Zhang X, Liu H, Zhou Z, Wang K, Jiao C, Wang J. Language-guided multimodal domain generalization for outcome prediction of head and neck cancer. Comput Biol Med. 2025 Oct;197(Pt A):110992. PubMed PMID: 40886643
• Tang S, Yen A, Wang K, Albuquerque K, Wang J. Progression-Free Survival Prediction for Locally Advanced Cervical Cancer After Chemoradiotherapy With MRI-based Radiomics. Clin Oncol (R Coll Radiol). 2025 Feb;38:103702. PubMed PMID: 39706142
• Tang S, Wang K, Hein D, Lin G, Sanford NN, Wang J. Recurrence-free survival prediction for anal squamous cell carcinoma after chemoradiotherapy using planning CT-based radiomics model. Br J Radiol. 2025 Feb 1;98(1166):296-304. PubMed PMID: 39535872
• Chen M, Wang K, Dohopolski M, Morgan H, Sher D, Wang J. TransAnaNet: Transformer-based anatomy change prediction network for head and neck cancer radiotherapy. Med Phys. 2025 May;52(5):3015-3029. PubMed PMID: 39887473
• Li Y, Chen M, Wang K, Ma J, Bovik AC, Zhang Y. SAMScore: A Content Structural Similarity Metric for Image Translation Evaluation. IEEE Transactions on Artificial Intelligence. 2025 Jan 29.
• Wang R, Chen J, Zhang X, Wang J, Liu H, Zhou Z, Wang K. MedPro-DG: Domain-Aware Masked Contrastive Prompt Learning of Institution Generalization for Outcome Prediction. InInternational Conference on Medical Image Computing and Computer-Assisted Intervention 2025 Sep 20 (pp. 413-422). Cham: Springer Nature Switzerland.
• Chen M, Wang K, Wang J. Multilabel learning and model visualization for reliable head and neck cancer radiotherapy outcome prediction. InMedical Imaging 2025: Computer-Aided Diagnosis 2025 Apr 4 (Vol. 13407, pp. 69-74). SPIE.Chen M, Wang K, Wang J. Multilabel learning and model visualization for reliable head and neck cancer radiotherapy outcome prediction. InMedical Imaging 2025: Computer-Aided Diagnosis 2025 Apr 4 (Vol. 13407, pp. 69-74). SPIE.
• Wang K, Shao HC, Tang S, Zhang Y, Wang J. Simultaneous Motion Estimation and Image Reconstruction with Spatiotemporal Implicit Neural Representation Initial (STINR-SMEIR) for Gas Bubble Motion Artifact Reduction in on-Board CBCT Imaging. InAAPM 67th Annual Meeting & Exhibition 2025 Jul 29. AAPM.
• Wang K, Huang K, Gopal A, Chen S, Sawant A, Molitoris JK, Cammin J. Feasibility of Efficient Offline Adaptive Replanning with Hypersight High-Performance Cone-Beam CT on Truebeam for Pelvis RT. InAAPM 67th Annual Meeting & Exhibition 2025 Jul 28. AAPM.
• Chen M, Wang K, Wang J. Vision Transformer-Based Multilabel Survival Prediction for Oropharynx Cancer After Radiation Therapy. Int J Radiat Oncol Biol Phys. 2024 Mar 15;118(4):1123-1134. doi: 10.1016/j.ijrobp.2023.10.022. Epub 2023 Nov 7. PubMed PMID: 37939732; PubMed Central PMCID: PMC11161220.
• Wang K, Karalis JD, Elamir A, Bifolco A, Wachsmann M, Capretti G, Spaggiari P, Enrico S, Balasubramanian K, Fatimah N, Pontecorvi G, Nebbia M, Yopp A, Kaza R, Pedrosa I, Zeh H 3rd, Polanco P, Zerbi A, Wang J, Aguilera T, Ligorio M. Delta Radiomic Features Predict Resection Margin Status and Overall Survival in Neoadjuvant-Treated Pancreatic Cancer Patients. Ann Surg Oncol. 2024 Apr;31(4):2608-2620. doi: 10.1245/s10434-023-14805-5. Epub 2023 Dec 27. PubMed PMID: 38151623; PubMed Central PMCID: PMC10908610.
• Li R, Zhuang T, Montalvo S, Wang K, Parsons D, Zhang Y, Iyengar P, Wang J, Godley A, Cai B, Lin MH, Westover K. Adapt-On-Demand: A Novel Strategy for Personalized Adaptive Radiation Therapy for Locally Advanced Lung Cancer. Pract Radiat Oncol. 2024 Sep-Oct;14(5):e395-e406. doi: 10.1016/j.prro.2024.02.007. Epub 2024 Apr 4. PubMed PMID: 38579986.
• Wang R, Mu Z, Wang J, Wang K, Liu H, Zhou Z, Jiao L. ASF-LKUNet: Adjacent-scale fusion U-Net with large kernel for multi-organ segmentation. Comput Biol Med. 2024 Oct;181:109050. doi: 10.1016/j.compbiomed.2024.109050. Epub 2024 Aug 27. PubMed PMID: 39205343.
• Jing B, Wang K, Schmitz E, Tang S, Li Y, Zhang Y, Wang J. Prediction of pathological complete response to chemotherapy for breast cancer using deep neural network with uncertainty quantification. Med Phys. 2024 Dec;51(12):9385-9393. doi: 10.1002/mp.17451. Epub 2024 Oct 6. PubMed PMID: 39369684; PubMed Central PMCID: PMC11656273.
• Morgan HE, Wang K, Yan Y, Desai N, Hannan R, Chambers E, Cai B, Lin MH, Sher DJ, Wang J, Wang AZ, Jiang S, Timmerman R, Park CJ, Garant A. Preliminary Evaluation of PTV Margins for Online Adaptive Radiation Therapy of the Prostatic Fossa. Pract Radiat Oncol. 2023 Jul-Aug;13(4):e345-e353. doi: 10.1016/j.prro.2022.11.003. Epub 2022 Dec 10. PubMed PMID: 36509197.
• Wang K, Dohopolski M, Zhang Q, Sher D, Wang J. Towards reliable head and neck cancers locoregional recurrence prediction using delta-radiomics and learning with rejection option. Med Phys. 2023 Apr;50(4):2212-2223. doi: 10.1002/mp.16132. Epub 2022 Dec 17. PubMed PMID: 36484346; PubMed Central PMCID: PMC10121744.
• Wang K, George-Jones NA, Chen L, Hunter JB, Wang J. Joint Vestibular Schwannoma Enlargement Prediction and Segmentation Using a Deep Multi-task Model. Laryngoscope. 2023 Oct;133(10):2754-2760. doi: 10.1002/lary.30516. Epub 2022 Dec 10. PubMed PMID: 36495306; PubMed Central PMCID: PMC10256836.
• Dohopolski M, Wang K, Morgan H, Sher D, Wang J. Use of deep learning to predict the need for aggressive nutritional supplementation during head and neck radiotherapy. Radiother Oncol. 2022 Jun;171:129-138. doi: 10.1016/j.radonc.2022.04.016. Epub 2022 Apr 21. PubMed PMID: 35461951.
• Wang R, Guo J, Zhou Z, Wang K, Gou S, Xu R, Sher D, Wang J. Locoregional recurrence prediction in head and neck cancer based on multi-modality and multi-view feature expansion. Phys Med Biol. 2022 Jun 8;67(12). doi: 10.1088/1361-6560/ac72f0. PubMed PMID: 35611711.
• Shao HC, Li T, Dohopolski MJ, Wang J, Cai J, Tan J, Wang K, Zhang Y. Real-time MRI motion estimation through an unsupervised k-space-driven deformable registration network (KS-RegNet). Phys Med Biol. 2022 Jun 29;67(13). doi: 10.1088/1361-6560/ac762c. PubMed PMID: 35667374; PubMed Central PMCID: PMC9309029.
• Zhang Q, Wang K, Zhou Z, Qin G, Wang L, Li P, Sher D, Jiang S, Wang J. Predicting local persistence/recurrence after radiation therapy for head and neck cancer from PET/CT using a multi-objective, multi-classifier radiomics model. Front Oncol. 2022;12:955712. doi: 10.3389/fonc.2022.955712. eCollection 2022. PubMed PMID: 36248979; PubMed Central PMCID: PMC9557184.
• George-Jones NA, Wang K, Wang J, Hunter JB. Automated Detection of Vestibular Schwannoma Growth Using a Two-Dimensional U-Net Convolutional Neural Network. Laryngoscope. 2021 Feb;131(2):E619-E624. doi: 10.1002/lary.28695. Epub 2020 Apr 18. PubMed PMID: 32304338.
• Chen L, Dohopolski M, Zhou Z, Wang K, Wang R, Sher D, Wang J. Attention Guided Lymph Node Malignancy Prediction in Head and Neck Cancer. Int J Radiat Oncol Biol Phys. 2021 Jul 15;110(4):1171-1179. doi: 10.1016/j.ijrobp.2021.02.004. Epub 2021 Feb 6. PubMed PMID: 33561508.
• George-Jones NA, Wang K, Wang J, Hunter JB. Prediction of Vestibular Schwannoma Enlargement After Radiosurgery Using Tumor Shape and MRI Texture Features. Otol Neurotol. 2021 Mar 1;42(3):e348-e354. doi: 10.1097/MAO.0000000000002938. PubMed PMID: 33065598.
• Morgan HE, Wang K, Dohopolski M, Liang X, Folkert MR, Sher DJ, Wang J. Exploratory ensemble interpretable model for predicting local failure in head and neck cancer: the additive benefit of CT and intra-treatment cone-beam computed tomography features. Quant Imaging Med Surg. 2021 Dec;11(12):4781-4796. doi: 10.21037/qims-21-274. PubMed PMID: 34888189; PubMed Central PMCID: PMC8611459.
• Wang K, Zhou Z, Wang R, Chen L, Zhang Q, Sher D, Wang J. A multi-objective radiomics model for the prediction of locoregional recurrence in head and neck squamous cell cancer. Medical physics. 2020 Oct;47(10):5392-400.

Professional Memberships

• The American Association of Physicists in Medicine, Member