Sweta Patel, PhD

Professional Titles

• Director of Hematology Education

Research Interests

Publications

• Patel SB, Moskop DR, Moreira S, Gipson S, Anderson CC, Crook A, McCabe M, Stephenson D, Terry HE, Kent A, Young TN, Krug AE, Thomas CI, Price C, Ransom M, Miller R, Vujovic A, Minhajuddin M, Althoff MJ, Saviola AJ, Stevens BM, Welner RS, Andrianova EL, Gudkov AV, Darehshouri A, Reisz JA, Nemkov T, D'Alessandro A, Gillen AE, Pollyea DA, Jordan CT, Pietras EM. The Nicotinamide Salvage Pathway Is a Metabolic Vulnerability of High-Risk MDS Stem Cells. Blood Cancer Discov. 2026 Sep 3;7(5):796-812. PubMed PMID: 42478712
• Wang Y, Turbitt W, Zhou L, Yan Z, Patel S, Yang W, Li Z, Buckley J, Welner R, Meador W, Raman C, Qin H, Benveniste E. Single-Cell RNA Sequencing Uncovers Neutrophil Clusters Associated with Autoimmune Neuroinflammation. Res Sq. 2025 Nov 19. PubMed PMID: 41333423
• Pollyea DA, Stevens BM, Abbott D, Amaya M, Gutman JA, Kent A, McMahon C, Schwartz M, Smith C, Dell-Martin J, Sohalski C, Ellis A, Haag M, Schowinsky J, Pan Z, Patel SB, Ransom M, Gillen A, Jordan CT, Pietras EM. Omacetaxine and azacitidine for untreated patients with myelodysplastic syndromes and excess blasts: a phase I/II clinical trial. EClinicalMedicine. 2025 Nov;89:103546. PubMed PMID: 41140451
• Kuznetsova V, Krishnan V, Costa A, Ren X, Ricketts TD, Patel SB, Connelly AN, Goel P, Knapp JP, Franceski AM, Luca F, Lobo de Figueiredo-Pontes L, Bhatia R, Prabhakar S, Ong ST, Welner RS. Chronic inflammation deters natural killer cell fitness and cytotoxicity in myeloid leukemia. Blood Adv. 2025 Feb 25;9(4):759-773. PubMed PMID: 39571169
• Sheth AI, Althoff MJ, Tolison H, Engel K, Amaya ML, Krug AE, Young TN, Minhajuddin M, Pei S, Patel SB, Winters A, Miller R, Shelton IT, St-Germain J, Ling T, Jones CL, Raught B, Gillen AE, Ransom M, Staggs S, Smith CA, Pollyea DA, Stevens BM, Jordan CT. Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium. Cancer Discov. 2024 Oct 4;14(10):1922-1939. PubMed PMID: 38787341
• Mills TS, Kain B, Burchill MA, Danis E, Lucas ED, Culp-Hill R, Cowan CM, Schleicher WE, Patel SB, Tran BT, Cao R, Goodspeed A, Ferrara S, Bevers S, Jirón Tamburini BA, Roede JR, D'Alessandro A, King KY, Pietras EM. A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice. Cell Stem Cell. 2024 Nov 7;31(11):1630-1649.e8. PubMed PMID: 39413777
• Patel SB, Moskop DR, Jordan CT, Pietras EM. Understanding MDS stem cells: Advances and limitations. Semin Hematol. 2024 Dec;61(6):409-419. PubMed PMID: 39472255
• Patel SB, Franceski AM, Crown BL, Welner RS. Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells. Current Stem Cell Reports. 2024 June; 10:108 - 125. doi: 10.1007/s40778-024-00240-z.
• Pei S, Shelton IT, Gillen AE, Stevens BM, Gasparetto M, Wang Y, Liu L, Liu J, Brunetti TM, Engel K, Staggs S, Showers W, Sheth AI, Amaya ML, Minhajuddin M, Winters A, Patel SB, Tolison H, Krug AE, Young TN, Schowinsky J, McMahon CM, Smith CA, Pollyea DA, Jordan CT. A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy. Cancer Discov. 2023 Sep 6;13(9):2032-2049. PubMed PMID: 37358260
• Chung JY, Ma Y, Zhang D, Bickerton HH, Stokes E, Patel SB, Tse HM, Feduska J, Welner RS, Banerjee RR. Pancreatic islet cell type-specific transcriptomic changes during pregnancy and postpartum. iScience. 2023 Apr 21;26(4):106439. PubMed PMID: 37020962
• Patel SB, Kuznetsova V, Matkins VR, Franceski AM, Bassal MA, Welner RS. Ex Vivo Expansion of Phenotypic and Transcriptomic Chronic Myeloid Leukemia Stem Cells. Exp Hematol. 2022 Nov;115:1-13. PubMed PMID: 36115580
• Patel SB, Pietras EM. B cells regulate hematopoietic stem cells via cholinergic signaling. Nat Immunol. 2022 Apr;23(4):476-478. PubMed PMID: 35347284
• Sunthankar KI, Jenkins MT, Cote CH, Patel SB, Welner RS, Ferrell PB. Isocitrate dehydrogenase mutations are associated with altered IL-1ß responses in acute myeloid leukemia. Leukemia. 2022 Apr;36(4):923-934. PubMed PMID: 34857894
• Patel S, Chopra S, Chaurasia S, Sarwat M. Plant based Bioavailability Enhancers. Curr Pharm Des. 2022;28(8):642-654. PubMed PMID: 35023453
• Patel SB, Nemkov T, D'Alessandro A, Welner RS. Deciphering Metabolic Adaptability of Leukemic Stem Cells. Front Oncol. 2022;12:846149. PubMed PMID: 35756656
• Wanet A, Bassal MA, Patel SB, Marchi F, Mariani SA, Ahmed N, Zhang H, Borchiellini M, Chen S, Zhang J, Di Ruscio A, Miyake K, Tsai M, Paranjape A, Park SY, Karasuyama H, Schroeder T, Dzierzak E, Galli SJ, Tenen DG, Welner RS. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021 Feb 5;6(56). PubMed PMID: 33547048
• Patel SB, Nemkov T, Stefanoni D, Benavides GA, Bassal MA, Crown BL, Matkins VR, Camacho V, Kuznetsova V, Hoang AT, Tenen DE, Wolock SL, Park J, Ying L, Yue Z, Chen JY, Yang H, Tenen DG, Ferrell PB, Lu R, Darley-Usmar V, D'Alessandro A, Bhatia R, Welner RS. Metabolic alterations mediated by STAT3 promotes drug persistence in CML. Leukemia. 2021 Dec;35(12):3371-3382. PubMed PMID: 34120146
• Camacho V, Matkins VR, Patel SB, Lever JM, Yang Z, Ying L, Landuyt AE, Dean EC, George JF, Yang H, Ferrell PB, Maynard CL, Weaver CT, Turnquist HR, Welner RS. Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. JCI Insight. 2020 Nov 19;5(22). PubMed PMID: 33208555
• Alabi T, Patel SB, Bhatia S, Wolfson JA, Singh P. Isolation of DNA-free RNA from human bone marrow mononuclear cells: comparison of laboratory methods. Biotechniques. 2020 Mar;68(3):159-162. PubMed PMID: 31870171
• Le J, Park JE, Ha VL, Luong A, Branciamore S, Rodin AS, Gogoshin G, Li F, Loh YE, Camacho V, Patel SB, Welner RS, Parekh C. Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development. Immunity. 2020 Jun 16;52(6):1105-1118.e9. PubMed PMID: 32553173
• Wolock SL, Krishnan I, Tenen DE, Matkins V, Camacho V, Patel S, Agarwal P, Bhatia R, Tenen DG, Klein AM, Welner RS. Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths. Cell Rep. 2019 Jul 9;28(2):302-311.e5. PubMed PMID: 31291568
• Zhang Y, Gc S, Patel SB, Liu Y, Paterson AJ, Kappes JC, Jiang J, Frank SJ. Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R). Mol Cell Endocrinol. 2019 Jul 15;492:110445. PubMed PMID: 31100495
• Camacho V, McClearn V, Patel S, Welner RS. Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment. Int J Hematol. 2017 May;105(5):566-577. PubMed PMID: 28176225
• Patel S, Sarwat M, Khan TH. Mechanism behind the anti-tumour potential of saffron (Crocus sativus L.): The molecular perspective. Crit Rev Oncol Hematol. 2017 Jul;115:27-35. PubMed PMID: 28602167
• Patel S, Maheshwari A, Chandra A. Biomarkers for wound healing and their evaluation. J Wound Care. 2016 Jan;25(1):46-55. PubMed PMID: 26762498
• Patel S, Maheshwari A, Chandra A. The role of lab-on-a-chip device in health care. International Journal of Pharmaceutical Science and Research. 2016 April; 7(4):1391-1395. doi: 10.13040/IJPSR.0975-8232.7(4).1391-95.
• Patel S, Maheshwari A, Chandra A. Microwave assisted synthesis of AgNP using aqueous leaves extract of Vinca Rosea and its therapeutic application. International Journal of Pharmacy and Pharmaceutical Sciences. 2015; 7(12):254-258.

Professional Memberships

• American Society of Hematology, Member
• International Society of Experimental Hematology, Member
• National Postdoctoral Association, Member