Randee Sedaka, PhD, BS
Instructor, Medicine-Renal Med Diseases/Hypertension
Graduate School
- PhD, University of Alabama at Birmingham (2020)
Undergraduate School
- BS, Pennsylvania State University (PA) (2013)
Department
Medicine-Renal Med Diseases/HypertensionProfessional Titles
- Director of the PKD Preclinical Murine Core
Publications
- Sedaka R, Lovelady C, Hallit E, Duyvestyn B, Shinde S, Moran-Reyna A, Lee G, Yamaguchi S, Maynard CL, Saigusa T. Intestinal barrier function declines during polycystic kidney disease progression. Am J Physiol Renal Physiol. 2025 Feb 1;328(2):F218-F229. PubMed PMID: 39694536
- Pati P, De Miguel C, Paul JR, Zhang D, Colson J, Allan JM, Edell CJ, Rhoads MK, Dunaway LS, Biswal SN, Zhong Y, Sedaka R, Millender-Swain T, Bailey SM, Gamble KL, Pollock DM, Pollock JS. Time-restricted feeding reduces cardiovascular disease risk in obese mice. JCI Insight. 2025 Jan 7. [Epub ahead of print] PubMed PMID: 39812779
- Yamaguchi S, Sedaka R, Kapadia C, Huang J, Hsu JS, Berryhill TF, Wilson L, Barnes S, Lovelady C, Oduk Y, Williams RM, Jaimes EA, Heller DA, Saigusa T. Rapamycin-encapsulated nanoparticle delivery in polycystic kidney disease mice. Sci Rep. 2024 Jul 2;14(1):15140. PubMed PMID: 38956234
- Dunaway LS, Cook AK, Kellum CE, Edell C, Botta D, Molina PA, Sedaka RS, d'Uscio LV, Katusic ZS, Pollock DM, Inscho EW, Pollock JS. Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet. Acta Physiol (Oxf). 2024 Sep;240(9):e14201. PubMed PMID: 39007513
- Sedaka R, Huang J, Yamaguchi S, Lovelady C, Hsu JS, Shinde S, Kasztan M, Crossman DK, Saigusa T. Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages. Front Med (Lausanne). 2023;10:1173674. PubMed PMID: 37538309
- Gohar EY, De Miguel C, Obi IE, Daugherty EM, Hyndman KA, Becker BK, Jin C, Sedaka R, Johnston JG, Liu P, Speed JS, Mitchell T, Kriegel AJ, Pollock JS, Pollock DM. Acclimation to a High-Salt Diet Is Sex Dependent. J Am Heart Assoc. 2022 Mar;11(5):e020450. PubMed PMID: 35191321
- Taylor CM, Kasztan M, Sedaka R, Molina PA, Dunaway LS, Pollock JS, Pollock DM. Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice. Am J Physiol Regul Integr Comp Physiol. 2021 May 1;320(5):R630-R640. PubMed PMID: 33624556
- Sedaka R, Hyndman KA, Mironova E, Stockand JD, Pollock JS. High salt intake induces collecting duct HDAC1-dependent NO signaling. Am J Physiol Renal Physiol. 2021 Mar 1;320(3):F297-F307. PubMed PMID: 33356953
- Pati P, Valcin JA, Zhang D, Neder TH, Millender-Swain T, Allan JM, Sedaka R, Jin C, Becker BK, Pollock DM, Bailey SM, Pollock JS. Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice. Am J Physiol Regul Integr Comp Physiol. 2021 Jun 1;320(6):R960-R971. PubMed PMID: 33881363
- Zhang DG, Gong CC, Wu XJ, Ren X, Sedaka RS, Chen WC, Huo FC, Chen C, Du WQ, Pei DS. P21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer. Signal Transduct Target Ther. 2021 Feb 5;6(1):47. PubMed PMID: 33542180
- Hyndman KA, Speed JS, Mendoza LD, Allan JM, Colson J, Sedaka R, Jin C, Jung HJ, El-Dahr S, Pollock DM, Pollock JS. Fluid-electrolyte homeostasis requires histone deacetylase function. JCI Insight. 2020 Aug 20;5(16). PubMed PMID: 32673289
- Gohar EY, Daugherty EM, Aceves JO, Sedaka R, Obi IE, Allan JM, Soliman RH, Jin C, De Miguel C, Lindsey SH, Pollock JS, Pollock DM. Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor. J Am Heart Assoc. 2020 May 18;9(10):e015110. PubMed PMID: 32390531
- Zhang D, Jin C, Obi IE, Rhoads MK, Soliman RH, Sedaka RS, Allan JM, Tao B, Speed JS, Pollock JS, Pollock DM. Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice. Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F710-F719. PubMed PMID: 31904281
- De Miguel C, Hamrick WC, Sedaka R, Jagarlamudi S, Asico LD, Jose PA, Cuevas S. Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice. J Am Heart Assoc. 2019 May 7;8(9):e011856. PubMed PMID: 30995881
- De Miguel C, Sedaka R, Kasztan M, Lever JM, Sonnenberger M, Abad A, Jin C, Carmines PK, Pollock DM, Pollock JS. Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation. Acta Physiol (Oxf). 2019 May;226(1):e13227. PubMed PMID: 30501003
- Tran AN, Walker K, Harrison DG, Chen W, Mobley J, Hocevar L, Hackney JR, Sedaka RS, Pollock JS, Goldberg MS, Hambardzumyan D, Cooper SJ, Gillespie Y, Hjelmeland AB. Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance. Neuro Oncol. 2018 Jul 5;20(8):1055-1067. PubMed PMID: 29409010
Professional Memberships
- American Society of Nephrology, member
- American Physiological Society, member
Public Speaking
Yes
Yes