Jonathan Boyd, PhD

Professional Titles

• Advanced Threats and Countermeasures

Research Interests

My expertise is in toxicology, and specifically my research explores cellular signal transduction networks related to organism robustness by investigating the molecular impacts of physical, chemical and biological insults on functional mechanisms. I have spent my career exploring the “point of no return” in living systems, which is a theoretical threshold that delineates the ability of an organism to recover from, or succumb to, its injuries. My goal is to develop techniques and tools that can diagnose and predict critical cellular changes associated with patient outcomes to enhance recovery. As such, much of my research has involved the study of occupational and environmental threats, drugs of abuse, and biological agents.

Publications

• Boyd J, Chaves M, Warner K, Reixinger C. Bioenergetic Analyses to Guide Toxicological Endpoints. Methods in Molecular Biology. (accepted 2025).
• Boyd J, Newman M, Warner K, Reixinger C, Chaves M, Brown J, Bauer A, Chakraborty N, Hammamieh R, Gautam A, Lin V, Smith J, Wright L, Colburn H. Lethality is Local, but Survival is Systemic: Temporal and Multi-Organ Responses to Chlorine Gas Exposure in a Murine Model. Current Research in Toxicology (revision submitted 2025).
• Patel M, Kannan S, Moyler C, Dimitrov G, Gautam A, Newman M, Hendry-Hofer T, Boyd J, Hammamieh R. Fentanyl-Induced Cortical and Cardiopulmonary Damage Linked to Apoptosis-Necrosis and Immune Response Functions in a Multi-Omics Mouse Model. Frontiers in Immunology (revision submitted 2025).
• Mills A, Dakhlallah D, Ranpara A, Goldsmith WT, Chantler PD, Huang YW, Boyd J, Olfert IM. Pregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester. Cardiovasc Toxicol. 2025 Mar;25(3):325-340. PubMed PMID: 39841346
• Morandini L, Heath T, Sheakley LS, Avery D, Grabiec M, Friedman M, Martin RK, Boyd J, Olivares-Navarrete R. Adoptive transfer of immunomodulatory macrophages reduces the pro-inflammatory microenvironment and increases bone formation on titanium implants. Acta Biomater. 2024 Oct 15;188:432-445. PubMed PMID: 39293568
• Newman M, Connery H, Kannan S, Gautam A, Hammamieh R, Chakraborty N, Boyd J. Fentanyl Overdose Causes Prolonged Cardiopulmonary Dysregulation in Male SKH1 Mice. Pharmaceuticals (Basel). 2024 Jul 14;17(7). PubMed PMID: 39065791
• Newman M, Lynch C, Connery H, Goldsmith W, Nurkiewicz T, Raylman R, Boyd J. Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice. Basic Clin Pharmacol Toxicol. 2024 Apr;134(4):460-471. PubMed PMID: 38284460
• Newman M, Lynch C, Connery H, Goldsmith W, Nurkiewicz T, Raylman R, Boyd J. Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice. Basic Clin Pharmacol Toxicol. 2024 Apr;134(4):460-471. PubMed PMID: 38284460
• Newman M, Connery H, Boyd J. Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk. Antioxidants (Basel). 2022 Jun 27;11(7). PubMed PMID: 35883757
• Penatzer JA, Miller JV, Prince N, Shaw M, Lynch C, Newman M, Hobbs GR, Boyd JW. Differential phosphoprotein signaling in the cortex in mouse models of Gulf War Illness using corticosterone and acetylcholinesterase inhibitors. Heliyon. 2021 Jul;7(7):e07552. PubMed PMID: 34307952
• Boyd JW, Penatzer JA, Prince N, Miller JV, Han AA, Currie HN. Bioenergetic Analyses of In Vitro and In Vivo Samples to Guide Toxicological Endpoints. Methods Mol Biol. 2020;2102:3-15. PubMed PMID: 31989547
• Cellular Signal Transduction In Toxicology and Pharmacology. Eds. J. Boyd and R. Neubig. John Wiley & Sons Limited, Hoboken, NJ. ISBN: 978-1-119-06026-0. 2019.

Practice Locations

UCHealth Emergency Care - Anschutz Medical Campus (Hospital-based)
12505 E. 16th Ave
Aurora, CO 80045
720-848-9111

Center Affiliations

• Center for COMBAT Research