Adekunle Alabi, PhD

Professional Titles

• Medical Director-Toxicology and Mass Spectrometry

Recognitions

• American Heart Postdoctoral Fellowship, American Heart Association (2022)
• Medstar Award of Academic Excellence, Faculty of Medicine & Dentistry University of Alberta (2021)
• Educational Grant, Mass Spectrometry & Advances in Clinical Lab (MSACL) (2024)
• Motyl Graduate Studentships in Cardiac Sciences, Faculty of Medicine & Dentistry University of Alberta (2019)

Research Interests

Publications

• Alabi A, Ge M, Momper JD, Tsunoda SM, Kelner MJ, Fitzgerald RL, Suhandynata RT. Measurement of Whole Blood Tacrolimus Concentrations by LC-MS/MS and Immunoassay Methods: Influence of Immediate-Release vs Extended-Release Tacrolimus Formulations. J Appl Lab Med. 2025 Jan 31. PubMed PMID: 39887045.
• Ge M, Alabi A, Kelner MJ, Fitzgerald RL, Suhandynata RT. Evaluation of a Benzodiazepine Immunoassay for Urine Drug Testing in Clinical Specimens. J Appl Lab Med. 2024 Nov 4;9(6):964-976. PubMed PMID: 39163145
• Xia XD, Gill G, Lin H, Roth DM, Gu HM, Wang XJ, Su FY, Alabi A, Alexiou M, Zhang Z, Wang GQ, Graf D, Zhang DW. Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis. Matrix Biol. 2023 Sep;122:10-17. PubMed PMID: 37598898
• Madhavan A, Kok BP, Rius B, Grandjean JMD, Alabi A, Albert V, Sukiasyan A, Powers ET, Galmozzi A, Saez E, Wiseman RL. Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat Commun. 2022 Feb 1;13(1):608. PubMed PMID: 35105890
• Wang M, Alabi A, Gu HM, Gill G, Zhang Z, Jarad S, Xia XD, Shen Y, Wang GQ, Zhang DW. Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor. Front Cardiovasc Med. 2022;9:917238. PubMed PMID: 36093157
• Alabi A, Xia XD, Gu HM, Wang F, Deng SJ, Yang N, Adijiang A, Douglas DN, Kneteman NM, Xue Y, Chen L, Qin S, Wang G, Zhang DW. Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis. Nat Commun. 2021 Mar 25;12(1):1889. PubMed PMID: 33767172
• Wang B, Shen Y, Zhai L, Xia X, Gu HM, Wang M, Zhao Y, Chang X, Alabi A, Xing S, Deng S, Liu B, Wang G, Qin S, Zhang DW. Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4. J Lipid Res. 2021;62:100091. PubMed PMID: 34118252
• Xia XD, Alabi A, Wang M, Gu HM, Yang RZ, Wang GQ, Zhang DW. Membrane-type I matrix metalloproteinase (MT1-MMP), lipid metabolism, and therapeutic implications. J Mol Cell Biol. 2021 Oct 21;13(7):513-526. PubMed PMID: 34297054
• Shen Y, Wang B, Deng S, Zhai L, Gu HM, Alabi A, Xia X, Zhao Y, Chang X, Qin S, Zhang DW. Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158555. PubMed PMID: 31676436
• Deng SJ, Alabi A, Gu HM, Adijiang A, Qin S, Zhang DW. Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding. J Lipid Res. 2019 Mar;60(3):516-527. PubMed PMID: 30617148
• Gu HM, Wang F, Alabi A, Deng S, Qin S, Zhang DW. Identification of an Amino Acid Residue Critical for Plasma Membrane Localization of ATP-Binding Cassette Transporter G1--Brief Report. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):253-5. PubMed PMID: 26695502
• Alabi A, Caballero-Casero N, Rubio S. Quick and simple sample treatment for multiresidue analysis of bisphenols, bisphenol diglycidyl ethers and their derivatives in canned food prior to liquid chromatography and fluorescence detection. J Chromatogr A. 2014 Apr 4;1336:23-33. PubMed PMID: 24594089

Practice Locations

• University of Colorado Hospital

Specialty Information

• National Registry of Certified Chemist, Board Certification (2024)
• Diplomate of American Board of Clinical Chemistry, Board Certification (2024)
• American Society for Clinical Pathology, Board Certification (2025)