Danielle Barber, MD, PhD

Professional Titles

• Assistant Professor

Research Interests

My clinical work, research and advocacy all center around Hypoxic Ischemic Encephalopathy. I care for neonates after HIE and throughout their development. In the lab, I model HIE in mice and study sex differences in the brain immune response to this injury. I am also leading the building of a national HIE Registry.

Publications

• Peeples ES, Mietzsch U, Molloy E, deVeber G, Mohammad K, Soul JS, Guez-Barber D, Pilon B, Chau V, Bonifacio S, Afifi J, Craig A, Wintermark P. Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries. J Pediatr. 2025 Apr;279:114476. PubMed PMID: 39863078
• Barber D, Chang J. EBNEO commentary: Reducing the percentage of surviving infants with acute symptomatic seizures discharged on anti-seizure medication. Acta Paediatr. 2025 Feb;114(2):456-457. PubMed PMID: 39630589
• Sewell E, Dingman A, Bonifacio S, Guez-Barber D, Pilon B, Smyser C. Building a Neonatal Neurocritical Care Program: A Practical Guide to Initial Implementation. Neoreviews. 2025 Nov 1;26(11):e755-e772. PubMed PMID: 41173295
• Kacsoh DB, Ayoub MC, Cejas D, Barber DG, Holler-Managan Y, Kim YM, Shear T, Kim J, Kitsis S, Christy E, Christy A. Depictions of Pediatric Neurologic Disability in Graphic Novels. J Child Neurol. 2025 Oct;40(9):772-773. PubMed PMID: 40462660
• Sewell E, Dingman A, Bonifacio S, Guez-Barber D, Pilon B, Smyser C. Building a Neonatal Neurocritical Care Program: A Practical Guide to Initial Implementation. Neoreviews. 2025 Nov 1;26(11):e755-e772. PubMed PMID: 41173295
• Peeples ES, Mietzsch U, Molloy E, deVeber G, Mohammad K, Soul JS, Guez-Barber D, Pilon B, Chau V, Bonifacio S, Afifi J, Craig A, Wintermark P. Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries. J Pediatr. 2025 Apr;279:114476. PubMed PMID: 39863078
• Barber D, Chang J. EBNEO commentary: Reducing the percentage of surviving infants with acute symptomatic seizures discharged on anti-seizure medication. Acta Paediatr. 2025 Feb;114(2):456-457. PubMed PMID: 39630589
• Kacsoh DB, Ayoub MC, Cejas D, Barber DG, Holler-Managan Y, Kim YM, Shear T, Kim J, Kitsis S, Christy E, Christy A. Depictions of Pediatric Neurologic Disability in Graphic Novels. J Child Neurol. 2025 Oct;40(9):772-773. PubMed PMID: 40462660
• Guez-Barber D, Nicolayevsky SE, Johnson KJD, Yun S, Eisch AJ. Microglial depletion worsens lesion in female but not male C57BL/6J mice after P10 hypoxia-ischemia. Under review, 2024 April. DGB is corresponding author. bioRxiv doi: 10.1101/2023.10.17.562542
• Abend N, Abramsky R, Acun C, Afifi J, Almansa AS, Alvarez MJ, Aly H, Anthony T, Ashoori M, Avellis F, Bacchini PL, Balasingam T, Baraldi E, Bastianelli M, Bates S, Beedgen B, Benedetti G, Bennett L, Bertini G, Blennow M, Boni E, Bonifacio S, Boulanger J, Boylan G, Bua B, Campbell S, Cantalupo G, Capizzi M, Cavicchiolo ME, Chalia M, Chau V, Chiodin E, Chu C, Cleary F, Colditz P, Corcoran B, Cornet M, Cossu C, Coviello C, Craig A, Culic I, Curró A, Damien J, Dani C, Dempsey EM, Dereymaeker A, deVeber G, Donofrio G, Duckworth E, Dwyer D, El-Dib M, El-Shibiny H, Farhath F, Faunes M, Ferri S, Foran A, Frassineti L, Fukasawa T, Gabbanini S, Gallagher A, Garvey A, Giamberti A, Gille C, Glass H, Goldshtein M, Gonzalez A, Griffin S, Guarguagli V, Guez-Barber D, Gumayan RL, Gupta M, Haffner D, Hansen A, Harsono M, Hashimoto M, Hermans T, Herzberg E, Hogan R, Huberman M, Huffelen ACV, Hunt R, Inder T, Isgró G, Ito Y, Jalbout RE, Jansen K, Joung K, Juul S, Kalika P, Kapellou O, Karnati S, Keohane C, Kidokoro H, Knox A, Komal K, Kovalcik J, Kubota T, Kumai S, Lanata A, Landers J, Lasagni C, Lavu R, Liu W, Livingstone V, Lori S, Luca A, Lunardi C, Madise-Wobo AD, Magarelli F, Magers J, Mainini N, Mallar C, Marandyuk B, Marangone M, Marks K, Marnane W, Massey S, Mastrangelo M, Mathieson SR, McDonald FB, Mehrkanoon S, Meneghelli M, Michaelovski A, Mietzsch U, Mitsumatsu T, Moen S, Mohammad K, Molloy E, Monaco S, Monsell S, Montano S, Moro L, Murphy C, Murray D, Nakata T, Naranje K, Narita H, Natsume J, Naulaers G, Nicoletti N, Numis A, O'Halloran KD, O'Shea A, Ostendorf A, O'Sullivan M, O'Toole JM, Ozalvo D, Paquette N, Pardo A, Parmeggiani L, Patrizi S, Pavel A, Pavlidis E, Peeples E, Perrone S, Petitpas L, Pilon B, Pinchefsky EF, Ponta A, Ponzetto E, Pourcyrous M, Pressler R, Priante E, Proietti J, Proietti J, Puthuraya S, Rana D, Ranucci M, Ream M, Redpath S, Rennie J, Rose M, Ryan MA, Sansevere A, Sato Y, Satriano A, Sauchella G, Schwarz CE, Seraglio S, Shah D, Shany E, Sh... Proceedings of the 15(th) International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring: Fota Island, Cork, Ireland, February 28(th) - March 2(nd) 2024. J Neonatal Perinatal Med. 2024 Aug 5;17(3):S345-S392. PubMed PMID: 41121627
• Guez-Barber D, Pilon B. Parental impact during and after neonatal intensive care admission. Semin Perinatol. 2024 Aug;48(5):151926. PubMed PMID: 38964994
• Lyons-Warren AM, Guez-Barber D, Thomas SP, Tantry EK, Mahat A, Aravamuthan B. Sensory Symptoms Across the Lifespan in People With Cerebral Palsy. Pediatr Neurol. 2024 Aug;157:157-166. PubMed PMID: 38924827
• Gavazzi F, Vaia Y, Woidill S, Formanowski B, Peixoto de Barcelos I, Sevagamoorthy A, Modesti NB, Charlton L, Cusack SV, Vincent A, D'Aiello R, Jawad A, Galli J, Varesio C, Fazzi E, Orcesi S, Glanzman AM, Lorch S, DeMauro SB, Guez-Barber D, Waldman AT, Vanderver A, Adang LA. Nonverbal Cognitive Skills in Children With Aicardi Goutières Syndrome. Neurology. 2024 Jul 9;103(1):e209541. PubMed PMID: 38857477
• Jaleel F, Rust A, Cheung S, Pearson TS, Ueda K, Robichaux-Viehoever A, Leger K, Chintalapati K, Guez-Barber D, Shusterman M, Aravamuthan B. Caregiver descriptions of dystonia in cerebral palsy. Ann Clin Transl Neurol. 2024 Feb;11(2):242-250. PubMed PMID: 38174361
• Guez-Barber D, Eisch AJ, Cristancho AG. Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery. Dev Neurosci. 2023;45(5):255-267. PubMed PMID: 37080174
• Guez-Barber D, Colon LM, Raphael D, Wragan MA, Yun S, Eisch AJ. Female and male microglia are not different in the dentate gyrus of postnatal day 10 mice. Neurosci Lett. 2023 Apr 23;803:137171. PubMed PMID: 36898652
• Guez-Barber D, Swami SK, Harrison JB, McGuire JL. Differentiating Bell's Palsy From Lyme-Related Facial Palsy. Pediatrics. 2022 Jun 1;149(6). PubMed PMID: 35586981
• Abdi K, Abramsky R, Andescavage N, Bambi J, Basu S, Bearer C, Benner EJ, Biselele T, Bliznyuk N, Breckpot J, Carey G, Chao A, Christiansen LI, Comani S, Croce P, De Vos M, Dereymaeker A, Dubois L, Eisch AJ, Epstein A, Geva N, Geva Y, Gewillig M, Gillis S, Goldberg RN, Gram M, Gregory S, Guez-Barber D, Hayakawa M, Henriksen NL, Hermans T, Hershkovitz R, Holgersen K, Holmqvist B, Jain V, Jansen K, Kandula V, Kapse K, Kawaguchi M, Khair A, Khazaei M, Kidokoro H, Kiffer FC, Kisilewicz K, Kumai S, Lacaille H, Ley D, Limperopoulos C, Lindholm SEH, Lukusa P, Lundberg R, MacFarlane P, Matak P, Mavinga L, Mayer C, Mbayabo G, Mitsumatsu T, Mubungu G, Murnick J, Nakata T, Narita H, Nataraj P, Natsume J, Naulaers G, Nikam R, Ortenlöf N, Ottolini K, Pan X, Pankratova S, Pegram K, Penn AA, Pradhan S, Raeisi K, Rickman N, Rikard B, Rotem R, Sangild PT, Sato Y, Sawamura F, Shany E, Shelef I, Shiraki A, Smets L, Sura L, Suzui R, Suzuki T, Tady BP, Taga G, Tamburro G, Thewissen L, Thompson JW, Thymann T, Tokat C, Vacher CM, Valdes C, Vallius S, Vatolin S, Watanabe H, Weintraub AY, Weiss M, Yamamoto H, Yaniv SS, Younge N, Yun S, Zappasodi F. Proceedings of the 13th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal. J Neonatal Perinatal Med. 2022;15(2):411-426. PubMed PMID: 35431185
• Cruz FC, Koya E, Guez-Barber DH, Bossert JM, Lupica CR, Shaham Y, Hope BT. New technologies for examining the role of neuronal ensembles in drug addiction and fear. Nat Rev Neurosci. 2013 Nov;14(11):743-54. PubMed PMID: 24088811
• Fanous S, Guez-Barber DH, Goldart EM, Schrama R, Theberge FR, Shaham Y, Hope BT. Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking. J Neurochem. 2013 Jan;124(1):100-8. PubMed PMID: 23113797
• Guez-Barber D, Fanous S, Harvey BK, Zhang Y, Lehrmann E, Becker KG, Picciotto MR, Hope BT. FACS purification of immunolabeled cell types from adult rat brain. J Neurosci Methods. 2012 Jan 15;203(1):10-8. PubMed PMID: 21911005
• Guez-Barber D, Fanous S, Golden SA, Schrama R, Koya E, Stern AL, Bossert JM, Harvey BK, Picciotto MR, Hope BT. FACS identifies unique cocaine-induced gene regulation in selectively activated adult striatal neurons. J Neurosci. 2011 Mar 16;31(11):4251-9. PubMed PMID: 21411666
• Koya E, Golden SA, Harvey BK, Guez-Barber DH, Berkow A, Simmons DE, Bossert JM, Nair SG, Uejima JL, Marin MT, Mitchell TB, Farquhar D, Ghosh SC, Mattson BJ, Hope BT. Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. Nat Neurosci. 2009 Aug;12(8):1069-73. PubMed PMID: 19620976
• Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005 Oct 14;310(5746):317-20. PubMed PMID: 16224024
• Pooler AM, Guez DH, Benedictus R, Wurtman RJ. Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected]. Neuroscience. 2005;134(1):207-14. PubMed PMID: 15939540
• Peeples ES, Mietzsch U, Molloy EJ, Pilon B, Guez-Barber D, Soul J, Mohammad K, deVeber G, Chau V, Bonifacio S, Craig A, Afifi J, Sabir H, Groenendaal F, Shany E, Dizon ML, Iwata O, Okulu E, Jermendy A, Yun Boo N, El-Dib M, Wintermark P. Expert consensus approach to developing inpatient common data elements for neonatal encephalopathy research. Neurology, 2025, In press.
• Pilon B, Cavaller-Bellaubi M, Daly M, Growth M, Guez-Barber D, Kemper R, Kucher K, Nagy L, Siche-Pantel F, Turner MA. Engaging families with experience of neonatal hypoxic ischemic encephalopathy: a call to action. Pediatric Research, Accepted with revisions.
• Guez-Barber D, Nicolayevsky SE, Johnson KJD, Narli I, Yun S, Eisch AJ. Microglial depletion worsens lesion in female but not male C57BL/6J mice after P10 hypoxia-ischemia. Resubmitting.

Professional Memberships

• Newborn Brain Society, Member
• Child Neurology Society, Member
• American Academy of Neurology, Member
• American Neurological Association, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado

Specialty Information

Specialties

• Child Neurology, Board Certification

Conditions & Treatments

• Brain and Nervous System - Cerebral Palsy
• Brain and Nervous System
• Brain and Nervous System - Traumatic and Acquired Brain Injuries
• Brain and Nervous System - Traumatic and Acquired Brain Injuries (e.g., traumatic brain injuries, strokes)