Graduate School
- PhD, Stanford University (2006)
Undergraduate School
- BS, University of Michigan (MI) (2000)
Department
Pediatrics-NeurologyProfessional Titles
- Professor
Publications
- Ajaib S, Winter-Luke J, Digby RJ, Pollock S, Hemmings G, Gusnanto A, Chakrabarty A, Ismail A, Wilson E, Hunter B, Filby A, McDonald D, Brockman AA, Ihrie RA, Stead LF. Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment. Neuro Oncol. 2025 Sep 1. [Epub ahead of print] PubMed PMID: 40898767
- Thirman HL, Grider-Hayes MJ, Geben LC, Ihrie RA, Brown LE, Porco JA Jr, Irish JM. Connecting chemical structure to single cell signaling profiles. Commun Biol. 2025 Jul 31;8(1):1137. PubMed PMID: 40745386
- Wanachottrakul N, Pinkaew D, Mukherjee S, Chunhacha P, Nakashima M, Brockman AA, Pal U, Halim HB, Wei Y, Tanaka L, Huynh H, Ramana K, Chen S, Ihrie RA, Fujise K. Fortilin deficiency induces anti-atherosclerotic phenotypes in macrophages and protects hypercholesterolemic mice against atherosclerosis. Commun Biol. 2025 Jul 11;8(1):1040. PubMed PMID: 40640354
- Guerin LN, Scott TJ, Yap JA, Johansson A, Puddu F, Charlesworth T, Yang Y, Simmons AJ, Lau KS, Ihrie RA, Hodges E. Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification. Cell Rep. 2025 May 27;44(5):115680. PubMed PMID: 40349339
- Chalkley ML, Guerin LN, Iyer T, Mallahan S, Nelson S, Sahin M, Hodges E, Ess KC, Ihrie RA. Human TSC2 mutant cells exhibit aberrations in early neurodevelopment accompanied by changes in the DNA Methylome. Hum Mol Genet. 2025 Apr 6;34(8):684-698. PubMed PMID: 39877967
- Guerin LN, Scott TJ, Yap JA, Johansson A, Puddu F, Charlesworth T, Yang Y, Simmons AJ, Lau KS, Ihrie RA, Hodges E. Temporally discordant chromatin accessibility and DNA demethylation define short and long-term enhancer regulation during cell fate specification. bioRxiv. 2024 Aug 27. PubMed PMID: 39253426
- Arceneaux JS, Brockman AA, Khurana R, Chalkley ML, Geben LC, Krbanjevic A, Vestal M, Zafar M, Weatherspoon S, Mobley BC, Ess KC, Ihrie RA. Multiparameter quantitative analyses of diagnostic cells in brain tissues from tuberous sclerosis complex. Cytometry B Clin Cytom. 2024 Jul 2. [Epub ahead of print] PubMed PMID: 38953209
- Chalkley ML, Guerin LN, Iyer T, Mallahan S, Nelson S, Sahin M, Hodges E, Ess KC, Ihrie RA. Human TSC2 Mutant Cells Exhibit Aberrations in Early Neurodevelopment Accompanied by Changes in the DNA Methylome. bioRxiv. 2024 Jun 6. PubMed PMID: 38895266
- Brown JA, Faley SL, Judge M, Ward P, Ihrie RA, Carson R, Armstrong L, Sahin M, Wikswo JP, Ess KC, Neely MD. Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit. J Neurodev Disord. 2024 May 23;16(1):27. PubMed PMID: 38783199
- Cross CE, Mayeda C, Medina S, Hayes MJ, Kaviany S, Connelly JA, Rathmell JC, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. Velociraptor: Cross-Platform Quantitative Search Using Hallmark Cell Features. bioRxiv. 2024 May 4. PubMed PMID: 38746337
- Medina S, Brockman AA, Cross CE, Hayes MJ, Mobley BC, Mistry AM, Chotai S, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma. bioRxiv. 2024 Mar 30. PubMed PMID: 38585888
- Bartkowiak T, Brockman AA, Mobley BC, Harmsen H, Moots P, Merrell R, Johnson DB, Thompson RC, Puduvalli VK, Ihrie RA. Pembrolizumab alters the tumor immune landscape in a patient with dMMR glioblastoma. medRxiv. 2023 Dec 26. PubMed PMID: 38234786