Mohamed Awad, MD, MBA

Publications

• Tracy JB, Gaffney BMM, Thomsen-Freitas PB, Awad ME, Melton DH, Christiansen CL, Stoneback JW. Hip joint mechanics during swing limb advancement with bone-anchored limb use. J Biomech. 2025 Nov;192:112978. PubMed PMID: 40992025
• Earley EJ, Milius DW, Awad ME, Melton DH, Ahmed K, Leijendekkers RA, Potter BK, Stevens PM, Gaffney BMM, Christiansen CL, Stoneback JW. Establishing Consensus for Prescription of Prosthetic Components for Transfemoral Bone-Anchored Limbs: An International Delphi Method Study. Arch Phys Med Rehabil. 2025 Oct;106(10):1565-1574. PubMed PMID: 40582447
• Awad ME, Lev G, Melton DH, Shaw KG, Thomsen-Freitas PB, Gaffney BMM, Christiansen CL, Stoneback JW. Colorado Limb Donning-Timed Up and Go (COLD-TUG) Test in Lower-Extremity Amputation: Less Donning Time with Osseointegrated Bone-Anchored Prosthetic Limb. J Bone Joint Surg Am. 2025 May 13;107(14):1611-1619. PubMed PMID: 40359258
• Stoneback JW, Wally MK, Abernethy A, Milius D, Awad ME. Screening and patient selection for bone-anchored limb implantation and rehabilitation: what makes a good candidate?. OTA Int. 2025 Mar;8(1 Suppl):e368. PubMed PMID: 40071174
• Thomsen-Freitas PB, Stoneback JW, Tracy JB, Awad ME, Melton DH, Gaffney BMM, Christiansen CL. Altered cumulative joint moments and increased joint moment symmetry during sit-to-stand transitions for transfemoral bone-anchored limb users: A case series. Clin Biomech (Bristol). 2025 Apr;124:106476. PubMed PMID: 40037117
• Shaw KG, Awad ME, Melton D, Gaffney BMM, Christiansen CL, Stoneback JW. Patient-Reported Outcomes of Pain and Related Quality of Life 1 Year After Bone-Anchored Limb Implantation in Patients with Lower-Limb Amputation. J Bone Joint Surg Am. 2025 Apr 16;107(8):e32. PubMed PMID: 40014677
• Sajid MI, Grayson W, John MP 2nd, Taylor S, Lauck BJ, Zaidi Z, Savage A, Griffin N, Awad M, Chen AT, Hwang J, Alfonso N, Mir HR. Efficacy of Topical Antibiotic Powder Application in the Emergency Department on Reducing Deep Fracture-Related Infection in Type III Open Lower Extremity Fractures: A Multicenter Study. J Am Acad Orthop Surg. 2025 Apr 1. [Epub ahead of print] PubMed PMID: 40179368
• Griffin, N. A., Epperson, A. B., Awad, M. E., Stoneback, J. W., & Alfonso, N. A. (2025). Meta-Analysis of Acute Systemic Antimicrobial Prophylaxis (ASAP) for Open Extremity Fracture Management: Subgroup Analysis and Methodological Guidelines. Preprints. https://doi.org/10.20944/preprints202509.2480.v1
• Pearl A, Awad ME, Hasan AI, Saleh KJ. Antimicrobial Incise Drapes in Knee and Hip Arthroplasties: Meta-analysis of Randomized Controlled and Prospective Cohort Studies. J Surg Orthop Adv. 2024 Winter;33(4):206-211. PubMed PMID: 39644283
• Hagan ML, Tuladhar A, Yu K, Alhamad DW, Bensreti H, Dorn J, Piedra VM, Cantu N, Stokes EG, Blumenthal D, Roberts RL, Balayan V, Bass SM, Dickerson T, Cartelle AL, Montesinos-Cartagena M, Awad ME, Castro AA, Garland T Jr, Cooley MA, Johnson M, Hamrick MW, McNeil PL, McGee-Lawrence ME. Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading. Calcif Tissue Int. 2024 Nov;115(5):725-743. PubMed PMID: 39276238
• Awad ME, Griffin NA, Epperson AB, Alfonso NA, Ou-Yang D. Extended Postoperative Antibiotic Prophylaxis Is Associated with No Clinical Value and Higher Projected Cost Following Adult Spinal Surgery: A Stratified Meta-Analysis and Probability-Based Cost Projections. JBJS Rev. 2024 Sep 1;12(9). PubMed PMID: 39226392
• Tracy JB, Gaffney BMM, Thomsen PB, Awad ME, Melton DH, Christiansen CL, Stoneback JW. Dynamic gait stability and stability symmetry for people with transfemoral amputation: A case-series of 19 individuals with bone-anchored limbs. J Biomech. 2024 Jun;171:112208. PubMed PMID: 38941842
• Thomsen PB, Gaffney BMM, Tracy JB, Vandenberg NW, Awad ME, Christiansen CL, Stoneback JW. Cumulative loading increases and loading asymmetries persist during walking for people with a transfemoral bone-anchored limb. Gait Posture. 2024 Sep;113:46-52. PubMed PMID: 38843706
• Vinson AL, Vandenberg NW, Awad ME, Christiansen CL, Stoneback JW, M M Gaffney B. The biomechanical influence of transtibial Bone-Anchored limbs during walking. J Biomech. 2024 May;168:112098. PubMed PMID: 38636112
• Awad ME, Melton D, Shaw KG, Lev G, Gaffney BMM, Christiansen CL, Stoneback JW. How Comprehensive and Efficient Are Patient-Reported Outcome Measures for Individuals with Lower Extremity Amputation Undergoing Implantation of Osseointegrated Bone Anchored Limbs?. JBJS Rev. 2024 Mar 1;12(3). PubMed PMID: 38489397
• Roda GF, Awad ME, Melton DH, Christiansen CL, Stoneback JW, Gaffney BMM. The Amputated Limb Gluteus Medius is Biomechanically Disadvantaged in Patients with Unilateral Transfemoral Amputation. Ann Biomed Eng. 2024 Mar;52(3):565-574. PubMed PMID: 37946055
• Richman EH, Richman OT, Lee MS, Qubain L, Heylmun L, Awad ME, Alfonso N. Social Media and Digital Footprints in Orthopaedic Trauma: An Analysis of 1465 Orthopaedic Trauma Association Members. J Orthop Trauma. 2024 Jan 1;38(1):e36. PubMed PMID: 37559214
• Gaffney BMM, Davis-Wilson HC, Awad ME, Tracy J, Melton DH, Lev G, Stoneback JW, Christiansen CL. Daily steps and stepping cadence increase one-year following prosthesis osseointegration in people with lower-limb amputation. Disabil Rehabil. 2024 Apr;46(7):1432-1437. PubMed PMID: 37073780
• Awad ME, Taylor-Diaz E, Tawfik A, Hussein K, Elmansi A, Elashiry M, et al. Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway. Bone Reports. 2024;23:101812. doi: https://doi.org/10.1016/j.bonr.2024.101812.
• Epperson AB, Awad ME, Gorman M, Loker K, Alfonso NA, Stoneback JW Clinical Practice Guidelines for Antimicrobial-loaded Cements and Beads in Orthopedic Trauma and Arthroplasty European Journal of Orthopaedic Surgery and Traumatology 2024 Oct. 26; DOI: 10.1007/s00590-024-04132-0
• Awad ME, Pearl A, Hasan AI, Saleh KJ. Antimicrobial Incise Drapes in Knee and Hip Arthroplasties: Meta-analysis of Randomized Controlled and Prospective Cohort Studies. J Surg Orthop Adv. 2024;33(4):10.3113/JSOA.2024.0206.
• Roldan M, Awad ME, VanAken TD, Saasouh W, Patel P, Mostafa G, Saleh KJ. Sub-chondroplasty Reduces Pain, Improves Function and Delays the Conversion to Arthroplasty in Patients with Advanced Knee Osteoarthritis: A Stratified Meta-analysis and Quality Assessment. J Surg Orthop Adv. 2023 Summer;32(2):65-74. PubMed PMID: 37668640
• Jarrahi A, Khodadadi H, Moore NS, Lu Y, Awad ME, Salles EL, Vaibhav K, Baban B, Dhandapani KM. Recombinant human DNase-I improves acute respiratory distress syndrome via neutrophil extracellular trap degradation. J Thromb Haemost. 2023 Sep;21(9):2473-2484. PubMed PMID: 37196848
• Awad ME, Chung JY, Griffin N, Stoneback JW, Alfonso NA. Prophylactic Intrawound Antibiotics Significantly Reduce the Risk of Deep Infections in Fracture Fixation: Subgroup Meta-analyses of the Type of Fracture, Antibiotics, and Organism. J Orthop Trauma. 2023 Oct 1;37(10):e400-e409. PubMed PMID: 37296086
• Awad ME, Farley BJ, Mostafa G, Darwiche HF, Saleh KJ. The risk of hospital readmission, revision, and intra- and postoperative complications between direct anterior versus posterior approaches in primary total hip arthroplasty: a stratified meta-analysis and a probability based cost projection. Hip Int. 2023 May;33(3):442-462. PubMed PMID: 35437055
• Vandenberg NW, Stoneback JW, Davis-Wilson H, Christiansen CL, Awad ME, Melton DH, Gaffney BMM. Unilateral transfemoral osseointegrated prostheses improve joint loading during walking. J Biomech. 2023 Jun;155:111658. PubMed PMID: 37276681
• Gaffney BMM, Davis-Wilson HC, Christiansen CL, Awad ME, Lev G, Tracy J, Stoneback JW. Osseointegrated prostheses improve balance and balance confidence in individuals with unilateral transfemoral limb loss. Gait Posture. 2023 Feb;100:132-138. PubMed PMID: 36521257
• Baldawi M, Awad ME, McKelvey G, Pearl AD, Mostafa G, Saleh KJ. Neuraxial Anesthesia Significantly Reduces 30-Day Venous Thromboembolism Rate and Length of Hospital Stay in Primary Total Hip Arthroplasty: A Stratified Propensity Score-Matched Cohort Analysis. J Arthroplasty. 2023 Jan;38(1):108-116. PubMed PMID: 35843379
• Farley BJ, Awad ME, Anderson P, Esseili AS, Hruska J, Mostafa G, Saleh KJ. Opioid-Related Genetic Polymorphisms of Cytochrome P450 Enzymes after Total Joint Arthroplasty: A Focus on Drug-Drug-Gene Interaction with Commonly Coprescribed Medications. Orthop Clin North Am. 2022 Oct;53(4):361-375. PubMed PMID: 36208880
• Eldahshan W, Sayed MA, Awad ME, Ahmed HA, Gillis E, Althomali W, Pillai B, Alshammari A, Jackson L, Dong G, Sullivan JC, Cooley MA, Elsalanty M, Ergul A, Fagan SC. Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke. Vascul Pharmacol. 2021 Dec;141:106904. PubMed PMID: 34481068
• Awad ME, Farley BJ, Mostafa G, Saleh KJ. Direct anterior approach has short-term functional benefit and higher resource requirements compared with the posterior approach in primary total hip arthroplasty : a meta-analysis of functional outcomes and cost. Bone Joint J. 2021 Jun;103-B(6):1078-1087. PubMed PMID: 34058867
• Hafez S, Khan MB, Awad ME, Wagner JD, Hess DC. Short-Term Acute Exercise Preconditioning Reduces Neurovascular Injury After Stroke Through Induced eNOS Activation. Transl Stroke Res. 2020 Aug;11(4):851-860. PubMed PMID: 31858409
• Elsayed R, Kurago Z, Cutler CW, Arce RM, Gerber J, Celis E, Sultan H, Elashiry M, Meghil M, Sun C, Auersvald CM, Awad ME, Zeitoun R, Elsayed R, Eldin M Elshikh M, Isales C, Elsalanty ME. Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. FASEB J. 2020 Feb;34(2):2595-2608. PubMed PMID: 31919918
• Awad ME, Rumley JCL, Vazquez JA, Devine JG. Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed COVID-19 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current COVID-19 Pandemic. J Am Acad Orthop Surg. 2020 Jun 1;28(11):451-463. PubMed PMID: 32282441
• Awad ME, Altman A, Elrefai R, Shipman P, Looney S, Elsalanty M. The use of vascularized fibula flap in mandibular reconstruction; A comprehensive systematic review and meta-analysis of the observational studies. J Craniomaxillofac Surg. 2019 Apr;47(4):629-641. PubMed PMID: 30782453
• Awad ME, Sun C, Jernigan J, Elsalanty M. Serum C-terminal cross-linking telopeptide level as a predictive biomarker of osteonecrosis after dentoalveolar surgery in patients receiving bisphosphonate therapy: Systematic review and meta-analysis. J Am Dent Assoc. 2019 Aug;150(8):664-675.e8. PubMed PMID: 31256803
• Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD. What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands. Pharmacol Ther. 2019 Jun;198:90-108. PubMed PMID: 30759373
• Awad ME, Padela MT, Sayeed Z, El-Othmani MM, Zekaj M, Darwiche HF, Saleh KJ. Pharmacogenomic Testing for Postoperative Pain Optimization Before Total Joint Arthroplasty: A Focus on Drug-Drug-Gene Interaction with Commonly Prescribed Drugs and Prior Opioid Use. JBJS Rev. 2019 May;7(5):e2. PubMed PMID: 31094889
• Sayeed Z, Anoushiravani AA, Simha S, Padela MT, Schafer P, Awad ME, Darwiche HF, Saleh KJ. Markers for Malnutrition and BMI Status in Total Joint Arthroplasty and Pharmaconutrient Therapy. JBJS Rev. 2019 May;7(5):e3. PubMed PMID: 31094890
• Bollag AE, Guo T, Ding KH, Choudhary V, Chen X, Zhong Q, Xu J, Yu K, Awad ME, Elsalanty M, Johnson MH, McGee-Lawrence ME, Bollag WB, Isales CM. Monomethylfumarate protects against ovariectomy-related changes in body composition. J Endocrinol. 2019 Oct;243(1):15-26. PubMed PMID: 31362266
• Khan MB, Hafez S, Hoda MN, Baban B, Wagner J, Awad ME, Sangabathula H, Haigh S, Elsalanty M, Waller JL, Hess DC. Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model. Transl Stroke Res. 2018 Feb;9(1):51-63. PubMed PMID: 28755277
• Elsayed R, Abraham P, Awad ME, Kurago Z, Baladhandayutham B, Whitford GM, Pashley DH, McKenna CE, Elsalanty ME. Removal of matrix-bound zoledronate prevents post-extraction osteonecrosis of the jaw by rescuing osteoclast function. Bone. 2018 May;110:141-149. PubMed PMID: 29408511
• Awad ME, Padela MT, Sayeed Z, Abaab L, El-Othmani MM, Saleh KJ. Pharmacogenomics Testing for Postoperative Pain Optimization Before Total Knee and Total Hip Arthroplasty. JBJS Rev. 2018 Oct;6(10):e3. PubMed PMID: 30300249