VIJAYALAKSHMI NANDAKUMAR, PhD

Professional Titles

• Associate Director, Exsera BioLabs
• Medical Director, Clinical Rheumatology
• Assistant Professor

Research Interests

My research interests center on advancing diagnostic approaches and laboratory medicine within immunology, with a particular emphasis on autoimmune and complement diseases. I am committed to investigating novel biomarkers, improving the stewardship and optimization of diagnostic tests, and contributing to the standardization and harmonization of immunology assays. Additionally, I am passionate about enhancing the education and training of medical students, residents and fellows in clinical immunology and laboratory medicine.

Publications

• Nelson HA, Novis CL, Lebiedz-Odrobina D, Nandakumar V. Performance of Anti-Carbamylated Protein Antibody Testing in the Routine Evaluation of Rheumatoid Arthritis from a Single Center. J Appl Lab Med. 2024 Mar 1;9(2):251-261. PubMed PMID: 38029448
• Zhang XS, Bizzaro N, Tebo AE, Nandakumar V, Infantino M, Carbone T, Bossuyt X, Damoiseaux J. Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research. Immunol Res. 2024 Jun;72(3):361-363. PubMed PMID: 38087183
• Saadalla A, Nandakumar V. Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study. Clin Chim Acta. 2024 Feb 1;554:117761. PubMed PMID: 38195020
• Saadalla A, Novis CL, Banerjee D, Martins T, Holloway B, Ann Aure M, Mahler M, Nandakumar V. Comparative assessment of the diagnostic performances of particle-based multianalyte technology and commercial ELISA for antiphospholipid autoantibody testing. Clin Chim Acta. 2024 Aug 15;562:119849. PubMed PMID: 38977171
• Nelson, Heather A., Martins, Thomas B., Saadalla, Abdulrahman and Nandakumar, Vijayalakshmi. "Evaluation of the clinical performance of anti-mutated citrullinated vimentin antibody and 14-3-3 eta testing in rheumatoid arthritis" Clinical Chemistry and Laboratory Medicine (CCLM), 2024. https://doi.org/10.1515/cclm-2024-1112
• Is the 99th Percentile Cut-off Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome. J Appl Lab Med. 2024 Oct (accepted)
• Nelson HA, Banerjee D, Novis CL, Deane KD, Feser ML, Nandakumar V. A comparison of anti-cyclic citrullinated peptides (CCP3 and CCP3.1) autoantibody tests in rheumatoid arthritis. Pract Lab Med. 2024 Aug;41:e00420. PubMed PMID: 39161944
• Jaskowski TD, Nandakumar V, Novis CL, Palmer M, Tebo AE. Presence of anti-gp210 or anti-sp100 antibodies in AMA-positive patients may help support a diagnosis of primary biliary cholangitis. Clin Chim Acta. 2023 Feb 1;540:117219. PubMed PMID: 36610465
• Novis CL, Wahl E, Camacho E, Aure MA, Mahler M, Nandakumar V. Performance Assessment of a Novel Multianalyte Methodology for Celiac Disease Biomarker Detection and Evaluation of the Serology-Alone Criteria for Biopsy-Free Diagnosis. Arch Pathol Lab Med. 2023 Dec 1;147(12):1422-1430. PubMed PMID: 36856668
• Nandakumar V, Profaizer T, Lozier BK, Elgort MG, Rychert J, Slev PR, Delgado JC. Evaluation of a Novel Multiplex Platform for Simultaneous Detection of IgG Antibodies Against the 4 Main SARS-CoV-2 Antigens. J Appl Lab Med. 2022 May 4;7(3):698-710. PubMed PMID: 34741514
• Nandakumar V, Profaizer T, Lozier BK, Elgort MG, Larragoite ET, Williams ESCP, Solis-Leal A, Lopez JB, Berges BK, Planelles V, Rychert J, Slev PR, Delgado JC. Evaluation of a Surrogate Enzyme-Linked Immunosorbent Assay-Based Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) cPass Neutralization Antibody Detection Assay and Correlation With Immunoglobulin G Commercial Serology Assays. Arch Pathol Lab Med. 2021 Oct 1;145(10):1212-1220. PubMed PMID: 34181714
• Nandakumar V, Dolan CT, Baumann NA, Block DR. Effect of pH on the Quantification of Common Chemistry Analytes in Body Fluid Specimens Using the Roche cobas Analyzer for Clinical Diagnostic Testing. Am J Clin Pathol. 2021 Oct 13;156(5):722-727. PubMed PMID: 34075393
• Nandakumar V, Bornhorst JA, Algeciras-Schimnich A. Evaluation of Phi Clinical Performance for the Detection of Prostate Cancer in Routine Clinical Practice. Ann Clin Lab Sci. 2021 Jan;51(1):3-11. PubMed PMID: 33653775
• Kottom TJ, Nandakumar V, Hebrink DM, Carmona EM, Limper AH. A critical role for CARD9 in pneumocystis pneumonia host defence. Cell Microbiol. 2020 Oct;22(10):e13235. PubMed PMID: 32548948
• Nandakumar V, Paul Theobald J, Algeciras-Schimnich A. Evaluation of plasma ACTH stability using the Roche Elecsys immunoassay. Clin Biochem. 2020 Jul;81:59-62. PubMed PMID: 32315613
• Nandakumar V, Mills JR. The Now and Beyond of Tumor Mutational Burden as a Predictor of Response to Immune Checkpoint Inhibitors. Clin Chem. 2019 Feb 1;65(2):357. PubMed PMID: 32100826
• Kottom TJ, Hebrink DM, Jenson PE, Nandakumar V, Wüthrich M, Wang H, Klein B, Yamasaki S, Lepenies B, Limper AH. The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection. J Immunol. 2017 May 1;198(9):3515-3525. PubMed PMID: 28298521
• Nandakumar V, Hebrink D, Jenson P, Kottom T, Limper AH. Differential Macrophage Polarization from Pneumocystis in Immunocompetent and Immunosuppressed Hosts: Potential Adjunctive Therapy during Pneumonia. Infect Immun. 2017 Mar;85(3). PubMed PMID: 27993972
• Huang XF, Nandakumar V, Tumurkhuu G, Wang T, Jiang X, Hong B, Jones L, Won H, Yoshii H, Ozato K, Masumi A, Chen SY. Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development. Cell Death Dis. 2016 Jun 9;7(6):e2260. PubMed PMID: 27277682
• Feng H, Wang X, Zhang Z, Tang C, Ye H, Jones L, Lou F, Zhang D, Jiang S, Sun H, Dong H, Zhang G, Liu Z, Dong Z, Guo B, Yan H, Yan C, Wang L, Su Z, Li Y, Nandakumar V, Huang XF, Chen SY, Liu D. Identification of Genetic Mutations in Human Lung Cancer by Targeted Sequencing. Cancer Inform. 2015;14:83-93. PubMed PMID: 26244006
• Won H, Nandakumar V, Yates P, Sanchez S, Jones L, Huang XF, Chen SY. Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1. Blood. 2014 Oct 23;124(17):2647-56. PubMed PMID: 25217698
• Xu Z, Huo X, Tang C, Ye H, Nandakumar V, Lou F, Zhang D, Jiang S, Sun H, Dong H, Zhang G, Liu Z, Dong Z, Guo B, Yan H, Yan C, Wang L, Su Z, Li Y, Gu D, Zhang X, Wu X, Wei X, Hong L, Zhang Y, Yang J, Gong Y, Tang C, Jones L, Huang XF, Chen SY, Chen J. Frequent KIT mutations in human gastrointestinal stromal tumors. Sci Rep. 2014 Aug 1;4:5907. PubMed PMID: 25080996
• Xu Z, Huo X, Ye H, Tang C, Nandakumar V, Lou F, Zhang D, Dong H, Sun H, Jiang S, Zhang G, Liu Z, Dong Z, Guo B, He Y, Yan C, Wang L, Su Z, Li Y, Gu D, Zhang X, Wu X, Wei X, Hong L, Zhang Y, Yang J, Gong Y, Tang C, Jones L, Huang XF, Chen SY, Chen J. Genetic mutation analysis of human gastric adenocarcinomas using ion torrent sequencing platform. PLoS One. 2014;9(7):e100442. PubMed PMID: 25025766
• Bai X, Zhang E, Ye H, Nandakumar V, Wang Z, Chen L, Tang C, Li J, Li H, Zhang W, Han W, Lou F, Zhang D, Sun H, Dong H, Zhang G, Liu Z, Dong Z, Guo B, Yan H, Yan C, Wang L, Su Z, Li Y, Jones L, Huang XF, Chen SY, Gao J. PIK3CA and TP53 gene mutations in human breast cancer tumors frequently detected by ion torrent DNA sequencing. PLoS One. 2014;9(6):e99306. PubMed PMID: 24918944
• Cai X, Sheng J, Tang C, Nandakumar V, Ye H, Ji H, Tang H, Qin Y, Guan H, Lou F, Zhang D, Sun H, Dong H, Zhang G, Liu Z, Dong Z, Guo B, Yan H, Yan C, Wang L, Su Z, Li Y, Jones L, Huang XF, Chen SY, Wu T, Lin H. Frequent mutations in EGFR, KRAS and TP53 genes in human lung cancer tumors detected by ion torrent DNA sequencing. PLoS One. 2014;9(4):e95228. PubMed PMID: 24760004
• Wang T, Nandakumar V, Jiang XX, Jones L, Yang AG, Huang XF, Chen SY. The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation. Blood. 2013 Oct 17;122(16):2812-22. PubMed PMID: 24014243
• Nandakumar V, Chou Y, Zang L, Huang XF, Chen SY. Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3927-36. PubMed PMID: 24062447
• Jiang XX, Nguyen Q, Chou Y, Wang T, Nandakumar V, Yates P, Jones L, Wang L, Won H, Lee HR, Jung JU, Müschen M, Huang XF, Chen SY. Control of B cell development by the histone H2A deubiquitinase MYSM1. Immunity. 2011 Dec 23;35(6):883-96. PubMed PMID: 22169041
• Nandakumar V, Vaid M, Katiyar SK. (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis. 2011 Apr;32(4):537-44. PubMed PMID: 21209038
• Nandakumar V, Singh T, Katiyar SK. Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett. 2008 Oct 8;269(2):378-87. PubMed PMID: 18457915
• Miller S, Tate J, Snyder M, Murray D, Peterson L, Johnson L, Nandakumar V, Genzen J & Delgado J (2022). Clinical Cases in Laboratory Medicine, Atlas of electrophoretic Patterns, (F1-F161). In Rifai N, Chiu R, Young, I, Burnham C, Wittwer C (Eds.), Tietz Textbook of Laboratory Medicine (7th edition). Elsevier Science.
• Nandakumar V, Delaney S, Jannetto P (2020). Mercury Poisoning from a High Seafood Diet: A Case Report. In Ketha H, Garg U (Eds.), Toxicology Cases for Clinical and Forensic Laboratory. Elsevier Science.
• Delaney S, Nandakumar V, Jannetto P (2020). Trust Your Gut: A case of Persistent GI Disturbances. In Ketha H, Garg U (Eds.), Toxicology Cases for Clinical and Forensic Laboratory. Elsevier Science.
• Saldanha SN, Nandakumar V, Elgavish A, Tollefsbol TO (2009). Chapter 11: Dietary and Environmental Influences on Histone Modifications in Cancer. In Tollefsbol T (Ed.), Cancer Epigenetics (pp. 197-216). CRC Press.

Professional Memberships

• The Association of Medical Laboratory Immunologists (AMLI), Member of Educational and CME Committee
• Association for Diagnostics & Laboratory Medicine (ADLM), Executive member of Clinical and Diagnostic Immunlology Committee

Practice Locations

UCHealth Rheumatology Clinic - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-7700

Specialty Information

Specialties

• Rheumatology
• Autoimmune and Complement Diseases, Other (0001)
• Diagnostic Immunology, Other (0001)
• Laboratory Medicine, Other (0001)