Zachary Clayton, PhD

Publications

• Singh P, Venkatasubramanian R, Mahoney SA, Darrah MA, Ludwig KR, Zhang A, Kaneshiro K, Najera LE, Wimer L, Shanmugam MM, Morazan E, Galligan JJ, Trujillo MN, Sarpong R, Seals DR, Kapahi P, Clayton ZS. Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence. Aging (Albany NY). 2025 Nov 14;17(11):2717-2743. PubMed PMID: 41247756
• Venkatasubramanian R, Mahoney SA, Hutton DA, VanDongen NS, Brunt VE, Greenberg NT, Longtine AG, Brandt L, Beyer AM, Melov S, Rossman MJ, Seals DR, Clayton ZS. Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment. Am J Physiol Heart Circ Physiol. 2025 Dec 1;329(6):H1672-H1683. PubMed PMID: 41143747
• Clayton ZS, Nguyen BL, Venkatasubramanian R, Kabos P. Exercise to Mitigate Premature Vascular Aging After Doxorubicin Breast Cancer Therapy. Exerc Sport Sci Rev. 2025 Oct 1;53(4):187-194. PubMed PMID: 40993046
• Mahoney SA, Bloom SI, Seals DR, Donato AJ, Rossman MJ, Clayton ZS. Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies. J Cardiovasc Aging. 2025;5(2). PubMed PMID: 40936799
• Mahoney SA, Mazan-Mamczarz K, Tsitsipatis D, VanDongen NS, Henry-Smith C, Okereke AN, Munk R, Darvish S, Murray KO, De S, Gorospe M, Seals DR, Rossman MJ, Herman AB, Clayton ZS. Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12. bioRxiv. 2025 Aug 18. PubMed PMID: 40894771
• Venkatasubramanian R, Darrah MA, Mahoney SA, Hutton DA, Maurer GS, Ludwig KR, Van Dongen NS, Greenberg NT, Longtine AG, Brunt VE, Singh P, Galligan JJ, Trujillo MN, Kapahi P, Melov S, Rossman MJ, Seals DR, Clayton ZS. Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress. Hypertension. 2025 Oct;82(10):1767-1777. PubMed PMID: 40747550
• Venkatasubramanian R, Darrah MA, Mahoney SA, Hutton DA, Maurer GS, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Brunt VE, Singh P, Galligan JJ, Trujillo MN, Kapahi P, Melov S, Campisi J, Rossman MJ, Seals DR, Clayton ZS. Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress. bioRxiv. 2025 May 16. PubMed PMID: 40463113
• Murray KO, Mahoney SA, Ludwig KR, Miyamoto-Ditmon JH, VanDongen NS, Banskota N, Herman AB, Seals DR, Mankowski RT, Rossman MJ, Clayton ZS. Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. Aging Cell. 2025 Aug;24(8):e70114. PubMed PMID: 40437670
• Mahoney SA, Darrah MA, Venkatasubramanian R, Ciotlos S, Rossman MJ, Campisi J, Seals DR, Melov S, Clayton ZS. Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice. Aging Cell. 2025 May 22;24(8):e70118. [Epub ahead of print] PubMed PMID: 40401595
• Bell CF, Clayton ZS. Novel biomarkers in cardio-oncology: from promise to practice through prospective study. Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H210-H212. PubMed PMID: 40387534
• Clayton ZS, Kehmeier MN, Rosenberry R, Larson EA, Debray A, Cheng S, Moreau KL. Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk. Curr Atheroscler Rep. 2025 May 16;27(1):56. PubMed PMID: 40374914
• Clayton ZS, Moreau KL. X's, Y's, and vascular ties: exploring the role of sex chromosomes in arterial stiffness and vascular aging. Am J Physiol Heart Circ Physiol. 2025 May 1;328(5):H1083-H1085. PubMed PMID: 40209721
• Nguyen BL, Clayton ZS. Aerobic Exercise and HFrEF: Impact of Sex and Biological Age. JACC Adv. 2025 Apr;4(4):101658. PubMed PMID: 40088735
• Singh P, Venkatasubramanian R, Mahoney SA, Darrah MA, Ludwig KR, Zhang A, Kaneshiro K, Najera LE, Wimer L, Shanmugam MM, Morazan E, Trujillo M, Galligan J, Sarpong R, Seals DR, Kapahi P, Clayton ZS. Methylglyoxal-induced glycation stress promotes aortic stiffening: Putative mechanistic roles of oxidative stress and cellular senescence. bioRxiv. 2025 Jan 6. PubMed PMID: 39829921
• Darrah MA, Longtine AG, Greenberg NT, Mahoney SA, Venkatasubramanian R, VanDongen NS, Reisz JA, D'Alessandro A, Seals DR, de Quiros Miranda YB, Clayton ZS. The influence of a human macronutrient-matched diet on phenotypes in old mice. Geroscience. 2025 Apr;47(2):2293-2308. PubMed PMID: 39514173
• Darrah MA, Longtine AG, Greenberg NT, Mahoney SA, Venkatasubramanian R, VanDongen NS, Reisz JA, D'Alessandro A, Seals DR, de Quiros Miranda YB, Clayton ZS. The influence of a human macronutrient-matched diet on phenotypes in old mice. Geroscience. 2024 Nov 8. [Epub ahead of print] PubMed PMID: 39514173
• Craighead DH, Clayton ZS. "When does it end?" Continuing to align career goals and work-life balance after graduate training. J Appl Physiol (1985). 2024 Oct 1;137(4):1057. PubMed PMID: 39401878
• Bernaldo de Quirós Y, Mahoney SA, VanDongen NS, Greenberg NT, Venkatasubramanian R, Saavedra P, Bossart G, Brunt VE, Clayton ZS, Fernández A, Seals DR. The bottlenose dolphin (Tursiops truncatus): a novel model for studying healthy arterial aging. Am J Physiol Heart Circ Physiol. 2024 Sep 1;327(3):H660-H665. PubMed PMID: 39058431
• Mahoney SA, Clayton ZS. Reply to Jaster. Am J Physiol Heart Circ Physiol. 2024 Jul 1;327(1):H000. PubMed PMID: 38958689
• Darvish S, Mahoney SA, Venkatasubramanian R, Rossman MJ, Clayton ZS, Murray KO. Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions. J Appl Physiol (1985). 2024 Jul 1;137(1):194-222. PubMed PMID: 38813611
• Wahl D, Clayton ZS. Peripheral vascular dysfunction and the aging brain. Aging (Albany NY). 2024 May 22;16(10):9280-9302. PubMed PMID: 38805248
• Mahoney SA, VanDongen NS, Greenberg NT, Venkatasubramanian R, Rossman MJ, Widlansky ME, Brunt VE, Bernaldo de Quirós Y, Seals DR, Clayton ZS. Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach. Am J Physiol Heart Circ Physiol. 2024 May 1;326(5):H1279-H1290. PubMed PMID: 38517225
• Clayton ZS, Murray KO. Aerobic Exercise and Obesity-related Insulin Resistance: Using Molecular Patterns to Inform Individualized Prescription. J Clin Endocrinol Metab. 2024 Aug 13;109(9):e1800-e1801. PubMed PMID: 38340335
• Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 Jun;46(3):3311-3324. PubMed PMID: 38265578
• Longtine AG, Greenberg NT, Gonzalez A, Lindquist A, VanDongen NS, Mahoney SA, Rahman G, Clayton ZS, Ziemba BP, Ludwig KR, Widlansky ME, Knight R, Seals DR, Brunt VE. Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Arterial Dysfunction in Mice. Aging Biol. 2024;2. PubMed PMID: 39897133
• Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 Mar;23(3):e14060. PubMed PMID: 38062873
• Cavalier AN, Clayton ZS, Wahl D, Hutton DA, McEntee CM, Seals DR, LaRocca TJ. Protective effects of apigenin on the brain transcriptome with aging. Mech Ageing Dev. 2024 Feb;217:111889. PubMed PMID: 38007051
• Moreau KL, Clayton ZS, DuBose LE, Rosenberry R, Seals DR. Effects of regular exercise on vascular function with aging: Does sex matter?. Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H123-H137. PubMed PMID: 37921669