Caitlin Lewis, PhD

Assistant Professor, Pediatrics-Critical Care Medicine

Publications

  • Elajaili H, Lyttle BD, Lewis CV, Bardill JR, Dee N, Seal S, Nozik ES, Liechty KW, Zgheib C. Increased ROS and Persistent Pro-Inflammatory Responses in a Diabetic Wound Healing Model (db/db): Implications for Delayed Wound Healing. Int J Mol Sci. 2025 May 20;26(10). PubMed PMID: 40430024
  • Lewis CV, Nguyen TN, Porfilio TE, Burciaga SD, Posey JN, Jordan M, Colon Hidalgo D, Stenmark KR, Mickael C, Sul C, Oberley-Deegan RE, Delaney C, Nozik ES. Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia. Am J Physiol Lung Cell Mol Physiol. 2025 Jun 1;328(6):L885-L900. PubMed PMID: 40332405
  • Nguyen TN, Lewis CV, Hidalgo DC, Posey JN, Jordan M, Porfilio TE, Grayck MR, Wright CJ, Delaney C, Nozik ES. A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes. Front Physiol. 2025;16:1513703. PubMed PMID: 40084179
  • Posey JN, Jordan M, Lewis CV, Sul C, Dobrinskikh E, Swindle D, Denorme F, Irwin D, Di Paola J, Stenmark K, Nozik ES, Delaney C. Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension. Blood Adv. 2025 Apr 8;9(7):1571-1584. PubMed PMID: 39693512
  • Sul C, Lewis CV, Posey J, Jordan M, Colon Hidalgo D, Porfilio T, Elajaili H, McCormack G, Burciaga S, Delaney C, Nozik ES. Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions. Am J Respir Cell Mol Biol. 2025 Jun;72(6):653-662. PubMed PMID: 39531632
  • Sul C, Lewis CV, Posey J, Jordan M, Colon Hidalgo D, Porfilio T, Elajaili H, McCormack G, Burciaga S, Delaney C, Nozik ES. Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions. Am J Respir Cell Mol Biol. 2024 Nov 12. [Epub ahead of print] PubMed PMID: 39531632
  • Lewis CV, Garcia AM, Burciaga SD, Posey JN, Jordan M, Nguyen TN, Stenmark KR, Mickael C, Sul C, Delaney C, Nozik ES. Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia. Physiol Genomics. 2024 Nov 1;56(11):776-790. PubMed PMID: 39311838
  • Colon Hidalgo D, Jordan M, Posey JN, Burciaga SD, Nguyen TN, Sul C, Lewis CV, Delaney C, Nozik ES. Lung EC-SOD Overexpression Prevents Hypoxia-Induced Platelet Activation and Lung Platelet Accumulation. Antioxidants (Basel). 2024 Aug 10;13(8). PubMed PMID: 39199221
  • Scott TE, Lewis CV, Zhu M, Wang C, Samuel CS, Drummond GR, Kemp-Harper BK. IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages. Sci Rep. 2023 Nov 10;13(1):19589. PubMed PMID: 37949903
  • Hurtado J, Sellak H, Joseph G, Lewis CV, Naudin CR, Garcia S, Wodicka JR, Archer DR, Taylor WR. Accelerated atherosclerosis in beta-thalassemia. Am J Physiol Heart Circ Physiol. 2023 Nov 1;325(5):H1133-H1143. PubMed PMID: 37682237
  • Sul C, Lewis C, Dee N, Burns N, Oshima K, Schmidt E, Vohwinkel C, Nozik E. Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation in Staphylococcus aureus pneumonia. Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L445-L455. PubMed PMID: 36749572
  • Lewis CV, Sellak H, Sawan MA, Joseph G, Darby TM, VanInsberghe D, Naudin CR, Archer DR, Jones RM, Taylor WR. Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis. FASEB Bioadv. 2023 May;5(5):199-210. PubMed PMID: 37151850
  • Posey et al. Nbeal2 Knockout Mice Are Not Protected Against Hypoxia-Induced Pulmonary Vascular Remodeling and Pulmonary Hypertension. Blood Advances (In Press)
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School of Medicine

CU Anschutz

Fitzsimons Building

13001 East 17th Place

Campus Box C290

Aurora, CO 80045


303.724.5375