Ocular immune responses, immune phenotyping, genomics, precision medicine, health equity.
Publications
Paley MA, Baker BJ, Dunham SR, Linskey N, Cantoni C, Lee K, Hassman LM, Laurent J, Roberson EDO, Clifford DB, Yokoyama WM. The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells. J Neuroimmunol. 2022 Jun 15;367:577860. PubMed PMID: 35405431
Hassman LM, Paley MA, Esaulova E, Paley GL, Ruzycki PA, Linskey N, Laurent J, Feigl-Lenzen L, Springer L, Montana CL, Hong K, Enright J, James H, Artyomov MN, Yokoyama WM. Clinicomolecular Identification of Conserved and Individualized Features of Granulomatous Uveitis. Ophthalmol Sci. 2021 Mar;1(1). PubMed PMID: 35937550
Rosenbaum JT, Harrington CA, Searles RP, Fei SS, Zaki A, Arepalli S, Paley MA, Hassman LM, Vitale AT, Conrady CD, Keath P, Mitchell C, Watson L, Planck SR, Martin TM, Choi D. Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis. Am J Ophthalmol. 2021 Jun;226:226-234. PubMed PMID: 33503442
Rosenbaum JT, Harrington CA, Searles RP, Fei SS, Zaki A, Arepalli S, Paley MA, Hassman LM, Vitale AT, Conrady CD, Keath P, Mitchell C, Watson L, Planck SR, Martin TM, Choi D. Revising the Diagnosis of Idiopathic Uveitis by Peripheral Blood Transcriptomics. Am J Ophthalmol. 2021 Feb;222:15-23. PubMed PMID: 32941857
Hassman LM, Chung MM, Gonzalez M, Bessette AP. Herpetic Panophthalmitis: A Diagnostic Dilemma. Ocul Immunol Inflamm. 2020;28(1):116-118. PubMed PMID: 30444434
Borah S, Nichols LA, Hassman LM, Kedes DH, Steitz JA. Tracking expression and subcellular localization of RNA and protein species using high-throughput single cell imaging flow cytometry. RNA. 2012 Aug;18(8):1573-9. PubMed PMID: 22745225
Hassman LM, Ellison TJ, Kedes DH. KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation. J Clin Invest. 2011 Feb;121(2):752-68. PubMed PMID: 21245574
Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME. Persistent effects induced by IL-13 in the lung. Am J Respir Cell Mol Biol. 2006 Sep;35(3):337-46. PubMed PMID: 16645178
Fulkerson PC, Fischetti CA, McBride ML, Hassman LM, Hogan SP, Rothenberg ME. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16418-23. PubMed PMID: 17060636
Fulkerson PC, Zimmermann N, Hassman LM, Finkelman FD, Rothenberg ME. Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. J Immunol. 2004 Dec 15;173(12):7565-74. PubMed PMID: 15585884
• Sabapathypillai A, Miller TJ, Shakoor A, Palestine AG, Thorne JE, Goldstein DA, Gaudio PA, Goldberg N, Vitale A, Schlaen A, Thomas A, Merrill PT, Rajii V, Lin P, Oliver A, Moorthy RS, Chandra G, Carreno E, Smith WM, Van Stavern G, Hassman LM. Optic disc edema is an under-recognized feature of birdshot chorioretinitis. Journal of Neuro-ophthalmology
Lin JB, Pepple, KL, Concepcion C, Korsunova Y, Paley MA, Paley GL, Laurent J, Apte AS, Hassman LM. Aqueous macrophages contribute to conserved CCL2 and CXCL10 gradients in uveitis. Ophthalmology science, in press
Guess R, Harocopos G, Bednarski JJ, Hassman LM, Bigley TM. Pediatric Necrobiotic Xanthogranuloma as a Novel Phenotype of IKAROS Gain of Function. Journal of Clinical Immunology
Clinical Interests
I provide comprehensive medical management for all forms of ocular inflammation, including uveitis. When necessary, I also prescribe immune suppression treatments.
Care Philosophy
I work closely with each patient to create a personalized care plan based on current best practices.
Additionally, I invite patients to partner with me as we invest in innovative future solutions through dedicated research partnerships
Personal Interests
I enjoy hiking, skiing and cooking with my family.
Volunteer Activities
I enjoy mentoring the next generation of ocular immunologists, vision scientists and ophthalmologists.
Public Speaking Yes
I regularly speak on various topics related to uveitis and ocular immunology.
General Information
Medical Schools:
MD, University of Virginia School of Medicine
(2012)
Graduate Schools:
PhD, University of Virginia - Charlottesville
(2010)
Undergraduate Schools:
BS, Evangel University (MO)
(2002)
Internships:
Case Western Reserve University (MetroHealth) Program
(2014)
Residency Programs:
University of Rochester Program, Ophthalmology (2017)