I have research interests which mirror my clinical focus, with an emphasis on investigating the impact of normothermic regional perfusion on heart and lung transplantation, evaluating the impact of right ventricular dysfunction in patients supported on extracorporeal membrane oxygenation, and the use of temporary ventricular assist devices for cardiogenic shock. Additionally, I have an interest in the investigating the roll of 4D flow cardiac MRI imaging in improving the evaluation of patients with chronic thromboembolic pulmonary hypertension.
Teaching
Assistant Professor
(2023)
School of Medicine,
Surgery
Publications
Suarez-Pierre A, Iguidbashian J, Kirsch MJ, Cain MT, Aftab M, Reece TB, Fullerton DA, Rove JY, Cleveland JC Jr, Hoffman JRH. Association of cardiac preservation solution with short-term outcomes after heart transplantation. J Cardiovasc Med (Hagerstown). 2024 Feb 1;25(2):158-164. PubMed PMID: 38149702
Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2023 Oct 30. [Epub ahead of print] PubMed PMID: 37902921
Dindi K, Cain MT, Odera A, Joyce DL, Joyce LD, Leta A, White RE. Building cardiac surgical programs in lower-middle income countries. JTCVS Open. 2023 Mar;13:252-259. PubMed PMID: 37063137
Cain MT, Joyce DL, Szabo A, Wu R, Kohmoto T, Joyce LD, Pearson PJ. Reduced Morbidity and Mortality Associated With Minimally Invasive Single-vessel Coronary Artery Bypass Compared With Conventional Sternotomy. Ann Surg. 2023 May 1;277(5):e1176-e1183. PubMed PMID: 35797604
Cain MT, Park SY, Schäfer M, Hay-Arthur E, Justison GA, Zhan QP, Campbell D, Mitchell JD, Randhawa SK, Meguid RA, David EA, Reece TB, Cleveland JC Jr, Hoffman JRH. Lung recovery utilizing thoracoabdominal normothermic regional perfusion during donation after circulatory death: The Colorado experience. JTCVS Tech. 2023 Dec;22:350-358. PubMed PMID: 38152164
Cain MT, Reece TB. Commentary: Antegrade cerebral perfusion versus retrograde cerebral perfusion: If only it was that easy. J Thorac Cardiovasc Surg. 2023 Aug;166(2):407-408. PubMed PMID: 34556358
Cain MT, Schäfer M, Ivy DD, Mitchell MB, Fenster BE, Bull TM, Barker AJ, Vargas D, Hoffman JRH. 4D-Flow MRI Intracardiac Flow Analysis Can Phenotype Diastolic Dysfunction Among Different Subtypes of Pulmonary Hypertension. Pulmonary circulation. 2023;13:e12307. DOI: https://doi.org/10.1002/pul2.12307
Cain MT, Taylor LJ, Colborn K, Teman NR, Hoffman J, Mayer KP, Etchill EW, Sevin CM, Jaishankar S, Ramanan R, Enfield K, Zwischenberger JB, Jolley SE, Rove JY. Worse Survival in Patients with Right Ventricular Dysfunction and COVID-19 Associated ARDS Requiring ECMO: A Multicenter Study from the ORACLE Group. Journal of Thoracic and Cardiovascular Surgery. 2023. DOI: https://doi.org/10.1016/j.jtcvs.2022.12.013
Bush EL, Cain MT. 2023 WTSA Annual Meeting Discussion to: Lung Recovery Utilizing Thoracoabdominal Normothermic Regional Perfusion During Donation After Circulatory Death: The Colorado Experience. JTCVS Techniques. October 02, 2023 DOI: https://doi.org/10.1016/j.xjtc.2023.09.029
Cain MT, Joyce D, Lahr BD, Day CN, Sandhu GS, Kushwaha S, Joyce LD. Do Right Heart Hemodynamic Improvements Persist After Pulmonary Thromboendarterectomy?. Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):80-89. PubMed PMID: 33691188
Smith NJ, Park S, Zundel MT, Dong H, Szabo A, Cain MT, Durham LA 3rd. Extracorporeal membrane oxygenation for COVID-19: An evolving experience through multiple waves. Artif Organs. 2022 Nov;46(11):2257-2265. PubMed PMID: 35957490
Ramamurthi A, Cain MT, Smith N, Espinal A, Joyce DL, Mohammed A, Joyce LD, Durham LA. Transcarotid Approach to Placement of an Impella 5.0. ASAIO J. 2022 Jan 1;68(1):e12-e15. PubMed PMID: 33741787
Cain MT, Smith NJ, Barash M, Simpson P, Durham LA 3rd, Makker H, Roberts C, Falcucci O, Wang D, Walker R, Ahmed G, Brown SA, Nanchal RS, Joyce DL. Extracorporeal Membrane Oxygenation with Right Ventricular Assist Device for COVID-19 ARDS. J Surg Res. 2021 Aug;264:81-89. PubMed PMID: 33789179
Cain MT, Firstenberg MS, Cleveland JC. Heart Transplant and Ventricular Assist: Cardiac Surgery and Heart Failure Perspective. US Cardiology Review. 2021; 15:e16 https://doi.org/10.15420/usc.2021.11
Schurman AM, Cain MT, Joyce DL, Durham LA, Ishizawar D, Mohammed A, Joyce LD. Minimally Invasive Mechanical Circulatory Support Through the Perioperative Pulmonary Thromboendarterectomy Period: A Case Report. Innovations (Phila). 2020 Mar Apr;15(2):173-176. PubMed PMID: 32352901
Badu B, Cain MT, Durham LA 3rd, Joyce LD, Sundararajan S, Gaglianello N, Ishizawar D, Saltzberg M, Mohammed A, Joyce DL. A Dual-Lumen Percutaneous Cannula for Managing Refractory Right Ventricular Failure. ASAIO J. 2020 Aug;66(8):915-921. PubMed PMID: 32740352
Smith NJ, Miles B, Cain MT, Joyce LD, Pearson P, Joyce DL. Minimally invasive single-vessel left internal mammary to left anterior descending artery bypass grafting improves outcomes over conventional sternotomy: A single-institution retrospective cohort study. J Card Surg. 2019 Sep;34(9):788-795. PubMed PMID: 31269282
Greaves SW, Dye L 3rd, Aranda PS, Cain MT, Haasler GB, Almassi GH, Pagel PS, Kreibich M, Beyersdorf F, Elefteriades JA. Perioperative Management of a Large Idiopathic Pulmonary Artery Aneurysm Without Pulmonary Arterial Hypertension. J Cardiothorac Vasc Anesth. 2018 Oct;32(5):2402-2408. PubMed PMID: 29887125
Pagel PS, Hendrix WA, Cain MT, Ali AKY, Muscato G, Mungara C, Rokkas C. Unexpected Findings in a Man with a Repaired Type A Aortic Dissection and a New Stroke. J Cardiothorac Vasc Anesth. 2018 Oct;32(5):2451-2454. PubMed PMID: 29331553
Cain MT, Cao Y, Ghanayem NS, Simpson PM, Trapp K, Mitchell ME, Tweddell JS, Woods RK. Transposition of the great arteries--outcomes and time interval of early neonatal repair. World J Pediatr Congenit Heart Surg. 2014 Apr;5(2):241-7. PubMed PMID: 24668972
Taff HT, Nett JE, Zarnowski R, Ross KM, Sanchez H, Cain MT, Hamaker J, Mitchell AP, Andes DR. A Candida biofilm-induced pathway for matrix glucan delivery: implications for drug resistance. PLoS Pathog. 2012;8(8):e1002848. PubMed PMID: 22876186
Nett JE, Sanchez H, Cain MT, Ross KM, Andes DR. Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation. Eukaryot Cell. 2011 Dec;10(12):1660-9. PubMed PMID: 21666076
Nett JE, Cain MT, Crawford K, Andes DR. Optimizing a Candida biofilm microtiter plate model for measurement of antifungal susceptibility by tetrazolium salt assay. J Clin Microbiol. 2011 Apr;49(4):1426-33. PubMed PMID: 21227984
Nett JE, Sanchez H, Cain MT, Andes DR. Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan. J Infect Dis. 2010 Jul 1;202(1):171-5. PubMed PMID: 20497051
Thoracic and Cardiac, Board Certification (2023, 2024)
Conditions & Treatments
Heart and Circulation
Heart and Circulation - Structural Heart Disease
Heart and Circulation - Heart Failure
Heart and Circulation - Circulatory Disorders
Surgery - Transplant Surgery
Surgery
Surgery - Cardiothoracic Surgery
Surgery - Adult Cardiac Surgery
Surgery - Heart Transplant Surgery
Surgery - Lung Transplant Surgery
Clinical Interests
I have a clinical focus on advanced heart and lung disease, including mechanical circulatory support and left ventricular assist device implantation, minimally invasive approaches to mechanical circulatory support, heart and lung transplantation, and surgical management of chronic thromboembolic pulmonary hypertension (CTEPH). In addition to these focuses, I provide the full spectrum of adult cardiac care at the University of Colorado and the Rocky Mountain Regional VA Medical Center and care for patients with coronary artery disease, valvular heart disease, arrhythmias including atrial fibrillation, as well as thoracic aortic aneurysms and dissection.
Care Philosophy
I am part of a world class multidisciplinary team focused on providing the best care for patients with advanced forms of heart and lung disease. I am driven to provide excellent care through tailored surgical approaches to each unique patient and believe strongly that shared decision making is important to achieve the best outcomes for my patients.
General Information
Medical Schools:
MD, Medical College of Wisconsin
(2015)
Undergraduate Schools:
BSc (Hons), University of Wisconsin–Madison (WI)
(2010)
Residency Programs:
Medical College of Wisconsin Affiliated Hospitals Program, Surgery (2020)
Fellowships:
University of Colorado, Thoracic and Cardiac
(2023)