Shyam Raghavan, MD

Professional Titles

• Associate Professor

Research Interests

I am particularly interested in the molecular basis for melanocytic neoplasms, namely, what alterations/genes are responsible for pathogenesis along with histogenesis. I love the opportunity to evaluate and consult on challenging melanocytic lesions. Furthermore, I am also interested in the evaluation of challenging dermal based soft tissue tumors. I additionally spend time signing out gastrointestinal pathology, and within this area I am interested in studying inflammatory disorders of the GI tract, along with diagnosing challenging and rare mesenchymal tumors.

Publications

• Zhao P, Luu LA, Gish TJ, Raghavan SS, Gru AA, Zlotoff BJ. Widespread livedo racemosa. Clin Exp Dermatol. 2023 Jul 21;48(8):945-948. PubMed PMID: 37052078
• Kreher MA, Wills AC, Duran J, Raghavan SS, Zlotoff BJ. Regressing Papules on the Sole of the Foot: Challenge. Am J Dermatopathol. 2023 Jul 1;45(7):e56-e57. PubMed PMID: 37338072
• Kreher MA, Wills AC, Duran J, Raghavan SS, Zlotoff BJ. Regressing Papules on the Sole of the Foot: Answer. Am J Dermatopathol. 2023 Jul 1;45(7):515-516. PubMed PMID: 37338069
• Chan D, Maikawa CL, d'Aquino AI, Raghavan SS, Troxell ML, Appel EA. Polyacrylamide-based hydrogel coatings improve biocompatibility of implanted pump devices. J Biomed Mater Res A. 2023 Jul;111(7):910-920. PubMed PMID: 36861657
• Pixley JN, Kozak M, Rusu C, Raghavan S, Flowers RH. Diffuse Vesicular Rash: Challenge. Am J Dermatopathol. 2023 Jan 1;45(1):e1-e2. PubMed PMID: 36484614
• Pixley JN, Kozak M, Rusu C, Raghavan S, Flowers RH. Diffuse Vesicular Rash: Answer. Am J Dermatopathol. 2023 Jan 1;45(1):69-70. PubMed PMID: 36484612
• McKenna B, Lee J, Raghavan S, Zlotoff B. Don't Go Breaking My Heart: Not Your Ordinary Tattoo Reaction. Am J Dermatopathol. 2023 Aug 1;45(8):582-584. PubMed PMID: 37377199
• Khan M, Jamil Z, Ehsan L, Zulqarnain F, Srivastava S, Siddiqui S, Fernandes P, Raghib M, Sengupta S, Mujahid Z, Ahmed Z, Idrees R, Ahmed S, Umrani F, Iqbal N, Moskaluk C, Raghavan S, Cheng L, Moore S, Ali SA, Iqbal J, Syed S. Quantitative Morphometry and Machine Learning Model to Explore Duodenal and Rectal Mucosal Tissue of Children with Environmental Enteric Dysfunction. Am J Trop Med Hyg. 2023 Apr 5;108(4):672-683. PubMed PMID: 36913924
• Gupta S, Noona SW, Pambuccian SE, Robinson B, Martin LW, Williams E, Stelow EB, Raghavan SS. Malignant undifferentiated and rhabdoid tumors of the gastroesophageal junction and esophagus with SMARCA4 loss: a case series. Hum Pathol. 2023 Apr;134:56-65. PubMed PMID: 36549598
• Miller EM, Linos K, Bacchi CE, Gru AA, Raghavan SS. Histopathologic and molecular characterization of BAP-1-inactivated melanoma. J Cutan Pathol. 2023 Apr;50(4):349-357. PubMed PMID: 36285428
• Gradecki SE, Gru AA, Rieger KE, Raghavan SS. Histopathology of primary cutaneous adenoid cystic carcinoma of the scrotum presenting with predominantly solid growth. J Cutan Pathol. 2022 Sep;49(9):761-764. PubMed PMID: 33314272
• Finberg A, Martin S, Gradecki S, Zlotoff B, Raghavan SS. Cutaneous Neurocristic Hamartoma Mimicking Basal Cell Carcinoma in a Patient With Xeroderma Pigmentosum. Am J Dermatopathol. 2022 May 1;44(5):e54-e56. PubMed PMID: 35170472
• Yi LG, Rusu CA, Cropley TG, Marchi E, Gru AA, Greer KE, Raghavan SS. Clonal cutaneous and neurosyphilis: A pitfall in pseudolymphoma diagnosis. J Cutan Pathol. 2022 Mar;49(3):288-292. PubMed PMID: 34655438
• Raghavan SS, Wang JY, Gru AA, Marqueling AL, Teng JMC, Brown RA, Novoa RA, Kim Y, Zehnder J, Zhang BM, Rieger KE. Next-generation sequencing confirms T-cell clonality in a subset of pediatric pityriasis lichenoides. J Cutan Pathol. 2022 Mar;49(3):252-260. PubMed PMID: 34614220
• Upchurch CM, Yeudall S, Pavelec CM, Merk D, Greulich J, Manjegowda M, Raghavan SS, Bochkis IM, Scott MM, Perez-Reyes E, Leitinger N. Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis. Sci Adv. 2022 Jul 15;8(28):eabn0050. PubMed PMID: 35857497
• Craddock AP, Kane WJ, Raghavan SS, Williams ES, Gru AA, Gradecki SE. Use of Ultrasensitive RNA In Situ Hybridization for Determining Clonality in Cutaneous B-Cell Lymphomas and Lymphoid Hyperplasia Decreases Subsequent Use of Molecular Testing and Is Cost-effective. Am J Surg Pathol. 2022 Jul 1;46(7):956-962. PubMed PMID: 35067516
• Saleem A, Narala S, Raghavan SS. Immunohistochemistry in melanocytic lesions: Updates with a practical review for pathologists. Semin Diagn Pathol. 2022 Jul;39(4):239-247. PubMed PMID: 35016807
• Hobbs LK, Kozak MD, Gradecki SE, McGahren ED, Raghavan SS. A rapidly growing nodule on the leg of an adolescent: A unique presentation of a non-neural granular cell tumor. J Cutan Pathol. 2022 Dec;49(12):1040-1043. PubMed PMID: 34981846
• Gru AA, Bacchi CE, Pulitzer M, Bhagat G, Kempf W, Robson A, Plaza JA, Pincus L, Raghavan S, Xu M, Vencato da Silva T, Salavaggione AL, Subtil A, Battistella M. Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients. J Cutan Pathol. 2021 Nov;48(11):1367-1378. PubMed PMID: 34089205
• Gru AA, Bhagat G, Subtil A, Raghavan SS, Pulitzer M, Chung C, Sangueza M, Plaza JA. Spindle-cell (Sarcomatoid) Variant of Cutaneous Anaplastic Large-cell Lymphoma (C-ALCL): An Unusual Mimicker of Cutaneous Malignant Mesenchymal Tumors-A Series of 11 Cases. Am J Surg Pathol. 2021 Jun 1;45(6):796-802. PubMed PMID: 33234878
• Brown RA, Wang JY, Raghavan SS, Zhang J, Wan DC, Born D, Koo M, Hazard FK, Novoa RA, Rieger KE. ALK-positive compound Spitz nevus with extensive perineural and intraneural neurotropism. J Cutan Pathol. 2021 Jan;48(1):154-159. PubMed PMID: 33034114
• Scapa JV, Cloutier JM, Raghavan SS, Peters-Schulze G, Varma S, Charville GW. DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma. Am J Surg Pathol. 2021 Feb 1;45(2):230-239. PubMed PMID: 32815829
• Plaza JA, Pootrakul L, Raghavan SS, Sangueza M, Gru AA. Reproducible Histopathologic Features in Cases of Basal Cell Carcinoma With Neuroendocrine Expression: A Clinicopathologic Study of 24 Cases With a Potential Diagnostic Pitfall. Am J Dermatopathol. 2021 Dec 1;43(12):903-907. PubMed PMID: 34783706
• Craddock AP, Gru AA, Mannschreck D, Wilson BB, Raghavan SS. Primary Cutaneous Monomorphic Post-transplant Lymphoproliferative Disorder Mimicking Squamous Cell Carcinoma In Situ. Am J Dermatopathol. 2021 Dec 1;43(12):e234-e236. PubMed PMID: 33899771
• Shen NW, Yi LG, Omesiete W, Peroutka CM, Raghavan SS, Greer KE. Cutaneous lesions in the setting of hypophosphatasia. JAAD Case Rep. 2023 Dec;42:23-25. PubMed PMID: 37965189
• Mascharak S, Guo JL, Foster DS, Khan A, Davitt MF, Nguyen AT, Burcham AR, Chinta MS, Guardino NJ, Griffin M, Lopez DM, Miller E, Januszyk M, Raghavan SS, Longacre TA, Delitto DJ, Norton JA, Longaker MT. Desmoplastic stromal signatures predict patient outcomes in pancreatic ductal adenocarcinoma. Cell Rep Med. 2023 Nov 21;4(11):101248. PubMed PMID: 37865092
• Hirotsu KE, Rana J, Wang JY, Raghavan SS, Rieger KE, Srinivas S, Fan AC, Kwong BY, Novoa RA, Zaba LC. Clinicopathologic characterization of enfortumab vedotin-associated cutaneous toxicity in patients with urothelial carcinoma. J Am Acad Dermatol. 2021 Dec;85(6):1610-1611. PubMed PMID: 33301805
• Hobbs LK, Noland MB, Raghavan SS, Gru AA. Pemphigus erythematosus: A case series from a tertiary academic center and literature review. J Cutan Pathol. 2021 Aug;48(8):1038-1050. PubMed PMID: 33609053
• Raghavan SS, Clark M, Louie CY, Jensen KC, Dietrich B, Beadle BM, El-Sawy T, Baik F, Kunder CA, Brown RA. Molecular profiling of a primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid. J Cutan Pathol. 2020 Sep;47(9):860-864. PubMed PMID: 32358805
• Raghavan SS, Saleem A, Wang JY, Rieger KE, Brown RA, Novoa RA. Diagnostic Utility of LEF1 Immunohistochemistry in Differentiating Deep Penetrating Nevi From Histologic Mimics. Am J Surg Pathol. 2020 Oct;44(10):1413-1418. PubMed PMID: 32520758
• Medernach JG, Li RC, Zhao XY, Yin B, Noonan EA, Etter EF, Raghavan SS, Borish LC, Wilson JM, Barnes BH, Platts-Mills TAE, Ewald SE, Sauer BG, McGowan EC. Immunoglobulin G4 in eosinophilic esophagitis: Immune complex formation and correlation with disease activity. Allergy. 2023 Jul 27. [Epub ahead of print] PubMed PMID: 37497566
• Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I. Spitz melanoma is a distinct subset of spitzoid melanoma. Mod Pathol. 2020 Jun;33(6):1122-1134. PubMed PMID: 31900433
• McKenna B, Lee J, Raghavan S, Zlotoff B. Don't Go Breaking My Heart: Not Your Ordinary Tattoo Reaction. Am J Dermatopathol. 2023 Aug 1;45(8):582-584. PubMed PMID: 37377199
• Kreher MA, Wills AC, Duran J, Raghavan SS, Zlotoff BJ. Regressing Papules on the Sole of the Foot: Challenge. Am J Dermatopathol. 2023 Jul 1;45(7):e56-e57. PubMed PMID: 37338072
• Alpert L, Al-Sabti R, Graham RP, Pai RK, Gonzalez RS, Zhang X, Smith V, Wang HL, Westbrook L, Goldblum JR, Bakhshwin A, Shetty S, Klimstra DS, Shia J, Askan G, Robert ME, Thomas C, Frankel WL, Alsomali M, Hagen C, Mostafa ME, Feely MM, Assarzadegan N, Misdraji J, Shih AR, Agostini-Vulaj D, Meis JM, Tang S, Chatterjee D, Kang LI, Hart J, Lee SM, Smith T, Yantiss RK, Hissong EM, Gao ZH, Wu J, Resnick MB, Wu EY, Pai RK, Zhao L, Doyle LA, Chopra S, Panarelli NC, Hu S, Longacre TA, Raghavan SS, Lauwers GY, Ghayouri M, Cooper HS, Nagarathinam R, Bellizzi AM, Kakar S, Hosseini M, Rong J, Greenson JK, Lamps LW, Dong Z, Bronner MP. Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases. Mod Pathol. 2020 Jul;33(7):1410-1419. PubMed PMID: 32051556
• Kreher MA, Wills AC, Duran J, Raghavan SS, Zlotoff BJ. Regressing Papules on the Sole of the Foot: Answer. Am J Dermatopathol. 2023 Jul 1;45(7):515-516. PubMed PMID: 37338069
• Zhao P, Luu LA, Gish TJ, Raghavan SS, Gru AA, Zlotoff BJ. Widespread livedo racemosa. Clin Exp Dermatol. 2023 Jul 21;48(8):945-948. PubMed PMID: 37052078
• Khan M, Jamil Z, Ehsan L, Zulqarnain F, Srivastava S, Siddiqui S, Fernandes P, Raghib M, Sengupta S, Mujahid Z, Ahmed Z, Idrees R, Ahmed S, Umrani F, Iqbal N, Moskaluk C, Raghavan S, Cheng L, Moore S, Ali SA, Iqbal J, Syed S. Quantitative Morphometry and Machine Learning Model to Explore Duodenal and Rectal Mucosal Tissue of Children with Environmental Enteric Dysfunction. Am J Trop Med Hyg. 2023 Apr 5;108(4):672-683. PubMed PMID: 36913924
• Chan D, Maikawa CL, d'Aquino AI, Raghavan SS, Troxell ML, Appel EA. Polyacrylamide-based hydrogel coatings improve biocompatibility of implanted pump devices. J Biomed Mater Res A. 2023 Jul;111(7):910-920. PubMed PMID: 36861657
• Kilmartin C, Westover C, Raghavan S, Dillon PM, Campbell CA. Desmoid Tumor and Implant-Based Breast Reconstruction. Case Rep Oncol. 2023 Jan-Dec;16(1):74-80. PubMed PMID: 36817360
• Wang JY, Hirotsu KE, Neal TM, Raghavan SS, Kwong BY, Khodadoust MS, Brown RA, Novoa RA, Kim YH, Rieger KE. Histopathologic Characterization of Mogamulizumab-associated Rash. Am J Surg Pathol. 2020 Dec;44(12):1666-1676. PubMed PMID: 32976123
• Gupta S, Noona SW, Pambuccian SE, Robinson B, Martin LW, Williams E, Stelow EB, Raghavan SS. Malignant undifferentiated and rhabdoid tumors of the gastroesophageal junction and esophagus with SMARCA4 loss: a case series. Hum Pathol. 2023 Apr;134:56-65. PubMed PMID: 36549598
• Pixley JN, Kozak M, Rusu C, Raghavan S, Flowers RH. Diffuse Vesicular Rash: Challenge. Am J Dermatopathol. 2023 Jan 1;45(1):e1-e2. PubMed PMID: 36484614
• Raghavan SS, Wang JY, Kwok S, Rieger KE, Novoa RA, Brown RA. PRAME expression in melanocytic proliferations with intermediate histopathologic or spitzoid features. J Cutan Pathol. 2020 Dec;47(12):1123-1131. PubMed PMID: 32700786
• Raghavan SS, Wang JY, Toland A, Bangs CD, Rieger KE, Novoa RA, Charville GW, Brown RA. Diffuse PRAME expression is highly specific for malignant melanoma in the distinction from clear cell sarcoma. J Cutan Pathol. 2020 Dec;47(12):1226-1228. PubMed PMID: 32681554
• Raghavan SS, Mooney KL, Folpe AL, Charville GW. OLIG2 is a marker of the fusion protein-driven neurodevelopmental transcriptional signature in alveolar rhabdomyosarcoma. Hum Pathol. 2019 Sep;91:77-85. PubMed PMID: 31299267
• Hom J, Marwaha S, Postolova A, Kittle J, Vasquez R, Davidson J, Kohler J, Dries A, Fernandez-Betancourt L, Majcherska M, Dearlove J, Raghavan S, Vogel H, Bernstein JA, Fisher P, Ashley E, Sampson J, Wheeler M. A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis. J Gen Intern Med. 2019 Jun;34(6):1058-1062. PubMed PMID: 30887439
• Raghavan SS, Hong EK, Kim YH, Kim J. Utility of CD30, Ki-67, and p53 in assisting with the diagnosis of mycosis fungoides with large cell transformation. J Cutan Pathol. 2019 Jan;46(1):33-43. PubMed PMID: 30328119
• Pixley JN, Kozak M, Rusu C, Raghavan S, Flowers RH. Diffuse Vesicular Rash: Answer. Am J Dermatopathol. 2023 Jan 1;45(1):69-70. PubMed PMID: 36484612
• Miller EM, Linos K, Bacchi CE, Gru AA, Raghavan SS. Histopathologic and molecular characterization of BAP-1-inactivated melanoma. J Cutan Pathol. 2023 Apr;50(4):349-357. PubMed PMID: 36285428
• Sceats LA, Sukerkar PA, Raghavan SS, Esmaeili Shandiz A, Shelton A, Kin C. Fragility of Life: Recurrent Intestinal Perforation Due to Vascular Ehlers-Danlos Syndrome. Dig Dis Sci. 2019 Aug;64(8):2120-2123. PubMed PMID: 30656563
• Raghavan SS, Kim J. Histopathologic approach to epidermotropic lymphocytic infiltrates. Semin Cutan Med Surg. 2018 Mar;37(1):56-60. PubMed PMID: 29719021
• Megerle K, Woon C, Kraus A, Raghavan S, Pham H, Chang J. Flexor Tendon Sheath Engineering Using Decellularized Porcine Pericardium. Plast Reconstr Surg. 2016 Oct;138(4):630e-641e. PubMed PMID: 27673534
• Vaughn CJ, Raghavan SS, Hansen SL, Terry MJ. Obstacles to the Care of Patients With Multicomponent Volar Wrist Lacerations at a County Hospital. Ann Plast Surg. 2016 May;76 Suppl 3:S238-40. PubMed PMID: 27015341
• Raghavan S, Peled AW, Hansen SL, Esserman LJ, Sbitany H. Approaches to microvascular breast reconstruction after total skin-sparing mastectomy: a comparison of techniques. Ann Plast Surg. 2015 May;74 Suppl 1:S46-51. PubMed PMID: 25875911
• Kraus A, Woon C, Raghavan S, Megerle K, Pham H, Chang J. Co-culture of human adipose-derived stem cells with tenocytes increases proliferation and induces differentiation into a tenogenic lineage. Plast Reconstr Surg. 2013 Nov;132(5):754e-766e. PubMed PMID: 24165627
• Raghavan SS, Woon CYL, Kraus A, Megerle K, Pham H, Chang J. Optimization of human tendon tissue engineering: synergistic effects of growth factors for use in tendon scaffold repopulation. Plast Reconstr Surg. 2012 Feb;129(2):479-489. PubMed PMID: 22286428
• Raghavan SS, Woon CY, Kraus A, Megerle K, Choi MS, Pridgen BC, Pham H, Chang J. Human flexor tendon tissue engineering: decellularization of human flexor tendons reduces immunogenicity in vivo. Tissue Eng Part A. 2012 Apr;18(7-8):796-805. PubMed PMID: 22011137
• Woon CY, Kraus A, Raghavan SS, Pridgen BC, Megerle K, Pham H, Chang J. Three-dimensional-construct bioreactor conditioning in human tendon tissue engineering. Tissue Eng Part A. 2011 Oct;17(19-20):2561-72. PubMed PMID: 21612572
• Song TK, Harris EJ Jr, Raghavan S, Norton JA. Major blood vessel reconstruction during sarcoma surgery. Arch Surg. 2009 Sep;144(9):817-22. PubMed PMID: 19797105
• Lee JT, Qiu M, Teshome M, Raghavan SS, Tedesco MM, Dalman RL. The utility of endovascular simulation to improve technical performance and stimulate continued interest of preclinical medical students in vascular surgery. J Surg Educ. 2009 Nov-Dec;66(6):367-73. PubMed PMID: 20142137
• Nguyen DN, Raghavan SS, Tashima LM, Lin EC, Fredette SJ, Langer RS, Wang C. Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine). Biomaterials. 2008 Jun;29(18):2783-93. PubMed PMID: 18400294

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Anatomic, Board Certification
• Dermatopathology, Board Certification
• American Society of Dermatopathology, Board Certification (2020)

Conditions & Treatments

• Skin, Hair and Nails - Biopsies and Excisions
• Skin, Hair and Nails
• Digestive System
• Cancers - Melanoma
• Cancers
• Cancers - Skin Cancer
• Cancers - Gastroenterologic Cancer (Colon, Stomach, Esophageal, Liver)
• Cancers - Sarcoma