Presented in the "CCTSI Pediatric Research Poster Session" held on June 21, 2024 from 12-2pm at the Princeton/Yale Conference room.
Alula KM, Delgado-Deida Y, Callahan R, Till A, Underwood L, Thompson WE, Souza RF, Dassopoulos T, Onyiah J, Venuprasad K, Theiss AL. Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy. Sci Rep. 2023 Jan 2;13(1):18. doi: 10.1038/s41598-022-26775-x. PMID: 36593241; PMCID: PMC9807637.
Kibrom Alula
Alexander Dowdell
Joseph Lee
Sean Colgan
Arianne Theiss
DOI:https://doi.org/10.1053/j.gastro.2023.03.120
Alula KM, Theiss AL. Autophagy in Crohn's Disease: Converging on Dysfunctional Innate Immunity. Cells. 2023 Jul 4;12(13):1779. doi: 10.3390/cells12131779. PMID: 37443813; PMCID: PMC10341259.
Amo-Aparicio J, Dominguez A, Atif SM, Dinarello A, Azam T, Alula KM, Piper M, Lieu CH, Lentz RW, Leal AD, Bagby SM, Messersmith WA, Karam SD, Dinarello CA, Pitts TM, Marchetti C. Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment. Cancer Res Commun. 2023 Sep 20;3(9):1899-1911. doi: 10.1158/2767-9764.CRC-23-0065. PMID: 37772994; PMCID: PMC10510589.
Collins CB, Nguyen TT, Leddy RS, Alula KM, Yeckes AR, Strassheim D, Aherne CM, Luck ME, Karoor V, Jedlicka P, Pierce A, de Zoeten EF. Heat shock factor 1 drives regulatory T cell induction to limit murine intestinal inflammation. Mucosal Immunol. 2023 Nov 7:S1933-0219(23)00086-7. doi: 10.1016/j.mucimm.2023.11.003. Epub ahead of print. PMID: 37944754.
Alula, K.M., Dowdell, A.S., LeBere, B. et al. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome 11, 256 (2023). https://doi.org/10.1186/s40168-023-01686-9
Celastrol, an HSF1 activator, enhances Treg function and reduces intestinal inflammation (In prep)
Pharmacologic activation of IRE1/XBP1s and PERK enhances Treg function in C57BL/6 mouse gut (In prep)
Title: Regulation of Intestinal Regulatory T Cells via Stress Response Pathways
Submitted to the "International Reviews of Immunology" journal.
