Jeremy Herrera, PhD

Professional Titles

• Assistant Professor - Research

Publications

• Chang J, Pickard A, Herrera JA, O'Keefe S, Garva R, Hartshorn M, Hoyle A, Dingle L, Knox J, Jowitt TA, Coy M, Wong J, Reid A, Lu Y, Zeltz C, Venkateswaran RV, Caswell PT, High S, Gullberg D, Kadler KE. Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis. Elife. 2025 Jan 15;13:RP95842. doi: 10.7554/eLife.95842. PMID: 39812558; PMCID: PMC11735028.
• Robinson CJ, Thiagarajan L, Maynard R, Aruketty M, Herrera J, Dingle L, Reid A, Wong J, Cao H, Dooley J, Liston A, Müllhaupt D, Hiebert P, Hiebert H, Kurinna S. Release of miR-29 Target Laminin C2 Improves Skin Repair. Am J Pathol. 2024 Feb;194(2):195-208. doi: 10.1016/j.ajpath.2023.11.002. Epub 2023 Nov 21. PMID: 37981221.
• Turner E, Roda G, Londono P, Herrera JA, Evans CM, Rangarajan S. Inhibition of Distal Glycolytic Enzymes Suppresses Fibroblast Activation without Deleterious Bioenergetic Effects. Am J Respir Cell Mol Biol. 2024 Jun;70(6):519-521. doi: 10.1165/rcmb.2023-0193LE. PMID: 38819122; PMCID: PMC11160416.
• Kurche JS, Cool CD, Blumhagen RZ, Dobrinskikh E, Heinz D, Herrera JA, Yang IV, Schwartz DA. MUC5B Idiopathic Pulmonary Fibrosis Risk Variant Promotes a Mucosecretory Phenotype and Loss of Small Airway Secretory Cells. Am J Respir Crit Care Med. 2024 Aug 15;210(4):517-521. doi: 10.1164/rccm.202311-2111LE. PMID: 38924494; PMCID: PMC11351810.
• The MUC5B promoter variant results in proteomic changes in the non-fibrotic lung Jeremy A. Herrera, Mark Maslanka, Rachel Z. Blumhagen, Rachel Blomberg, Nyan Ye Lwin, Janna Brancato, Carlyne D. Cool, Jonathan P. Huber, Jonathan S. Kurche, Chelsea M. Magin, Kirk C. Hansen, Ivana V. Yang, David A. Schwartz bioRxiv 2024.11.26.625453; doi: https://doi.org/10.1101/2024.11.26.625453
• Yang L, Gilbertsen A, Xia H, Benyumov A, Smith K, Herrera J, Racila E, Bitterman PB, Henke CA. Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1a pathway. JCI Insight. 2023 Feb 22;8(4). PubMed PMID: 36656644
• Herrera JA, Dingle LA, Monetero MA, Venkateswaran RV, Blaikley JF, Granato F, Pearson S, Lawless C, Thornton DJ. Morphologically intact airways in lung fibrosis have an abnormal proteome. Respir Res. 2023 Apr 1;24(1):99. PubMed PMID: 37005656
• Revell CK, Herrera JA, Lawless C, Lu Y, Kadler KE, Chang J, Jensen OE. Modeling collagen fibril self-assembly from extracellular medium in embryonic tendon. Biophys J. 2023 Aug 22;122(16):3219-3237. PubMed PMID: 37415335
• Robinson CJ, Thiagarajan L, Maynard R, Aruketty M, Herrera J, Dingle L, Reid A, Wong J, Cao H, Dooley J, Liston A, Müllhaupt D, Hiebert P, Hiebert H, Kurinna S. Release of miR-29 Target Laminin C2 Improves Skin Repair. Am J Pathol. 2023 Nov 21. [Epub ahead of print] PubMed PMID: 37981221
• Herrera JA et al. Morphologically intact airways in lung fibrosis have an abnormal proteome. 2023 BMC Respiratory Research (In Press)
• Herrera JA, et al. The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix. JCI Insight. 2022 Aug 22;7(16):e156115. PMID: 35852874
• Herrera JA, Schwartz MA. MicroRNAs in Mechanical Homeostasis. Cold Spring Harb Perspect Med. 2022 Aug 15;12(8):a041220. PMID: 35379658
• Chenery AL, Rosini S, Parkinson JE, Ajendra J, Herrera JA, Lawless C, Chan BH, Loke P, MacDonald AS, Kadler KE, Sutherland TE, Allen JE. IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection. Life Sci Alliance. 2021 Aug;4(8). PubMed PMID: 34127548
• Xia H, Herrera J, Smith K, Yang L, Gilbertsen A, Benyumov A, Racila E, Bitterman PB, Henke CA. Hyaluronan/CD44 axis regulates S100A4-mediated mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L926-L941. PubMed PMID: 33719561
• Herrera JA. et al. Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues. Clinical Proteomics. 2020. PMID: 32565759
• Herrera J., et al. Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis. JCI Insights. 2019. PMID: 30626754
• Herrera J, Beisang DJ, Peterson M, Forster C, Gilbertsen A, Benyumov A, Smith K, Korenczuk CE, Barocas VH, Guenther K, Hite R, Zhang L, Henke CA, Bitterman PB. Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis. Am J Respir Crit Care Med. 2018 Aug 15;198(4):486-496. PubMed PMID: 29579397
• Yang L, Herrera J, Gilbertsen A, Xia H, Smith K, Benyumov A, Bitterman PB, Henke CA. IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L127-L136. PubMed PMID: 28860143
• Herrera J, Henke CA, Bitterman PB. Extracellular matrix as a driver of progressive fibrosis. J Clin Invest. 2018 Jan 2;128(1):45-53. PubMed PMID: 29293088
• Chan SC, Zhang Y, Shao A, Avdulov S, Herrera J, Aboudehen K, Pontoglio M, Igarashi P. Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease. J Am Soc Nephrol. 2018 Oct;29(10):2493-2509. PubMed PMID: 30097458
• Xia H, Gilbertsen A, Herrera J, Racila E, Smith K, Peterson M, Griffin T, Benyumov A, Yang L, Bitterman PB, Henke CA. Calcium-binding protein S100A4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis. J Clin Invest. 2017 Jun 30;127(7):2586-2597. PubMed PMID: 28530639
• Avdulov S*, Herrera J*, Smith K, Peterson M, Gomez-Garcia JR, Beadnell TC, Schwertfeger KL, Benyumov AO, Manivel JC, Li S, Bielinsky AK, Yee D, Bitterman PB, Polunovsky VA. eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells. Cancer Res. 2015 Feb 15;75(4):687-97. PubMed PMID: 25524901 [*Co-First Author]
• Khalil W, Xia H, Bodempudi V, Kahm J, Hergert P, Smith K, Peterson M, Parker M, Herrera J, Bitterman PB, Henke CA. Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts. Am J Respir Cell Mol Biol. 2015 Sep;53(3):391-9. PubMed PMID: 25612003
• Bodempudi V, Hergert P, Smith K, Xia H, Herrera J, Peterson M, Khalil W, Kahm J, Bitterman PB, Henke CA. miR-210 promotes IPF fibroblast proliferation in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L283-94. PubMed PMID: 24951777
• Xia H, Bodempudi V, Benyumov A, Hergert P, Tank D, Herrera J, Braziunas J, Larsson O, Parker M, Rossi D, Smith K, Peterson M, Limper A, Jessurun J, Connett J, Ingbar D, Phan S, Bitterman PB, Henke CA. Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis. Am J Pathol. 2014 May;184(5):1369-83. PubMed PMID: 24631025
• Benyumov AO, Hergert P, Herrera J, Peterson M, Henke C, Bitterman PB. A novel zebrafish embryo xenotransplantation model to study primary human fibroblast motility in health and disease. Zebrafish. 2012 Mar;9(1):38-43. PubMed PMID: 22356695
• Li F, Herrera J, Zhou S, Maslov DA, Simpson L. Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editing. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3542-7. PubMed PMID: 21321231

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