Quantifying the type and severity of neurocognitive dysfunction experienced by childhood cancer survivors; identifying implications of cognitive dysfunction (e.g., in school performance); understanding biological mechanisms for cognitive dysfunction and how those can be measured with biomarkers.
Publications
Fraley CE, Neiman JS, Feddersen CR, James C, Jones TG, Mikkelsen M, Miller K, Dillon P, Green AL, Compas BE. Identifying Patters of Neurocognitive Dysfunction Through Direct Comparison of Patients with Leukemia, CNS Tumors, & Sickle Cell Disease. In: Children’s Oncology Group (COG) Young Investigators Committee; September 22, 2022
Fraley CE, Neiman JS, Feddersen CR, James C, Jones TG, Mikkelsen M, Miller K, Dillon P, Green AL, Compas BE. Identifying Patters of Neurocognitive Dysfunction Through Direct Comparison of Patients with Leukemia, CNS Tumors, & Sickle Cell Disease. In: 64th American Society of Hematology (ASH) Annual Meeting & Expo; December 12, 2022.
Friedman D, Schremp E, Koyama T, Sun L, Kehler LA, Daniels A, Shah A, Leahey A, Dimaras H, Nagarajan R, Hayashi R, Schmidt ML, Chintagumpala M, Herzog C, Luna-Fineman S, Fraley C, Weinstein J, Crooks B, Olson T, Schwartz C, Neglia J. Visual Outcomes Following Intra-Arterial Chemotherapy for Retinoblastoma: A Report from the RIVERBOAT Consortium. In: 54th Congress of the International Society of Paediatric Oncology (SIOP); September 30, 2022.
Pacheco D, Fraley C, Walker D, Green AL. Creation, use, and effectiveness of a primary provider education tool for timely pediatric CNS tumor diagnosis based on HeadSmart. In: Cancer Center Community Impact Forum; June 23, 2022; Philadelphia, PA
Pacheco D, Fraley C, Walker D, Green AL. Creation, use, and effectiveness of a primary provider education tool for timely pediatric CNS tumor diagnosis based on HeadSmart. In: ISPNO; June 12-15, 2022; Hamburg, Germany
Friedman D, Schremp E, Koyama T, Sun L, Kehler LA, Daniels A, Shah A, Leahey A, Dimaras H, Nagarajan R, Hayashi R, Schmidt ML, Chintagumpala M, Herzog C, Luna-Fineman S, Fraley C, Weinstein J, Crooks B, Olson T, Schwartz C, Neglia J. Outcomes of patients with bilateral retinoblastoma: A report from the RIVERBOAT consortium. In: ASCO; June 6, 2022; Chicago, IL
Friedman D, Schremp E, Koyama T, Sun L, Kehler LA, Daniels A, Shah A, Leahey A, Dimaras H, Nagarajan R, Hayashi R, Schmidt ML, Chintagumpala M, Herzog C, Luna-Fineman S, Fraley C, Weinstein J, Crooks B, Olson T, Schwartz C, Neglia J. Outcomes of patients with unilateral retinoblastoma: A report from the RIVERBOAT consortium. In: ASCO; June 6, 2022; Chicago, IL
Hilliard A, Mellies A, Kreis A, Marable M, Fraley C, Pacheco D, Green AL. Patient-level analysis of pediatric CNS tumor survival based on demographic/socioeconomic variables. In: ASPHO; May 4-7, 2022; Pittsburgh, PA
Fraley CE, Thigpen JC, Pearson MM, Kuttesch JF Jr, Desjardins L, Hoskinson KR, Alvarado-Gonzalez A, Esbenshade AJ, Pastakia D, Friedman DL, Wellons JC, McNally CM, Siciliano RE, Compas BE. Predictors of cognitive function in pediatric brain tumor patients: Pre-surgery through 24-month follow-up. Appl Neuropsychol Child. 2021 Oct-Dec;10(4):340-347. PubMed PMID: 31887256
Fraley CE, Pettersson DR, Nolt D. Encephalitis in Previously Healthy Children. Pediatr Rev. 2021 Feb;42(2):68-77. PubMed PMID: 33526572
Fraley C, Milgrom SA, Kondapalli L, Taylor MRG, Mestroni L, Miyamoto SD. Mechanisms and Insights for the Development of Heart Failure Associated with Cancer Therapy. Children (Basel). 2021 Sep 21;8(9). PubMed PMID: 34572260
Desjardins L, Thigpen JC, Kobritz M, Bettis AH, Gruhn MA, Ichinose M, Hoskinson K, Fraley C, Vreeland A, McNally C, Compas BE. Parent reports of children's working memory, coping, and emotional/behavioral adjustment in pediatric brain tumor patients: A pilot study. Child Neuropsychol. 2018 Oct;24(7):959-974. PubMed PMID: 28969482
Thigpen JC, Pearson M, Robinson KE, Andreotti C, Dunbar JP, Watson KH, Dejardins L, Holmes L, Byram R, Fraley C, Compas BE. Presurgical assessment of cognitive function in pediatric brain tumor patients: feasibility and initial findings. Neurooncol Pract. 2016 Dec;3(4):261-267. PubMed PMID: 27833756
Robinson KE, Fraley CE, Pearson MM, Kuttesch JF Jr, Compas BE. Neurocognitive late effects of pediatric brain tumors of the posterior fossa: a quantitative review. J Int Neuropsychol Soc. 2013 Jan;19(1):44-53. PubMed PMID: 23095276
Fraley CE, McKinney C, Nuss R, Franklin ARK. Minimizing acute toxicity and late effects in the treatment of Hodgkin Lymphoma in patients with sickle cell disease. (In press).