Jeffrey Bennett, MD, PhD

Professional Titles

• Professor, Ophthalmology

Recognitions

• Basil O'Connor Starter Scholar Award, March of Dimes (1999)
  
• Stephen C. Reingold Research Award, National Multiple Sclerosis Society (2006)
  

Research Interests

My research focuses on antigen identification in optic neuritis, multiple sclerosis, neuromyelitis optica, and ocular inflammatory disorders.

Publications

• Awad, A., Hemmer, B., Hartung, H.-P., Kieseier, B., Bennett, J.L., Stüve, O.: Analyses of cerebrospinal fluid in the diagnosis and monitoring of multiple sclerosis. J. Neuroimmunol. 219:1-7, 2010.
• Teunissen, C.E., Tumani, H.T., Bennett, J.L., Berven, F.S., Brundin, L., Comabella, M., Franciotta, D., Frederiksen, J.L., Fleming, J.O., Furlan, R., Hintzen, R.Q., Hughes, S.G., Johnson, M.H., Krasulova, E., Kuhle, J., Magnone, M.C., Petzold, A., Rajda, C., Rejdak, K., Schmidt, H.K., van Pesch, V., Waubant, E., Wolf, C., Hemmer, B., Deisenhammer, F., Giovannoni, G.: Short commentary on ‘a consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.’ Mult. Scler. 16:129-132, 2010.
• Sargsyan, S.A., Shearer, A.J., Ritchie, A.M., Burgoon, M.P., Anderson, S., Hemmer, B., Stadelmann, C., Gattenlöhner, S., Owens, G.P., Gilden, D., Bennett, J.L.: Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis. Neurology 74:1127-1135, 2010.
• Warnke, C., Menge, T., Hartung, H.P., Racke, M.K., Cravens, P.D., Bennett, J.L., Frohman, E.M., Greenberg, B.M., Zamvil, S.S., Gold, R., Hemmer, B., Kieseier, B.C., Stüve, O.: Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors? Can it be avoided? Arch. Neurol. 67:923-930, 2010.
• Kalluri, S.R., Illes, Z., Srivastava, R., Cree, B., Menge, T., Bennett, J.L., Berthele, A., Hemmer, B.: Quantification and functional characterization of antibodies to native aquaporin-4 in neuromyelitis optica. Arch. Neurol. 67:1201-1208, 2010.
• Gordon, L.K., Bennett, J.L.: Preserving and restoring optic nerve function. J. Neuroophthalmol. 30:303-304, 2010.
• Weintraub, J.A., Bennett, J., Gaspar, L.E.: Successful treatment of radiation-induced optic neuropathy. Practical Radiation Oncology (PRO) 1:40-44, 2011.
• Yu, X., Gilden, D., Schambers, L., Barmina, O., Burgoon, M., Bennett, J., Owens, G.: Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSF. J. Neuroimmunol., 2011, in press.
• Levin MH, Bennett JL, Verkman AS. Optic neuritis in neuromyelitis optica. Prog Retin Eye Res. 2013 Sep;36:159-71. PubMed PMID: 23545439
• Owens, G.P., Gilden, D., Burgoon, M.P., Yu, X., Bennett, J.L.: Viruses and multiple sclerosis. Neuroscientist, 2011, in press.
• Nagel MA, Bennett JL, Khmeleva N, Choe A, Rempel A, Boyer PJ, Gilden D. Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis. Neurology. 2013 May 28;80(22):2017-21. PubMed PMID: 23635966
• Crane, J.M., Lam, C., Rossi, A., Gupta, T., Bennett, J.L., Verkman, A.S.: Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays. J. Biol. Chem. 286:16516-16524, 2011.
• Yu, X., Green, M., Gilden, D., Lam, C., Bautista, K., Bennett, J.L.: Identification of peptide targets in neuromyelitis optica. J. Neuroimmunol. 236:65-71, 2011.
• Crane, J.M., Rossi, A., Gupta, T., Bennett, J.L., Verkman, A.S.: Orthogonal array formation by human aquaporin-4: examination of neuromyelitis optica-associated aquaporin-4 polymorphisms. J. Neuroimmunol. 236:93-98, 2011.
• Brennan, K.M., Galban-Horcajo, F., Rinaldi, S., O’Leary, C.P., Goodyear, C.S., Kalna, G., Arthur, A., Elliot, C., Barnett, S., Linington, C., Bennett, J.L., Owens, G.P., Willison, H.J.: Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. J. Neuroimmunol. 238:87-95, 2011.
• Saadoun S, Waters P, Leite MI, Bennett JL, Vincent A, Papadopoulos MC. Neuromyelitis optica IgG causes placental inflammation and fetal death. J Immunol. 2013 Sep 15;191(6):2999-3005. PubMed PMID: 23935196
• Lassmann, H., Niedobitek, G., Aloisi, F., Middeldorp, J.M., the NeuroproMiSe EBV Working Group: Epstein-Barr virus in the multiple sclerosis brain: a controversial issue – report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria. Brain. 2772-2786, 2011.
• Ratelade J, Asavapanumas N, Ritchie AM, Wemlinger S, Bennett JL, Verkman AS. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Acta Neuropathol. 2013 Nov;126(5):699-709. PubMed PMID: 23995423
• Owens, G.P., Gilden, D., Burgoon, M.P., Yu, X., Bennett, J.L.: Viruses and multiple sclerosis. Neuroscientist. 16:659-676, 2011.
• Mathias M, Nagel MA, Khmeleva N, Boyer PJ, Choe A, Durairaj VD, Bennett JL, Mandava N, Gilden D. VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash. J Neurol Sci. 2013 Feb 15;325(1-2):180-2. PubMed PMID: 23312850
• Kumpe, D.A., Bennett, J.L., Seinfeld, J., Pelak, V., Chawla, A., Tierney, M.: Dural sinus stent placement for idiopathic intracranial hypertension. J. Neurosurg. 10:3171, 2011.
• Bucca, B., Klingensmith, G., Bennett, J.L.: Wolfram syndrome: a rare optic neuropathy in youth and type 1 diabetes. Optom. Vis. Sci. 88(11):E1383-E1390, 2011.
• Zhang, H., Bennett, J.L., Verkman, A.S.: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immune immunopathogenic mechanisms. Ann. Neurol. 70(6):943-954, 2011.
• Tradtrantip, L., Zhang, H., Saadoun, S., Phuan, P.W., Lam, C., Papadopoulos, M.C., Bennett, J.L., Verkman, A.S.: Anti-Aquaporin-4 Monoclonal Antibody Blocker Therapy for Neuromyelitis Optica. Ann Neurol. 10:1002, 2011.
• Ratelade, J., Bennett, J.L., Verkman, A.S.: Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 Peripheral Organs and Area Postrema. PLoS ONE. 6(11): e27412, 2011.
• Bennett JL, Nickerson M, Costello F, Sergott RC, Calkwood JC, Galetta SL, Balcer LJ, Markowitz CE, Vartanian T, Morrow M, Moster ML, Taylor AW, Pace TW, Frohman T, Frohman EM. Re-evaluating the treatment of acute optic neuritis. J Neurol Neurosurg Psychiatry. 2014 Oct 29. [Epub ahead of print] PubMed PMID: 25355373
• Papadopoulos MC, Bennett JL, Verkman AS. Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. Nat Rev Neurol. 2014 Sep;10(9):493-506. PubMed PMID: 25112508
• Ratelade, J., Bennett, J.L., Verkman, A.S.: Evidence against cellular internalization in vivo of NMO-IgG, aquaporin-4, and excitatory amino acid transporter 2 in neuromyelitis optica. J Biol Chem. 286(52):45156-45164, 2011.
• Tradtrantip, L., Zhang, H., Saadoun, S., Phuan, P.W., Lam, C., Papadopoulos, M.C., Bennett, J.L., Verkman, A.S.: Anti-Aquaporin-4 Monoclonal Antibody Blocker Therapy for Neuromyelitis Optica. Ann Neurol. 71(3):314-322, 2012
• Tradtrantip, L., Zhang, H., Anderson, M.O., Saadoun, S., Phuan, P.W., Papadopoulos, M.C., Bennett, J.L., Verkman, A.S.: Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica. FASEB J. 26(5): 2197-208, 2012
• Saadoun S, Waters P, Owens GP, Bennett JL, Vincent A, Papadopoulos MC. Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain. Acta Neuropathol Commun. 2014 Mar 31;2:35. PubMed PMID: 24685353
• Kowarik MC, Soltys J, Bennett JL. The treatment of neuromyelitis optica. J Neuroophthalmol. 2014 Mar;34(1):70-82. PubMed PMID: 24531318
• Asavapanumas N, Ratelade J, Papadopoulos MC, Bennett JL, Levin MH, Verkman AS. Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G. J Neuroinflammation. 2014 Jan 27;11:16. PubMed PMID: 24468108
• Ratelade, J., Zhang, H., Saadoun, S., Bennett, J.L., Papadopoulos, M., Verkman, A.S.: Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss. Acta Neuropathol. 123(6):861-872, 2012
• Wrzos C, Winkler A, Metz I, Kayser DM, Thal DR, Wegner C, Brück W, Nessler S, Bennett JL, Stadelmann C. Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions. Acta Neuropathol. 2014 Apr;127(4):523-38. PubMed PMID: 24292009
• Rossi, A., Ratelade, J., Papadopoulos, M., Bennett, J.L., Verkman, A.S.: Consequences of NMO-IgG binding to aquaporin-4 in neuromyelitis optica [Letter]. PNAS. 109(24):1511, 2012
• Waters, P.J., Pittock, S.J., Bennett, J.L., Jarius, S., Weinshenker, B.G., and Wingerchuk, D.M.: Evaluation of aquaporin-4 antibody assays. Clin Exp Neuroimmunol, 5: 290–303, 2014
• Bennett, J.L. and Owens, G.P.: Cerebrospinal fluid proteomics: a new window for understanding human demyelinating disorders? Ann Neurol. 71(5): 586-88
• Arellano, B., Hussain, R., Zacharias, T., Yoon,, J., David, C., Zein, S., Steinman, L., Forsthuber, T., Greenberg, B.M., Lambracht-Washington, D., Ritchie, A., Bennett, J.L., Stüve, O.: Human aquaporin 4281-300 is the immunodominant linear determinant in the context of HLA-DRB1*03:01. Arch Neurol, 69:1125-31, 2012.
• Owens, G.P. and Bennett, J.L.: Trigger, pathogen, or bystander: the complex nexus linking Epstein– Barr virus and multiple sclerosis. Mult Scler J. 18:1204-08, 2012.
• Bennett JL, Nickerson M, Costello F, Sergott RC, Calkwood JC, Galetta SL, Balcer LJ, Markowitz CE, Vartanian T, Morrow M, Moster ML, Taylor AW, Pace TW, Frohman T, Frohman EM. Re-evaluating the treatment of acute optic neuritis. J Neurol Neurosurg Psychiatry. 2015 Jul;86(7):799-808. PubMed PMID: 25355373
• Srivastava, R., Aslam, M., Kalluri, S. R., Schirmer, L., Buck, D., Tackenberg, B., Rothhammer, V., Chan, A., Gold, R., Berthele, A., Bennett, J.L., Korn, T., and Hemmer, B.: Potassium channel KIR4.1 as an immune target in multiple sclerosis. NEJM, 367(2): 115–123, 2012.
• Gilden D, White T, Khmeleva N, Heintzman A, Choe A, Boyer PJ, Grose C, Carpenter JE, Rempel A, Bos N, Kandasamy B, Lear-Kaul K, Holmes DB, Bennett JL, Cohrs RJ, Mahalingam R, Mandava N, Eberhart CG, Bockelman B, Poppiti RJ, Tamhankar MA, Fogt F, Amato M, Wood E, Durairaj V, Rasmussen S, Petursdottir V, Pollak L, Mendlovic S, Chatelain D, Keyvani K, Brueck W, Nagel MA. Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis. Neurology. 2015 May 12;84(19):1948-55. PubMed PMID: 25695965
• Kowarik MC, Dzieciatkowska M, Wemlinger S, Ritchie AM, Hemmer B, Owens GP, Bennett JL. The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations. J Neuroinflammation. 2015 Jan 28;12:19. PubMed PMID: 25626447
• Rossi, A., Ratelade, J., Papadopoulos, M.C., Bennett, J.L., and Verkman, A.S.: Neuromyelitis optica (NMO) IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content or supramolecular assembly. Glia, 60:2027–2039, 2012.
• Phuan, P.W., Anderson, M.O., Tradtrantip, L., Zhang, H., Tan, J., Lam, C., Bennett, J.L. and Verkman, A.S.: A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica-immunoglobulin G binding to aquaporin-4. J Biol Chem, 287:36837–36844, 2012
• Geis C, Ritter C, Ruschil C, Weishaupt A, Grünewald B, Stoll G, Holmoy T, Misu T, Fujihara K, Hemmer B, Stadelmann C, Bennett JL, Sommer C, Toyka KV. The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model. Exp Neurol. 2015 Mar;265:8-21. PubMed PMID: 25542977
• Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S, Tenembaum S, Banwell B, Greenberg B, Levy M, Fujihara K, Chan KH, Kim HJ, Asgari N, Sato DK, Saiz A, Wuerfel J, Zimmermann H, Green A, Villoslada P, Paul F. Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Mult Scler. 2015 May;21(6):678-88. PubMed PMID: 25662342
• Weinshenker BG, Barron G, Behne JM, Bennett JL, Chin PS, Cree BA, de Seze J, Flor A, Fujihara K, Greenberg B, Higashi S, Holt W, Khan O, Knappertz V, Levy M, Melia AT, Palace J, Smith TJ, Sormani MP, Van Herle K, VanMeter S, Villoslada P, Walton MK, Wasiewski W, Wingerchuk DM, Yeaman MR. Challenges and opportunities in designing clinical trials for neuromyelitis optica. Neurology. 2015 Apr 28;84(17):1805-15. PubMed PMID: 25841026
• Owens GP, Ritchie A, Rossi A, Schaller K, Wemlinger S, Schumann H, Shearer A, Verkman AS, Bennett JL. Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG. J Biol Chem. 2015 May 8;290(19):12123-34. PubMed PMID: 25792738
• Sergott RC, Bennett JL, Rieckmann P, Montalban X, Mikol D, Freudensprung U, Plitz T, van Beek J. ATON: results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis. J Neurol Sci. 2015 Apr 15;351(1-2):174-8. PubMed PMID: 25758472
• Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C. B lymphocytes in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm. 2015 Jun;2(3):e104. PubMed PMID: 25977932
• Golas L, Bennett JL, White TM, Skarf B, Lesser R, Nagel MA, Gilden D. Varicella Zoster Virus in Ischemic Optic Neuropathy. Ophthalmology. 2015 Oct;122(10):2142-5. PubMed PMID: 26050536
• Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, Villoslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul F, Kim HJ, de Seze J, Wuerfel JT, Cabre P, Marignier R, Tedder T, van Pelt D, Broadley S, Chitnis T, Wingerchuk D, Pandit L, Leite MI, Apiwattanakul M, Kleiter I, Prayoonwiwat N, Han M, Hellwig K, van Herle K, John G, Hooper DC, Nakashima I, Sato D, Yeaman MR, Waubant E, Zamvil S, Stüve O, Aktas O, Smith TJ, Jacob A, O'Connor K. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder. JAMA Neurol. 2015 Jul;72(7):815-22. PubMed PMID: 26010909
• Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, Nakashima, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, Würfel J, Zamvil S. Update on biomarkers in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm. 2015 Aug;2(4):e134. PubMed PMID: 26236760
• Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015 Jul 14;85(2):177-89. PubMed PMID: 26092914
• Nagel MA, White T, Khmeleva N, Rempel A, Boyer PJ, Bennett JL, Haller A, Lear-Kaul K, Kandasmy B, Amato M, Wood E, Durairaj V, Fogt F, Tamhankar MA, Grossniklaus HE, Poppiti RJ, Bockelman B, Keyvani K, Pollak L, Mendlovic S, Fowkes M, Eberhart CG, Buttmann M, Toyka KV, Meyer-Ter-Vehn T, Petursdottir V, Gilden D. Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis. JAMA Neurol. 2015 Nov 1;72(11):1281-7. PubMed PMID: 26349037
• Cree BA, Bennett JL, Sheehan M, Cohen J, Hartung HP, Aktas O, Kim HJ, Paul F, Pittock S, Weinshenker B, Wingerchuk D, Fujihara K, Cutter G, Patra K, Flor A, Barron G, Madani S, Ratchford JN, Katz E. Placebo-controlled study in neuromyelitis optica-Ethical and design considerations. Mult Scler. 2015 Dec 14. [Epub ahead of print] PubMed PMID: 26666258
• Blauth K, Owens GP, Bennett JL. The Ins and Outs of B Cells in Multiple Sclerosis. Front Immunol. 2015;6:565. PubMed PMID: 26594215
• Blauth K, Soltys J, Matschulat A, Reiter CR, Ritchie A, Baird NL, Bennett JL, Owens GP. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants. Acta Neuropathol. 2015 Dec;130(6):765-81. PubMed PMID: 26511623
• Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B. In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol. 2016 Mar 6. [Epub ahead of print] PubMed PMID: 26946517
• Vogel AL, Knier B, Lammens K, Kalluri SR, Kuhlmann T, Bennett JL, Korn T. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol. 2017 Mar;47(3):458-469. PubMed PMID: 28058717
• Rodríguez-Colón G, Bratton EM, Serracino H, Bennett JL, Hink EM. Sphenoid Wing Meningioma with Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation. Ophthal Plast Reconstr Surg. 2016 Feb 12. [Epub ahead of print] PubMed PMID: 26882057
• Soltys JN, Meyer SA, Schumann H, Gibson EA, Restrepo D, Bennett JL. Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy. Biophys J. 2017 Apr 25;112(8):1692-1702. PubMed PMID: 28445760
• Bennett JL, Owens GP. Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy. J Neuroophthalmol. 2017 Sep;37(3):291-299. PubMed PMID: 28410278
• Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun. 2017 Mar 24;5(1):25. PubMed PMID: 28340598
• Rodríguez-Colón G, Bratton EM, Serracino H, Bennett JL, Hink EM. Sphenoid Wing Meningioma With Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation. Ophthal Plast Reconstr Surg. 2017 May Jun;33(3S Suppl 1):S97-S99. PubMed PMID: 26882057
• Yan Y, Li Y, Fu Y, Yang L, Su L, Shi K, Li M, Liu Q, Borazanci A, Liu Y, He Y, Bennett JL, Vollmer TL, Shi FD. Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD. Sci China Life Sci. 2016 Feb 26. [Epub ahead of print] PubMed PMID: 26920678
• Cree BA, Bennett JL, Sheehan M, Cohen J, Hartung HP, Aktas O, Kim HJ, Paul F, Pittock S, Weinshenker B, Wingerchuk D, Fujihara K, Cutter G, Patra K, Flor A, Barron G, Madani S, Ratchford JN, Katz E. Placebo-controlled study in neuromyelitis optica-Ethical and design considerations. Mult Scler 22:862-872, 2016.
• Alberga D, Trisciuzzi D, Lattanzi G, Bennett JL, Verkman AS, Mangiatordi GF, Nicolotti O. Comparative molecular dynamics study of neuromyelitis optica-immunoglobulin G binding to aquaporin-4 extracellular domains. Biochim Biophys Acta. 2017 Aug;1859(8):1326-1334. PubMed PMID: 28477975
• Weil MT, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett JL, Enz L, Goebels N, Nave KA, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M. Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep. 2016 Jul 12;16(2):314-22. PubMed PMID: 27346352
• Kowarik MC, Astling D, Gasperi C, Wemlinger S, Schumann H, Dzieciatkowska M, Ritchie AM, Hemmer B, Owens GP, Bennett JL. CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder. Ann Clin Transl Neurol. 2017 Jun;4(6):369-380. PubMed PMID: 28589164
• Shimizu F, Schaller KL, Owens GP, Cotleur AC, Kellner D, Takeshita Y, Obermeier B, Kryzer TJ, Sano Y, Kanda T, Lennon VA, Ransohoff RM, Bennett JL. Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica. Sci Transl Med. 2017 Jul 5;9(397). PubMed PMID: 28679661
• Bennett JL. Finding NMO: The Evolving Diagnostic Criteria of Neuromyelitis Optica. J Neuroophthalmol. 2016 Sep;36(3):238-45. PubMed PMID: 27529327
• Grünewald B, Bennett JL, Toyka KV, Sommer C, Geis C. Efficacy of Polyvalent Human Immunoglobulins in an Animal Model of Neuromyelitis Optica Evoked by Intrathecal Anti-Aquaporin 4 Antibodies. Int J Mol Sci. 2016 Aug 26;17(9). PubMed PMID: 27571069
• Kumpe DA, Seinfeld J, Huang X, Mei Q, Case DE, Roark CD, Subramanian PS, Lind KE, Pelak VS, Bennett JL. Dural sinus stenting for idiopathic intracranial hypertension: Factors associated with hemodynamic failure and management with extended stenting. J Neurointervent Surg 0:1-8, 2016. doi:10.1136/neurintsurg-2016-012810.
• Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016 Dec 1;13(1):301. PubMed PMID: 27905992
• Liu Y, Given KS, Owens GP, Macklin WB, Bennett JL. Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica. Glia. 2018 Sep 21. [Epub ahead of print] PubMed PMID: 30240044
• Mader S, Brimberg L, Soltys JN, Bennett JL, Diamond B. Mutations of Recombinant Aquaporin-4 Antibody in the Fc Domain Can Impair Complement-Dependent Cellular Cytotoxicity and Transplacental Transport. Front Immunol. 2018;9:1599. PubMed PMID: 30057582
• Chen JJ, Flanagan EP, Jitprapaikulsan J, López-Chiriboga ASS, Fryer JP, Leavitt JA, Weinshenker BG, McKeon A, Tillema JM, Lennon VA, Tobin WO, Keegan BM, Lucchinetti CF, Kantarci OH, McClelland CM, Lee MS, Bennett JL, Pelak VS, Chen Y, VanStavern G, Adesina OO, Eggenberger ER, Acierno MD, Wingerchuk DM, Brazis PW, Sagen J, Pittock SJ. Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG)-Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues and Outcome. Am J Ophthalmol. 2018 Jul 26. [Epub ahead of print] PubMed PMID: 30055153
• Horton L, Bennett JL. Acute Management of Optic Neuritis: An Evolving Paradigm. J Neuroophthalmol. 2018 Sep;38(3):358-367. PubMed PMID: 30106803
• Soltys J, Liu Y, Ritchie A, Wemlinger S, Schaller K, Schumann H, Owens GP, Bennett JL. Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica. J Clin Invest. 2019 Apr 8;129(5):2000-2013. PubMed PMID: 30958797
• Bennett JL. Optic Neuritis. Continuum (Minneap Minn). 2019 Oct;25(5):1236-1264. PubMed PMID: 31584536
• Cotzomi E, Stathopoulos P, Lee CS, Ritchie AM, Soltys JN, Delmotte FR, Oe T, Sng J, Jiang R, Ma AK, Vander Heiden JA, Kleinstein SH, Levy M, Bennett JL, Meffre E, O'Connor KC. Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production. Brain. 2019 Jun 1;142(6):1598-1615. PubMed PMID: 31056665
• Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 Aug;318:32-41. PubMed PMID: 31029597
• Cook LJ, Rose JW, Alvey JS, Jolley AM, Kuhn R, Marron B, Pederson M, Enriquez R, Yearley J, McKechnie S, Han MH, Tomczak AJ, Levy M, Mealy MA, Coleman J, Bennett JL, Johnson R, Barnes-Garcia M, Traboulsee AL, Carruthers RL, Lee LE, Schubert JJ, McMullen K, Kister I, Rimler Z, Reid A, Sicotte NL, Planchon SM, Cohen JA, Ivancic D, Sedlak JL, Sand IK, Repovic P, Amezcua L, Pruitt A, Amundson E, Chitnis T, Mullin DS, Klawiter EC, Russo AW, Riley CS, Onomichi KB, Levine L, Nelson KE, Nealon NM, Engel C, Kruse-Hoyer M, Marcille M, Tornes L, Rumpf A, Greer A, Kenneally Behne M, Rodriguez RR, Behne DW, Blackway DW, Coords B, Blaschke TF, Sheard J, Smith TJ, Behne JM, Yeaman MR. Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD. Neurol Neuroimmunol Neuroinflamm. 2019 Sep;6(5):e583. PubMed PMID: 31355319
• Piquet AL, Khan M, Warner JEA, Wicklund MP, Bennett JL, Leehey MA, Seeberger L, Schreiner TL, Paz Soldan MM, Clardy SL. Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases. Neurol Neuroimmunol Neuroinflamm. 2019 Sep;6(5):e592. PubMed PMID: 31355325
• Cree BAC, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, Lublin FD, Drappa J, Barron G, Madani S, Ratchford JN, She D, Cimbora D, Katz E. Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial. Lancet. 2019 Sep 5. [Epub ahead of print] PubMed PMID: 31495497
• Chen JJ, Flanagan EP, Bhatti MT, Jitprapaikulsan J, Dubey D, Lopez Chiriboga ASS, Fryer JP, Weinshenker BG, McKeon A, Tillema JM, Lennon VA, Lucchinetti CF, Kunchok A, McClelland CM, Lee MS, Bennett JL, Pelak VS, Van Stavern G, Adesina OO, Eggenberger ER, Acierno MD, Wingerchuk DM, Lam BL, Moss H, Beres S, Gilbert AL, Shah V, Armstrong G, Heidary G, Cestari DM, Stiebel-Kalish H, Pittock SJ. Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder. Neurology. 2020 Jul 14;95(2):e111-e120. PubMed PMID: 32554760
• Duan T, Tradtrantip L, Phuan PW, Bennett JL, Verkman AS. Affinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders. Neuropharmacology. 2020 Jan 1;162:107827. PubMed PMID: 31654702
• Jonzzon S, Suleiman L, Yousef A, Young B, Hart J, Peschl P, Reindl M, Schaller KL, Bennett JL, Waubant E, Graves JS. Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis. J Child Neurol. 2020 Jan;35(1):77-83. PubMed PMID: 31566057
• Traboulsee A, Greenberg BM, Bennett JL, Szczechowski L, Fox E, Shkrobot S, Yamamura T, Terada Y, Kawata Y, Wright P, Gianella-Borradori A, Garren H, Weinshenker BG. Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial. Lancet Neurol. 2020 May;19(5):402-412. PubMed PMID: 32333898
• Tsymala I, Nigritinou M, Zeka B, Schulz R, Niederschick F, Matkovic M, Bauer IJ, Szalay M, Schanda K, Lerch M, Misu T, Fujihara K, Bennett JL, Dahle C, Pache F, Rommer P, Leutmezer F, Illes Z, Leite MI, Palace J, Scholze P, Reindl M, Lassmann H, Bradl M. Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes. Acta Neuropathol Commun. 2020 Apr 15;8(1):49. PubMed PMID: 32293546
• Whittam DH, Cobo-Calvo A, Lopez-Chiriboga AS, Pardo S, Gornall M, Cicconi S, Brandt A, Berek K, Berger T, Jelcic I, Gombolay G, Oliveira LM, Callegaro D, Kaneko K, Misu T, Capobianco M, Gibbons E, Karthikeayan V, Brochet B, Audoin B, Mathey G, Laplaud D, Thouvenot E, Cohen M, Tourbah A, Maillart E, Ciron J, Deschamps R, Biotti D, Rostasy K, Neuteboom R, Hemingway C, Forsyth R, Matiello M, Webb S, Hunt D, Murray K, Hacohen Y, Lim M, Leite MI, Palace J, Solomon T, Lutterotti A, Fujihara K, Nakashima I, Bennett JL, Pandit L, Chitnis T, Weinshenker BG, Wildemann B, Sato DK, Kim SH, Huda S, Kim HJ, Reindl M, Levy M, Jarius S, Tenembaum S, Paul F, Pittock S, Marignier R, Jacob A. Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients. Mult Scler Relat Disord. 2020 Jun 2;44:102251. [Epub ahead of print] PubMed PMID: 32629363
• Zhang C, Zhang M, Qiu W, Ma H, Zhang X, Zhu Z, Yang CS, Jia D, Zhang TX, Yuan M, Feng Y, Yang L, Lu W, Yu C, Bennett JL, Shi FD. Safety and efficacy of tocilizumab versus azathioprine in highly relapsing neuromyelitis optica spectrum disorder (TANGO): an open-label, multicentre, randomised, phase 2 trial. Lancet Neurol. 2020 May;19(5):391-401. PubMed PMID: 32333897
• Martin Paez Y, Bennett JL, Subramanian PS, Pelak VS. Considerations for the Treatment of Inflammatory Neuro-Ophthalmologic Disorders During the COVID-19 Pandemic. J Neuroophthalmol. 2020 Sep;40(3):305-314. PubMed PMID: 32804456
• Fujihara K, Bennett JL, de Seze J, Haramura M, Kleiter I, Weinshenker BG, Kang D, Mughal T, Yamamura T. Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology. Neurol Neuroimmunol Neuroinflamm. 2020 Sep 3;7(5). PubMed PMID: 32820020
• Whittam DH, Karthikeayan V, Gibbons E, Kneen R, Chandratre S, Ciccarelli O, Hacohen Y, de Seze J, Deiva K, Hintzen RQ, Wildemann B, Jarius S, Kleiter I, Rostasy K, Huppke P, Hemmer B, Paul F, Aktas O, Pröbstel AK, Arrambide G, Tintore M, Amato MP, Nosadini M, Mancardi MM, Capobianco M, Illes Z, Siva A, Altintas A, Akman-Demir G, Pandit L, Apiwattankul M, Hor JY, Viswanathan S, Qiu W, Kim HJ, Nakashima I, Fujihara K, Ramanathan S, Dale RC, Boggild M, Broadley S, Lana-Peixoto MA, Sato DK, Tenembaum S, Cabre P, Wingerchuk DM, Weinshenker BG, Greenberg B, Matiello M, Klawiter EC, Bennett JL, Wallach AI, Kister I, Banwell BL, Traboulsee A, Pohl D, Palace J, Leite MI, Levy M, Marignier R, Solomon T, Lim M, Huda S, Jacob A. Treatment of MOG antibody associated disorders: results of an international survey. J Neurol. 2020 Jul 4. [Epub ahead of print] PubMed PMID: 32623595
• De Lott LB, Bennett JL, Costello F. The changing landscape of optic neuritis: a narrative review. J Neurol. 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389032
• Aktas O, Smith MA, Rees WA, Bennett JL, She D, Katz E, Cree BAC. Serum Glial Fibrillary Acidic Protein: A Neuromyelitis Optica Spectrum Disorder Biomarker. Ann Neurol. 2021 May;89(5):895-910. PubMed PMID: 33724534
• Winkler A, Wrzos C, Haberl M, Weil MT, Gao M, Möbius W, Odoardi F, Thal DR, Chang M, Opdenakker G, Bennett JL, Nessler S, Stadelmann C. Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration. J Clin Invest. 2021 Mar 1;131(5). PubMed PMID: 33645550
• Marignier R, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk D, Fujihara K, Paul F, Cutter GR, Green AJ, Aktas O, Hartung HP, Lublin FD, Williams IM, Drappa J, She D, Cimbora D, Rees W, Smith M, Ratchford JN, Katz E, Cree BAC. Disability Outcomes in the N-MOmentum Trial of Inebilizumab in Neuromyelitis Optica Spectrum Disorder. Neurol Neuroimmunol Neuroinflamm. 2021 May;8(3). PubMed PMID: 33771837
• Cree BA, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk D, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, Williams IM, Drappa J, She D, Cimbora D, Rees W, Ratchford JN, Katz E. Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD. Mult Scler. 2021 Feb 4;:1352458521988926. [Epub ahead of print] PubMed PMID: 33538237
• Havla J, Pakeerathan T, Schwake C, Bennett JL, Kleiter I, Felipe-Rucián A, Joachim SC, Lotz-Havla AS, Kümpfel T, Krumbholz M, Wendel EM, Reindl M, Thiels C, Lücke T, Hellwig K, Gold R, Rostasy K, Ayzenberg I. Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well?. J Neuroinflammation. 2021 May 29;18(1):121. PubMed PMID: 34051804
• Herwerth M, Kenet S, Schifferer M, Winkler A, Weber M, Snaidero N, Wang M, Lohrberg M, Bennett JL, Stadelmann C, Hemmer B, Misgeld T. A new form of axonal pathology in a spinal model of neuromyelitis optica. Brain. 2022 Jun 3;145(5):1726-1742. PubMed PMID: 35202467
• Kowarik MC, Astling D, Lepennetier G, Ritchie A, Hemmer B, Owens GP, Bennett JL. Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients. Neurotherapeutics. 2021 Jan;18(1):364-377. PubMed PMID: 33258072
• Chen JJ, Huda S, Hacohen Y, Levy M, Lotan I, Wilf-Yarkoni A, Stiebel-Kalish H, Hellmann MA, Sotirchos ES, Henderson AD, Pittock SJ, Bhatti MT, Eggenberger ER, Di Nome M, Kim HJ, Kim SH, Saiz A, Paul F, Dale RC, Ramanathan S, Palace J, Camera V, Leite MI, Lam BL, Bennett JL, Mariotto S, Hodge D, Audoin B, Maillart E, Deschamps R, Pique J, Flanagan EP, Marignier R. Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. JAMA Neurol. 2022 May 1;79(5):518-525. PubMed PMID: 35377395
• Obaid AH, Zografou C, Vadysirisack DD, Munro-Sheldon B, Fichtner ML, Roy B, Philbrick WM, Bennett JL, Nowak RJ, O'Connor KC. Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis. Neurol Neuroimmunol Neuroinflamm. 2022 Jul;9(4). PubMed PMID: 35473886
• De Lott LB, Bennett JL, Costello F. The changing landscape of optic neuritis: a narrative review. J Neurol. 2022 Jan;269(1):111-124. PubMed PMID: 33389032
• Huang A, Jin W, Fahad AS, Mussman BK, Nicchia GP, Madan B, de Souza MO, Griffin JD, Bennett JL, Frigeri A, Berkland CJ, DeKosky BJ. Strategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries. Antibodies (Basel). 2022 Jun 5;11(2). PubMed PMID: 35735358
• Mader S, Brimberg L, Vo A, Strohl JJ, Crawford JM, Bonnin A, Carrión J, Campbell D, Huerta TS, La Bella A, Berlin R, Dewey SL, Hellman M, Eidelberg D, Dujmovic I, Drulovic J, Bennett JL, Volpe BT, Huerta PT, Diamond B. In utero exposure to maternal anti-aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring. Sci Transl Med. 2022 Apr 20;14(641):eabe9726. PubMed PMID: 35442708
• Bennett JL, Costello F, Chen JJ, Petzold A, Biousse V, Newman NJ, Galetta SL. Optic Neuropathies 2. Optic neuritis and autoimmune optic neuropathies: advances in diagnosis and treatment. Lancet Neurol 2022. Published online September 22, 2022. https://doi.org/10.1016/ S1474-4422(22)00187-9
• Bennett JL, Costello F, Chen JJ, Petzold A, Biousse V, Newman NJ, Galetta SL. Optic neuritis and autoimmune optic neuropathies: advances in diagnosis and treatment. Lancet Neurol. 2023 Jan;22(1):89-100. PubMed PMID: 36155661
• Shinoda K, Li R, Rezk A, Mexhitaj I, Patterson KR, Kakara M, Zuroff L, Bennett JL, von Büdingen HC, Carruthers R, Edwards KR, Fallis R, Giacomini PS, Greenberg BM, Hafler DA, Ionete C, Kaunzner UW, Lock CB, Longbrake EE, Pardo G, Piehl F, Weber MS, Ziemssen T, Jacobs D, Gelfand JM, Cross AH, Cameron B, Musch B, Winger RC, Jia X, Harp CT, Herman A, Bar-Or A. Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2207291120. PubMed PMID: 36634138
• Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. Lancet Neurol. 2023 Mar;22(3):268-282. PubMed PMID: 36706773
• Kleiter I, Traboulsee A, Palace J, Yamamura T, Fujihara K, Saiz A, Javed A, Mayes D, Büdingen HV, Klingelschmitt G, Stokmaier D, Bennett JL. Long-term Efficacy of Satralizumab in AQP4-IgG-Seropositive Neuromyelitis Optica Spectrum Disorder From SAkuraSky and SAkuraStar. Neurol Neuroimmunol Neuroinflamm. 2023 Jan;10(1). PubMed PMID: 36724181
• Pittock SJ, Barnett M, Bennett JL, Berthele A, de Sèze J, Levy M, Nakashima I, Oreja-Guevara C, Palace J, Paul F, Pozzilli C, Yountz M, Allen K, Mashhoon Y, Kim HJ. Ravulizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder. Ann Neurol. 2023 Jun;93(6):1053-1068. PubMed PMID: 36866852
• Marin AI, Zarubina AV, Bennett JL, Subramanian PS. Seropositive Neuromyelitis Optica Spectrum Disorder Presenting With Optic Nerve Sheath Enhancement and Optic Disc Edema Resembling Optic Nerve Sheath Meningioma. J Neuroophthalmol. 2023 May 29. [Epub ahead of print] PubMed PMID: 37247229
• Aktas O, Hartung HP, Smith MA, Rees WA, Fujihara K, Paul F, Marignier R, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Cutter G, She D, Gunsior M, Cimbora D, Katz E, Cree BA. Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in neuromyelitis optica spectrum disorder. J Neurol Neurosurg Psychiatry. 2023 Sep;94(9):757-768. PubMed PMID: 37221052
• Bennett JL. Optical Coherence Tomography, Retinal Atrophy, and Neurodegeneration in Progressive Multiple Sclerosis: Sprinting to the Finish. Neurology. 2023 Sep 5;101(10):420-421. PubMed PMID: 37460230
• Bennett JL, Fujihara K, Kim HJ, Marignier R, O'Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, Künzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ. SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab. Front Neurol. 2023;14:1114667. PubMed PMID: 36873431
• Majed M, Valencia Sanchez C, Bennett JL, Fryer J, Mulligan MD, Redenbaugh V, McKeon A, Mills JR, Wingerchuk DM, Lennon VA, Weinshenker B, Chen JJ, Flanagan EP, Pittock SJ, Kunchok A. Alterations in Aquaporin-4-IgG Serostatus in 986 Patients: A Laboratory-Based Longitudinal Analysis. Ann Neurol. 2023 Oct;94(4):727-735. PubMed PMID: 37314750
• Paul F, Marignier R, Palace J, Arrambide G, Asgari N, Bennett JL, Cree BAC, De Sèze J, Fujihara K, Kim HJ, Hornby R, Huda S, Kissani N, Kleiter I, Kuwabara S, Lana-Peixoto M, Law L, Leite MI, Pandit L, Pittock SJ, Quan C, Ramanathan S, Rotstein D, Saiz A, Sato DK, Vaknin-Dembinsky A. International Delphi Consensus on the Management of AQP4-IgG NMOSD: Recommendations for Eculizumab, Inebilizumab, and Satralizumab. Neurol Neuroimmunol Neuroinflamm. 2023 Jul;10(4). PubMed PMID: 37258412
• Weinshenker BG, Wingerchuk DM, Green AJ, Bennett JL, Kim HJ, Pittock SJ, Fujihara K, Paul F, Cutter G, Marignier R, Aktas O, Hartung HP, She D, Smith M, Rees W, Patterson K, Cimbora D, Katz E, Cree BA. Attack adjudication in neuromyelitis optica spectrum disorder: Substantiation of criteria by magnetic resonance imaging and biomarkers in N-MOmentum. Mult Scler. 2023 Jul;29(8):945-955. PubMed PMID: 37282545
• Bennett JL, Grove NC, Johnson RK, Mizenko C, DuPont JC, Wagner BD, Lynch AM, Frohman TC, Shindler KS, Frohman EM. A Randomized Prospective Trial Comparing Repository Corticotropin Injection and Intravenous Methylprednisolone for Neuroprotection in Acute Optic Neuritis. J Neuroophthalmol. 2023 Sep 1;43(3):323-329. PubMed PMID: 37261907
• Remlinger J, Bagnoud M, Meli I, Massy M, Linington C, Chan A, Bennett JL, Hoepner R, Enzmann V, Salmen A. Modelling MOG antibody-associated disorder and neuromyelitis optica spectrum disorder in animal models: Spinal cord manifestations. Mult Scler Relat Disord. 2023 Jul 17;78:104892. [Epub ahead of print] PubMed PMID: 37499337
• Remlinger J, Bagnoud M, Meli I, Massy M, Hoepner R, Linington C, Chan A, Bennett JL, Enzmann V, Salmen A. Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Visual System Manifestations. Neurol Neuroimmunol Neuroinflamm. 2023 Sep;10(5). PubMed PMID: 37429715
• Owens GP, Fellin TJ, Matschulat A, Salas V, Schaller KL, Given KS, Ritchie AM, Navarro A, Blauth K, Hughes EG, Macklin WB, Bennett JL. Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains. J Clin Invest. 2023 Oct 2;133(19). PubMed PMID: 37561592
• Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. J Immunol. 2024 Mar 1;212(5):785-800. PubMed PMID: 38251887
• Hickman JL, Lafreniere M, Bennett JL, Forbes E, Feuerstein J. Periodic Alternating Nystagmus, Ataxia, and Spasticity: A Unique Presentation of Spastic Paraplegia 7-Related Hereditary Spastic Paraplegia. Mov Disord Clin Pract. 2024 Apr;11(4):441-443. PubMed PMID: 38396346
• Cross AH, Gelfand JM, Thebault S, Bennett JL, von Büdingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A. Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis. JAMA Neurol. 2024 Mar 11;81(4):373-83. [Epub ahead of print] PubMed PMID: 38466277
• Gupta M, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL, Stroud RM. Structural Basis of Aquaporin-4 Autoantibody Binding in Neuromyelitis Optica. bioRxiv. 2024 May 14. PubMed PMID: 38798537
• Cree BAC, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, She D, Rees W, Smith M, Cimbora D, Katz E, Bennett JL. Safety and efficacy of inebilizumab for the treatment of neuromyelitis optica spectrum disorder: end-of-study results from the open-label period of the N-MOmentum trial. Lancet Neurol. 2024 Jun;23(6):588-602. PubMed PMID: 38760098
• Kammeyer R, Ogbu EA, Cooper JC, Stolz E, Piquet AL, Fuhlbrigge RC, Bennett JL, Hutaff-Lee C. [Formula: see text] Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions. Child Neuropsychol. 2024 Jul;30(5):818-846. PubMed PMID: 37902575
• Samadzadeh S, Adnan R, Berglova P, Barzegar M, Debrabant B, Roikjaer SG, Levy M, Petzold A, Palace J, Flanagan EP, Mariotto S, Skou ST, Froelich A, Lotan I, Messina S, Geraldes R, Asseyer S, Stiebel-Kalish H, Oertel FC, Shaygannejad V, Sahraian MA, Kim HJ, Bennett JL, Böttcher C, Zimmermann HG, Weinshenker BG, Paul F, Asgari N. Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT). Front Immunol. 2024;15:1380025. PubMed PMID: 39021565
• Kammeyer R, Chapman K, Furniss A, Hsieh E, Fuhlbrigge R, Ogbu EA, Boackle S, Zell J, Nair KV, Borko TL, Cooper JC, Bennett JL, Piquet AL. Blood-based biomarkers of neuronal and glial injury in active major neuropsychiatric systemic lupus erythematosus. Lupus. 2024 Sep;33(10):1116-1129. PubMed PMID: 39148457
• Marin AI, Zarubina AV, Bennett JL, Subramanian PS. Seropositive Neuromyelitis Optica Spectrum Disorder Presenting With Optic Nerve Sheath Enhancement and Optic Disc Edema Resembling Optic Nerve Sheath Meningioma. J Neuroophthalmol. 2024 Sep 1;44(3):e350-e352. PubMed PMID: 37247229
• Callen AL, Han L, Pisani Petrucci SL, Andonov N, Lennarson P, Birlea M, O'Brien C, Wilhour D, Anderson A, Bennett JL, Carroll IR. Patterns of clinical and imaging presentations in patients with spontaneous intracranial hypotension due to spinal cerebrospinal fluid venous fistula: A single-center retrospective cross-sectional study. Headache. 2024 Sep;64(8):939-949. PubMed PMID: 39129307
• Bennett JL, Pittock SJ, Paul F, Kim HJ, Irani SR, O'Connor KC, Patterson KR, Smith MA, Gunsior M, Mittereder N, Rees WA, Cimbora D, Cree BAC. B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity. Ann Clin Transl Neurol. 2024 Sep 2. [Epub ahead of print] PubMed PMID: 39222408
• Pisani Petrucci SL, Andonov N, Lennarson P, Birlea M, O'Brien C, Wilhour D, Anderson A, Bennett JL, Callen AL. Assessing the Diagnostic Value of Brain White Matter Hyperintensities and Clinical Symptoms in Predicting the Detection of CSF Venous Fistula in Patients with Suspected Spontaneous Intracranial Hypotension. AJNR Am J Neuroradiol. 2024 Oct 23. [Epub ahead of print] PubMed PMID: 39443147

Professional Memberships

• American Academy of Neurology, Member
• North American Neuro-Ophthalmologic Society, Member
• Association for Research in Vision and Ophthalmology, Member
• American Neurological Association, Member

Practice Locations

UCHealth Sue Anschutz-Rodgers Eye Center
1675 Aurora Ct
Aurora, CO 80045
720-848-2020

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• Center for Neuroscience

Specialty Information

Specialties

• Neurology, Board Certification (1998, 2008)
• Neuroimmunology
• Neuro-ophthalmology
• Neuro-Ophthalmology, Specialized Training (0001)

Conditions & Treatments

• Brain and Nervous System
• Eyes and Vision
• Brain and Nervous System - Multiple Sclerosis
• Brain and Nervous System - Pituitary Disorders
• Eyes and Vision - Neuro-Ophthalmology