Janani Ravi, PhD
Assistant Professor, Biomedical Informatics

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Graduate School :
  • PhD, Virginia Polytechnic Institute And State University (Virginia Tech) (2011)
Internship:
  • National Institutes of Health (NIH) (2017)
Languages: English, Tamil, Hindi, Telugu
Department: Biomedical Informatics

Professional Titles

  • Assistant Professor

Research Interests

My research group works on developing computational approaches to study the molecular basis of pathogenesis and intervention of infectious diseases, using protein sequence-structure-function relationships, comparative genomics, and drug repurposing. I am also actively engaged in training, education, and outreach. I am committed to creating and sustaining a diverse and inclusive ecosystem in data science and R for learners and professionals alike, focusing on increasing the participation of underrepresented minorities in data science and R programming. Towards this effort, I founded R-Ladies East Lansing and co-founded Women+ Data Science and AsiaR.

Publications

  • Conner KN*, Burke JT*, Ravi J^, Hardy JW^. Novel internalin P homologs in Listeria . Microb Genom. 2022 Jul;8(7). PubMed PMID: 35904424. [*Co-primary; ^Co-corresponding]
  • Joo R*, Sánchez-Tapia A*, Mortara S, Bellini Saibene Y, Turner H, Hug Peter D, Morandeira NS, Bannert M, Almazrouq B, Hare E, Ación L, Narváez-Gómez JP, Alfaro Córdoba M, Marini F, Giordano R, Canelón S, Ebou A, Upadhya AR, Chávez J, Ravi J^. Ten simple rules to host an inclusive conference. PLoS Comput Biol. 2022 Jul;18(7):e1010164. PubMed PMID: 35862309. [*Co-primary; ^Corresponding]
  • Hsueh BY*, Severin GB*, Elg CA, Waldron EJ, Kant A, Wessel AJ, Dover JA, Rhoades CR, Ridenhour BJ, Parent KN, Neiditch MB, Ravi J, Top EM, Waters CM. Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria. Nat Microbiol. 2022 Aug;7(8):1210-1220. PubMed PMID: 35817890 [*Co-primary]
  • Joseph T Burke*, Samuel Z Chen*, Lo M Sosinski*, John B Johnston, Janani Ravi^. MolEvolvR: A web-app for characterizing proteins using molecular evolution and phylogeny. bioRxiv 2022.02.18.461833; doi: https://doi.org/10.1101/2022.02.18.461833 [*Co-primary; ^Corresponding]
  • Mary Jo Cantoria*, Elaheh Alizadeh*, Janani Ravi, Nawat Bunnag, Arminja N. Kettenbach, Yashi Ahmed, Andrew L Paek, John J. Tyson, Konstantin Doubrovinski, Ethan Lee, Curtis A. Thorne. Feedback in the ß-catenin destruction complex imparts bistability and cellular memory. bioRxiv 2022.01.28.478206; doi: https://doi.org/10.1101/2022.01.28.478206. [*Co-primary]
  • Samart K*, Tuyishime P*, Krishnan A^, Ravi J^. Reconciling multiple connectivity scores for drug repurposing. Brief Bioinform. 2021 Nov 5;22(6). PubMed PMID: 34013329. [*Co-primary; ^Co-corresponding]
  • Ravi J*^, Fioravanti A*^. S-layers: The Proteinaceous Multifunctional Armors of Gram-Positive Pathogens. Front Microbiol. 2021;12:663468. PubMed PMID: 33889148. [*Co-primary; ^Co-corresponding]
  • Joshua M. Lensmire, Michael R. Wischer, Lo M. Sosinski, Elliot Ensink, Jack P. Dodson, John C. Shook, Phillip C. Delekta, Christopher C. Cooper, Daniel Havlichek Jr., Martha H. Mulks, Sophia Y. Lunt, Janani Ravi, Neal D. Hammer. The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition. bioRxiv 2021.10.26.465763; doi: https://doi.org/10.1101/2021.10.26.465763
  • Lensmire JM, Dodson JP, Hsueh BY, Wischer MR, Delekta PC, Shook JC, Ottosen EN, Kies PJ, Ravi J, Hammer ND. The Staphylococcus aureus Cystine Transporters TcyABC and TcyP Facilitate Nutrient Sulfur Acquisition during Infection. Infect Immun. 2020 Feb 20;88(3). PubMed PMID: 31843961
  • Janani Ravi^, Vivek Anantharaman, Samuel Zorn Chen, Pratik Datta, L Aravind^, Maria Laura Gennaro^. The Phage-shock-protein (PSP) Envelope Stress Response: Discovery of Novel Partners and Evolutionary History. bioRxiv 2020.09.24.301986; doi: https://doi.org/10.1101/2020.09.24.301986. [^Co-corresponding]
  • Ravi J, Anantharaman V, Aravind L, Gennaro ML. Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria. Antonie Van Leeuwenhoek. 2018 May;111(5):753-760. PubMed PMID: 29488183
  • Datta P, Ravi J, Guerrini V, Chauhan R, Neiditch MB, Shell SS, Fortune SM, Hancioglu B, Igoshin OA, Gennaro ML. The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions. Mol Microbiol. 2015 Aug;97(3):408-22. PubMed PMID: 25899163
  • Salamon H, Bruiners N, Lakehal K, Shi L, Ravi J, Yamaguchi KD, Pine R, Gennaro ML. Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection. J Immunol. 2014 Jul 1;193(1):30-34. PubMed PMID: 24899504
View All (13 Total) View Less
Volunteer Activities
Founder and Co-organizer R-Ladies East Lansing Women+ Data Science AsiaR

Public Speaking
Yes
Computational Biology & Biomedical Data Science; Computational approaches to study infectious diseases/pathogens; Education; Diversity; Training/Mentoring;

General Information

Graduate Schools:
  • PhD, Virginia Polytechnic Institute And State University (Virginia Tech) (2011)
Internships:
  • National Institutes of Health (NIH) (2017)
Languages: English, Tamil, Hindi, Telugu
Department: Biomedical Informatics
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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