Kyla Ost, PhD

Publications

• Cohen S, Crossen AJ, Neely MN, Doare KL, Nobbs AH, Ost KS, Doran KS. A fungal pathobiont promotes Streptococcus agalactiae vaginal persistence and pathogenesis through physical and metabolic interactions. bioRxiv. 2025 Sep 8. PubMed PMID: 40964356
• Weis AM, Bauer KM, Tang WW, Stephen-Victor E, Bell R, Brown DG, Ekiz HA, Tran V, Klag KA, Swanson EA, Barrios L, Harwood M, Hill JH, Ost KS, Gigic B, Schneider M, Ose J, Hardikar S, Toriola AT, Shibata D, Li CI, Figueiredo JC, Byrd DA, Siegel EM, Arnolds K, Lozupone C, Ulrich CM, O'Connell RM, Stephens WZ, Round JL. A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy. Cell Rep. 2025 Sep 23;44(9):116172. PubMed PMID: 40849910
• Davis FA, Singh K, Krampen JM, Bryant JA, Ost KS, Righi SE, Balunas MJ, Wang T, O'Meara TR. Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi. bioRxiv. 2025 Jul 27. PubMed PMID: 40777320
• Case NT, Gurr SJ, Fisher MC, Blehert DS, Boone C, Casadevall A, Chowdhary A, Cuomo CA, Currie CR, Denning DW, Ene IV, Fritz-Laylin LK, Gerstein AC, Gow NAR, Gusa A, Iliev ID, James TY, Jin H, Kahmann R, Klein BS, Kronstad JW, Ost KS, Peay KG, Shapiro RS, Sheppard DC, Shlezinger N, Stajich JE, Stukenbrock EH, Taylor JW, Wright GD, Cowen LE, Heitman J, Segre JA. Fungal impacts on Earth's ecosystems. Nature. 2025 Feb;638(8049):49-57. PubMed PMID: 39910383
• Chiaro TR, Greenewood M, Bauer KM, Ost KS, Stephen-Victor E, Murphy M, Weis AM, Nelson MC, Hill JH, Bell R, Voth W, Jackson T, Klag KA, O'Connell RM, Zac Stephens W, Round JL. Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals. Cell Host Microbe. 2025 Jan 8;33(1):89-103.e7. PubMed PMID: 39788099
• Jensen O, Trujillo E, Hanson L, Ost KS. Controlling Candida: immune regulation of commensal fungi in the gut. Infect Immun. 2024 Sep 10;92(9):e0051623. PubMed PMID: 38647290
• Cohen S, Ost KS, Doran KS. Impact of interkingdom microbial interactions in the vaginal tract. PLoS Pathog. 2024 Mar;20(3):e1012018. PubMed PMID: 38457371
• Chiaro TR, Bauer KM, Ost KS, Stephen-Victor E, Nelson MC, Hill JH, Bell R, Harwood M, Voth W, Jackson T, Klag KA, Oâ Connell RM, Zac Stephens W, Round JL. Clec12a tempers inflammation while restricting expansion of a colitogenic commensal. bioRxiv. 2023 Mar 16. PubMed PMID: 36993296
• Ost KS, Round JL. Commensal fungi in intestinal health and disease. Nat Rev Gastroenterol Hepatol. 2023 Nov;20(11):723-734. PubMed PMID: 37479823

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000