Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at a5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biol Psychiatry. 2022 Aug 1;92(3):216-226. PubMed PMID: 35120711
Fox ME, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK. Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence. Biol Psychiatry. 2022 Aug 30. [Epub ahead of print] PubMed PMID: 36435669
Cole AB, Montgomery K, Bale TL, Thompson SM. What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF PVN neurons. Neurobiol Stress. 2022 Sep;20:100473. PubMed PMID: 35982732
Hopp J, Pahlavan A, Richert M, Grimes K, Turlington K, Cassady M, Kvarta MD, Thompson SM. Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures. Front Psychiatry. 2022;13:912697. PubMed PMID: 35935419
Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at a5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biol Psychiatry. 2022 Aug 1;92(3):216-226. PubMed PMID: 35120711
Hopp J, Pahlavan A, Richert M, Grimes K, Turlington K, Cassady M, Kvarta MD, Thompson SM. Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures. Front Psychiatry. 2022;13:912697. PubMed PMID: 35935419
Georgiou P, Zanos P, Mou TM, An X, Gerhard DM, Dryanovski DI, Potter LE, Highland JN, Jenne CE, Stewart BW, Pultorak KJ, Yuan P, Powels CF, Lovett J, Pereira EFR, Clark SM, Tonelli LH, Moaddel R, Zarate CA Jr, Duman RS, Thompson SM, Gould TD. Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nat Neurosci. 2022 Sep;25(9):1191-1200. PubMed PMID: 36042309
Thompson SM. Optimizing psychedelic compounds for neuropsychiatric therapy. Neuropsychopharmacology. 2021 Jul;46(8):1397-1398. PubMed PMID: 33820954
Ramsey AM, Tang AH, LeGates TA, Gou XZ, Carbone BE, Thompson SM, Biederer T, Blanpied TA. Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength. Sci Adv. 2021 Aug;7(34). PubMed PMID: 34417170
Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM. Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17). PubMed PMID: 33850049
Morrison KE, Cole AB, Kane PJ, Meadows VE, Thompson SM, Bale TL. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology. 2020 Jul;45(8):1263-1271. PubMed PMID: 32045935
Wulff AB, Cooper P, Kodjo E, Abel E, Thompson SM. How Sucrose Preference Is Gained and Lost: An In-Depth Analysis of Drinking Behavior during the Sucrose Preference Test in Mice. eNeuro. 2023 Sep;10(9). PubMed PMID: 37699705
Wulff AB, Nichols CD, Thompson SM. Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders. Neuropharmacology. 2023 Jun 15;231:109504. PubMed PMID: 36921889
Bailey AM, Barrett A, Havens L, Leyder E, Merchant T, Starnes H, Thompson SM. Changes in social, sexual, and hedonic behaviors in rats in response to stress and restoration by a negative allosteric modulator of a5-subunit containing GABA receptor. Behav Brain Res. 2023 Aug 24;452:114554. PubMed PMID: 37356670
Zanos P, Brown KA, Georgiou P, Yuan P, Zarate CA Jr, Thompson SM, Gould TD. NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine. J Neurosci. 2023 Feb 8;43(6):1038-1050. PubMed PMID: 36596696
Fox ME, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK. Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence. Biol Psychiatry. 2023 Mar 15;93(6):489-501. PubMed PMID: 36435669
Thompson SM. Plasticity of synapses and reward circuit function in the genesis and treatment of depression. Neuropsychopharmacology. 2023 Jan;48(1):90-103. PubMed PMID: 36057649
Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA Jr, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD. Antidepressant-relevant concentrations of the ketamine metabolite (2 R ,6 R )-hydroxynorketamine do not block NMDA receptor function. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5160-5169. PubMed PMID: 30796190
Bale TL, Abel T, Akil H, Carlezon WA Jr, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM. The critical importance of basic animal research for neuropsychiatric disorders. Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. PubMed PMID: 31048727
Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD. (R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses. Br J Pharmacol. 2019 Jul;176(14):2573-2592. PubMed PMID: 30941749
Gould TD, Zarate CA Jr, Thompson SM. Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:213-236. PubMed PMID: 30296896
LeGates TA, Kvarta MD, Thompson SM. Sex differences in antidepressant efficacy. Neuropsychopharmacology. 2019 Jan;44(1):140-154. PubMed PMID: 30082889
Divakaruni SS, Van Dyke AM, Chandra R, LeGates TA, Contreras M, Dharmasri PA, Higgs HN, Lobo MK, Thompson SM, Blanpied TA. Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction. Neuron. 2018 Nov 21;100(4):860-875.e7. PubMed PMID: 30318410
LeGates TA, Kvarta MD, Tooley JR, Francis TC, Lobo MK, Creed MC, Thompson SM. Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses. Nature. 2018 Dec;564(7735):258-262. PubMed PMID: 30478293
Zanos P, Nelson ME, Highland JN, Krimmel SR, Georgiou P, Gould TD, Thompson SM. A Negative Allosteric Modulator for a5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice. eNeuro. 2017 Jan-Feb;4(1). PubMed PMID: 28275719
Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. 2016 May 26;533(7604):481-6. PubMed PMID: 27144355
Kvarta MD, Bradbrook KE, Dantrassy HM, Bailey AM, Thompson SM. Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses. J Neurophysiol. 2015 Sep;114(3):1713-24. PubMed PMID: 26180121
Fischell J, Van Dyke AM, Kvarta MD, LeGates TA, Thompson SM. Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors. Neuropsychopharmacology. 2015 Oct;40(11):2499-509. PubMed PMID: 25900119
Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, LeGates TA, Cai X. An excitatory synapse hypothesis of depression. Trends Neurosci. 2015 May;38(5):279-94. PubMed PMID: 25887240
Kallarackal AJ, Kvarta MD, Cammarata E, Jaberi L, Cai X, Bailey AM, Thompson SM. Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses. J Neurosci. 2013 Oct 2;33(40):15669-74. PubMed PMID: 24089474