Michael David, PhD

Research Interests

My research integrates spatial histopathology, transcriptomics, and medical imaging using machine learning (ML) to study and diagnose post-traumatic joint conditions of contracture and osteoarthritis. I develop ML models end-to-end to identify tissue and cellular subtypes, phenotypes, and predictive relationships. My ML models are built upon preclinical and clinical datasets involving the ankle, elbow, and knee. Topic areas: Machine Learning, Deep Learning, Post-Traumatic Osteoarthritis, Musculoskeletal Biology, Biomedical Engineering, Multi-omics, Medical Imaging, Spatial histopathology

Publications

• David MA, Reiter AJ, Dunham CL, Castile RM, Abraham JA, Iannucci LE, Shah ID, Havlioglu N, Chamberlain AM, Lake SP. Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture. Front Bioeng Biotechnol. 2022;10:803403. PubMed PMID: 35265595
• Iannucci LE, Dranoff CS, David MA, Lake SP. Optical Imaging of Dynamic Collagen Processes in Health and Disease. Frontiers in Mechanical Engineering. 2022:18.
• David MA, Chamberlain AM, Lake SP. Preclinical Models of Elbow Injury and Pathology. Ann Jt. 2021 Jan;6. PubMed PMID: 35990575
• David MA, Smith MK, Pilachowski RN, White AT, Locke RC, Price C. Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse. J Orthop Res. 2017 Mar;35(3):537-547. PubMed PMID: 27664978
• Luo T, David MA, Dunshee LC, Scott RA, Urello MA, Price C, Kiick KL. Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices. Biomacromolecules. 2017 Aug 14;18(8):2539-2551. PubMed PMID: 28719196
• Zhou Y, David MA, Chen X, Wan LQ, Duncan RL, Wang L, Lu XL. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Ann Biomed Eng. 2016 Apr;44(4):1138-47. PubMed PMID: 26219403
• David MA, Yuan Y, Bacon A, Shah S, Movva A, Lang B, Gan W, Berke I, Kamilov U, Lake S. Machine Learning Approaches To Segment And Cluster Cells Of The Cartilage And Capsule In Rat Elbow Histology Sections. Osteoarthritis and Cartilage. 2023; 31, S55-S56. https://doi.org/10.1016/j.joca.2023.01.550
• Buckley SE, David MA, Hamati MC, Hewitt MA, Adams DJ, Ackert-Bicknell CL, Zuscik, MJ, Hunt KJ. Rna Sequencing And Machine Learning Reveal A Unique Synovial Signature In Ankle Osteoarthritis. Osteoarthritis and Cartilage. 2023; 31, S54-S55. https://doi.org/10.1016/j.joca.2023.01.549
• Buckley SE, David MA, Hewitt MA, Zuscik MJ, Hunt KJ. Exploration of RNA-Sequencing Data from Knee and Ankle Synovium using Machine Learning. Foot & Ankle Orthopaedics. 2023; 8 (4). https://doi.org/10.1177/2473011423S00308
• Ross DJ, Buckley SE, David MA, Hewitt MA, Adams DJ, Zuscik MJ, Hunt KJ. Peroneal Tendon Disorders: Cellular Profiles and Gene Expression. Foot & Ankle Orthopaedics. 2023; 8 (4). https://doi.org/10.1177/2473011423S00381

Professional Memberships

• Orthopaedic Research Society, Member; Ambassador
• Osteoarthritis Research Society International, Member
• The American Society for Bone and Mineral Research, Member