Graduate School :
Department: Orthopedics
- PhD, University of Delaware (2019)
- BS, University of Rochester (NY) (2013)
Department: Orthopedics
Research Interests
My research integrates spatial histopathology, transcriptomics, and medical imaging using machine learning (ML) to study and diagnose post-traumatic joint conditions of contracture and osteoarthritis. I develop ML models end-to-end to identify tissue and cellular subtypes, phenotypes, and predictive relationships. My ML models are built upon preclinical and clinical datasets involving the ankle, elbow, and knee.
Topic areas: Machine Learning, Deep Learning, Post-Traumatic Osteoarthritis, Musculoskeletal Biology, Biomedical Engineering, Multi-omics, Medical Imaging, Spatial histopathology
Publications
- David MA, Reiter AJ, Dunham CL, Castile RM, Abraham JA, Iannucci LE, Shah ID, Havlioglu N, Chamberlain AM, Lake SP. Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture. Front Bioeng Biotechnol. 2022;10:803403. PubMed PMID: 35265595
- Iannucci LE, Dranoff CS, David MA, Lake SP. Optical Imaging of Dynamic Collagen Processes in Health and Disease. Frontiers in Mechanical Engineering. 2022:18.
- David MA, Chamberlain AM, Lake SP. Preclinical Models of Elbow Injury and Pathology. Ann Jt. 2021 Jan;6. PubMed PMID: 35990575
- David MA, Smith MK, Pilachowski RN, White AT, Locke RC, Price C. Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse. J Orthop Res. 2017 Mar;35(3):537-547. PubMed PMID: 27664978
- Luo T, David MA, Dunshee LC, Scott RA, Urello MA, Price C, Kiick KL. Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices. Biomacromolecules. 2017 Aug 14;18(8):2539-2551. PubMed PMID: 28719196
- Zhou Y, David MA, Chen X, Wan LQ, Duncan RL, Wang L, Lu XL. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Ann Biomed Eng. 2016 Apr;44(4):1138-47. PubMed PMID: 26219403
Public Speaking
Yes
Yes
General Information
Graduate Schools:
- PhD, University of Delaware (2019)
Undergraduate Schools:
- BS, University of Rochester (NY) (2013)
Department: Orthopedics