Alyssa Castillo, MD

Assistant Professor, Medicine-Infectious Disease

Faculty Photo
Medical School
  • MD, University of Colorado Denver School of Medicine (2015)
Internship
  • Massachusetts General Hospital Program (2016)
Residency
  • Massachusetts General Hospital Program, Chief Resident, Internal Medicine (2018)
Fellowships
  • University of Washington Program, Infectious Disease (2022)
Languages
English, Spanish
Department
Medicine-Infectious Disease

Professional Titles

  • Medical Director, UCH Antimicrobial Stewardship

Publications

  • Hartlage W, Castillo AY, Kassamali Escobar Z, Bajenov M, Martinez-Paz N, Lynch JB, Bryson-Cahn C, Chan JD. Stewarding the inappropriate diagnosis and treatment of urinary tract infection: leveraging the urinalysis to understand true antibiotic overuse. Antimicrob Steward Healthc Epidemiol. 2025;5(1):e49. PubMed PMID: 40026777
  • Mitaka H, Brade K, Castillo AY. Underdosed and Underappreciated: Why Japanese Community-Acquired Pneumonia Outcomes With Ampicillin-Sulbactam May Not Translate Globally. Open Forum Infect Dis. 2025 Jul;12(7):ofaf348. PubMed PMID: 40599487
  • Castillo A, Hartlage W, and Bryson-Cahn C. "Protectors vs Police: How Antimicrobial Stewardship Interventions Come Across and How to Change the Narrative." Contagion. 2025;10,3.
  • Castillo AY, Frost HM, Poole NM, Jenkins TC, Seibert AM, and Stenehjem E. Implementing with Intention: Advantages, Challenges, and Tactics to Optimally Utilize the AXR Metric. Antimicrob Steward Healthc Epidemiol. 2024.
  • Hartlage W, Castillo AY, Kassamali Escobar Z, Bajenov M, Martinez-Paz N, Lynch JB, Bryson-Cahn C, and Chan JD. Stewarding the Inappropriate Diagnosis and Treatment of UTI: Leveraging the Urinalysis to Understand True Antibiotic Overuse. Antimicrob Steward Healthc Epidemiol. 2024.
  • Ruchman SG, Fitzgerald B, Roda G, Van Ochten N, Castillo AY, and Kaplan SR. A 52-Year-Old Man with a Chronic Nasal Wound. NEJM Evid. 2024;3(6).??
  • Castillo AY, Hudziec M, Totten SE, and Pisney L. Team-based IP Review Improves Inter-rater Reliability in Identification of Hospital Acquired Infections. Infect Control Hosp Epidemiol. 2024;1-3.
  • Kassamali-Escobar Z, Hartlage W, Chan JD, Castillo A, et al. Antimicrobial Stewardship and Quality Improvement Strategies in Critical Access Hospitals: Findings from an Intensive Quality Improvement Cohort. Infect Control Hosp Epidemiol. 2024.
  • McCormick C, Galatowitsch, J, Castillo, A. A 35-year-old Man with Fever, Liver Dysfunction, and Pancytopenia. NEJM Evidence. 2023.
  • Castillo AY, Chan JD, Lynch JB, Bryson-Cahn C. How to disagree better: utilizing advocacy-inquiry techniques to improve communication and spur behavior change. Antimicrob Steward Healthc Epidemiol 2023.
  • Hartlage W, Bryson-Cahn C, Castillo AY, et al. Asymptomatic bacteriuria in critical-access hospitals: Prevalence and patient characteristics driving treatment. Infect Control Hosp Epidemiol 2023.
  • Castillo, A, Zelikoff, A, Chan, J, Lynch, J, Bryson-Cahn, C. Rapid Molecular SARS-CoV-2 Testing in Hospital Employees with Mild Non-specific Respiratory Symptoms Facilitates Expedient Return to Work. Infection Control & Hospital Epidemiology. 2022.
  • Ankomah, A, Castillo, A, O’Neil, J, and Andrews, H. A 66-year-old Man with Fever and Confusion. NEJM Evidence. 2022 Jan; 1(1).
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Professional Memberships

  • Infectious Diseases Society of America (IDSA), Member
  • Society for Healthcare Epidemiology of America (SHEA), Member

Practice Locations

UCHealth Infectious Disease Clinic - Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0191

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2018)
  • Infectious Disease, Board Certification (2022)

School of Medicine

CU Anschutz

Fitzsimons Building

13001 East 17th Place

Campus Box C290

Aurora, CO 80045


303.724.5375