Charles Tharp, MD

Publications

• Tharp CA, McKinsey TA. Tissue is the issue: Endomyocardial biopsies to elucidate molecular mechanisms and tailor therapy for HFpEF. J Mol Cell Cardiol. 2022 Aug;169:111-112. PubMed PMID: 35660295
• Travers JG, Tharp CA, Rubino M, McKinsey TA. Therapeutic targets for cardiac fibrosis: from old school to next-gen. J Clin Invest. 2022 Mar 1;132(5). PubMed PMID: 35229727
• Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H, Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H, McKinsey TA. Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7). PubMed PMID: 35149557
• Tharp CA, Haywood ME, Sbaizero O, Taylor MRG, Mestroni L. The Giant Protein Titin's Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease. Front Physiol. 2019;10:1436. PubMed PMID: 31849696
• Begay RL, Tharp CA, Martin A, Graw SL, Sinagra G, Miani D, Sweet ME, Slavov DB, Stafford N, Zeller MJ, Alnefaie R, Rowland TJ, Brun F, Jones KL, Gowan K, Mestroni L, Garrity DM, Taylor MR. FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. JACC Basic Transl Sci. 2016 Aug;1(5):344-359. PubMed PMID: 28008423
• Tharp C, Mestroni L, Taylor M. Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure. J Clin Med. 2020 Aug 26;9(9). PubMed PMID: 32859027
• Eldemire R, Tharp CA, Taylor MRG, Sbaizero O, Mestroni L. The Sarcomeric Spring Protein Titin: Biophysical Properties, Molecular Mechanisms, and Genetic Mutations Associated with Heart Failure and Cardiomyopathy. Curr Cardiol Rep. 2021 Jul 16;23(9):121. PubMed PMID: 34269900
• Cunningham JM, Mackey A, Tharp C. Atypical Wenckebach without grouped beating due to dual AV nodal conduction. J Electrocardiol. 2024 Jan-Feb;82:83-85. PubMed PMID: 38070250