Ian Cartwright, PhD

Recognitions

• Experimental Pathologist-in-Training Award, American Society for Experimental Pathology (2022)
  For meritorious research in experimental pathology
• ASIP 2021 Trainee Scholar Award, American Society for Experimental Pathology (2021)
  Outstanding Research in Experimental Pathology
• Translational Research Scholar Program Award, University of Colorado School of Medicine (2023)
• George K. Michalopoulos Junior Faculty Scholar Award, American Society for Experimental Pathology (2023)
• Monga Family Junior Faculty Scholar Award, American Society for Experimental Pathology (2024)
• Rising Star, University of Colorado Department of Medicine (2024)

Research Interests

My research interests are primarily focused on investigating the impact of acidosis on the inflammatory microenvironment. I am currently studying how extracellular pH alters inflammatory signaling in epithelial cells and the role of neutrophils in inflammatory acidosis in an effort to identify novel therapeutic targets for inflammatory bowel disease.

Publications

• Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 May 18;118(20). PubMed PMID: 33972436
• Cartwright IM, Colgan SP. Lung neutrophils on a paleo diet: lean, mean inflammatory machines. J Clin Invest. 2021 May 17;131(10). PubMed PMID: 33998602
• Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2021 Mar;14(2):479-490. PubMed PMID: 33004979
• Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell. 2020 Sep 15;31(20):2249-2258. PubMed PMID: 32726170
• Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2020 Mar;13(2):230-244. PubMed PMID: 31792360
• Cartwright IM. Modified PNA Telomere and Centromere FISH Protocols. Methods Mol Biol. 2019;1984:101-105. PubMed PMID: 31267425
• Cartwright IM, Haskins JS, Kato TA. PNA Telomere and Centromere FISH Staining for Accurate Analysis of Radiation-Induced Chromosomal Aberrations. Methods Mol Biol. 2019;1984:95-100. PubMed PMID: 31267424
• Curtis VF, Cartwright IM, Lee JS, Wang RX, Kao DJ, Lanis JM, Burney KM, Welch N, Hall CHT, Goldberg MS, Campbell EL, Colgan SP. Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling. Mol Biol Cell. 2018 Nov 1;29(22):2687-2699. PubMed PMID: 30188771
• Sunada S, Cartwright IM, Hirakawa H, Fujimori A, Uesaka M, Kato TA. Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells. Oncol Lett. 2017 Jun;13(6):4911-4916. PubMed PMID: 28599495
• Maeda J, Cartwright IM, Haskins JS, Fujii Y, Fujisawa H, Hirakawa H, Uesaka M, Kitamura H, Fujimori A, Thamm DH, Kato TA. Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles. Oncol Lett. 2016 Aug;12(2):1597-1601. PubMed PMID: 27446477
• Maeda J, Fujii Y, Fujisawa H, Hirakawa H, Cartwright IM, Uesaka M, Kitamura H, Fujimori A, Kato TA. Hyperthermia-induced radiosensitization in CHO wild-type, NHEJ repair mutant and HR repair mutant following proton and carbon-ion exposure. Oncol Lett. 2015 Nov;10(5):2828-2834. PubMed PMID: 26722249
• Cartwright IM, Bell JJ, Maeda J, Genet MD, Romero A, Fujii Y, Fujimori A, Kitamuta H, Kamada T, Chen DJ, Kato TA. Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity. Oncol Lett. 2015 Apr;9(4):1621-1627. PubMed PMID: 25789011
• Cartwright IM, Kato TA. Role of various DNA repair pathways in chromosomal inversion formation in CHO mutants. Int J Radiat Biol. 2015;91(12):925-33. PubMed PMID: 26513271
• Sunada S, Fujisawa H, Cartwright IM, Maeda J, Brents CA, Mizuno K, Aizawa Y, Kato TA, Uesaka M. Monoglucosyl-rutin as a potential radioprotector in mammalian cells. Mol Med Rep. 2014 Jul;10(1):10-4. PubMed PMID: 24788331
• Cartwright IM, Genet MD, Kato TA. A simple and rapid fluorescence in situ hybridization microwave protocol for reliable dicentric chromosome analysis. J Radiat Res. 2013 Mar 1;54(2):344-8. PubMed PMID: 23161278
• Cartwright IM, Liu X, Zhou M, Li F, Li CY. Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis. Elife. 2017 Jul 10;6. doi: 10.7554/eLife.26371. PubMed PMID: 28691902; PubMed Central PMCID: PMC5550274.
• Cartwright IM, Colgan SP. In vitro Monitoring of Extracellular pH in Real-Time. J Vis Exp. 2021 Jun 3;(172). doi: 10.3791/62169. PubMed PMID: 34152309.
• Genet MD, Cartwright IM, Kato TA. Direct DNA and PNA probe binding to telomeric regions without classical in situ hybridization. Mol Cytogenet. 2013 Oct 8;6(1):42. doi: 10.1186/1755-8166-6-42. PubMed PMID: 24103162; PubMed Central PMCID: PMC3852893.
• Cartwright IM, Genet MD, Fujimori A, Kato TA. Role of LET and chromatin structure on chromosomal inversion in CHO10B2 cells. Genome Integr. 2014 Jan 28;5(1):1. doi: 10.1186/2041-9414-5-1. PubMed PMID: 24467838; PubMed Central PMCID: PMC3917374.
• Cartwright IM, Su C, Haskins JS, Salinas VA, Sunada S, Yu H, Uesaka M, Hirakawa H, Chen DJ, Fujimori A, Kato TA. DNA Repair Deficient Chinese Hamster Ovary Cells Exhibiting Differential Sensitivity to Charged Particle Radiation under Aerobic and Hypoxic Conditions. Int J Mol Sci. 2018 Jul 30;19(8). doi: 10.3390/ijms19082228. PubMed PMID: 30061540; PubMed Central PMCID: PMC6121575.
• Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, Vögeli B, Colgan SP. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J. 2021 May;35(5):e21552. PubMed PMID: 33826788
• Schaefer REM, Callahan RC, Atif SM, Orlicky DJ, Cartwright IM, Fontenot AP, Colgan SP, Onyiah JC. Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation. Mucosal Immunol. 2022 Feb;15(2):244-256. PubMed PMID: 34916594
• Larsen LD, Dockstader K, Olbrich CL, Cartwright IM, Spencer LA. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils. J Leukoc Biol. 2022 May;111(5):943-952. PubMed PMID: 35141942
• Cartwright IM, Dowdell AS, Hanson C, Kostelecky RE, Welch N, Steiner CA, Colgan SP. Contact-dependent, polarized acidification response during neutrophil-epithelial interactions. J Leukoc Biol. 2022 Dec;112(6):1543-1553. PubMed PMID: 35674095
• Steiner CA, Cartwright IM, Taylor CT, Colgan SP. Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis. Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C866-C878. PubMed PMID: 35912990
• Dowdell AS, Cartwright IM, Kitzenberg DA, Kostelecky RE, Mahjoob O, Saeedi BJ, Welch N, Glover LE, Colgan SP. Essential role for epithelial HIF-mediated xenophagy in control of Salmonella infection and dissemination. Cell Rep. 2022 Sep 27;40(13):111409. PubMed PMID: 36170839
• Littlefield KM, Schneider JM, Neff CP, Soesanto V, Siebert JC, Nusbacher NM, Moreno-Huizar N, Cartwright IM, Armstrong AJS, Colgen SP, Lozupone CA, Palmer BE. Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function. Front Immunol. 2022;13:1072720. PubMed PMID: 36605218
• Cartwright IM, Colgan SP. The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution. Front Immunol. 2023;14:1124774. PubMed PMID: 36742292
• Steiner CA, Koch SD, Evanoff T, Welch N, Kostelecky R, Callahan R, Murphy EM, Hall CHT, Lu S, Weiser-Evans MC, Cartwright IM, Colgan SP. The TNF (?ARE) mouse as a model of intestinal fibrosis. bioRxiv. 2023 Jan 14. PubMed PMID: 36712048