Xueni Chen, MD, PhD
Assistant Research Professor, Medicine-Allergy/Clinical Immunology
Publications
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- Ara h 2 and Ara h 6 Have Similar Allergenic Activity and Are Substantially Redundant. Int Arch Allergy Immunol. 2013; 160:251-258 Xueni Chen, Qian Wang ,Rabab El-Mezayen Yonghua Zhuang, Stephen C. Dreskin
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- Chen X, Zhuang Y, Wang Q, Moutsoglou D, Ruiz G, Yen SE, Dreskin SC. (2011).Analysis of the effector activity of Ara h 2 and Ara h 6 by selective depletion from a crude peanut extract.J Immunol Methods. 30;372(1-2):65-70
- Kulis M, Chen X, Lew J, Wang Q, Patel OP, Zhuang Y, Murray KS, Duncan MW, Porterfield HS, W Burks A, Dreskin SC. (2012). The 2S albumin allergens of Arachis hypogaea, Ara h 2 and Ara h 6, are the major elicitors of anaphylaxis and can effectively desensitize peanut-allergic mice.Clin Exp Allergy. 42(2):326-36.
- Yonghua Zhuang, Sandy Durrani, Britanny Hodges, Stephen C Dreskin, Xueni Chen.(2012). Expression of recombinant Ara h 6 in Pichia pastoris but not in E. coli preserves allergic effector function and allows assessment of specific mutations. AAAA annual meeting
- Conformational IgE epitopes of peanut allergens Ara h 2 and Ara h 6 Xueni Chen, Surendra S. Negi, Sumei Liao, Valerie Gao, Werner Braun, Stephen C. Dreskin Clin Exp Allergy. Author manuscript; available in PMC 2017 Aug 1. Published in final edited form as: Clin Exp Allergy. 2016 Aug; 46(8): 1120–1128. Published online 2016 Jun 27. doi: 10.1111/cea.12764 PMCID: PMC4963300
- Application of phage peptide display technology for the study of food allergen epitopes. Chen X, Dreskin SC. Mol Nutr Food Res. 2016 Dec 20. doi: 10.1002/mnfr.201600568. [Epub ahead of print] Review. PMID: 27995755
- Zhuang Y, Durrani S, Hodges BD, Dreskin SC, X Chen: Expression of recombinant Ara h 6 in Pichia pastoris but not in Escherichia coli preserves allergic effector function and allows assessment of specific mutations. Molecular nutrition & food research 2012, 56:986-995.
- X Chen, Wang Q, EI-Mezayen R, Zhuang Y, Dreskin SC: Ara h2 and Ara h 6 have similar allergenic activity and are substantially redudent. Int Arch Allergy Immunol 2012, 160:251-258.
- Application of phage peptide display technology for the study of food allergen epitopes. Mol Nutr Food Res. 2017 Jun;61(6). doi: 10.1002/mnfr.201600568. Epub 2017 Feb 8.
- Liao S, Patil SU, Shreffler WG, Dreskin SC, Chen X. Human monoclonal antibodies to Ara h 2 inhibit allergen-induced, IgE-mediated cell activation. Clin Exp Allergy. 2019 Aug;49(8):1154-1157. PubMed PMID: 31134696
- Dreskin SC, Germinaro M, Reinhold D, Chen X, Vickery BP, Kulis M, Burks AW, Negi SS, Braun W, Chambliss JM, Eglite S, McNulty CMG. IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy. Pediatr Allergy Immunol. 2019 Dec;30(8):817-823. PubMed PMID: 31437325
- The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds. PMCID: PMC8035160
- Canon N, Schein CH, Braun W, Negi SS, Chen X, Kulis MD, Kim EH, Pathy V, Pozzoli M, Liu W, Dreskin SC. Alanine Scanning of the Unstructured Region of Ara h 2 and of a Related Mimotope Reveals Critical Amino Acids for IgE Binding. Mol Nutr Food Res. 2023 Nov;67(22):e2300134. PubMed PMID: 37706599
Specialty Information
Specialties- Psychology