Mi-Hyun Nam, PhD

Professional Titles

• Assistant Professor

Research Interests

Publications

• Cooksley G, Nam MH, Nahomi RB, Rankenberg J, Smith AJO, Wormstone YM, Wormstone IM, Nagaraj RH. Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts. Aging Cell. 2024 Oct;23(10):e14249. PubMed PMID: 39384405
• Nam MH, Dhillon A, Nahomi RB, Carrillo NL, Hougen CS, Nagaraj RH. Peptain-1 blocks ischemia/reperfusion-induced retinal capillary degeneration in mice. Front Cell Neurosci. 2024;18:1441924. PubMed PMID: 39149168
• Lo J, Mehta K, Dhillon A, Huang YK, Luo Z, Nam MH, Al Diri I, Chang KC. Therapeutic strategies for glaucoma and optic neuropathies. Mol Aspects Med. 2023 Dec;94:101219. PubMed PMID: 37839232
• Panja S, Nahomi RB, Rankenberg J, Michel CR, Gaikwad H, Nam MH, Nagaraj RH. Aggrelyte-2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia. Aging Cell. 2023 Apr;22(4):e13797. PubMed PMID: 36823285
• Panja S, Gaikwad H, Rankenberg J, Nam MH, Nagaraj RH. Promotion of Protein Solubility and Reduction in Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia. Int J Mol Sci. 2023 Jan 22;24(3). PubMed PMID: 36768517
• Panja S, Nahomi RB, Rankenberg J, Michel CR, Gaikwad H, Nam MH, Nagaraj RH. Aggrelyte-2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia. Aging Cell. 2023 Apr;22(4):e13797. PubMed PMID: 36823285
• Nam MH, Stankowska DL, Johnson GA, Nahomi RB, Pantcheva MB, Nagaraj RH. Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma. Cell Death Dis. 2022 Nov 15;13(11):958. PubMed PMID: 36379926
• Nam MH, Nahomi RB, Pantcheva MB, Dhillon A, Chiodo VA, Smith WC, Nagaraj RH. AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension. Transl Vis Sci Technol. 2022 Nov 1;11(11):8. PubMed PMID: 36355386
• Rajeswaren V, Wong JO, Yabroudi D, Nahomi RB, Rankenberg J, Nam MH, Nagaraj RH. Small Heat Shock Proteins in Retinal Diseases. Front Mol Biosci. 2022;9:860375. PubMed PMID: 35480891
• Nam MH, Pantcheva MB, Rankenberg J, Nagaraj RH. Transforming growth factor-ß2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE. Biochem J. 2021 Jun 25;478(12):2285-2296. PubMed PMID: 34143864
• Jeon GY, Nam MH, Lee KW. Inhibitory effect of caffeic acid on advanced glycation end product-induced renal fibrosis in vitro: A potential therapeutic target. J Food Sci. 2021 Feb;86(2):579-586. PubMed PMID: 33448051
• Nam HK, Jeong SR, Pyo MC, Ha SK, Nam MH, Lee KW. Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways. Biol Pharm Bull. 2021;44(11):1697-1706. PubMed PMID: 34719646
• Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFß2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. PubMed PMID: 31815277
• Nam MH, Chun MS, Seong JK, Kim HG. Ensuring reproducibility and ethics in animal experiments reporting in Korea using the ARRIVE guideline. Lab Anim Res. 2018 Mar;34(1):11-19. PubMed PMID: 29628972
• Han AR, Nam MH, Lee KW. Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-?B Pathways in HaCaT Cells. Photochem Photobiol. 2016 Sep;92(5):708-19. PubMed PMID: 27346084
• Hong CO, Nam MH, Oh JS, Lee JW, Kim CT, Park KW, Lee DH, Lee KW. Erratum for: Pheophorbide a from Capsosiphon fulvescens Inhibits Advanced Glycation End Products Mediated Endothelial Dysfunction. Planta Med. 2016 Jan;82(1-02):E1. PubMed PMID: 26393934
• Hong CO, Nam MH, Oh JS, Lee JW, Kim CT, Park KW, Lee DH, Lee KW. Pheophorbide a from Capsosiphon fulvescens Inhibits Advanced Glycation End Products Mediated Endothelial Dysfunction. Planta Med. 2016 Jan;82(1-2):46-57. PubMed PMID: 26308358
• Koo YC, Pyo MC, Nam MH, Hong CO, Yang SY, Lee KW. Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway. Toxicol In Vitro. 2016 Aug;34:8-15. PubMed PMID: 27021876
• Nam MH, Son WR, Lee YS, Lee KW. Glycolaldehyde-derived advanced glycation end products (glycol-AGEs)-induced vascular smooth muscle cell dysfunction is regulated by the AGES-receptor (RAGE) axis in endothelium. Cell Commun Adhes. 2015 Apr-Dec;22(2-6):67-78. PubMed PMID: 27602595
• Hong YJ, Yang SY, Nam MH, Koo YC, Lee KW. Caffeic acid inhibits the uptake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by inducing the efflux transporters expression in Caco-2 cells. Biol Pharm Bull. 2015;38(2):201-7. PubMed PMID: 25399682
• Hyun D, Park HS, Seo S, Choo IW, Lim S, Nam MH, Do YS, Choo SW, Shin SW, Park KB, Cho SK. A novel animal model of gastrointestinal obstruction for the development of stent. J Surg Res. 2014 Apr;187(2):445-9. PubMed PMID: 24267615
• Sohn YB, Lee J, Cho SY, Kim SJ, Ko AR, Nam MH, Jin DK. Improvement of CNS defects via continuous intrathecal enzyme replacement by osmotic pump in mucopolysaccharidosis type II mice. Am J Med Genet A. 2013 May;161A(5):1036-43. PubMed PMID: 23529876
• Son DH, Nam MH, Hong CO, Seol HM, Yang JE, Kim YB, Kim CT, Lee KW. 5-a Reductase inhibitory effect and astringent activity of green apple rind extract on human keratinocytes and fibroblast cells. Biosci Biotechnol Biochem. 2013;77(4):714-21. PubMed PMID: 23563562
• Nam MH, Lee HS, Seomun Y, Lee Y, Lee KW. Monocyte-endothelium-smooth muscle cell interaction in co-culture: proliferation and cytokine productions in response to advanced glycation end products. Biochim Biophys Acta. 2011 Sep;1810(9):907-12. PubMed PMID: 21708226
• Lee HS, Cho HY, Park KW, Kim IH, Kim JT, Nam MH, Lee KW. Inhibitory effects of Terminalia chebula extract on glycation and endothelial cell adhesion. Planta Med. 2011 Jul;77(10):1060-7. PubMed PMID: 21308613
• Choi EW, Shin IS, Lee HW, Park SY, Park JH, Nam MH, Kim JS, Woo SK, Yoon EJ, Kang SK, Ra JC, Youn HY, Hong SH. Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. J Gene Med. 2011 Jan;13(1):3-16. PubMed PMID: 21259404
• Sun JM, Nam MH, Chung JY, Im B, Lee SY, Suh YL, Ahn JS, Park K, Ahn MJ. Safety and pharmacokinetics of intrathecal administration of pemetrexed in rats. Cancer Chemother Pharmacol. 2011 Aug;68(2):531-8. PubMed PMID: 21107572
• Ryu HJ, Kim WS, Lee JH, Min SW, Kim SJ, Lee YS, Lee YH, Nam SW, Eo GS, Seo SG, Nam MH. Asan medical information system for healthcare quality improvement. Healthc Inform Res. 2010 Sep;16(3):191-7. PubMed PMID: 21818439
• Park SW, Shin S, Kim CH, Ko AR, Kwak MJ, Nam MH, Park SY, Kim SJ, Sohn YB, Galinsky RE, Kim H, Yeo Y, Jin DK. Differential effects of insufflated, subcutaneous, and intravenous growth hormone on bone growth, cognitive function, and NMDA receptor subunit expression. Endocrinology. 2010 Sep;151(9):4418-27. PubMed PMID: 20610568
• Kim JS, Nam MH, Do YS, Lee CJ, Kim CS, Sim WS, Park KB, Lee SH, Han JS, Shin BS, Kim HY. Efficacy of milrinone versus nitroglycerin in controlling pulmonary arterial hypertension induced by intravenous injections of absolute ethanol in anesthetized dogs. J Vasc Interv Radiol. 2010 Jun;21(6):882-7. PubMed PMID: 20418111
• Kwak MJ, Park HJ, Nam MH, Kwon OS, Park SY, Lee SY, Kim MJ, Kim SJ, Paik KH, Jin DK. Comparative study of the effects of different growth hormone doses on growth and spatial performance of hypophysectomized rats. J Korean Med Sci. 2009 Aug;24(4):729-36. PubMed PMID: 19654960