John Kappler, PhD

Publications

• Zhang L, Stadinski BD, Michels A, Kappler JW, & Eisenbarth GS (2011) Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev 27(8):784-789
• Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, & Kappler JW (2011) A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers. Immunity 35(1):23-33 PMCID No. 3160269.
• Jordan KR, Buhrman JD, Sprague J, Moore BL, Gao D, Kappler JW, & Slansky JE (2012) TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines. Cancer Immunol Immunother (In Press, Published on line).
• Scott-Browne JP, Crawford F, Young MH, Kappler JW, Marrack P, & Gapin L (2011) Evolutionarily conserved features contribute to alphabeta T cell receptor specificity. Immunity 35(4):526-535 PMCID No. 3245739.
• Rubtsov AV, Rubtsova K, Fischer A, Meehan RT, Gillis JZ, Kappler JW, & Marrack P (2011) Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c B-cell population is important for the development of autoimmunity. Blood 118(5):1305-1315 PMCID No. 3152497.
• MacLeod MK, McKee AS, David A, Wang J, Mason R, Kappler JW, & Marrack P (2011) Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A 108(19):7914-7919 PMCID No. 3093483.
• MacLeod MK, David A, McKee AS, Crawford F, Kappler JW, & Marrack P (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol 186(5):2889-2896 PMCID No. 3069687
• Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, & Henson PM (2011) IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol 187(5):2101-2111 PMCID No. 3159788.
• Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, & Kappler JW (2011) Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A 108(40):16729-16734 PMCID No. 3189014.
• Bowerman NA, Falta MT, Mack DG, Kappler JW, & Fontenot AP (2011) Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition. J Immunol 187(7):3694-3703 PMCID No. 3178675
• Marrack P & Kappler JW (2012) Do MHCII-presented neoantigens drive type-1 diabetes and other autoimmune diseases? Diabetes, Cold Spring Harbor Perspect Medine ed J. A. Bluestone MAA, P. Arvan (Cold Spring Harbor Press), In Press.