Aurélie Ledreux, PhD, MS

Professional Titles

• Associate Professor

Research Interests

My current research interests encompass neurodegenerative diseases and healthy brain aging. My lab uses clinical samples as well as animal models to investigate neurodegeneration and neuroinflammation as underlying mechanisms in Alzheimer’s disease, Down syndrome as well as traumatic brain injury.

Publications

• Iulita MF, Granholm AC, Carmona-Iragui M, Hamlett ED, Fortea J, Ledreux A. Fluid biomarkers for Alzheimer’s disease in Down syndrome: current status and novel trends. In: The neurobiology of aging and Alzheimer disease in Down syndrome. Head E, Lott I (Eds), Elsevier, pp. 97-128.
• Ledreux A, Thomas S, Hamlett ED, Gilmore A, Trautman CW, Margittai M, Fortea J, Granholm A-C (2021). Small neuron-derived extracellular vesicles from individuals with Down syndrome propagate Tau pathology in the wildtype mouse brain. Journal of Clinical Medicine 10 (17), 3931
• Grossberg AN, Bettcher B, Gorgens K, Ledreux A (2021). A 6-week learning intervention increases serum BDNF levels in healthy older adults. Frontiers in Aging 35.
• Granholm A-C, Ledreux A (2021). Biomarkers show value of studying dementia in Down syndrome. Nature Reviews Neurology https://doi.org/10.1038/s41582-021-00558-w
• Bharani KL, Ledreux A, Gilmore A, Carroll SL, Granholm AC. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiol Aging. 2020 Mar;87:49-59. PubMed PMID: 31882186
• Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 Jul;68(7):1347-1360. PubMed PMID: 31944407
• Grossberg AN, Koza LA, Ledreux A, Prusmack C, Krishnamurthy HK, Jayaraman V, Granholm A-C, Linseman DA (2021). A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients. Nature Communications 12, 740 https://doi.org/10.1038/s41467-021-21040-7
• Goetzl EJ, Yaffe K, Peltz CB, Ledreux A, Gorgens K, Davidson B, Granholm AC, Mustapic M, Kapogiannis D, Tweedie D, Greig NH. Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins. FASEB J. 2020 Feb;34(2):3359-3366. PubMed PMID: 31916313
• Nicastri CM, McFeeley B, Simon SS, Ledreux A, Håkansson K, Granholm A-C, Mohammed A, Daffner K. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Submitted to Alzheimer’s and Dementia, Nov. 2021
• Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 Feb;134:104616. PubMed PMID: 31678403
• Pryhoda MK, Shelburne KB, Gorgens K, Ledreux A, Granholm AC, Davidson BS. Centre of pressure velocity shows impairments in NCAA Division I athletes six months post-concussion during standing balance. J Sports Sci. 2020 Dec;38(23):2677-2687. PubMed PMID: 32715955
• Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS, Granholm AC. Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers. Front Neurosci. 2020;14:761. PubMed PMID: 32848549
• Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 Jul;79(7):639-655. PubMed PMID: 31347291
• Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm AC, Ledreux A. Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019 Apr;33(4):5082-5088. PubMed PMID: 30605353
• Ledreux A, Håkansson K, Carlsson R, Kidane M, Columbo L, Terjestam Y, Ryan E, Tusch E, Winblad B, Daffner K, Granholm AC, Mohammed AKH. Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. J Alzheimers Dis. 2019;71(4):1245-1261. PubMed PMID: 31498125
• Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy. Front Neurosci. 2019;13:452. PubMed PMID: 31133789
• Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 Jan;114:110-121. PubMed PMID: 28882786
• Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May;13(5):541-549. PubMed PMID: 27755974
• Bharani KL, Derex R, Granholm AC, Ledreux A. A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. PLoS One. 2017;12(12):e0189821. PubMed PMID: 29261743
• Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad B, Granholm AC, Mohammed AK. BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function. J Alzheimers Dis. 2017;55(2):645-657. PubMed PMID: 27716670
• Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behav Brain Res. 2016 Oct 1;312:294-304. PubMed PMID: 27343935
• Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Ball TD, Bassil MM, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes D, Kumar S. Foldamers reveal and validate therapeutic targets associated with toxic a-synuclein self-assembly. Nat Commun. 2022 Apr 27;13(1):2273. PubMed PMID: 35477706
• Nicastri CM, McFeeley BM, Simon SS, Ledreux A, Håkansson K, Granholm AC, Mohammed AH, Daffner KR. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Alzheimers Dement (N Y). 2022;8(1):e12337. PubMed PMID: 36089933
• Saternos H, Trautman CW, Gilmore A, Davidson BS, Gorgens KA, Ledreux A (2022). Fluid Biomarkers in Sports-Related Mild Traumatic Brain Injuries: Current Status and Novel Trends. In: Biomarkers in Trauma, Injury and Critical Care. Biomarkers in Disease: Methods, Discoveries and Applications Rajendram R, Preedy VR, Patel VB (Eds). Springer, doi.org/10.1007/978-3-030-87302-8_25-1
• Colvett I, Saternos H, Coughlan C, Vielle A, Ledreux A. Extracellular vesicles from the CNS play pivotal roles in neuroprotection and neurodegeneration: lessons from in vitro experiments. Extracell Vesicles Circ Nucl Acids. 2023 Mar;4(1):72-89. PubMed PMID: 37859665
• Colvett I, Gilmore A, Guzman S, Ledreux A, Quintero JE, Ginjupally DR, Gurwell JA, Slevin JT, Guduru Z, Gerhardt GA, van Horne CG, Granholm AC. Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain. J Clin Med. 2023 Sep 22;12(19). PubMed PMID: 37834764
• Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, Ledreux A, Zizzo Z, Lundt M, Alvarez E, Yu X. Plasma IgG aggregates as biomarkers for multiple sclerosis. Clin Immunol. 2023 Nov;256:109801. PubMed PMID: 37816415
• Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Grotta JC, Jones WJ, Graner MW. Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Stroke. 2023 Mar;54(3):e52-e57. PubMed PMID: 36727508
• Badhwar A, Hirschberg Y, Tamayo NV, Iulita MF, Udeh-Momoh CT, Matton A, Tarawneh RM, Rissman RA, Ledreux A, Winston CN, Haqqani AS. Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview. bioRxiv. 2023 Oct 2. PubMed PMID: 37873207
• Granholm AC, Ledreux A. Biomarkers show value of studying dementia in Down syndrome. Nat Rev Neurol. 2021 Oct;17(10):599-600. PubMed PMID: 34465922
• Wang Z, Fuquay JM, Ledreux A, Barbieri M, Ramsdell JS. Sample preparation and liquid chromatography-tandem mass spectrometry for the analysis of selected Pacific ciguatoxins in blood samples. J Chromatogr A. 2020 Jun 21;1621:461050. PubMed PMID: 32265050
• Rosenberger DS, Falangola MF, Ledreux A, Nie X, Suhre WM, Boger HA, Granholm AC. Memory and hippocampal architecture following short-term midazolam in western diet-treated rats. Neurosci Lett. 2016 May 16;621:68-74. PubMed PMID: 27080429
• Ledreux A, Boger HA, Hinson VK, Cantwell K, Granholm AC. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson?s disease. Brain Res. 2016 Jan 15;1631:34-45. PubMed PMID: 26607251
• Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 2016;13(1):35-52. PubMed PMID: 26391050
• Alvarenga LM, Muzard J, Ledreux A, Bernard C, Billiald P. Colorimetric engineered immunoprobe for the detection and quantification of microcystins. J Immunol Methods. 2014 Apr;406:124-30. PubMed PMID: 24607607
• Ledreux A, Ramsdell JS. Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats. Toxicon. 2013 Mar 15;64:81-6. PubMed PMID: 23319077
• Sérandour AL, Ledreux A, Morin B, Derick S, Augier E, Lanceleur R, Hamlaoui S, Moukha S, Furger C, Biré R, Krys S, Fessard V, Troussellier M, Bernard C. Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part I: screening strategy and pre-validation study with lipophilic marine toxins. Anal Bioanal Chem. 2012 Jun;403(7):1983-93. PubMed PMID: 22538779
• Ledreux A, Sérandour AL, Morin B, Derick S, Lanceleur R, Hamlaoui S, Furger C, Biré R, Krys S, Fessard V, Troussellier M, Bernard C. Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part II: application to shellfish extracts spiked with lipophilic marine toxins. Anal Bioanal Chem. 2012 Jun;403(7):1995-2007. PubMed PMID: 22535441

Professional Memberships

• International Society for Extracellular Vesicles, Member
• Trisomy 21 Research Society, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000