Aurélie Ledreux, PhD, MS
Assistant Professor, Neurosurgery

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Languages: English, French
Department: Neurosurgery

Professional Titles

  • Assistant Professor

Research Interests

My current research interests encompass neurodegenerative diseases and healthy brain aging. My lab uses clinical samples as well as animal models to investigate neurodegeneration and neuroinflammation as underlying mechanisms in Alzheimer’s disease, Down syndrome as well as traumatic brain injury.


  • Iulita MF, Granholm AC, Carmona-Iragui M, Hamlett ED, Fortea J, Ledreux A. Fluid biomarkers for Alzheimer’s disease in Down syndrome: current status and novel trends. In: The neurobiology of aging and Alzheimer disease in Down syndrome. Head E, Lott I (Eds), Elsevier, pp. 97-128.
  • Nicastri CM, McFeeley B, Simon SS, Ledreux A, Håkansson K, Granholm A-C, Mohammed A, Daffner K. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Submitted to Alzheimer’s and Dementia, Nov. 2021
  • Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Bassil MA, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes DA, Kumar S. Foldamers reveal and validate novel therapeutic targets associated with toxic a-synuclein self-assembly. Submitted to Nature Communications, Nov 2021.
  • Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Ball TD, Bassil MM, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes D, Kumar S. Foldamers reveal and validate therapeutic targets associated with toxic a-synuclein self-assembly. Nat Commun. 2022 Apr 27;13(1):2273. PubMed PMID: 35477706
  • Nicastri CM, McFeeley BM, Simon SS, Ledreux A, Håkansson K, Granholm AC, Mohammed AH, Daffner KR. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Alzheimers Dement (N Y). 2022;8(1):e12337. PubMed PMID: 36089933
  • Saternos H, Trautman CW, Gilmore A, Davidson BS, Gorgens KA, Ledreux A (2022). Fluid Biomarkers in Sports-Related Mild Traumatic Brain Injuries: Current Status and Novel Trends. In: Biomarkers in Trauma, Injury and Critical Care. Biomarkers in Disease: Methods, Discoveries and Applications Rajendram R, Preedy VR, Patel VB (Eds). Springer,
  • Ledreux A, Thomas S, Hamlett ED, Gilmore A, Trautman CW, Margittai M, Fortea J, Granholm A-C (2021). Small neuron-derived extracellular vesicles from individuals with Down syndrome propagate Tau pathology in the wildtype mouse brain. Journal of Clinical Medicine 10 (17), 3931
  • Grossberg AN, Bettcher B, Gorgens K, Ledreux A (2021). A 6-week learning intervention increases serum BDNF levels in healthy older adults. Frontiers in Aging 35.
  • Granholm A-C, Ledreux A (2021). Biomarkers show value of studying dementia in Down syndrome. Nature Reviews Neurology
  • Grossberg AN, Koza LA, Ledreux A, Prusmack C, Krishnamurthy HK, Jayaraman V, Granholm A-C, Linseman DA (2021). A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients. Nature Communications 12, 740
  • Bharani KL, Ledreux A, Gilmore A, Carroll SL, Granholm AC. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiol Aging. 2020 Mar;87:49-59. PubMed PMID: 31882186
  • Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 Jul;68(7):1347-1360. PubMed PMID: 31944407
  • Goetzl EJ, Yaffe K, Peltz CB, Ledreux A, Gorgens K, Davidson B, Granholm AC, Mustapic M, Kapogiannis D, Tweedie D, Greig NH. Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins. FASEB J. 2020 Feb;34(2):3359-3366. PubMed PMID: 31916313
  • Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 Feb;134:104616. PubMed PMID: 31678403
  • Pryhoda MK, Shelburne KB, Gorgens K, Ledreux A, Granholm AC, Davidson BS. Centre of pressure velocity shows impairments in NCAA Division I athletes six months post-concussion during standing balance. J Sports Sci. 2020 Dec;38(23):2677-2687. PubMed PMID: 32715955
  • Ledreux A, Pryhoda MK, Gorgens K, Shelburne K, Gilmore A, Linseman DA, Fleming H, Koza LA, Campbell J, Wolff A, Kelly JP, Margittai M, Davidson BS, Granholm AC. Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers. Front Neurosci. 2020;14:761. PubMed PMID: 32848549
  • Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 Jul;79(7):639-655. PubMed PMID: 31347291
  • Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm AC, Ledreux A. Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019 Apr;33(4):5082-5088. PubMed PMID: 30605353
  • Ledreux A, Håkansson K, Carlsson R, Kidane M, Columbo L, Terjestam Y, Ryan E, Tusch E, Winblad B, Daffner K, Granholm AC, Mohammed AKH. Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. J Alzheimers Dis. 2019;71(4):1245-1261. PubMed PMID: 31498125
  • Goetzl EJ, Ledreux A, Granholm AC, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy. Front Neurosci. 2019;13:452. PubMed PMID: 31133789
  • Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 Jan;114:110-121. PubMed PMID: 28882786
  • Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May;13(5):541-549. PubMed PMID: 27755974
  • Bharani KL, Derex R, Granholm AC, Ledreux A. A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. PLoS One. 2017;12(12):e0189821. PubMed PMID: 29261743
  • Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad B, Granholm AC, Mohammed AK. BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function. J Alzheimers Dis. 2017;55(2):645-657. PubMed PMID: 27716670
  • Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behav Brain Res. 2016 Oct 1;312:294-304. PubMed PMID: 27343935
  • Kowalski RG, Ledreux A, Violette JE, Neumann RT, Grotta JC, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Jones, WJ, Graner MW. Rapid Activation of the Neuroinflammatory Cascade Following Acute Stroke: Plasma and 5 Extracellular Vesicle Factors Obtained on a Mobile Stroke Unit
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Professional Memberships

  • International Society for Extracellular Vesicles, Member
  • Trisomy 21 Research Society, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

General Information

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Languages: English, French
Department: Neurosurgery
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CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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