Peter Moore, MD

Professional Titles

• Assistant Professor

Recognitions

• Paper of the Year, American Journal of Physiology-Lung Cellular and Molecular Physiology (2025)
• Top Rapid-Fire Abstract Award, CHEST (2023)
• Faculty Research Award, Shock Society (2023)
• Mohammed Sayeed Presidential Travel Award, Shock Society (2022)
• Trainee Abstract Scholarship, American Thoracic Society (2021)
• Daron J. Williams Award for Equanimity in Medicine,, UCSF Internal Medicine Residency (2016)
• Commencement Speaker, University of Colorado Denver School of Medicine (2012)
• Joseph and Regina Glaser Research Prize “Best MD Research Award”, University of Colorado Denver School of Medicine (2012)
• Alden Harken Basic Science Research Award, University of Colorado Denver School of Medicine (2012)
• Mentored Scholarly Activity Award: Best Basic Science Research, University of Colorado Denver School of Medicine (2012)
• Alpha Omega Alpha Honors Medical Society, Alpha Omega Alpha Honors Society (2010)
• Outstanding Medical Student Award, Academic Surgical Congress (2010)
• Phi Beta Kappa Honors Society, Phi Beta Kappa Honors Society (2007)
• Graduation with Distinction, University of Colorado Boulder (2007)

Research Interests

My research focuses on the intricate interplay between the innate immune system and coagulation/fibrinolytic systems during acute inflammation. Our lab pursues both mechanistic and translational projects, exploring several interrelated themes: 1) The influence of coagulation factor XIII on inflammation and repair processes in acute lung injury. 2) The role of inflammatory protease-mediated plasminogen degradation in pleural space infections. 3) Fibrinolytic abnormalities and their implications in critical illness. Through these investigations, we aim to uncover novel therapeutic targets and develop innovative strategies for managing disease in critically ill patients, particularly those affecting the respiratory system. Our work bridges the gap between basic science and clinical applications, with the potential to improve outcomes for patients with critical illness.

Publications

• Barrett CD, Moore PK, Moore EE, Moore HB, Chandler JG, Siddiqui H, Maginot ER, Sauaia A, Pérez-Calatayud AA, Buesing K, Wang J, Davila-Chapa C, Hershberger D, Douglas I, Pieracci FM, Yaffe MB. Neutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis. Chest. 2025 Jan;167(1):67-75. PubMed PMID: 38710463
• Barrett CD, Moore PK, Yaffe MB. Response. Chest. 2025 Feb;167(2):e64-e65. PubMed PMID: 39939066
• Rodriguez IE, Saben JL, Moore EE, Knudson MM, Moore PK, Pieracci F, Sauaia A, Moore HB. Fibrinolysis Resistance After Injury Is a Risk Factor for a Hospital-Acquired Pneumonia-Like Disease Pattern. Surg Infect (Larchmt). 2024 Mar;25(2):87-94. PubMed PMID: 38394296
• King EM, Zhao Y, Moore CM, Steinhart B, Anderson KC, Vestal B, Moore PK, McManus SA, Evans CM, Mould KJ, Redente EF, McCubbrey AL, Janssen WJ. Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung. JCI Insight. 2024 Dec 20;9(24). PubMed PMID: 39509324
• Haeger S, Moore CM, McManus SA, Moore PK, Janssen WJ, Mould KJ. The bronchoalveolar lavage dilution conundrum: an updated view on a long-standing problem. Am J Physiol Lung Cell Mol Physiol. 2024 Nov 1;327(5):L807-L813. PubMed PMID: 39378107
• Moore PK, Anderson KC, McManus SA, Tu TH, King EM, Mould KJ, Redente EF, Henson PM, Janssen WJ, McCubbrey AL. Single-Cell RNA Sequencing Reveals Unique Monocyte-derived Interstitial Macrophage Subsets during Lipopolysaccharide-Induced Acute Lung Inflammation. Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28. [Epub ahead of print] PubMed PMID: 36852927
• Moore PK, Anderson KC, McManus SA, Tu TH, King EM, Mould KJ, Redente EF, Henson PM, Janssen WJ, McCubbrey AL. Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L536-L549. PubMed PMID: 36852927
• Barrett CD, Moore HB, Moore EE, Benjamin Christie D 3rd, Orfanos S, Anez-Bustillos L, Jhunjhunwala R, Hussain S, Shaefi S, Wang J, Hajizadeh N, Baedorf-Kassis EN, Al-Shammaa A, Capers K, Banner-Goodspeed V, Wright FL, Bull T, Moore PK, Nemec H, Thomas Buchanan J, Nonnemacher C, Rajcooar N, Ramdeo R, Yacoub M, Guevara A, Espinal A, Hattar L, Moraco A, McIntyre R, Talmor DS, Sauaia A, Yaffe MB. MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID-19 severe respiratory failure (MUST COVID): A retrospective cohort study. Res Pract Thromb Haemost. 2022 Feb;6(2):e12669. PubMed PMID: 35341072
• Barrett CD, Moore HB, Moore EE, Wang J, Hajizadeh N, Biffl WL, Lottenberg L, Patel PR, Truitt MS, McIntyre RC Jr, Bull TM, Ammons LA, Ghasabyan A, Chandler J, Douglas IS, Schmidt EP, Moore PK, Wright FL, Ramdeo R, Borrego R, Rueda M, Dhupa A, McCaul DS, Dandan T, Sarkar PK, Khan B, Sreevidya C, McDaniel C, Grossman Verner HM, Pearcy C, Anez-Bustillos L, Baedorf-Kassis EN, Jhunjhunwala R, Shaefi S, Capers K, Banner-Goodspeed V, Talmor DS, Sauaia A, Yaffe MB. Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial. Chest. 2022 Mar;161(3):710-727. PubMed PMID: 34592318
• Moore HB, Barrett CD, Moore EE, McIntyre RC, Moore PK, Talmor DS, Moore FA, Yaffe MB. Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome?. J Trauma Acute Care Surg. 2020 Jun;88(6):713-714. PubMed PMID: 32281766
• Wang J, Hajizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA, Yaffe MB, Moore HB, Barrett CD. Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series. J Thromb Haemost. 2020 Jul;18(7):1752-1755. PubMed PMID: 32267998
• Wright FL, Vogler TO, Moore EE, Moore HB, Wohlauer MV, Urban S, Nydam TL, Moore PK, McIntyre RC Jr. Fibrinolysis Shutdown Correlation with Thromboembolic Events in Severe COVID-19 Infection. J Am Coll Surg. 2020 Aug;231(2):193-203.e1. PubMed PMID: 32422349
• Edward JA, Lee JS, Moore PK, Levy AK. A Man in His 50s With Hemoptysis, Dyspnea, and Bilateral Patchy Ground-Glass Opacities. Chest. 2019 Aug;156(2):e41-e45. PubMed PMID: 31395267
• Moore PK, Hsu RK, Liu KD. Management of Acute Kidney Injury: Core Curriculum 2018. Am J Kidney Dis. 2018 Jul;72(1):136-148. PubMed PMID: 29478864
• Moore PK, Raffel KE, Whitman IR. Macroscopic T-Wave Alternans: A Red Flag for Code Blue. JAMA Intern Med. 2017 Oct 1;177(10):1520-1522. PubMed PMID: 28783809
• Riley ED, Hsue PY, Vittinghoff E, Wu AH, Coffin PO, Moore PK, Lynch KL. Higher prevalence of detectable troponin I among cocaine-users without known cardiovascular disease. Drug Alcohol Depend. 2017 Mar 1;172:88-93. PubMed PMID: 28157591
• Moore PK, Matthay MA. Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful?. JAMA Intern Med. 2016 Nov 1;176(11):1660-1661. PubMed PMID: 27599363
• Moore PK, Marzec LN, Krantz MJ. Signs of stress: deep symmetric T-wave inversions. Am J Med. 2013 Aug;126(8):682-4. PubMed PMID: 23764264
• Moore PK, Lee JK, Garcia JA, Krantz MJ. A case of swallow syncope. Tex Heart Inst J. 2013;40(5):606-7. PubMed PMID: 24391337
• Moore PK. Remember why we went into this field in the first place. J Trauma Acute Care Surg. 2012 Sep;73(3):539-41. PubMed PMID: 22929482
• Moore HB, Moore PK, Grant AR, Tello TL, Knudson MM, Kornblith LZ, Song TE, Sauaia A, Zuckerbahn B, Moore EE. Future of acute care surgery: a perspective from the next generation. J Trauma Acute Care Surg. 2012 Jan;72(1):94-9. PubMed PMID: 22310121
• Moore PK, Benson D, Kehler M, Moore EE, Fragoso M, Silliman CC, Barnett CC Jr. The plasma fraction of stored erythrocytes augments pancreatic cancer metastasis in male versus female mice. J Surg Res. 2010 Nov;164(1):23-7. PubMed PMID: 20828763
• Moore PK, Moore EE, Moore FA. Exception from informed consent requirements for emergency research. Surgery. 2009 Jun;145(6):630-5. PubMed PMID: 19486764
• Masuno T, Moore EE, Cheng AM, Moore PK, Grant AR, Johnson JL. Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury. Surgery. 2005 Aug;138(2):335-41. PubMed PMID: 16153445
• Cheng AM, Moore EE, Johnson JL, Walsh MD, Ao L, Moore PK, Banerjee A. Polymerized hemoglobin induces heme oxygenase-1 protein expression and inhibits intercellular adhesion molecule-1 protein expression in human lung microvascular endothelial cells. J Am Coll Surg. 2005 Oct;201(4):579-84. PubMed PMID: 16183497
• Rezende-Neto JB, Moore EE, Masuno T, Moore PK, Johnson JL, Sheppard FR, Cunha-Melo JR, Silliman CC. The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury. Shock. 2003 Oct;20(4):303-8. PubMed PMID: 14501942

Professional Memberships

• American Thoracic Society, Member
• Shock Society, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital
• Denver Health Medical Center
• National Jewish Health

Specialty Information

Specialties

• Internal Medicine, Board Certification
• Pulmonary Disease, Board Certification
• Critical Care Medicine, Board Certification