I work at the intersection of epidemiology and
precision medicine, striving to impact population health through
equity-minded personalized prevention. My lab accomplishes this goal by leveraging high-dimensional -omics data (metabolomics, genetics, DNA methylation, gene expression) from large consortia and population-based studies to elucidate factors contributing to immune and autoimmune disease development and progression.
Publications
Carry PM, Waugh K, Vanderlinden LA, Johnson RK, Buckner T, Rewers M, Steck AK, Yang I, Fingerlin TE, Kechris K, Norris JM. Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY). Diabetes. 2022 Sep 1;71(9):2048-2057. PubMed PMID: 35724268
Johnson RK, Marker KM, Mayer D, Shortt J, Kao D, Barnes KC, Lowery JT, Gignoux CR. COVID-19 Surveillance in the Biobank at the Colorado Center for Personalized Medicine: Observational Study. JMIR Public Health Surveill. 2022 Jun 13;8(6):e37327. PubMed PMID: 35486493
Johnson RK, Manke J, Campbell M, Armstrong M, Boorgula MP, Pinheiro G, Santana CVN, Mathias RA, Barnes KC, Cruz A, Reisdorph N, Figueiredo CA. Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects. J Allergy Clin Immunol. 2022 Oct;150(4):965-971.e8. PubMed PMID: 35304161
Vanderlinden LA, Johnson RK, Carry PM, Dong F, DeMeo DL, Yang IV, Norris JM, Kechris K. An effective processing pipeline for harmonizing DNA methylation data from Illumina's 450K and EPIC platforms for epidemiological studies. BMC Res Notes. 2021 Sep 8;14(1):352. PubMed PMID: 34496950
Vigers T, Vanderlinden LA, Johnson RK, Carry PM, Yang I, DeFelice BC, Kaizer AM, Pyle L, Rewers M, Fiehn O, Norris JM, Kechris K. A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes. Metabolites. 2021 Aug 14;11(8). PubMed PMID: 34436483
Carry PM, Vanderlinden LA, Johnson RK, Buckner T, Fiehn O, Steck AK, Kechris K, Yang I, Fingerlin TE, Rewers M, Norris JM. Phospholipid Levels at Seroconversion Are Associated With Resolution of Persistent Islet Autoimmunity: The Diabetes Autoimmunity Study in the Young. Diabetes. 2021 Jul;70(7):1592-1601. PubMed PMID: 33863802
Johnson RK, Tamura R, Frank N, Uusitalo U, Yang J, Niinistö S, Andrén Aronsson C, Ziegler AG, Hagopian W, Rewers M, Toppari J, Akolkar B, Krischer J, Virtanen SM, Norris JM. Maternal food consumption during late pregnancy and offspring risk of islet autoimmunity and type 1 diabetes. Diabetologia. 2021 Jul;64(7):1604-1612. PubMed PMID: 33783586
Walker-Short E, Buckner T, Vigers T, Carry P, Vanderlinden LA, Dong F, Johnson RK, Yang IV, Kechris K, Rewers M, Norris JM. Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes. Nutrients. 2021 Nov 13;13(11). PubMed PMID: 34836312
Johnson RK, Brunetti T, Quinn K, Doenges K, Campbell M, Arehart C, Taub MA, Mathias RA, Reisdorph N, Barnes KC, Daya M. Discovering metabolite quantitative trait loci in asthma using an isolated population. J Allergy Clin Immunol. 2021 Nov 12. [Epub ahead of print] PubMed PMID: 34780848
Webb-Robertson BM, Bramer LM, Stanfill BA, Reehl SM, Nakayasu ES, Metz TO, Frohnert BI, Norris JM, Johnson RK, Rich SS, Rewers MJ. Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers. J Diabetes. 2021 Feb;13(2):143-153. PubMed PMID: 33124145
Buckner T, Vanderlinden LA, Johnson RK, DeFelice BC, Carry PM, Seifert J, Waugh K, Dong F, Fiehn O, Clare-Salzler M, Rewers M, Norris JM. Predictors of oxylipins in a healthy pediatric population. Pediatr Res. 2021 May;89(6):1530-1540. PubMed PMID: 32726799
Walker-Short E, Buckner T, Vigers T, Carry P, Vanderlinden LA, Dong F, Johnson RK, Yang IV, Kechris K, Rewers M, Norris JM. Epigenome-Wide Association Study of Infant Feeding and DNA Methylation in Infancy and Childhood in a Population at Increased Risk for Type 1 Diabetes. Nutrients. 2021 Nov 13;13(11). PubMed PMID: 34836312
Johnson RK, Vanderlinden LA, DeFelice BC, Uusitalo U, Seifert J, Fan S, Crume T, Fiehn O, Rewers M, Kechris K, Norris JM. Metabolomics-related nutrient patterns at seroconversion and risk of progression to type 1 diabetes. Pediatr Diabetes. 2020 Nov;21(7):1202-1209. PubMed PMID: 32686271
Gardner JA, Johnson RK, Dong F, Hoffman M, Steck AK, Frohnert BI, Rewers M, Norris JM. Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY). Endocrine. 2020 Nov;70(2):331-337. PubMed PMID: 32651851
Henze MM, Bemis EA, Seifert JA, Johnson RK, Dong F, Rewers M, Norris JM. Association between change in self-reported sugar intake and a sugar biomarker (d(13)C) in children at increased risk for type 1 diabetes. J Nutr Sci. 2020;9:e16. PubMed PMID: 32477498
Norris JM, Johnson RK, Stene LC. Type 1 diabetes-origins and epidemiology - Authors' reply. Lancet Diabetes Endocrinol. 2020 May;8(5):369-370. PubMed PMID: 32333871
Johnson RK, Vanderlinden LA, Dong F, Carry PM, Seifert J, Waugh K, Shorrosh H, Fingerlin T, Frohnert BI, Yang IV, Kechris K, Rewers M, Norris JM. Longitudinal DNA methylation differences precede type 1 diabetes. Sci Rep. 2020 Feb 28;10(1):3721. PubMed PMID: 32111940
Carry PM, Vanderlinden LA, Johnson RK, Dong F, Steck AK, Frohnert BI, Rewers M, Yang IV, Kechris K, Norris JM. DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2020 Jun;21(4):597-605. PubMed PMID: 32061050
Norris JM, Johnson RK, Stene LC. Type 1 diabetes-early life origins and changing epidemiology. Lancet Diabetes Endocrinol. 2020 Mar;8(3):226-238. PubMed PMID: 31999944
DeFelice BC, Pedersen TL, Shorrosh H, Johnson RK, Seifert JA, Norris JM, Fiehn O. Utilizing cooled liquid chromatography and chemical derivatization to separate and quantify C3-epimers of 25-hydroxy vitamin D and low abundant 1a,25(OH)(2)D3: Application in a pediatric population. J Steroid Biochem Mol Biol. 2020 Mar;197:105519. PubMed PMID: 31715316
Johnson RK, Lamb M, Anderson H, Pieters-Arroyo M, Anderson BT, Bolaños GA, Asturias EJ. The global school-based student health survey as a tool to guide adolescent health interventions in rural Guatemala. BMC Public Health. 2019 Feb 22;19(1):226. PubMed PMID: 30795754
Lund-Blix NA, Dong F, Mårild K, Seifert J, Barón AE, Waugh KC, Joner G, Størdal K, Tapia G, Stene LC, Johnson RK, Rewers MJ, Norris JM. Gluten Intake and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in Children at Increased Risk of the Disease: The Diabetes Autoimmunity Study in the Young (DAISY). Diabetes Care. 2019 May;42(5):789-796. PubMed PMID: 30796108
Johnson RK, Vanderlinden L, DeFelice BC, Kechris K, Uusitalo U, Fiehn O, Sontag M, Crume T, Beyerlein A, Lernmark Å, Toppari J, Ziegler AG, She JX, Hagopian W, Rewers M, Akolkar B, Krischer J, Virtanen SM, Norris JM. Metabolite-related dietary patterns and the development of islet autoimmunity. Sci Rep. 2019 Oct 15;9(1):14819. PubMed PMID: 31616039
Mårild K, Dong F, Lund-Blix NA, Seifert J, Barón AE, Waugh KC, Taki I, Størdal K, Tapia G, Stene LC, Johnson RK, Liu E, Rewers MJ, Norris JM. Gluten Intake and Risk of Celiac Disease: Long-Term Follow-up of an At-Risk Birth Cohort. Am J Gastroenterol. 2019 Aug;114(8):1307-1314. PubMed PMID: 31082869
Goldthwaite LM, Duca L, Johnson RK, Ostendorf D, Sheeder J. Adverse Birth Outcomes in Colorado: Assessing the Impact of a Statewide Initiative to Prevent Unintended Pregnancy. Am J Public Health. 2015 Sep;105(9):e60-6. PubMed PMID: 26180990