Anthony Saviola, PhD

Publications

• Abdelazeem KNM, Nguyen D, Corbo S, Darragh LB, Matsumoto MW, Van Court B, Neupert B, Yu J, Olimpo NA, Osborne DG, Gadwa J, Ross RB, Nguyen A, Bhatia S, Kapoor M, Friedman RS, Jacobelli J, Saviola AJ, Knitz MW, Pasquale EB, Karam SD. Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC. Oncogene. 2025 Feb;44(3):130-146. PubMed PMID: 39489818
• Chakraborty N, Momirov J, Radakovic A, Chatterjee S, Kirchhoff AM, Kolb AL, West TJ, Sanchez BB, Martinez-Bartolome S, Saviola A, McClatchy D, Yates JR 3rd, Chen JS, Lairson LL, Felding BH, Boger DL. Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs. ACS Chem Biol. 2025 Feb 9. [Epub ahead of print] PubMed PMID: 39924956
• Borja M, Castañeda-Gaytán G, Alagón A, Strickland JL, Parkinson CL, Gutiérrez-Martínez A, Rodriguez-López B, Zarzosa V, Lomonte B, Saviola AJ, Fernández J, Smith CF, Hansen KC, Pérez-Robles A, Castañeda-Pérez S, Hirst SR, Olvera-Rodríguez F, Fernández-Badillo L, Sigala J, Jones J, Montaño-Ruvalcaba C, Ramírez-Chaparro R, Margres MJ, Acosta-Campaña G, Neri-Castro E. Venom variation and ontogenetic changes in the Crotalus molossus complex: Insights into composition, activities, and antivenom neutralization. Comp Biochem Physiol C Toxicol Pharmacol. 2025 Jan 30;290:110129. [Epub ahead of print] PubMed PMID: 39892555
• Gadwa J, Yu J, Piper M, Knitz MW, Darragh LB, Olimpo N, Corbo S, Beynor JI, Neupert B, Nguyen AT, Hodgson C, Nguyen D, Abdelazeem KN, Saviola A, Pousse L, Bransi A, Pincha M, Klein C, Amann M, Karam SD. Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment. J Immunother Cancer. 2025 Jan 7;13(1). PubMed PMID: 39773568
• Lee E, Saviola A, Bevers S, Redzic JS, Maroney SP, Shaw S, Tamkin E, Fulte S, Nemkov T, Meyer N, D'Alessandro A, Hansen KC, Clark SE, Eisenmesser E. Streptococcus pneumoniae GAPN is a key metabolic player necessary for host infection. Protein Sci. 2025 Jan;34(1):e5253. PubMed PMID: 39660954
• Upadhyay V, Ray S, Panja S, Saviola AJ, Maluf NK, Mallela KMG. Biophysical characterization of the dystrophin C-terminal domain: Dystrophin interacts differentially with dystrobrevin isoforms. J Biol Chem. 2024 Dec;300(12):108002. PubMed PMID: 39551137
• Williams J, Iheagwam FN, Maroney SP, Schmitt LR, Brown RD, Krafsur GM, Frid MG, McCabe MC, Gandjeva A, Williams KJ, Luyendyk JP, Saviola AJ, Tuder RM, Stenmark K, Hansen KC. A bovine model of hypoxia-induced pulmonary hypertension reveals a gradient of immune and matrisome response with a complement signature found in circulation. Am J Physiol Cell Physiol. 2024 Dec 1;327(6):C1666-C1680. PubMed PMID: 39495247
• McCabe MC, Saviola AJ, Hansen KC. Compartment-Resolved Proteomics with Deep Extracellular Matrix Coverage. Bio Protoc. 2024 Dec 5;14(23):e5123. PubMed PMID: 39677022
• Van Court B, Ciccaglione M, Neupert B, Knitz MW, Maroney SP, Nguyen D, Abdelazeem KNM, Exner AA, Saviola AJ, Benninger RKP, Karam SD. Heterogeneous Kinetics of Nanobubble Ultrasound Contrast Agent and Angiogenic Signaling in Head and Neck Cancer. bioRxiv. 2024 Sep 24. PubMed PMID: 39386624
• Piper M, Gadwa J, Hodgson C, Knitz M, Yee E, Zhu Y, Larson KY, Klein C, Amann M, Saviola A, Karam SD. IL15/IL15Ra complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to induce expansion of progenitor TCF1 CD8 T cells. bioRxiv. 2024 Sep 22. PubMed PMID: 39345626
• Corbo S, Nguyen D, Bhatia S, Darragh LB, Abdelazeem KNM, Court BV, Olimpo NA, Gadwa J, Yu J, Hodgson C, Samedi V, Garcia ES, Siu L, Saviola A, Heasley LE, Knitz MW, Pasquale EB, Karam SD. The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression. bioRxiv. 2024 Aug 13. PubMed PMID: 39211197
• Abdelazeem KNM, Nguyen D, Corbo S, Darragh LB, Matsumoto MW, Court BV, Neupert B, Yu J, Olimpo NA, Osborne DG, Gadwa J, Ross RB, Nguyen A, Bhatia S, Kapoor M, Friedman RS, Jacobelli J, Saviola AJ, Knitz MW, Pasquale EB, Karam SD. Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC. bioRxiv. 2024 Jul 23. PubMed PMID: 39091728
• Niemeyer CS, Frietze S, Coughlan C, Lewis SWR, Bustos Lopez S, Saviola AJ, Hansen KC, Medina EM, Hassell JE Jr, Kogut S, Traina-Dorge V, Nagel MA, Bruce KD, Restrepo D, Mahalingam R, Bubak AN. Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles. J Virol. 2024 Aug 20;98(8):e0084824. PubMed PMID: 39051773
• Gopalan SS, Perry BW, Francioli YZ, Schield DR, Guss HD, Bernstein JM, Ballard K, Smith CF, Saviola AJ, Adams RH, Mackessy SP, Castoe TA. Diverse Gene Regulatory Mechanisms Alter Rattlesnake Venom Gene Expression at Fine Evolutionary Scales. Genome Biol Evol. 2024 Jul 3;16(7). PubMed PMID: 38753011
• Chalivendra S, Shi S, Li X, Kuang Z, Giovinazzo J, Zhang L, Rossi J, Wang J, Saviola AJ, Welty R, Liu S, Vaeth KF, Zhou ZH, Hansen KC, Taliaferro JM, Zhao R. Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. RNA. 2024 Jul 16;30(8):1070-1088. PubMed PMID: 38688558
• Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR. Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2315597121. PubMed PMID: 38687786
• Smith CF, Modahl CM, Ceja Galindo D, Larson KY, Maroney SP, Bahrabadi L, Brandehoff NP, Perry BW, McCabe MC, Petras D, Lomonte B, Calvete JJ, Castoe TA, Mackessy SP, Hansen KC, Saviola AJ. Assessing Target Specificity of the Small Molecule Inhibitor MARIMASTAT to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling. Mol Cell Proteomics. 2024 Jun;23(6):100779. PubMed PMID: 38679388
• Sun Q, Chen W, Wu R, Tao B, Wang P, Sun B, Alvarez JF, Ma F, Galindo DC, Maroney SP, Saviola AJ, Hansen KC, Li S, Deb A. Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction. Cardiovasc Res. 2024 Jul 2;120(8):943-953. PubMed PMID: 38666458
• Darula Z, McCabe MC, Barrett A, Schmitt LR, Maslanka MD, Saviola AJ, Orgel J, Burlingame A, Staab-Weijnitz CA, Stenmark K, Weaver V, Chalkley RJ, Hansen KC. Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry. bioRxiv. 2024 Mar 31. PubMed PMID: 38585857
• Yu J, Gadwa J, Ross RB, Knitz M, Darragh LB, Abdelazeem KNM, Beynor J, Neupert B, Nguyen A, Nguyen D, Olimpo N, Corbo S, Van Court B, D'Alessandro A, Saviola A, Karam SD. IL7 in combination with radiotherapy stimulates a memory T-cell response to improve outcomes in HNSCC models. Cancer Immunol Immunother. 2024 Mar 30;73(5):90. PubMed PMID: 38554147
• Darragh LB, Nguyen A, Pham TT, Idlett-Ali S, Knitz MW, Gadwa J, Bukkapatnam S, Corbo S, Olimpo NA, Nguyen D, Van Court B, Neupert B, Yu J, Ross RB, Corbisiero M, Abdelazeem KNM, Maroney SP, Galindo DC, Mukdad L, Saviola A, Joshi M, White R, Alhiyari Y, Samedi V, Van Bokhoven A, St John M, Karam SD. Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs. Med. 2024 Mar 8;5(3):254-270.e8. PubMed PMID: 38423011
• Ross RB, Gadwa J, Yu J, Darragh LB, Knitz MW, Nguyen D, Olimpo NA, Abdelazeem KNM, Nguyen A, Corbo S, Van Court B, Beynor J, Neupert B, Saviola AJ, D'Alessandro A, Karam SD. PPARa Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counteraction. Clin Cancer Res. 2024 May 1;30(9):1916-1933. PubMed PMID: 38363297
• Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain Res. 2024 Apr 15;1829:148772. PubMed PMID: 38244754
• Stincone P, Naimi A, Saviola AJ, Reher R, Petras D. Decoding the molecular interplay in the central dogma: An overview of mass spectrometry-based methods to investigate protein-metabolite interactions. Proteomics. 2024 Jun;24(12-13):e2200533. PubMed PMID: 37929699
• Calvete JJ, Lomonte B, Saviola AJ, Calderón Celis F, Ruiz Encinar J. Quantification of snake venom proteomes by mass spectrometry-considerations and perspectives. Mass Spectrom Rev. 2024 Sep-Oct;43(5):977-997. PubMed PMID: 37155340
• Smith CF, Brandehoff NP, Pepin L, McCabe MC, Castoe TA, Mackessy SP, Nemkov T, Hansen KC, Saviola AJ. 2023. Feasibility of detecting snake envenomation biomarkers from dried blood spots. Analytical Science Advances. 2023 Feb 1.
• Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze T, Hansen KC, Zhao R, Ahn N, Sluchanko NN, Eisenmesser E. Molecular insight into the specific interactions of the SARS-CoV-2 Nucleocapsid with RNA and host protein. Protein Sci. 2023 Feb 20;:e4603. [Epub ahead of print] PubMed PMID: 36807437
• McCabe MC, Saviola AJ, Hansen KC. Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs. J Proteome Res. 2023 Mar 3;22(3):790-801. PubMed PMID: 36763087
• Grabowsky ER, Saviola AJ, Alvarado-Díaz J, Mascareñas AQ, Hansen KC, Yates JR 3rd, Mackessy SP. Montane Rattlesnakes in México: Venoms of Crotalus tancitarensis and Related Species within the Crotalus intermedius Group. Toxins (Basel). 2023 Jan 13;15(1). PubMed PMID: 36668891
• Chalivendra S, Shi S, Li X, Kuang Z, Giovinazzo J, Zhang L, Rossi J, Saviola AJ, Wang J, Welty R, Liu S, Vaeth K, Zhou ZH, Hansen KC, Taliaferro JM, Zhao R. Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. bioRxiv. 2023 Dec 15. PubMed PMID: 38168357
• Stincone P, Naimi A, Saviola AJ, Reher R, Petras D. Decoding the molecular interplay in the central dogma: An overview of mass spectrometry-based methods to investigate protein-metabolite interactions. Proteomics. 2023 Nov 6;:e2200533. [Epub ahead of print] PubMed PMID: 37929699
• McCabe MC, Okamura DM, Erickson CB, Perry BW, Brewer CM, Nguyen ED, Saviola AJ, Majesky MW, Hansen KC. ECM-Focused Proteomic Analysis of Ear Punch Regeneration in Acomys Cahirinus. bioRxiv. 2023 Oct 17. PubMed PMID: 37873317
• Bowers SLK, Meng Q, Kuwabara Y, Huo J, Minerath R, York AJ, Sargent MA, Prasad V, Saviola AJ, Galindo DC, Hansen KC, Vagnozzi RJ, Yutzey KE, Molkentin JD. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023 Aug 30;12(17). PubMed PMID: 37681905
• McCabe MC, Gejji V, Barnebey A, Siuzdak G, Hoang LT, Pham T, Larson KY, Saviola AJ, Yannone SM, Hansen KC. From volcanoes to the bench: Advantages of novel hyperthermoacidic archaeal proteases for proteomics workflows. J Proteomics. 2023 Oct 30;289:104992. PubMed PMID: 37634627
• Gadwa J, Amann M, Bickett TE, Knitz MW, Darragh LB, Piper M, Van Court B, Bukkapatnam S, Pham TT, Wang XJ, Saviola AJ, Deak LC, Umaña P, Klein C, D'Alessandro A, Karam SD. Selective targeting of IL2Rß? combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC. Cell Rep Med. 2023 Aug 15;4(8):101150. PubMed PMID: 37586327
• Plewes MR, Talbott HA, Saviola AJ, Woods NT, Schott MB, Davis JS. Luteal Lipid Droplets: A Novel Platform for Steroid Synthesis. Endocrinology. 2023 Aug 1;164(9). PubMed PMID: 37586092
• Duran P, Boscolo Sesillo F, Cook M, Burnett L, Menefee SA, Do E, French S, Zazueta-Damian G, Dzieciatkowska M, Saviola AJ, Shah MM, Sanvictores C, Osborn KG, Hansen KC, Shtrahman M, Christman KL, Alperin M. Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury. Sci Transl Med. 2023 Aug 2;15(707):eabj3138. PubMed PMID: 37531414
• Smith CF, Nikolakis ZL, Perry BW, Schield DR, Meik JM, Saviola AJ, Castoe TA, Parker J, Mackessy SP. The best of both worlds? Rattlesnake hybrid zones generate complex combinations of divergent venom phenotypes that retain high toxicity. Biochimie. 2023 Oct;213:176-189. PubMed PMID: 37451532
• Westfall AK, Gopalan SS, Perry BW, Adams RH, Saviola AJ, Mackessy SP, Castoe TA. Single-Cell Heterogeneity in Snake Venom Expression Is Hardwired by Co-Option of Regulators from Progressively Activated Pathways. Genome Biol Evol. 2023 Jun 1;15(6). PubMed PMID: 37311204
• Smith CF, Nikolakis ZL, Ivey K, Perry BW, Schield DR, Balchan NR, Parker J, Hansen KC, Saviola AJ, Castoe TA, Mackessy SP. Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake. BMC Biol. 2023 Jun 6;21(1):136. PubMed PMID: 37280596
• Calvete JJ, Lomonte B, Saviola AJ, Calderón Celis F, Ruiz Encinar J. Quantification of snake venom proteomes by mass spectrometry-considerations and perspectives. Mass Spectrom Rev. 2023 May 8. [Epub ahead of print] PubMed PMID: 37155340
• Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Umaña P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Simultaneous targeting of PD-1 and IL-2Rß? with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023 May 8;41(5):950-969.e6. PubMed PMID: 37116489
• Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze T, Hansen KC, Zhao R, Ahn N, Sluchanko NN, Eisenmesser E. Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein. Protein Sci. 2023 Apr;32(4):e4603. PubMed PMID: 36807437
• McCabe MC, Saviola AJ, Hansen KC. Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs. J Proteome Res. 2023 Mar 3;22(3):790-801. PubMed PMID: 36763087
• Grabowsky ER, Saviola AJ, Alvarado-Díaz J, Mascareñas AQ, Hansen KC, Yates JR 3rd, Mackessy SP. Montane Rattlesnakes in México: Venoms of Crotalus tancitarensis and Related Species within the Crotalus intermedius Group. Toxins (Basel). 2023 Jan 13;15(1). PubMed PMID: 36668891
• Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2023 Apr 18;227(8):993-1001. PubMed PMID: 36200236
• Hunter JD, Hancko A, Shakya P, Hill R, Saviola AJ, Hansen KC, Davis ME, Christman KL. Characterization of decellularized left and right ventricular myocardial matrix hydrogels and their effects on cardiac progenitor cells. J Mol Cell Cardiol. 2022 Oct;171:45-55. PubMed PMID: 35780862
• Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14;27(14). PubMed PMID: 35889366
• Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2022 Oct 6. [Epub ahead of print] PubMed PMID: 36200236
• Modahl CM, Saviola AJ, Mackessy SP. Integration of transcriptomic and proteomic approaches for snake venom profiling. Expert Rev Proteomics. 2021 Oct;18(10):827-834. PubMed PMID: 34663159
• Kalita B, Saviola AJ, Samuel SP, Mukherjee AK. State-of-the-art review - A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?. Int J Biol Macromol. 2021 Dec 1;192:1040-1057. PubMed PMID: 34656540
• Das B, Saviola AJ, Mukherjee AK. Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins. Front Pharmacol. 2021;12:710680. PubMed PMID: 34650430
• Robinson KE, Holding ML, Whitford MD, Saviola AJ, Yates JR 3rd, Clark RW. Phenotypic and functional variation in venom and venom resistance of two sympatric rattlesnakes and their prey. J Evol Biol. 2021 Sep;34(9):1447-1465. PubMed PMID: 34322920
• Calvete JJ, Lomonte B, Saviola AJ, Bonilla F, Sasa M, Williams DJ, Undheim EAB, Sunagar K, Jackson TNW. Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance. Toxicon X. 2021 Jul;9-10:100070. PubMed PMID: 34195606
• Kalita B, Saviola AJ, Mukherjee AK. From venom to drugs: a review and critical analysis of Indian snake venom toxins envisaged as anticancer drug prototypes. Drug Discov Today. 2021 Apr;26(4):993-1005. PubMed PMID: 33486112
• Saviola AJ, Calvete JJ. Reptile Venom Disintegrins. In Handbook of Venoms and Toxins of Reptiles. 2021: 211-224. CRC Press.