Yen-Rei Yu, MD, PhD

Publications

• Fonseca DLM, Jäpel M, Gyamfi MA, Filgueiras IS, Baiochi GC, Ostrinski Y, Halpert G, Lavi YB, Vojdani E, Silva-Sousa T, Usuda JN, E Silva JCS, Freire PP, Nóbile AL, Adri AS, Barcelos PM, Corrêa YLG, do Vale FYN, Lopes LO, Schmidt SL, Wang X, Vahldieck C, Fels B, Schimke LF, Cabral-Miranda G, Hirata MH, AKhan TA, Yu YA, Dalmolin RJ, Amital H, Vojdani A, Dias HD, Nakaya H, Ochs HD, Silverberg JI, Zimmerman J, Zyskind I, Rosenberg AZ, Schulze-Forster K, Heidecke H, Catar R, Moll G, Hackel A, Kusche-Vihrog K, Shoenfeld Y, Riemekasten G, Akbarzadeh R, Marques AHC, Cabral-Marques O. Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms. NPJ Syst Biol Appl. 2025 Jan 13;11(1):7. PubMed PMID: 39805853
• Ahn JH, da Silva Pedrosa M, Lopez LR, Tibbs TN, Jeyachandran JN, Vignieri EE, Rothemich A, Cumming I, Irmscher AD, Haswell CJ, Zamboni WC, Yu YA, Ellermann M, Denson LA, Arthur JC. Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease. Cell Host Microbe. 2025 Jan 8;33(1):71-88.e9. PubMed PMID: 39701098
• Tighe RM, Birukova A, Malakhau Y, Kobayashi Y, Vose AT, Chandramohan V, Cyphert-Daly JM, Cumming RI, Fradin Kirshner H, Tata PR, Ingram JL, Gunn MD, Que LG, Yu YA. Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness. Front Immunol. 2024;15:1371764. PubMed PMID: 38983858
• Kumar S, Mickael C, Kumar R, Prasad RR, Campbell NV, Zhang H, Li M, McKeon BA, Allen TE, Graham BB, Yu YA, Stenmark KR. Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension. Front Immunol. 2024;15:1372959. PubMed PMID: 38690277
• Rajagopal S, Yu YR. Determining the Architecture of Inflammation in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2024 Jan 15;209(2):131-133. PubMed PMID: 38033319
• Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2024 Feb;40(2):425-439. PubMed PMID: 37902921
• Rajagopal S, Yu YR. Determining the Architecture of Inflammation in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2024 Jan 15;209(2):131-133. PubMed PMID: 38033319
• Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2023 Oct 30. [Epub ahead of print] PubMed PMID: 37902921
• Fini MA, Monks JA, Li M, Gerasimovskaya E, Paucek P, Wang K, Frid MG, Pugliese SC, Bratton D, Yu YR, Irwin D, Karin M, Wright RM, Stenmark KR. Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration. bioRxiv. 2023 Jul 21. PubMed PMID: 37502951
• Arao Y, Stumpo DJ, Hoenerhoff MJ, Tighe RM, Yu YR, Sutton D, Kashyap A, Beerman I, Blackshear PJ. Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized Csf2 mRNA. FASEB J. 2023 Aug;37(8):e23100. PubMed PMID: 37462673
• Tighe RM, Birukova A, Malakhau Y, Kobayashi Y, Vose AT, Chandramohan V, Cyphert-Daly JM, Cumming RI, Kirshner HF, Tata PR, Ingram JL, Gunn MD, Que LG, Yu YA. Allergic Asthma Responses Are Dependent on Macrophage Ontogeny. bioRxiv. 2023 Feb 16. PubMed PMID: 36824904
• Viswanathan G, Kirshner HF, Nazo N, Ali S, Ganapathi A, Cumming I, Zhuang Y, Choi I, Warman A, Jassal C, Almeida-Peters S, Haney J, Corcoran D, Yu YR, Rajagopal S. Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension. Am J Respir Crit Care Med. 2023 May 15;207(10):1358-1375. PubMed PMID: 36803741
• Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon JE 2nd, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V. Immunotoxin-aCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models. Sci Transl Med. 2023 Feb 8;15(682):eabn5649. PubMed PMID: 36753564
• Gu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KR. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Compr Physiol. 2023 Jan 30;13(1):4295-4319. PubMed PMID: 36715285
• Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension Gayathri Viswanathan, Hélène Fradin Kirshner, Nour Nazo, Asvin Ganapathi, Ian Cummings, Issac Choi, Anmol Warman, Susana Almeida-Peters, John Haney, David Corcoran, Yen-Rei Yu, Sudarshan Rajagopal bioRxiv 2022.01.26.477878; doi: https://doi.org/10.1101/2022.01.26.477878
• Proliferation-competent Slamf6+CD8+ TILs mediate immunotoxin-aCD40 antitumor response in glioblastoma models. Science Translational Medicine (In Press)
• Rajagopal S, Yu YA. The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin. 2022 Feb;40(1):1-12. PubMed PMID: 34809910
• Matusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Curr Cardiol Rep. 2021 Aug 19;23(10):147. PubMed PMID: 34410530
• Alba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Curr Cardiol Rep. 2021 Aug 19;23(10):141. PubMed PMID: 34410515
• Alba GA, Samokhin AO, Wang RS, Zhang YY, Wertheim BM, Arons E, Greenfield EA, Lundberg Slingsby MH, Ceglowski JR, Haley KJ, Bowman FP, Yu YR, Haney JC, Eng G, Mitchell RN, Sheets A, Vargas SO, Seo S, Channick RN, Leary PJ, Rajagopal S, Loscalzo J, Battinelli EM, Maron BA. NEDD9 Is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. Am J Respir Crit Care Med. 2021 Jun 15;203(12):1533-1545. PubMed PMID: 33523764

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Pulmonary Vascular Disease Clinic
(PH, PE/CTEPH, HHT, High Altitude) 
12505 E. 16th Ave, 3rd Floor, Inpatient Pavilion 2
Aurora, CO 80045
720-848-5300

Specialty Information

Specialties

• Pulmonary Disease and Critical Care Medicine