Laura Graham, MD

Assistant Professor, Medicine-Medical Oncology


FacultyPhoto
Medical School
  • MD, Rush Medical College of Rush University Medical Center (2015)
Undergraduate School
  • BA, University of Chicago (IL) (2009)
Residency
  • University of Washington Program, Internal Medicine (2018)
Fellowships
  • University of Washington Program, Medical Oncology (2021)
Department
Medicine-Medical Oncology

Professional Titles

  • Assistant Professor

Recognitions

  • Alpha Omega Alpha Medical Honor Society, Medical Honor Society (2015)
  • Chief Fellow, Fred Hutchinson Cancer Research Center (2020)
  • Young Investigator Award, American Society of Clinical Oncology (2021)
  • Nicholas Vogelzang SWOG GU Scholarship, Southwest Oncology Group ( SWOG) (2023)
  • National Comprehensive Care Network (NCCN) Testicular Cancer Guideline Committee Member, NCCN (2023)

Research Interests

I am interested in translational and clinical research in patients with genitourinary cancers, with a particular focus on biomarker development and novel therapeutics. I was granted an ASCO Young Investigator Award to study how patients with prostate cancer who have certain genetic markers respond to therapy.

Publications

  • Yurkovetskiy L, Burrows M, Khan AA, Graham L, Volchkov P, Becker L, Antonopoulos D, Umesaki Y, Chervonsky AV. Gender Bias in Autoimmunity is Influenced by Microbiota. Immunity. 2013 Aug 22;39(2):400–12
  • Graham L, Krass L, Zariffard MR, Spear GT, Mirmonsef P. Effects of Succinic Acid and Other Microbial Fermentation Products on HIV Expression in Macrophages. Biores Open Access. 2013 Oct;2(5):385–91
  • Graham L, Schweizer MT. Targeting Persistent Androgen Receptor Signaling in Castration-Resistant Prostate Cancer. Med Oncol. 2016 May; 33 (5): 44
  • Graham L, Schwartz E, Wilson N, Ording J, Daley K, Khandan S, Lake J, Grinder C, Wood-Molo M, Kent PM. Fertility Preservation in Adolescents and Young Adults with Cancer: Patient Behavior and Provider Attitudes. Women’s Reproductive Health. 2017 March; 4 (1): 1-13
  • Graham LS, Pritchard CC, Schweizer MT. Hypermutation, Mismatch Repair Deficiency, and Defining Predictors of Response to Checkpoint Blockade. Clin Cancer Res. 2021 Dec 15;27(24):6662-6665. PubMed PMID: 34580112
  • Graham LS, True LD, Gulati R, Schade GR, Wright J, Grivas P, Yezefski T, Nega K, Alexander K, Hou WM, Yu EY, Montgomery B, Mostaghel EA, Matsumoto AA, Marck B, Sharifi N, Ellis WJ, Reder NP, Lin DW, Nelson PS, Schweizer MT. Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high-risk localized prostate cancer. Prostate. 2021 May;81(7):418-426. PubMed PMID: 33755225
  • Graham L, True L, Schweizer MT. Metastatic Adenocarcinoma of the Epididymis: A Case Report and Brief Literature Review. Clinical Genitourinary Cancer. 2018 Apr;16(2):e335-e338
  • Graham LS, Sokolova AO, Khaki AR, Wu QV, Davidson NE. Gender Differences in Faculty Rank and Subspecialty Choice among Academic Medical Oncologists. Cancer Invest. 2021 Jan;39(1):21-24. PubMed PMID: 33131319
  • Graham L, Banda K, Torres A, Pisano K, Shelley G, Curley T, Scher H, Lotan T, Hsieh A, Rathkopf D. A Phase II Study of the Dual mTOR inhibitor MLN0128 in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC). Investigational New Drugs. 2018 Jun;36(3):458-467
  • Graham L, Schade G, Schweizer M. Multimodality Treatment of Bilateral Wilms Tumor in a Pregnant Female. Urology. 2019 Sep. DOI: 10.1016
  • Graham LS, Schweizer MT. Mismatch repair deficiency and clinical implications in prostate cancer. Prostate. 2022 Aug;82 Suppl 1:S37-S44. PubMed PMID: 35358351
  • Graham L, Montgomery B, Cheng H, Yu E, Nelson P, Pritchard C, Erickson S, Alva A, Schweizer M. Mismatch Repair Deficiency in Metastatic Prostate Cancer (PC): Response to PD-1 Blockade and Standard Therapies. PLoSOne. 2020 May: 15(5). DOI: 10.1371
  • Koshkin VS, Patel VG, Ali A, Bilen MA, Ravindranathan D, Park JJ, Kellezi O, Cieslik M, Shaya J, Cabal A, Brown L, Labriola M, Graham LS, Pritchard C, Tripathi A, Nusrat S, Barata P, Jang A, Chen SR, Garje R, Acharya L, Hwang C, Pilling A, Oh W, Jun T, Natesan D, Nguyen C, Kilari D, Pierro M, Thapa B, Cackowski F, Mack A, Heath E, Marshall CH, Tagawa ST, Halabi S, Schweizer MT, Armstrong A, Dorff T, Alva A, McKay R. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer. Prostate Cancer Prostatic Dis. 2022 Sep;25(3):388-396. PubMed PMID: 34363009
  • Graham LS, Sokolova AO, Khaki AR, Wu QV, Davidson NE. Gender Differences in Faculty Rank and Subspecialty Choice among Academic Medical Oncologists. Cancer Investigation. 2020 Nov 11:1-4.
  • Graham L, Reder N, Gulati R, Grivas P, Wright J, Yu E, Hou W, Nega K, Yezefski T, Montgomery RB, Mostaghel E, Ellis W, True L, Lin D, Nelson P, Schweizer M. Targeting Backdoor Androgen Synthesis Through AKR1C3 Inhibition: A Presurgical Hormonal Ablative Neoadjuvant Trial in High Risk Localized Prostate Cancer. The Prostate. 2021 Mar: 1-9.
  • Graham LS, Schweizer MT. Mismatch repair deficiency and clinical implications in prostate cancer. Prostate. 2022 Aug;82 Suppl 1:S37-S44. PubMed PMID: 35358351
  • Koshkin V, Patel V, Ali A, Bilen M, Ravindranathan D, Park J, Kellezi O, Cieslik M, Shaya J, Cabal A, Brown L, Labriola M, Graham L, Pritchard C, Tripathi A, Nusrat S, Barata P, Jang A, Chen S, Garje R, Acharya L, Hwang C, Pilling A, Oh W, Jun T, Natesan D, Nguyen C, Kilari D, Pierro M, Thapa B, Cackowski F, Mack A, Marshall C, Tagawa S, Heath E, Haalbi S, Schweizer M, Armstrong A, Dorff T, Alva A. McKay R. PROMISE: A Real World Clinical-Genomic Database to Address Knowledge Gaps in Prostate Cancer. Prostate Cancer and Prostatic Diseases. 2021 July.
  • Koshkin VS, Patel VG, Ali A, Bilen MA, Ravindranathan D, Park JJ, Kellezi O, Cieslik M, Shaya J, Cabal A, Brown L, Labriola M, Graham LS, Pritchard C, Tripathi A, Nusrat S, Barata P, Jang A, Chen SR, Garje R, Acharya L, Hwang C, Pilling A, Oh W, Jun T, Natesan D, Nguyen C, Kilari D, Pierro M, Thapa B, Cackowski F, Mack A, Heath E, Marshall CH, Tagawa ST, Halabi S, Schweizer MT, Armstrong A, Dorff T, Alva A, McKay R. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer. Prostate Cancer Prostatic Dis. 2022 Sep;25(3):388-396. PubMed PMID: 34363009
  • Graham L, Prtichard C, Schweizer M. Hypermutation, Mismatch Repair Deficiency and Defining Predictors of Response to Checkpoint Blockade. Clinical Cancer Research. 2021 Sep 27
  • Dorff T, Zengin Z, Henderson N, Ali A, Nguyen C, Hwang C, Barata PC, Bilen M, Graham L, Mo G, Kilari D, Tripathi A, Labriola M, Rothstein S, Garje R, Koshkin V, Patel V, Schweizer M, Armstrong A, McKay R, Alva A. Clinical implications of AR alterations in advanced prostate cancer: A multi-institutional collaboration. Res Sq. 2023 Aug 10. PubMed PMID: 37609284
  • Graham LS, Lin JK, Lage DE, Kessler ER, Parikh RB, Morgans AK. Management of Prostate Cancer in Older Adults. Am Soc Clin Oncol Educ Book. 2023 May;43:e390396. PubMed PMID: 37207299
  • Gillette CM, Yette GA, Cramer SD, Graham LS. Management of Advanced Prostate Cancer in the Precision Oncology Era. Cancers (Basel). 2023 Apr 29;15(9). PubMed PMID: 37174018
  • Graham LS, Haffner MC, Sayar E, Gawne A, Schweizer MT, Pritchard CC, Coleman I, Nelson PS, Yu EY. Clinical, pathologic, and molecular features of amphicrine prostate cancer. Prostate. 2023 May;83(7):641-648. PubMed PMID: 36779357
  • Graham LS, Schweizer MT. Mismatch repair deficiency and clinical implications in prostate cancer. Prostate. 2022 Aug;82 Suppl 1:S37-S44. PubMed PMID: 35358351
  • Koshkin VS, Patel VG, Ali A, Bilen MA, Ravindranathan D, Park JJ, Kellezi O, Cieslik M, Shaya J, Cabal A, Brown L, Labriola M, Graham LS, Pritchard C, Tripathi A, Nusrat S, Barata P, Jang A, Chen SR, Garje R, Acharya L, Hwang C, Pilling A, Oh W, Jun T, Natesan D, Nguyen C, Kilari D, Pierro M, Thapa B, Cackowski F, Mack A, Heath E, Marshall CH, Tagawa ST, Halabi S, Schweizer MT, Armstrong A, Dorff T, Alva A, McKay R. PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer. Prostate Cancer Prostatic Dis. 2022 Sep;25(3):388-396. PubMed PMID: 34363009
  • Purdue MP, Dutta D, Machiela MJ, Gorman BR, Winter T, Okuhara D, Cleland S, Ferreiro-Iglesias A, Scheet P, Liu A, Wu C, Antwi SO, Larkin J, Zequi SC, Sun M, Hikino K, Hajiran A, Lawson KA, Cárcano F, Blanchet O, Shuch B, Nepple KG, Margue G, Sundi D, Diver WR, Folgueira MAAK, van Bokhoven A, Neffa F, Brown KM, Hofmann JN, Rhee J, Yeager M, Cole NR, Hicks BD, Manning MR, Hutchinson AA, Rothman N, Huang WY, Linehan WM, Lori A, Ferragu M, Zidane-Marinnes M, Serrano SV, Magnabosco WJ, Vilas A, Decia R, Carusso F, Graham LS, Anderson K, Bilen MA, Arciero C, Pellegrin I, Ricard S, Scelo G, Banks RE, Vasudev NS, Soomro N, Stewart GD, Adeyoju A, Bromage S, Hrouda D, Gibbons N, Patel P, Sullivan M, Protheroe A, Nugent FI, Fournier MJ, Zhang X, Martin LJ, Komisarenko M, Eisen T, Cunningham SA, Connolly DC, Uzzo RG, Zaridze D, Mukeria A, Holcatova I, Hornakova A, Foretova L, Janout V, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Gaborieau V, Abedi-Ardekani B, McKay J, Johansson M, Phouthavongsy L, Hayman L, Li J, Lungu I, Bezerra SM, Souza AG, Sares CTG, Reis RB, Gallucci FP, Cordeiro MD, Pomerantz M, Lee GM, Freedman ML, Jeong A, Greenberg SE, Sanchez A, Thompson RH, Sharma V, Thiel DD, Ball CT, Abreu D, Lam ET, Nahas WC, Master VA, Patel AV, Bernhard JC, Freedman ND, Bigot P, Reis RM, Colli LM, Finelli A, Manley BJ, Terao C, Choueiri TK, Carraro DM, Houlston R, Eckel-Passow JE, Abbosh PH, Ganna A, Brennan P, Gu J, Chanock SJ. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nat Genet. 2024 May;56(5):809-818. PubMed PMID: 38671320
  • Kohlmann W, Nix DA, Pauley K, Greenberg S, Atkinson A, Boucher KM, Kolesar J, Singer EA, Edge SB, Churchman ML, Graham L, Salhia B, Sanchez A, Zakharia Y, Nepple KG, Schneider BP, Byrne L, Jain RK, Chahoud J, Feng BJ, Gupta S. Inherited Germline Variants in Urinary Tract Cancer: A Multicenter Whole-Exome Sequencing Analysis and Correlation With Clinical Features and Tumor Genomics. JCO Precis Oncol. 2024 Jun;8:e2300697. PubMed PMID: 38976819
  • Raychaudhuri R, Mo G, Tuchayi AM, Graham L, Gulati R, Pritchard CC, Haffner MC, Yezefski T, Hawley JE, Cheng HH, Yu EY, Grivas P, Montgomery RB, Nelson PS, Chen DL, Hope T, Iravani A, Schweizer MT. Genomic Correlates of Prostate-Specific Membrane Antigen Expression and Response to (177)Lu-PSMA-617: A Retrospective Multicenter Cohort Study. JCO Precis Oncol. 2024 Apr;8:e2300634. PubMed PMID: 38662984
  • Park JJ, Chu A, Li J, Ali A, McKay RR, Hwang C, Labriola MK, Jang A, Kilari D, Mo G, Ravindranathan D, Graham LS, Sokolova A, Tripathi A, Pilling A, Jindal T, Ravindra A, Cackowski FC, Sweeney PL, Thapa B, Amery TS, Heath EI, Garje R, Zakharia Y, Koshkin VS, Bilen MA, Schweizer MT, Barata PC, Dorff TB, Cieslik M, Alva AS, Armstrong AJ. Repeat Next-Generation Sequencing Testing on Progression in Men With Metastatic Prostate Cancer Can Identify New Actionable Alterations. JCO Precis Oncol. 2024 Apr;8:e2300567. PubMed PMID: 38579192
  • Graham LS, Henderson NC, Kellezi O, Hwang C, Barata PC, Bilen MA, Kilari D, Pierro M, Thapa B, Tripathi A, Mo G, Labriola M, Park JJ, Rothstein S, Garje R, Koshkin VS, Patel VG, Dorff T, Armstrong AJ, McKay RR, Alva A, Schweizer MT. DNA-Damaging Therapies in Patients With Prostate Cancer and Pathogenic Alterations in Homologous Recombination Repair Genes. JCO Precis Oncol. 2024 Aug;8:e2400014. PubMed PMID: 39178368

Practice Locations

UCHealth Tony Grampsas Urologic Cancer Care Clinic - Anschutz Medical Campus
1665 Aurora Ct
1st Floor
Aurora, CO 80045
720-848-0170

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Medical Oncology, Board Certification (2021)
  • Internal Medicine, Board Certification (2018)
  • ABIM Board Certification in Medical Oncology, Board Certification (2021)
  • ABIM Board Certification in Internal Medicine, Board Certification (2018)
Conditions & Treatments
  • Cancers
  • Cancers - Kidney Cancer
  • Cancers - Prostate Cancer
  • Cancers - Testicular Cancer
  • Cancers - Urologic Cancer
  • Cancers - Bladder Cancer
Care Philosophy
I am committed to providing outstanding evidence-based and compassionate patient care and advancing the science of oncology. I specialize in genitourinary (GU) cancers (Prostate, Bladder, Testicular/Germ Cell Tumors, Penile, and Kidney Cancers) as well as adrenal cortical carcinoma. We strive to provide patient-focused, personalized, multi-disciplinary care for patients with GU cancers. I collaborate closely with specialized colleagues in a variety of disciplines to provide excellent care and achieve the best outcomes for our patients.