Mark Dell'acqua, PhD

Publications

• Lin L, Sun W, Kung F, Dell'Acqua ML, Hoffman DA AKAP79/150 Impacts Intrinsic Excitability of Hippocampal Neurons through Phospho-Regulation of A-type K+ Channel Trafficking. J Neurosci 31:1323-1332 (2011)
• Clapp P, Gibson ES, Dell'Acqua ML, Hoffman PL Phosphorylation regulates removal of synaptic NMDA receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther 332:720-729 (2010)
• Sanderson JL, Dell'Acqua ML AKAP signaling complexes in regulation of excitatory synaptic plasticity. The Neuroscientist (In Press) (2010)
• Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci 30:8214-8220 (2010)
• Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem 285:17930-17933 (2010)
• Clapp P, Gibson ES, Dell'Acqua ML, Hoffman PL Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther 332:720-729 (2010)
• Nystoriak, M.A., Nieves, M., Hinke, S.A., Nichols, C.B., Chen, C-Y., Dell’Acqua, M.L., Scott, J.D., Santana, L.F., Navedo, M.F. (2013) AKAP150-anchored phosphatase mediates vascular BKCa channel remodeling and enhanced arterial tone in diabetes. Circulation Research 114:607-15.
• 29. Coultrap. S.J., Freund, R.K., O’Leary, H., Buard, I., Barcomb, K., Kulbe, J.R., Sanderson, J.L., Roche, K.W., Benke, T.A., *Dell’Acqua, M.L., *Bayer, K.U. (2014) Autonomous” CaMKII mediates both LTP and LTD using a novel mechanism for differential substrate selection. Cell Reports 6:431-7. (*co-senior/corresponding author)
• Murphy, J.G., Sanderson, J.L., Gorski, J.A., Scott, J.D., Catterall, W.A., Sather, W.A., Dell’Acqua, M.L. (2014) AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling. Cell Reports In press
• 29. Coultrap. S.J., Freund, R.K., O’Leary, H., Buard, I., Barcomb, K., Kulbe, J.R., Sanderson, J.L., Roche, K.W., Benke, T.A., *Dell’Acqua, M.L., *Bayer, K.U. (2014) Autonomous” CaMKII mediates both LTP and LTD using a novel mechanism for differential substrate selection. Cell Reports 6:431-7. (*co-senior/corresponding author)
• 32. Corser-Jensen, CE, Goodell, DJ, Freund, RK, Serbedzija, P, Murphy, RC, Farias, SE, Dell’Acqua, ML, Frey, LC, Serkova, N, Heidenreich, KA (2014) Blocking leukotriene production attenuates secondary brain damage and cognitive deficits induced by traumatic brain injury. Experimental Neurology 256:7-16.
• Dittmer, P.J., Dell’Acqua, M.L. (2014) Ca2+/Calcineurin-Dependent Inactivation of Neuronal L-type Ca2+ Channels Requires Priming by AKAP-Anchored Protein Kinase A. Cell Reports In Press
• 30. Murphy, J.G., Sanderson, J.L., Gorski, J.A., Scott, J.D., Catterall, W.A., Sather, W.A., Dell’Acqua, M.L. (2014) AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling. Cell Reports 7: 1577-1588.
• 31. Dittmer, P.J., Dell’Acqua, M.L., Sather, W.A. (2014) Ca2+/Calcineurin-Dependent Inactivation of Neuronal L-type Ca2+ Channels Requires Priming by AKAP-Anchored Protein Kinase A. Cell Reports 7: 1410-1416.
• 33. Woolfrey, KM, Sanderson JL, Dell’Acqua, ML (2015) The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmityolation of AKAP79/150. J. Neurosci. 35: 442-456.
• Corser-Jensen, CE, Goodell, DJ, Freund, RK, Serbedzija, P, Murphy, RC, Farias, SE, Dell’Acqua, ML, Frey, LC, Serkova, N, Heidenreich, KA (2014) Blocking leukotriene production attenuates secondary brain damage and cognitive deficits induced by traumatic brain injury. Experimental Neurology In press.
• 34. Nieves-Cintron M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF (2015) Selective Down-regulation of KV2.1 Function Contributes to Enhanced Arterial Tone During Diabetes. J. Biol. Chem. In Press
• 35. Tian, Y., Taussig, M.D., DiPatrizio, N.V., Astarita, G., Piomelli, D., Dell’Acqua, M.L., Eckel, R.H., Wang, H. (2015) Deficiency in Lipoprotein Lipase in neurons decreases AMPA receptor phosphorylation and leads to neurobehavioral abnormalities J. Biol. Chem. Revision Submitted
• Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K( ) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2015 Dec 24. [Epub ahead of print] PubMed PMID: 26724383
• Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 Aug 3;627:1-6. PubMed PMID: 27233215
• Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ß-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May;89(5):552-9. PubMed PMID: 26957206
• Sanderson JL, Gorski JA, Dell'Acqua ML. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²?-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 2;89(5):1000-15. PubMed PMID: 26938443
• Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 4;291(10):4912. PubMed PMID: 26945093
• Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K( ) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 Jul;28(7):733-40. PubMed PMID: 26724383
• Guercio LA, Hofmann ME, Swinford-Jackson SE, Sigman JS, Wimmer ME, Dell'Acqua ML, Schmidt HD, Pierce RC. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology. 2017 Dec 12. [Epub ahead of print] PubMed PMID: 29317777
• Wild AR, Dell'Acqua ML. Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. Pharmacol Ther. 2017 Dec 17. [Epub ahead of print] PubMed PMID: 29262295
• Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the de-palmitoylation and synaptic removal of AKAP79/150 to mediate structural LTD. J Biol Chem. 2017 Dec 1. [Epub ahead of print] PubMed PMID: 29196604
• Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA. STIM1 Ca(2 ) Sensor Control of L-type Ca(2 )-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep. 2017 Apr 11;19(2):321-334. PubMed PMID: 28402855
• Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 8;93(3):646-660.e5. PubMed PMID: 28132827
• Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca(2 )-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 Oct 23;25(4):974-987.e4. PubMed PMID: 30355502
• Dell'Acqua ML, Woolfrey KM. FRETting over postsynaptic PKC signaling. Nat Neurosci. 2018 Aug;21(8):1021-1022. PubMed PMID: 30013172
• Sanderson JL, Scott JD, Dell'Acqua ML. Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca(2 )-Permeable AMPA Receptors. J Neurosci. 2018 Mar 14;38(11):2863-2876. PubMed PMID: 29440558
• Guercio LA, Hofmann ME, Swinford-Jackson SE, Sigman JS, Wimmer ME, Dell'Acqua ML, Schmidt HD, Pierce RC. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology. 2018 May;43(6):1395-1404. PubMed PMID: 29317777
• Woolfrey KM, Dell'Acqua ML. Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity. J Biol Chem. 2015 Nov 27;290(48):28604-12. PubMed PMID: 26453308
• Wild AR, Dell'Acqua ML. Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. Pharmacol Ther. 2018 May;185:99-121. PubMed PMID: 29262295
• Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018 Feb 2;293(5):1551-1567. PubMed PMID: 29196604
• Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015;10(8):e0135113. PubMed PMID: 26263173
• Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD. A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem. 2015 May 29;290(22):14107-19. PubMed PMID: 25882844
• Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20;290(12):7918-29. PubMed PMID: 25670860
• Woolfrey KM, Sanderson JL, Dell'Acqua ML. The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. J Neurosci. 2015 Jan 14;35(2):442-56. PubMed PMID: 25589740
• Dittmer PJ, Dell'Acqua ML, Sather WA. Synaptic crosstalk conferred by a zone of differentially regulated Ca(2 ) signaling in the dendritic shaft adjoining a potentiated spine. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13611-13620. PubMed PMID: 31209051
• Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca(2 ) channels. Mol Biol Cell. 2019 Jul 1;30(14):1743-1756. PubMed PMID: 31091162
• Wild AR, Sinnen BL, Dittmer PJ, Kennedy MJ, Sather WA, Dell'Acqua ML. Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca(2 ) Channel Ca(2 ) Spike Propagation to the Soma. Cell Rep. 2019 Mar 26;26(13):3537-3550.e4. PubMed PMID: 30917310
• Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR. Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse. Cell Rep. 2019 Mar 19;26(12):3284-3297.e3. PubMed PMID: 30893601
• Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 Jan;95(1):20-32. PubMed PMID: 30404891
• Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR. Local miRNA-Dependent Translational Control of GABA(A)R Synthesis during Inhibitory Long-Term Potentiation. Cell Rep. 2020 Jun 23;31(12):107785. PubMed PMID: 32579917
• Purkey AM, Dell'Acqua ML. Phosphorylation-Dependent Regulation of Ca(2 )-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity. Front Synaptic Neurosci. 2020;12:8. PubMed PMID: 32292336
• Cochrane, VA, Yang, Z, Dell’Acqua, ML, Shyng S-L (2020) AKAP79/150 coordinates leptin-induced PKA activation to regulate KATP channel trafficking in pancreatic beta-cells. J Biol Chem – under revision. bioRxiv https://www.biorxiv.org/content/10.1101/2020.11.25.397059v1.abstract
• Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, Kennedy MJ. Precision Mapping of Amyloid-ß Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. eNeuro. 2021 Nov 17. [Epub ahead of print] PubMed PMID: 34789478
• Hansen KB, Wollmuth LP, Bowie D, Furukawa H, Menniti FS, Sobolevsky AI, Swanson GT, Swanger SA, Greger IH, Nakagawa T, McBain CJ, Jayaraman V, Low CM, Dell'Acqua ML, Diamond JS, Camp CR, Perszyk RE, Yuan H, Traynelis SF. Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacol Rev. 2021 Oct;73(4):298-487. PubMed PMID: 34753794
• Sanderson JL, Freund RK, Gorski JA, Dell'Acqua ML. ß-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca(2 )-permeable AMPA receptors. Cell Rep. 2021 Oct 5;37(1):109786. PubMed PMID: 34610314
• Cochrane VA, Yang Z, Dell'Acqua ML, Shyng SL. AKAP79/150 coordinates leptin-induced PKA signaling to regulate K(ATP) channel trafficking in pancreatic ß-cells. J Biol Chem. 2021 Jan-Jun;296:100442. PubMed PMID: 33617875
• Lucero EM, Freund RK, Johnson NR, Dooling B, Sullivan E, Prikhodko O, Ahmed MM, Dell’Acqua ML, Chial HJ, Potter H. (2021) Kif11 overexpression rescues cognition, long-term potentiation, and spine defects in mouse and cell models of Alzheimer’s disease. bioRxiv, https://doi.org/10.1101/2021.09.09.459627
• Lucero EM, Freund RK, Smith A, Johnson NR, Dooling B, Sullivan E, Prikhodko O, Ahmed MM, Bennett DA, Hohman TJ, Dell'Acqua ML, Chial HJ, Potter H. Increased KIF11/kinesin-5 expression offsets Alzheimer Aß-mediated toxicity and cognitive dysfunction. iScience. 2022 Nov 18;25(11):105288. PubMed PMID: 36304124
• Chen X, Crosby KC, Feng A, Purkey AM, Aronova MA, Winters CA, Crocker VT, Leapman RD, Reese TS, Dell'Acqua ML. Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines. Front Synaptic Neurosci. 2022;14:1004154. PubMed PMID: 36186623
• Sanderson JL, Freund RK, Castano AM, Benke TA, Dell'Acqua ML. The Ca(V)1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca(2 ) channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome. Neuropharmacology. 2022 Dec 1;220:109271. PubMed PMID: 36162529
• Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR. Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses. Front Synaptic Neurosci. 2022;14:852227. PubMed PMID: 35463850
• Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep;621(7977):146-153. PubMed PMID: 37648853
• Simmons SC, Flerlage WJ, Langlois LD, Shepard RD, Bouslog C, Thomas EH, Gouty KM, Sanderson JL, Gouty S, Cox BM, Dell'Acqua ML, Nugent FS. AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula. bioRxiv. 2023 Dec 7. PubMed PMID: 38106086
• Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. bioRxiv. 2023 Dec 12. PubMed PMID: 38168421
• Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU. Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice. Sci Signal. 2023 Jul 25;16(795):eade5892. PubMed PMID: 37490545
• Martinez TP, Larsen ME, Sullivan E, Dell’Acqua ML (2023) Amyloid-ß-induced dendritic spine elimination requires Ca2+-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling and the NFAT target gene Mdm2. eNeuro – In Press