Brent Palmer, PhD

Baumgartner J, Wilson C, Palmer B, Richter D, Banerjee A, McCarter M. Melanoma induces immunosuppression by upregulating FOXP3+ regulatory T cells. J Surg Research (Submitted Journal of Surgery Research)

Lucy Golden-Mason, Brent Palmer, Jared Klarquist, John A. Mengshol, Nicole Castelblanco, Hugo R. Rosen. UPREGULATION OF PD-1 EXPRESSION ON CIRCULATING AND INTRAHEPATIC HCV-SPECIFIC CD8+ T CELLS ASSOCIATED WITH REVERSIBLE IMMUNE DYSFUNCTION (Submitted J. Virology)

Joseph Anderson, Ming-Jie Li, Brent Palmer, Leila Remling, Shirley Li, Priscilla Yam, Jiing-Kuan Yee, John Rossi, John Zaia, Ramesh Akkina. In vivo derivation of HIV-1 resistant transgenic T cells by lentiviral vector transduction of a triple combination of anti-HIV genes anti-CCR5 ribozyme, tat-rev siRNA and a TAR decoy Molecular Therapy.

Brent E. Palmer, Douglas G. Mack, Allison K. Martin, Lisa A. Maier, and Andrew P. Fontenot. CD57 Expression Correlates with Alveolitis Severity in Subjects with Beryllium-Induced Disease. (Aspen Lung Conference June 2006)

Michelle D’Souza, Andrew P. Fontenot, Doug G. Mack, Catherine Lozupone, Stephanie Dillon, Amie Meditz, Cara C. Wilson, Elizabeth Connick, Brent E. Palmer*. PD-1 Expression on HIV-specific CD4+ T Cells is Driven by Viral Replication and Associated with T Cell Dysfunction (Oral abstract #70, CROI Feb 2007)

R. Howe, S. Dillion, J. Forster, R. Schlichtemeier, G. Ray, S. MaWhinney, B. Palmer, E. Connick, C. Wilson. Phenotypic and Functional Characterization of HIV-1-specific CD4+CD8+ T cells in subjects with primary infection. (Abstract 337 CROI Feb 2007)

Anderson J, Li MJ, Palmer BE, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. In vivo derivation of HIV-1 resistant transgenic T cells by lentiviral vector transduction of a triple combination of anti-HIV genes anti-CCR5 ribozyme, tat-rev siRNA and a TAR decoy. Molecular Therapy. 15(6): 1182-8 June 2007

Palmer BE, Mack DG, Martin AK, Maier LA, and Fontenot AP. CD57 Expression Correlates with Alveolitis Severity in Subjects with Beryllium-Induced Disease. Journal of Allergy and Clinical Immunology 120(1): 184-91 July 2007

Baumgartner J, Wilson C, Palmer BE, Richter D, Banerjee A, McCarter M. Melanoma induces immunosuppression by upregulating FOXP3+ regulatory T cells. Journal of Surgery Research 141(1): 72-77, July 2007

Golden-Mason l., Palmer BE., Klarquist J, Mengshol JA, Castelblanco N, Rosen HR.. Upregulation of PD-1 expression on circulating and intrahepatic HCV-specific CD8+ T cells is associated with reversible immune dysfunction. Journal of Virology 2007 Sept;81(17):9249-58.

McCarter MD, Baumgartner J, Escobar GA, Richter D, Lewis K, Robinson W, Wilson C, Palmer BE, Gonzales R. Immunosuppressive Dendritic and Regulatory T Cells are Upregulated in Melanoma Patients. Ann Surg Oncol. 2007 Oct;14(10):2854-60.

D’Souza M., Fontenot AP., Mack DG., Lozupone CA, Dillon S., Meditz A., Wilson CC., Connick E., BE. Palmer. PD-1 Expression on HIV-specific CD4+ T Cells is Driven by Viral Replication and Associated with T Cell Dysfunction. Journal of Immunology 179(3): 1979-87 August 2007

Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L, and Rosen HR. Spontaneous Recovery in Acute Human HCV infection: Functional T Cell Thresholds and Relative Importance of CD4 help. Journal of Virology 2008 Feb;82(4):1827-37

Palmer BE, Mack DG, Martin AK, Maier LA, and Fontenot AP. PD-1 is a potential target for the down regulation of beryllium-specific CD4+ T cells in the lungs. Journal of Immunology 2008 Feb 15;180(4):2704-12.

Brent E. Palmer, Douglas G. Mack, Allison K. Martin, Lisa A. Maier, and Andrew P. Fontenot. CD57 Expression Correlates with Alveolitis Severity in Subjects with Beryllium-Induced Disease. (American Thoracic Society, May 2007)

Fontenot AP, Mack DG, Martin AK, Maier LA, and Palmer BE. PD-1 is a potential target for the down regulation of beryllium-specific CD4+ T cells in the lungs. Accepted American Thoracic Society meeting May 2008.

Baumgartner JM, Gonzalez R, Lewis K, Robinson W, Richter D, Palmer BE, Wilson CC, McCarter MD. Increased Survival from Stage IV Melanoma Associated with Fewer Regulatory T Cells. Surg Res. 2008 Jun 2. [Epub ahead of print]

María C. López, Brent E. Palmer and David A. Lawrence. Phenotypic differences between cord blood and adult peripheral blood. Clinical Cytometry, Epub ahead of print July 18, 2008

Mack DG, Martin, AK., Palmer BE., Maier LA., Watts TH., Fontenot AP. 4-1BB Enhances Proliferation of Beryllium-Specific T cell in the lung of Subjects with Chronic Beryllium Disease. Journal of Immunology, Sept 15;181(6) 4381-8 2008

Cheryll Williams-Skipp, Thiagarajan Raman, Robert J. Valuck, Herschel Watkins, and Brent E. Palmer, Robert I. Scheinman. Unmasking of a Protective TNFR1 Mediated Signal in the Collagen Arthritis Model. Arthritis and Rheumatism, 2009 Jan 29; 60(2):408-418

Howe, R., Dillon, S., Rogers, L., Schichtemeier, R., Rietmeijer, C., Ray, G., Palmer BE., Connick, E., Wilson, CC. Phenotypic and functional characteristics of CD4+CD8+ T cells in HIV-1 infected individuals. (In press JAIDS)

Kassu A, D’Souza M, O'Connor BP, Kelly E, Akkina R, Fontenot AP, and Palmer BE. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. Clin. Immunol. In press.

Mack DG, Martin AK, Palmer BE, Maier LA, and Fontenot AP. CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung. J. Immunol. In press.

Kassu A, D’Souza M, O'Connor BP, Kelly E, Akkina R, Fontenot AP, and Palmer BE. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. CROI Montreal Feb 2009

28. Kassu A, D’Souza M, O'Connor BP, Kelly E, Akkina R, Fontenot AP, and Palmer BE. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. Clin Immunol. 2009 Aug;132(2):234-45

Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Negative Immune Regulator TIM-3 is overexpressed in Hepatitis C Infection and its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells. J. Virol. 2009 Sep;83(18):9122-30

Mack DG, Martin AK, Palmer BE, Maier LA, and Fontenot AP. CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung. J Immunol. 2009 Jun 1;182(11):7317-24.

Baumgartner JM, Gonzalez R, Lewis K, Robinson W, Richter D, Palmer BE, Wilson CC, McCarter MD. Increased Survival from Stage IV Melanoma Associated with Fewer Regulatory T Cells. J Surg Res. 2009 Jun 1;154(1):13-20

Shay Matalona, MD, Brent E. Palmer, PhD, Marcel F. Nolda, MD, Antonio Furlana, MD, Afework Kassua, PhD, Gianluca Fossatib, PhD, Paolo Mascagnib, PhD and Charles A. Dinarello, MD The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro In Press JAIDS

Kassu A, Marcus R, D'Souza M, Kelly E, Akkina R, Fontenot AP, Wilson CC and Palmer BE. Dysfunction of HIV-specific CD4+ T cells is assciated with elevated concurrent expression of multiple inhbitory receptors

Shay Matalona, MD, Brent E. Palmer, PhD, Marcel F. Nolda, MD, Antonio Furlana, MD, Afework Kassua, PhD, Gianluca Fossatib, PhD, Paolo Mascagnib, PhD and Charles A. Dinarello, MD. Histone deacetylase inhbitory ITF2357 decreases surface CXCR4 and CCR5 expression on CD4 T cells and momcytes and is superior to valproic acid for latent HIV expresion in vitro.

Dubie, L., Wei, Q., Lovell, M., Palmer, B. QUANTITATIVE ANALYSIS OF LINEAGE-SPECIFIC CHIMERISM FOR MONITORING POST-HAEMATOPOIETIC STEM CELL TRANSPLANTATION ENGRAFTMENT

Douglas G. Mack, Allison M. Lanham, Michael T. Falta, Brent E. Palmer, Lisa A. Maier, and Andrew P. Fontenot. Deficient and Dysfunctional Regulatory T Cells in the Lungs of Chronic Beryllium Disease Subjects

Kassu A, Marcus RA, DSouza M, Kelly-McKnight E, Akkina R, Fontenot A, Wilson, CC, and Palmer, BE. Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection J. Immunol. 2010 Sep 1;185(5):3007-18.

Kassu A, Marcus RA, D’Souza M, Kelly-McKnight E, and Palmer, BE. Suppression of HIV Replication by Antiretroviral Therapy Reduces TIM-3 Expression on HIV-specific CD8+ T Cells AIDS Research and Human Retroviruses, 2011 Jan;27(1):1-3

Nold MF, Nold-Petry CA, Zepp, JA, Palmer BE, Bufler P, Dinarello, CA. IL-37 is a fundamental inhibitor of immune responses. Nature Immunology. 2010 Nov;11(11):1014-22.

Mack DG, Lanham AM, Falta MT, Palmer BE, Maier LA, Fontenot AP. Deficient and dysfunctional regulatory T cells in the lungs of chronic beryllium disease subjects. Am J Respir Crit Care Med. 2010 Jun 1;181(11):1241-9.

Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA. The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. J Acquir Immune Defic Syndr. 2010 May 1;54(1):1-9.

Kassu A, Marcus RA, D’Souza M, Kelly-McKnight E, and Palmer, BE.Dysfunction of HIV-specific CD4+ T cells is associated with elevated concurrent expression of multiple inhbitory receptors. CROI 2010 San Francisco CA. Feb 16-19 Abstract # 320

Matalon S, Palmer BE, Nold MF, Fossati G, Mascagni P, Dinarello CA. The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. CROI 2010 San Francisco CA. Feb 16-19 Abstract # 260

Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA. IL-36 (fromerly IL-1F7) suppresses innate immunity by inhibiting inflammatory cytokines and reducing dendritic cell activation by association with SMAD3. Cytokine 2010 Chicago Oct 3 Abstract # PL1-4

Ramesh Akkina; Bradford K Berges; Brent E Palmer; Leila Remling; C. Preston Neff; Jes Kuruvilla; Elizabeth Connick; Joy Folkvord; Kathy Gaglairdi; Afework Kassu; Sarah R Akkina Humanized Rag1-/-gc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes".

Akkina, R., B. K. Berges, B. E. Palmer, L. Remling, C. P. Neff, J. Kuruvilla, E. Connick, J. Folkvord, K. Gagliardi, A. Kassu, and S. R. Akkina. 2011. Humanized Rag1-/- gammac-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes. PLoS One 6:e20169.

Gonzalez, A., J. C. Clemente, A. Shade, J. L. Metcalf, S. Song, B. Prithiviraj, B. E. Palmer, and R. Knight. 2011. Our microbial selves: what ecology can teach us. EMBO Rep 12:775.

Kassu, A., R. A. Marcus, M. B. D'Souza, E. A. Kelly-McKnight, and B. E. Palmer. 2011. Suppression of HIV replication by antiretroviral therapy reduces TIM-3 expression on HIV-specific CD8(+) T cells. AIDS Res Hum Retroviruses 27:1.

Brent Palmer, Derek Linderman, Michelle D’Souza, Marcella Li, Thomas Campbell and Andrew Fontenot. Differential Expression of Inhibitory Receptors on HIV-1-Specific T cells in the Lung and Blood of HIV-1 Infected Subjects. D189 Conference on Retroviruses and Opportunistic Infections. Seattle, Washington 2012 #309

Brent E. Palmer, C. Preston Neff, Andrew Fontenot, Alan Korman, Michelled D'souza, Ramesh Akkina. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice Keystone HIV Vaccine Meeting, Keystone Colorado March 2012

In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice. Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. J Immunol. 2013 Jan 1;190(1):211-9. doi: 10.4049/jimmunol.1201108. Epub 2012 Dec 3.

Widespread Colonization of the Lung by Tropheryma whipplei in HIV Infection. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP; for the Lung HIV Microbiome Project. Am J Respir Crit Care Med. 2013 Feb 7. [Epub ahead of print]

Galectin-9 functionally impairs natural killer (NK) cells in humans and mice. Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR. J Virol. 2013 Feb 13. [Epub ahead of print]

Association of Functional Impairment with Inflammation and Immune Activation in HIV-1-Infected Adults on Effective Antiretroviral Therapy. Kristine M Erlandson, MD1,2. Amanda A Allshouse, MS3. Catherine M Jankowski, PhD2. Eric J Lee, MS1. Kevin M Rufner, MD, MPH4. Brent Palmer, PhD5. Cara C Wilson, MD1. Samantha MaWhinney, ScD3. Wendy M Kohrt, PhD2. Thomas B Campbell, MD1. Journal of Infectious Diseases. In Press

Brent Palmer, C. Preston Neff, Andrew Fontenot, Alan Korman, Michelle Dsouza and Ramesh Akkina. In vivo blockade of the PD-1 receptor suppresses HIV viral loads and improves CD4+ T cell levels in humanized mice. Keystone HIV Pathogenesis Meeting, Keystone Colorado. March 21-26 2012

FluoroFinder.com: A free flow cytometry resource to simplify polychromatic panel design. Marcus R., Powell T., O’Connor B., Dsouza M., Kelly E., Palmer B. Accepted at Cyto ISAC 2013 San Diego CA May 19-22

Interleukin 32 promotes angiogenesis: a new role for a versatile cytokine. Monash, I., Zepp, J., Oliver, H., Palmer, B, Taraseviciene, L., Kim, S., Dinarello, C., Voelkel, N., Nold, C., Nold, M. Accepted to Immunology 2013 Hawaii.

James SF, Traina-Dorge V, Deharo E, Wellish M, Palmer BE, Gilden D, Mahalingam R. T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus. J Neurovirol. 2014 Feb 19. [Epub ahead of print] PubMed PMID: 24549971

Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. IL-32 promotes angiogenesis. J Immunol. (Epub ahead of print) Dec 11 2013 PMID: 24337385

Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013 Sep 11;14(3):329-39. PubMed PMID: 24034618

Chain JL, Martin AK, Mack DG, Maier LA, Palmer BE, Fontenot AP. Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation. J Immunol. 2013 Aug 15;191(4):1648-56. PubMed PMID: 23851684

Erlandson KM, Allshouse AA, Jankowski CM, Lee EJ, Rufner KM, Palmer BE, Wilson CC, MaWhinney S, Kohrt WM, Campbell TB. Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy. J Infect Dis. 2013 Jul 15;208(2):249-59. PubMed PMID: 23559466

Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013 May;87(9):4835-45. PubMed PMID: 23408620

Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP, Lung HIV Microbiome Project. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15;187(10):1110-7. PubMed PMID: 23392441

Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4 T cell levels in humanized mice. J Immunol. 2013 Jan 1;190(1):211-9. PubMed PMID: 23209326

Meya D, Okurut S, Zziwa G, Rolfes, M, Melander D, Naiuyima, P Palmer, BE, Kambugu A, Bohjanen PR, Eller M, Wahl SM, Doulware DR, Janoff EN. Local cellular immune responses in cerebrospinal fluid from HIV infected person with cryptococcal meningitis with or without immune reconstitution inflammatory syndrome Present IDSA Oct 2013

Gutman J, Sen S, Schmidt C, Palmer BE. Global and CMV specific T cell PD-1` expression is varied early post transplantation depending on donor source, T cell maturation profile, and effectivenss of CMV control. ASH 2013 New Orleans, LA

Li S, Neff CP, Barber K, Hong J, Luo Y, Azam T, Palmer BE, Fujita M, Garlanda C, Mantovani A, Kim S, Dinarello CA. Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci U S A. 2015 Feb 5. [Epub ahead of print] PubMed PMID: 25654981

Neff CP, Chain JL, MaWhinney S, Martin AK, Linderman DJ, Flores SC, Campbell TB, Palmer BE, Fontenot AP. Lymphocytic Alveolitis Is Associated with the Accumulation of Functionally Impaired HIV-Specific T Cells in the Lung of Antiretroviral Therapy-Naive Subjects. Am J Respir Crit Care Med. 2015 Feb 15;191(4):464-73. PubMed PMID: 25536276 Co-corresponding Author

Meya DB, Okurut S, Zziwa G, Rolfes MA, Kelsey M, Cose S, Joloba M, Naluyima P, Palmer BE, Kambugu A, Mayanja-Kizza H, Bohjanen PR, Eller MA, Wahl SM, Boulware DR, Manabe YC, Janoff EN. Cellular Immune Activation in Cerebrospinal Fluid From Ugandans With Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome. J Infect Dis. 2014 Dec 9. [Epub ahead of print] PubMed PMID: 25492918

Lozupone CA, Rhodes ME, Neff CP, Fontenot AP, Campbell TB, Palmer BE. HIV-induced alteration in gut microbiota: driving factors, consequences, and effects of antiretroviral therapy. Gut Microbes. 2014 Jul 1;5(4):562-70. PubMed PMID: 25078714

Morou A, Palmer BE, Kaufmann DE. Distinctive features of CD4 T cell dysfunction in chronic viral infections. Curr Opin HIV AIDS. 2014 Sep;9(5):446-51. PubMed PMID: 25023623 Co-corresponding Author

López MC, Palmer BE, Lawrence DA. Naïve T cells, unconventional NK and NKT cells, and highly responsive monocyte-derived macrophages characterize human cord blood. Immunobiology. 2014 Oct;219(10):756-65. PubMed PMID: 24986635

James SF, Traina-Dorge V, Deharo E, Wellish M, Palmer BE, Gilden D, Mahalingam R. T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus. J Neurovirol. 2014 Jun;20(3):309-13. PubMed PMID: 24549971

Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF. IL-32 promotes angiogenesis. J Immunol. 2014 Jan 15;192(2):589-602. PubMed PMID: 24337385

C lozupone, CP Neff, M Rhodes, J Donnelly, S Mazmanian, T Campbell, BE Palmer. Alterations in the gut microbiota associated with HIV-1 infection. Keystone Symposia Exploiting and Understanding Chemical Biotransformations in the human Microbiome. Big Sky, Montana. April 2014.

Brent Palmer, Preston Neff, Jody Donnelly, Catherine Lozupone. Alteration in gut microbiota associated with HIV infection. Keystone Symposia HIV Vaccine and Pathogenesis. Banff, CA. March 2014

Neff CP, Fontenot AP, Lozupone C, Palmer BE. Gut microbiota of HIV infected subjects induce inflammatory cytokines but not T regulatory cells. Abstract #236, Conference on Retroviruses and Opportunistic Infections. Boston, MA 2014

Kristine M. Erlandson, Amanda A. Allshouse, Rick Rapaport, Brent E. Palmer, Cara C. Wilson, Samantha MaWhinney, Thomas B. Campbell. Cell-Mediated CMV responses in HIV-infected persons with impaired physical function. Abstract #764, Conference on Retroviruses and Opportunistic Infections. Boston, MA 2014

Jose R. Castillo-Mancilla, Amie Meditz, Sharon Seifert, Jia-Hua Zheng, Becky J. Kerr, Edward M. Gardner, Brent E. Palmer, Lane Bushman, Samantha MaWhinney, Peter L. Anderson. Reduced Immune Activation During Tenofovir-Emtricitabine Therapy in HIV-Negative Individuals Abstract # 340. Conference on Retroviruses and Opportunistic Infections. Boston, MA 2014.

Cavalli G, Hayashi M, Jin Y, Yorgov D, Santorico SA, Holcomb C, Rastrou M, Erlich H, Tengesdal IW, Dagna L, Neff CP, Palmer BE, Spritz RA, Dinarello CA. MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1363-8. PubMed PMID: 26787888

Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8 T Cell Killing. PLoS Pathog. 2015 Dec;11(12):e1005364. PubMed PMID: 26684741

Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8 T Cell Killing. PLoS Pathog. 2015 Oct;11(10):e1005224. PubMed PMID: 26484769

Beck JM, Schloss PD, Venkataraman A, Twigg H 3rd, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB. Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1335-44. PubMed PMID: 26247840

Traina-Dorge V, Doyle-Meyers LA, Sanford R, Manfredo J, Blackmon A, Wellish M, James S, Alvarez X, Midkiff C, Palmer BE, Deharo E, Gilden D, Mahalingam R. Simian Varicella Virus Is Present in Macrophages, Dendritic Cells, and T Cells in Lymph Nodes of Rhesus Macaques after Experimental Reactivation. J Virol. 2015 Oct;89(19):9817-24. PubMed PMID: 26178993

Erlandson KM, Allshouse AA, Rapaport E, Palmer BE, Wilson CC, Weinberg A, MaWhinney S, Campbell TB. Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response. AIDS Res Hum Retroviruses. 2015 Sep;31(9):905-12. PubMed PMID: 26061347

Castillo-Mancilla JR, Meditz A, Wilson C, Zheng JH, Palmer BE, Lee EJ, Gardner EM, Seifert S, Kerr B, Bushman LR, MaWhinney S, Anderson PL. Reduced immune activation during tenofovir-emtricitabine therapy in HIV-negative individuals. J Acquir Immune Defic Syndr. 2015 Apr 15;68(5):495-501. PubMed PMID: 25763783

Li S, Neff CP, Barber K, Hong J, Luo Y, Azam T, Palmer BE, Fujita M, Garlanda C, Mantovani A, Kim S, Dinarello CA. Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2497-502. PubMed PMID: 25654981

Neff CP, Chain JL, MaWhinney S, Martin AK, Linderman DJ, Flores SC, Campbell TB, Palmer BE, Fontenot AP. Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. Am J Respir Crit Care Med. 2015 Feb 15;191(4):464-73. PubMed PMID: 25536276

Meya DB, Okurut S, Zziwa G, Rolfes MA, Kelsey M, Cose S, Joloba M, Naluyima P, Palmer BE, Kambugu A, Mayanja-Kizza H, Bohjanen PR, Eller MA, Wahl SM, Boulware DR, Manabe YC, Janoff EN. Cellular immune activation in cerebrospinal fluid from ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome. J Infect Dis. 2015 May 15;211(10):1597-606. PubMed PMID: 25492918

Thompson M, Heath SL, Sweeton B, Williams K, Cunningham P, Keele BF, Sen S, Palmer BE, Chomont N, Xu Y, Basu R, Hellerstein MS, Kwa S, Robinson HL. DNA/MVA Vaccination of HIV-1 Infected Participants with Viral Suppression on Antiretroviral Therapy, followed by Treatment Interruption: Elicitation of Immune Responses without Control of Re-Emergent Virus. PLoS One. 2016 Oct 6;11(10):e0163164. PubMed PMID: 27711228

Neff CP, Rhodes ME, Arnolds KL, Collins CB, Donnelly J, Nusbacher N, Jedlicka P, Schneider JM, McCarter MD, Shaffer M, Mazmanian SK, Palmer BE, Lozupone CA. Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory Properties. Cell Host Microbe. 2016 Oct 12;20(4):535-547. PubMed PMID: 27693306

Jones D, Blackmon A, Neff CP, Palmer BE, Gilden D, Badani H, Nagel MA. Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts. J Virol. 2016 Dec 1;90(23):10527-10534. PubMed PMID: 27630241

Seifert SM, Chen X, Meditz AL, Castillo-Mancilla JR, Gardner EM, Predhomme JA, Clayton C, Austin G, Palmer BE, Zheng JH, Klein B, Kerr BJ, Guida LA, Rower C, Rower JE, Kiser JJ, Bushman LR, MaWhinney S, Anderson PL. Intracellular Tenofovir and Emtricitabine Anabolites in Genital, Rectal, and Blood Compartments from First Dose to Steady State. AIDS Res Hum Retroviruses. 2016 Oct Nov;32(10-11):981-991. PubMed PMID: 27526873

Jin Y, Roberts GHL, Ferrara TM, Ben S, van Geel N, Wolkerstorfer A, Ezzedine K, Siebert J, Neff CP, Palmer BE, Santorico SA, Spritz RA. Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression. Nat Commun. 2019 Jan 23;10(1):391. PubMed PMID: 30674883

Logue EC, Neff CP, Mack DG, Martin AK, Fiorillo S, Lavelle J, Vandivier RW, Campbell TB, Palmer BE, Fontenot AP. Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers. J Immunol. 2019 Jan 21. [Epub ahead of print] PubMed PMID: 30665939 (Fontenot and Palmer contributed equally to this work)

Traina-Dorge V, Palmer BE, Coleman C, Hunter M, Frieman A, Gilmore A, Altrock K, Doyle-Meyers L, Nagel MA, Mahalingam R. Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion. J Virol. 2019 Feb 1;93(3). PubMed PMID: 30404798

Armstrong AJS, Shaffer M, Nusbacher NM, Griesmer C, Fiorillo S, Schneider JM, Preston Neff C, Li SX, Fontenot AP, Campbell T, Palmer BE, Lozupone CA. An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men. Microbiome. 2018 Nov 5;6(1):198. PubMed PMID: 30396369 (Lozupone and Palmer are co senior authors)

Nicholson LK, Pratap H, Bowers E, Gunzburger E, Bandi SR, Gardner EM, Palmer BE, Wright T, Kittelson J, Janoff EN. Effective B cell activation in vitro during viremic HIV-1 infection with surrogate T cell stimulation. Immunobiology. 2018 Dec;223(12):839-849. PubMed PMID: 30219203

Neff CP, Krueger O, Xiong K, Arif S, Nusbacher N, Schneider JM, Cunningham AW, Armstrong A, Li S, McCarter MD, Campbell TB, Lozupone CA, Palmer BE. Fecal Microbiota Composition Drives Immune Activation in HIV-infected Individuals. EBioMedicine. 2018 Apr;30:192-202. PubMed PMID: 29650491

Mahalingam R, Kaufer BB, Ouwendijk WJD, Verjans GMGM, Coleman C, Hunter M, Das A, Palmer BE, Clambey E, Nagel MA, Traina-Dorge V. Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol. 2018 Apr 1;92(7). PubMed PMID: 29343566

Sam X Li, Sharon Sen, Jennifer M Schneider, Ka-Na Xiong, Nichole M Nusbacher, Nancy Moreno-Huizar, Michael Shaffer, Abigail JS Armstrong, Erin Severs4, Kristine Kuhn, Charles P Neff, Martin McCarter, Thomas Campbell, Catherine A Lozupone, and Brent E Palmer. Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection

Janet Siebert, Carston Jorg, Brent E. Palmer and Catherine Lozupone. Visualizing microbiome–immune system interplay. Future Medicine, Immunotherapy Vol 11, #2 January 9, 2019

Coleman SL, Neff CP, Li SX, Armstrong AJS, Schneider JM, Sen S, Fennimore B, Campbell TB, Lozupone CA, Palmer BE. Can gut microbiota of men who have sex with men influence HIV transmission?. Gut Microbes. 2020 Feb 10;:1-10. [Epub ahead of print] PubMed PMID: 32036739

Okurut S, Meya DB, Bwanga F, Olobo J, Eller MA, Cham-Jallow F, Bohjanen PR, Pratap H, Palmer BE, Hullsiek KH, Manabe YC, Boulware DR, Janoff EN. B cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV- Infected Ugandans with Cryptococcal Meningitis. Infect Immun. 2019 Dec 23. [Epub ahead of print] PubMed PMID: 31871098

Siebert JC, Görg C, Palmer B, Lozupone C. Visualizing microbiome–immune system interplay. Immunotherapy. 2019 Feb;11(2):63-67

Siebert JC, Neff CP, Schneider JM, Regner EH, Ohri N, Kuhn KA, Palmer BE, Lozupone CA, Görg C. VOLARE: visual analysis of disease-associated microbiome-immune system interplay. BMC Bioinformatics. 2019 Aug 20;20(1):432. PubMed PMID: 31429723

Li SX, Sen S, Schneider JM, Xiong KN, Nusbacher NM, Moreno-Huizar N, Shaffer M, Armstrong AJS, Severs E, Kuhn K, Neff CP, McCarter M, Campbell T, Lozupone CA, Palmer BE. Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection. PLoS Pathog. 2019 Apr;15(4):e1007611. PubMed PMID: 30947289

Jones D, Como CN, Jing L, Blackmon A, Neff CP, Krueger O, Bubak AN, Palmer BE, Koelle DM, Nagel MA. Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8 T cell effector function. PLoS Pathog. 2019 Mar;15(3):e1007650. PubMed PMID: 30870532

Li S, Amo-Aparicio J, Neff CP, Tengesdal IW, Azam T, Palmer BE, López-Vales R, Bufler P, Dinarello CA. Role for nuclear interleukin-37 in the suppression of innate immunity. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4456-4461. PubMed PMID: 30792349

Jin Y, Roberts GHL, Ferrara TM, Ben S, van Geel N, Wolkerstorfer A, Ezzedine K, Siebert J, Neff CP, Palmer BE, Santorico SA, Spritz RA. Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression. Nat Commun. 2019 Jan 23;10(1):391. PubMed PMID: 30674883

Logue EC, Neff CP, Mack DG, Martin AK, Fiorillo S, Lavelle J, Vandivier RW, Campbell TB, Palmer BE, Fontenot AP. Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers. J Immunol. 2019 Mar 1;202(5):1363-1372. PubMed PMID: 30665939

Traina-Dorge V, Palmer BE, Coleman C, Hunter M, Frieman A, Gilmore A, Altrock K, Doyle-Meyers L, Nagel MA, Mahalingam R. Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion. J Virol. 2019 Feb 1;93(3). PubMed PMID: 30404798

Schade H, Sen S, Neff CP, Freed BM, Gao D, Gutman JA, Palmer BE. Programmed Death 1 Expression on CD4( ) T Cells Predicts Mortality after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 Dec;22(12):2172-2179. PubMed PMID: 27519280

Isak W. Tengesdal, Dinoop R Menon, Douglas G. Osborne, Charles P Neff, Nicholas E Powers, Fabia Gamboni, Adolfo G Mauro, Angelo D'Alessandro, Davide Stefoni, Morkos A Henen, Taylor S Mills, Dennis M DeGraaf, Tania Azam, Beat Vogeli, Brent E. Palmer, Eric M Pietras, James DeGregori, Aik Choon Tan Leo A. B. Joosten, Mayumi Fujita Charles A Dinarello, Carlo Marchetti. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion" PNAS (In Press)

Neff CP, Atif SM, Logue EC, Siebert J, Görg C, Lavelle J, Fiorillo S, Twigg H, Campbell TB, Fontenot AP, Palmer BE. HIV Infection Is Associated with Loss of Anti-Inflammatory Alveolar Macrophages. J Immunol. 2020 Nov 1;205(9):2447-2455. PubMed PMID: 32929038

Walker ZJ, VanWyngarden MJ, Stevens BM, Abbott D, Hammes A, Langouët-Astrie C, Smith CA, Palmer BE, Forsberg PA, Mark TM, Jordan CT, Sherbenou DW. Measurement of ex vivo resistance to proteasome inhibitors, IMiDs, and daratumumab during multiple myeloma progression. Blood Adv. 2020 Apr 28;4(8):1628-1639. PubMed PMID: 32311014

Armstrong AJS, Shaffer M, Nusbacher NM, Griesmer C, Fiorillo S, Schneider JM, Neff CP, Li SX, Fontenot AP, Campbell T, Palmer BE, Lozupone CA. Correction to: An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men. Microbiome. 2020 Apr 6;8(1):50. PubMed PMID: 32252810

Coleman SL, Neff CP, Li SX, Armstrong AJS, Schneider JM, Sen S, Fennimore B, Campbell TB, Lozupone CA, Palmer BE. Can gut microbiota of men who have sex with men influence HIV transmission?. Gut Microbes. 2020 May 3;11(3):610-619. PubMed PMID: 32036739

Okurut S, Meya DB, Bwanga F, Olobo J, Eller MA, Cham-Jallow F, Bohjanen PR, Pratap H, Palmer BE, Hullsiek KH, Manabe YC, Boulware DR, Janoff EN. B Cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis. Infect Immun. 2020 Feb 20;88(3). PubMed PMID: 31871098

Palmer BE, Li SX, Lozupone CA. The HIV-Associated Enteric Microbiome Has Gone Viral. Cell Host Microbe. 2016 Mar 9;19(3):270-2. PubMed PMID: 26962936

Li SX, Armstrong A, Neff CP, Shaffer M, Lozupone CA, Palmer BE. Complexities of Gut Microbiome Dysbiosis in the Context of HIV Infection and Antiretroviral Therapy. Clin Pharmacol Ther. 2016 Jun;99(6):600-11. PubMed PMID: 26940481

Cavalli G, Hayashi M, Jin Y, Yorgov D, Santorico SA, Holcomb C, Rastrou M, Erlich H, Tengesdal IW, Dagna L, Neff CP, Palmer BE, Spritz RA, Dinarello CA. MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1363-8. PubMed PMID: 26787888

Yamada E, Martin CG, Moreno-Huizar N, Fouquier J, Neff CP, Coleman SL, Schneider JM, Huber J, Nusbacher NM, McCarter M, Campbell TB, Lozupone CA, Palmer BE. Intestinal microbial communities and Holdemanella isolated from HIV /- men who have sex with men increase frequencies of lamina propria CCR5( ) CD4( ) T cells. Gut Microbes. 2021 Jan-Dec;13(1):1997292. PubMed PMID: 34818131

Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 Jun 6;219(6). PubMed PMID: 35420627

Siebert JC, Görg C, Palmer B, Lozupone C. Visualizing microbiome-immune system interplay. Immunotherapy. 2019 Feb;11(2):63-67. PubMed PMID: 30730269

Neff CP, Krueger O, Xiong K, Arif S, Nusbacher N, Schneider JM, Cunningham AW, Armstrong A, Li S, McCarter MD, Campbell TB, Lozupone CA, Palmer BE. Fecal Microbiota Composition Drives Immune Activation in HIV-infected Individuals. EBioMedicine. 2018 Apr;30:192-202. PubMed PMID: 29650491

Bruno TC, Ebner PJ, Moore BL, Squalls OG, Waugh KA, Eruslanov EB, Singhal S, Mitchell JD, Franklin WA, Merrick DT, McCarter MD, Palmer BE, Kern JA, Slansky JE. Antigen-Presenting Intratumoral B Cells Affect CD4(+) TIL Phenotypes in Non-Small Cell Lung Cancer Patients. Cancer Immunol Res. 2017 Oct;5(10):898-907. PubMed PMID: 28848053

Presti RM, Flores SC, Palmer BE, Atkinson JJ, Lesko CR, Lau B, Fontenot AP, Roman J, McDyer JF, Twigg HL 3rd. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest. 2017 Nov;152(5):1053-1060. PubMed PMID: 28427967

Morou A, Palmer BE, Kaufmann DE. Distinctive features of CD4+ T cell dysfunction in chronic viral infections. Curr Opin HIV AIDS. 2014 Sep;9(5):446-51. PubMed PMID: 25023623

Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013 Sep 11;14(3):329-39. PubMed PMID: 24034618

Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice. J Immunol. 2013 Jan 1;190(1):211-9. PubMed PMID: 23209326

Kassu A, Marcus RA, D'Souza MB, Kelly-McKnight EA, Palmer BE. Suppression of HIV replication by antiretroviral therapy reduces TIM-3 expression on HIV-specific CD8(+) T cells. AIDS Res Hum Retroviruses. 2011 Jan;27(1):1-3. PubMed PMID: 20860535

Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, Connick E, Folkvord J, Gagliardi K, Kassu A, Akkina SR. Humanized Rag1-/- ?c-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes. PLoS One. 2011;6(6):e20169. PubMed PMID: 21695116

Kassu A, Marcus RA, D'Souza MB, Kelly-McKnight EA, Golden-Mason L, Akkina R, Fontenot AP, Wilson CC, Palmer BE. Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection. J Immunol. 2010 Sep 1;185(5):3007-18. PubMed PMID: 20656923

Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol. 2010 Nov;11(11):1014-22. PubMed PMID: 20935647

Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA. The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro. J Acquir Immune Defic Syndr. 2010 May 1;54(1):1-9. PubMed PMID: 20300007

Mack DG, Lanham AM, Falta MT, Palmer BE, Maier LA, Fontenot AP. Deficient and dysfunctional regulatory T cells in the lungs of chronic beryllium disease subjects. Am J Respir Crit Care Med. 2010 Jun 1;181(11):1241-9. PubMed PMID: 20299529

Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol. 2009 Sep;83(18):9122-30. PubMed PMID: 19587053

Mack DG, Lanham AM, Palmer BE, Maier LA, Fontenot AP. CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung. J Immunol. 2009 Jun 1;182(11):7317-24. PubMed PMID: 19454729

Baumgartner JM, Gonzalez R, Lewis KD, Robinson WA, Richter DA, Palmer BE, Wilson CC, McCarter MD. Increased survival from stage IV melanoma associated with fewer regulatory T Cells. J Surg Res. 2009 Jun 1;154(1):13-20. PubMed PMID: 19062042

López MC, Palmer BE, Lawrence DA. Phenotypic differences between cord blood and adult peripheral blood. Cytometry B Clin Cytom. 2009 Jan;76(1):37-46. PubMed PMID: 18642326

Williams-Skipp C, Raman T, Valuck RJ, Watkins H, Palmer BE, Scheinman RI. Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model. Arthritis Rheum. 2009 Feb;60(2):408-18. PubMed PMID: 19180511

Kassu A, D'Souza M, O'Connor BP, Kelly-McKnight E, Akkina R, Fontenot AP, Palmer BE. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. Clin Immunol. 2009 Aug;132(2):234-45. PubMed PMID: 19406689

Howe R, Dillon S, Rogers L, Palmer B, MaWhinney S, Blyveis N, Schlichtemeier R, D'Souza M, Ingoldby L, Harwood JE, Rietmeijer C, Ray G, Connick E, Wilson CC. Phenotypic and functional characterization of HIV-1-specific CD4+CD8+ double-positive T cells in early and chronic HIV-1 infection. J Acquir Immune Defic Syndr. 2009 Apr 15;50(5):444-56. PubMed PMID: 19360930

Mack DG, Lanham AK, Palmer BE, Maier LA, Watts TH, Fontenot AP. 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. J Immunol. 2008 Sep 15;181(6):4381-8. PubMed PMID: 18768897

Palmer BE, Mack DG, Martin AK, Gillespie M, Mroz MM, Maier LA, Fontenot AP. Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium disease. J Immunol. 2008 Feb 15;180(4):2704-12. PubMed PMID: 18250483

Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L, Rosen HR. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol. 2008 Feb;82(4):1827-37. PubMed PMID: 18045940

Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007 Sep;81(17):9249-58. PubMed PMID: 17567698

McCarter MD, Baumgartner J, Escobar GA, Richter D, Lewis K, Robinson W, Wilson C, Palmer BE, Gonzalez R. Immunosuppressive dendritic and regulatory T cells are upregulated in melanoma patients. Ann Surg Oncol. 2007 Oct;14(10):2854-60. PubMed PMID: 17593331

Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells. Mol Ther. 2007 Jun;15(6):1182-1188. PubMed PMID: 28182923

Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells. Mol Ther. 2007 Jun;15(6):1182-8. PubMed PMID: 17406343

Baumgartner J, Wilson C, Palmer B, Richter D, Banerjee A, McCarter M. Melanoma induces immunosuppression by up-regulating FOXP3(+) regulatory T cells. J Surg Res. 2007 Jul;141(1):72-7. PubMed PMID: 17574040

Palmer BE, Mack DG, Martin AK, Maier LA, Fontenot AP. CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease. J Allergy Clin Immunol. 2007 Jul;120(1):184-91. PubMed PMID: 17416406

D'Souza M, Fontenot AP, Mack DG, Lozupone C, Dillon S, Meditz A, Wilson CC, Connick E, Palmer BE. Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J Immunol. 2007 Aug 1;179(3):1979-87. PubMed PMID: 17641065

Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O'Brien RL, Fontenot AP. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J Immunol. 2006 Oct 1;177(7):4436-43. PubMed PMID: 16982878

Rohr JR, Sager T, Sesterhenn TM, Palmer BD. Exposure, postexposure, and density-mediated effects of atrazine on amphibians: breaking down net effects into their parts. Environ Health Perspect. 2006 Jan;114(1):46-50. PubMed PMID: 16393657

Fontenot AP, Palmer BE, Sullivan AK, Joslin FG, Wilson CC, Maier LA, Newman LS, Kotzin BL. Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response. J Clin Invest. 2005 Oct;115(10):2886-93. PubMed PMID: 16151531

Pott GB, Palmer BE, Sullivan AK, Silviera L, Maier LA, Newman LS, Kotzin BL, Fontenot AP. Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease. J Allergy Clin Immunol. 2005 May;115(5):1036-42. PubMed PMID: 15867863

Palmer BE, Blyveis N, Fontenot AP, Wilson CC. Functional and phenotypic characterization of CD57+CD4+ T cells and their association with HIV-1-induced T cell dysfunction. J Immunol. 2005 Dec 15;175(12):8415-23. PubMed PMID: 16339584

Boritz E, Palmer BE, Wilson CC. Human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levels. J Virol. 2004 Nov;78(22):12638-46. PubMed PMID: 15507650

Palmer BE, Boritz E, Wilson CC. Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function. J Immunol. 2004 Mar 1;172(5):3337-47. PubMed PMID: 14978142

Anderson PD, Palmer B, Houpis JL, Smith MK, Pushnik JC. Chloroplastic responses of ponderosa pine (Pinus ponderosa) seedlings to ozone exposure. Environ Int. 2003 Jun;29(2-3):407-13. PubMed PMID: 12676234

Boritz E, Palmer BE, Livingston B, Sette A, Wilson CC. Diverse repertoire of HIV-1 p24-specific, IFN-gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy. J Immunol. 2003 Jan 15;170(2):1106-16. PubMed PMID: 12517980

Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC. Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis. 2003 Jan 1;187(1):26-37. PubMed PMID: 12508143

Palmer BE, Boritz E, Blyveis N, Wilson CC. Discordance between frequency of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-producing CD4(+) T cells and HIV-1-specific lymphoproliferation in HIV-1-infected subjects with active viral replication. J Virol. 2002 Jun;76(12):5925-36. PubMed PMID: 12021325

Rehage JS, Lynn SG, Hammond JI, Palmer BD, Sih A. Effects of larval exposure to triphenyltin on the survival, growth, and behavior of larval and juvenile Ambystoma barbouri salamanders. Environ Toxicol Chem. 2002 Apr;21(4):807-15. PubMed PMID: 11951955

Halsey WA Jr, Palmer BE, DeMartini JC, Howell MD. Analysis of sheep T-cell receptor beta-chain heterogeneity. Immunogenetics. 1999 Mar;49(3):206-14. PubMed PMID: 9914334

Beck JM, Newbury RL, Palmer BE, Warnock ML, Byrd PK, Kaltreider HB. Role of CD8+ lymphocytes in host defense against Pneumocystis carinii in mice. J Lab Clin Med. 1996 Nov;128(5):477-87. PubMed PMID: 8900290

Beck JM, Newbury RL, Palmer BE. Pneumocystis carinii pneumonia in scid mice induced by viable organisms propagated in vitro. Infect Immun. 1996 Nov;64(11):4643-7. PubMed PMID: 8890219

Littlefield KM, Schneider JM, Neff CP, Soesanto V, Siebert JC, Nusbacher NM, Moreno-Huizar N, Cartwright IM, Armstrong AJS, Colgen SP, Lozupone CA, Palmer BE. Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function. Front Immunol. 2022;13:1072720. PubMed PMID: 36605218

Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022;13:988125. PubMed PMID: 36131937

Littlefield KM, Watson RO, Schneider JM, Neff CP, Yamada E, Zhang M, Campbell TB, Falta MT, Jolley SE, Fontenot AP, Palmer BE. SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2. PLoS Pathog. 2022 May;18(5):e1010359. PubMed PMID: 35617421

Arnolds KL, Yamada E, Neff CP, Schneider JM, Palmer BE, Lozupone CA. Disruption of Genes Encoding Putative Zwitterionic Capsular Polysaccharides of Diverse Intestinal Bacteroides Reduces the Induction of Host Anti-Inflammatory Factors. Microb Ecol. 2022 May 21. [Epub ahead of print] PubMed PMID: 35596750

Littlefield KM, Schneider JM, Neff CP, Soesanto V, Siebert JC, Nusbacher NM, Moreno-Huizar N, Cartwright IM, Armstrong AJS, Colgen SP, Lozupone CA, Palmer BE. Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function. Front Immunol. 2022;13:1072720. PubMed PMID: 36605218

Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022;13:988125. PubMed PMID: 36131937

Mahalingam R, Feia B, Coleman C, Anupindi K, Saravanan P, Luthens A, Bustillos A, Das A, de Haro E, Doyle-Meyers L, Looper J, Bubak AN, Niemeyer CS, Palmer B, Nagel MA, Traina-Dorge V. Simian Varicella Virus Pathogenesis in Skin during Varicella and Zoster. Viruses. 2022 May 27;14(6). PubMed PMID: 35746639

Littlefield KM, Watson RO, Schneider JM, Neff CP, Yamada E, Zhang M, Campbell TB, Falta MT, Jolley SE, Fontenot AP, Palmer BE. SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2. PLoS Pathog. 2022 May;18(5):e1010359. PubMed PMID: 35617421

Arnolds KL, Yamada E, Neff CP, Schneider JM, Palmer BE, Lozupone CA. Disruption of Genes Encoding Putative Zwitterionic Capsular Polysaccharides of Diverse Intestinal Bacteroides Reduces the Induction of Host Anti-Inflammatory Factors. Microb Ecol. 2022 May 21. [Epub ahead of print] PubMed PMID: 35596750

Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 Jun 6;219(6). PubMed PMID: 35420627

Leao V, Littlefield K., Palmer BE., Lozupone C. Inflammation-associated gut microbiome in post-acute sequelae of SARS-CoV-2 points towards new therapeutic targets. Gut Co-senior Author with Catherine Lozupone

Krsak M, Harry BL, Palmer BE, Franco-Paredes C. Response to Mishra et al . re "Postinfectious Immunity After COVID-19 and Vaccination Against SARS-CoV-2". Viral Immunol. 2021 Nov;34(9):659-660. PubMed PMID: 34672802

Arnold CG, Monte AA, Littlefield K, Vest A, Palmer BE. Vaccination Hesitancy and Postacute Sequelae of SARS-CoV-2: Is It Time to Reconsider?. Viral Immunol. 2021 Dec;34(10):666-668. PubMed PMID: 34491119

Krsak M, Harry BL, Palmer BE, Franco-Paredes C. Postinfectious Immunity After COVID-19 and Vaccination Against SARS-CoV-2. Viral Immunol. 2021 Oct;34(8):504-509. PubMed PMID: 34227891

Armstrong AJS, Quinn K, Fouquier J, Li SX, Schneider JM, Nusbacher NM, Doenges KA, Fiorillo S, Marden TJ, Higgins J, Reisdorph N, Campbell TB, Palmer BE, Lozupone CA. Systems Analysis of Gut Microbiome Influence on Metabolic Disease in HIV-Positive and High-Risk Populations. mSystems. 2021 May 18;6(3). PubMed PMID: 34006628

Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). PubMed PMID: 33649199

Burkhart Colorado AS, Lazzaro A, Neff CP, Nusbacher N, Boyd K, Fiorillo S, Martin C, Siebert JC, Campbell TB, Borok M, Palmer BE, Lozupone C. Differential effects of antiretroviral treatment on immunity and gut microbiome composition in people living with HIV in rural versus urban Zimbabwe. Microbiome. 2024 Feb 3;12(1):18. PubMed PMID: 38310301

Lazzaro A, Colorado ASB, Neff CP, Nusbacher N, Boyd K, Fiorillo S, Martin C, Siebert J, Campbell T, Borok M, Palmer B, Lozupone C. Antiretroviral treatment is less effective at reducing gut microbiome-associated inflammation and T cell activation in people living with HIV in rural versus urban Zimbabwe. Res Sq. 2023 Aug 31. PubMed PMID: 37693491

Schreiber AR, Santos J, McMahon B, Buckner TW, Olson C, Alberti MO, Guimarães-Young A, Knoeckel C, Broussard L, Aubrey M, Palmer BE, Weiss E, Connors GR, Brunner S, Wisell JA, Pacheco T, Aisner DL, Gutman JA. A Case of Fetal-Induced Graft-versus-Host Disease. N Engl J Med. 2023 Aug 17;389(7):668-670. PubMed PMID: 37585636

Carneiro VL, Littlefield KM, Watson R, Palmer BE, Lozupone C. Inflammation-associated gut microbiome in postacute sequelae of SARS-CoV-2 points towards new therapeutic targets. Gut. 2024 Jan 5;73(2):376-378. PubMed PMID: 36717218

Arnolds KL, Yamada E, Neff CP, Schneider JM, Palmer BE, Lozupone CA. Disruption of Genes Encoding Putative Zwitterionic Capsular Polysaccharides of Diverse Intestinal Bacteroides Reduces the Induction of Host Anti-Inflammatory Factors. Microb Ecol. 2023 May;85(4):1620-1629. PubMed PMID: 35596750

Associate Professor, Medicine-Allergy/Clinical Immunology

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