Todd Bull, MD

Professional Titles

• Director Center for Lungs and Breathing
• Director Pulmonary Vascular Disease Center

Recognitions

• Top Doctor in Denver- Critical Care, 5280 Magazine (2009)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Critical Care, 5280 Magazine (2012)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Critical Care, 5280 Magazine (2013)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Pulmonary Medicine, 5280 Magazine (2013)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Critical Care, 5280 Magazine (2014)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Pulmonary Medicine, 5280 Magazine (2014)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Critical Care, 5280 Magazine (2015)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Pulmonary Medicine, 5280 Magazine (2015)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Critical Care, 5280 Magazine (2016)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver - Pulmonary Medicine, 5280 Magazine (2016)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver - Critical Care, 5280 Magazine (2017)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor In Denver- Pulmonary Medicine, 5280 Magazine (2017)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver- Critical Care, 5280 Magazine (2018)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver - Pulmonary Medicine, 5280 Magazine (2018)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver - Critical Care, 5280 Magazine (2019)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver - Pulmonary Medicine, 5280 magazine (2019)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Top Doctor in Denver - Critical Care, 5280 magazine (2020)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"
• Pulmonary Hypertension Physician of the Year, Pulmonary Hypertension Association (2018)
  National Physician of the Year
• Physician of the Year, Colorado Society for Respiratory Care (2013)
  For outstanding contributions towards the advancement of respiratory care

Publications

• Microarray analysis of peripheral blood cells in pulmon ary arterial hypertension, surrogate to biopsy. Chest 2005 Dec, Dec;128(6 Suppl):584s
• Prostacyclin Synthase promoter regulation and familial pulmonary hypertension. Chest 2005 Dec, Dec;128(6 Suppl):612s
• Metastatic cancer while receiving continuous prostacyclin therapy. Chest 2005 Dec, Dec;128(6 Suppl):619s-620s
• New and Future Therapies in Pulmonary Arterial Hypertension. Semin Respir Crit Care Med 2005 Aug;26(4):429-36
• Gomberg-Maitland M, Bull TM, Saggar R, Barst RJ, Elgazayerly A, Fleming TR, Grimminger F, Rainisio M, Stewart DJ, Stockbridge N, Ventura C, Ghofrani AH, Rubin LJ. New trial designs and potential therapies for pulmonary artery hypertension. J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D82-91. PubMed PMID: 24355645
• Clark BJ, Bull TM, Benson AB, Stream AR, Macht M, Gaydos J, Meadows C, Burnham EL, Moss M, the ARDS Network Investigators. Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study. Crit Care. 2013 May 24;17(3):R92. [Epub ahead of print] PubMed PMID: 23706007
• Bull TM, Stenmark KR. Mechanics and mechanisms of pulmonary hypertension: An introduction to the 55(th) annual Thomas L. Petty Aspen Lung Conference. Pulm Circ. 2013 Jan;3(1):127. PubMed PMID: 23662188
• Meyer S, McLaughlin VV, Seyfarth HJ, Bull TM, Vizza CD, Gomberg-Maitland M, Preston IR, Barberà JA, Hassoun PM, Halank M, Jaïs X, Nickel N, Hoeper MM, Humbert M. Outcomes of noncardiac, nonobstetric surgery in patients with PAH: an international prospective survey. Eur Respir J. 2013 Jun;41(6):1302-7. PubMed PMID: 23143546
• Pulmonary Vascular Manifestations of Mixed Connective Tissue Disease. Rheum Dis Clin North Am 2005 Aug, 31(3) 451-64
• 3) Fox DL, Stream AR, Bull T. Perioperative management of the Patient with Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2014 May 13. Epub. PMID 24828282
• 2) Hunt JM, Hunt JM, Risbano MG, Messenger JC, Carroll J, Badesch D, Lowes BD, Casserly IP, Kay J, Bull TM Timed response to inhaled nitric oxide in Pulmonary Hypertension. Pulm Circ. 2014 Mar;4(1):103-9.
• 1) Fox DL, Stream AR, Bull T. Perioperative management of the Patient with Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2014 Dec; 18(4):310-8. PMID 24828282
• Pulmonary Circulation: Endothelin Receptor Antgonists
• Speckle Tracking Echocardiography to Evaluate for Pulmonary Hypertension in Chronic Obstructive Pulmonary Journal of Chronic Obstructive Pulmonary Disease. In Press
• Clinical use of extended-release oral treprostinil in the treatment of pulmonary arterial hypertension Integrated Blood Pressure Control In Press
• Right Ventricular Longitudinal Strain Is Depressed In A Bovine Model Of Pulmonary Hypertension Anesthesia and Analgesia In Press.
• Circulating Endothelial Cells, biomarker of vascular disease. Thromb Haem 2005; 93: 228-35
• Physical Examination in Pulmonary Arterial Hypertension. Advances in Pulmonary Hypertension 2005; 4(3) 6-10
• Pulmonary Hypertension, an Interactive Guide.
• Long-Term Health Outcomes in High-Altitude Pulmonary Hypertension. Robinson JC, Abbott C, Meadows CA, Roach RC, Honigman B, Bull TM. High Alt Med Biol. 2017 Jan 6. [Epub ahead of print] PMID: 28061144
• Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension. Bartels K, Brown RD, Fox DL, Bull TM, Neary JM, Dorosz JL, Fonseca BM, Stenmark KR. Anesth Analg. 2016 May;122(5):1280-6. PMID: 26974020
• The Solitary Pulmonary Nodule. Pulmonary Secretes (in press).
• Clinical use of extended-release oral treprostinil in the treatment of pulmonary arterial hypertension. Pugliese SC, Bull TM. Integr Blood Press Control. 2016 Jan 25;9:1-7. Review. PMID: 26869810
• Speckle Tracking Echocardiography to Evaluate for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease. Rice JL, Stream AR, Fox DL, Geraci MW, Vandivier RW, Dorosz JL, Bull TM. COPD. 2016 Oct;13(5):595-600. PMID: 26829151
• Steps forward in the treatment of pulmonary arterial hypertension: latest developments and clinical opportunities. Badlam, J. Bull TM. Ther Adv Chronic Dis 2017 pending publication
• Bull TM, Coldren CD, Geraci MW, Voelkel NF Gene Expression Profiling in Pulmonary Hypertension Proc Am Thorac Soc 2007 Jan;4(1) 117-20
• Nana-Sinkam P, Deog Lee J, Sotto-Santiago S, Stearman R, Keith RC, Cool C, Parr J, Moore MD, Bull TM, Voelkel N, Geraci M. Prostacyclin Prevents Pulmonary Endothelial Cell Apoptosis Induced by Cigarette Smoke. Am J Respir Crit Care Med. 2007 Jan 25;
• Pulmonary Embolism; Clinical Respiratory Medicine, 3rd Edition Mosby inc
• HHV-8 infection of pulmonary microvascular endothelial Cells …A potential mechanism for the development of Pulmonary Arterial Hypertension: Bull, TM. Meadows, CA. Campbell, TB*. Geraci, MA.
• Pulmonary Hypertension in Critically Ill Patients. Poor, H., Ventetuolo V, Bull TM. Diagnosis and Management of Pulmonary Hypertension 2016
• Timed Response to Inhaled Nitric Oxide in Pulmonary Arterial Hypertension: TRINO: Hunt J.M. MD, Barker S. RN, Messenger J. MD, Groves B. MD, Lowes B. MD, Carroll J.D. MD, Bull T.M. MD University of Colorado Health Sciences Center.
• Screening and Therapy for Pulmonary Hypertension in Systemic Sclerosis. Curr Opin Rheumatol. 2007 Nov;19(6):598-603
• Gruber, M. Bull, TM. Pulmonary Embolism. Clinical Respiratory Medicine, 3rd Edition. Pg 763-782.
• Risbano, M. Bull, TM. Pulmonary Thromboembolic Disease. The Oxford Handbook Pg 407-412.
• Vieillard-Baron A, Naeije R, Haddad F, Bogaard HJ, Bull TM, Fletcher N, Lahm T, Magder S, Orde S, Schmidt G, Pinsky MR. Diagnostic workup, etiologies and management of acute right ventricle failure : A state-of-the-art paper. Intensive Care Med. 2018 May 9. [Epub ahead of print] PubMed PMID: 29744563
• HHV-8 Infection of Pulmonary Microvascular Endothelial Cells- A Potential Mechanism for the Development of Pulmonary Arterial Hypertension. ATS, San Diego CA, May 2007
• Naeije R, Saggar R, Badesch D, Rajagopalan S, Gargani L, Rischard F, Ferrara F, Marra AM, D' Alto M, Bull TM, Saggar R, Grünig E, Bossone E. Exercise-Induced Pulmonary Hypertension: Translating Pathophysiological Concepts Into Clinical Practice. Chest. 2018 Jul;154(1):10-15. PubMed PMID: 29382472
• Hunt J.M., Barker S., Messenger J., Groves B., Lowes B., Carol J., Gruber M.P., Bull T.M. Inhaled Nitric Oxide in the Assessment of Pulmonary Hypertension. ATS, San Diego CA, May 2007
• Growth-Differentiation Factor-15 in Scleroderma Associated Pulmonary Arterial Hypertension Associated with Scleroderma M G Risbano, MD, C A Meadows, M W Geraci, MD, L Zhang1, T M Tuder, MD and T M Bull, MD Uiversity of Colorado Denver, Denver, CO, United States.
• Inferior Vena Cava filters in Venous Thromboembolism Springer
• Gene Microarray Expression Analysis of Peripheral Blood Cells in Scleroderma-Associated Pulmonary Hypertension M G Risbano, MD, C A Meadows, MS, C D Coldren, PhD, W DeSilva, MD, M W Geraci, MD and T M Bull, MD. University of Colorado, Denver, CO, United States.
• Pulmonary hypertension is independently associated with poor outcome in patients with acute lung injury. Todd M Bull MD, Kim Mc Fann Ph.D., Marc Moss MD for the ARDS network investigators. University of Colorado Denver, Division of Pulmonary Sciences and Critical Care Medicine. N01-HR-56167 K24-HL-089223
• CARDIAC CATHETERIZATION of PATIENTS with PULMONARY HYPERTENSION Todd M Bull MD, Bertron M. Groves, M.D. , David B. Badesch, M.D. PULMONARY CIRCULATION 4th Edition Edited by Dr. Andrew J. Peacock and Dr. Lewis J. Rubin
• Pulmonary Thromboembolic disease Michael G. Risbano, MD and Todd M. Bull, MD Oxford Handbook
• Unusual Case of Acquired Hypoxemia Following Left Ventricular Assist Device Implantation. Purohit SN, Lee PJ, Strobel AL, Desai AA, Marsala MT, Bull TM, Brieke A, Vargas D, Kay JD, Altman NL. Circ Heart Fail. 2020 Jan;13(1) PMID 31896269
• The role of pulmonary arterial hypertension-targeted therapy in systemic sclerosis Lee, M; Bull TM F1000 Reviews in press
• Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. Nana-Sinkam SP, Lee JD, Sotto-Santiago S, Stearman RS, Keith RL, Choudhury Q, Cool C, Parr J, Moore MD, Bull TM, Voelkel NF, Geraci MW. Am J Respir Crit Care Med. 2007 Apr 1;175(7):676-85. Epub 2007 Jan 25. PMID: 17255567
• Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells. Bull TM, Meadows CA, Coldren CD, Moore M, Sotto-Santiago SM, Nana-Sinkam SP, Campbell TB, Geraci MW. Am J Respir Cell Mol Biol. 2008 Dec;39(6):706-16. Epub 2008 Jun 27.PMID: 18587055
• Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells. Bull TM, Meadows CA, Coldren CD, Moore M, Sotto-Santiago SM, Nana-Sinkam SP, Campbell TB, Geraci MW. Am J Respir Cell Mol Biol. 2008 Dec;39(6):706-16. Epub 2008 Jun 27. PMID: 18587055
• Hountras P, Bull TM. Advanced therapies for pulmonary embolism. Curr Opin Pulm Med. 2020 Sep;26(5):397-405. PubMed PMID: 32740381
• Elevation of transpulmonary gradient and PVRi is associated with poor outcomes in patients with acute lung injury. Todd M Bull MD, Kim McFann Ph.D., Marc Moss MD. AJRCCM: 2010
• Rochon ER, Krowka MJ, Bartolome S, Heresi GA, Bull T, Roberts K, Hemnes A, Forde KA, Krok KL, Patel M, Lin G, McNeil M, Al-Naamani N, Roman BL, Yu PB, Fallon MB, Gladwin MT, Kawut SM. BMP9/10 in Pulmonary Vascular Complications of Liver Disease. Am J Respir Crit Care Med. 2020 Jun 15;201(12):1575-1578. PubMed PMID: 32083953
• Geraci, MW. Bull, TM. Tuder, RM Genomics of pulmonary arterial hypertension: implications for therapy. Heart Fail Clin. 2010 Jan(6)1:101-14
• Purohit SN, Lee PJ, Strobel AL, Desai AA, Marsala MT, Bull TM, Brieke A, Vargas D, Kay JD, Altman NL. Unusual Case of Acquired Hypoxemia Following Left Ventricular Assist Device Implantation. Circ Heart Fail. 2020 Jan;13(1):e006394. PubMed PMID: 31896269
• White D, MacDonald S, Bull T, Hayman M, de Monteverde-Robb D, Sapsford D, Lavinio A, Varley J, Johnston A, Besser M, Thomas W. Correction to: Heparin resistance in COVID-19 patients in the intensive care unit. J Thromb Thrombolysis. 2020 Aug;50(2):478. PubMed PMID: 32572676
• Role of Vasopressin and aldosterone in pulmonary arterial hypertenion: A pilot study. Bansal S, Badesch D, Bull T, Schrier RW. Contemp Clin Trials. 2009 Sep;30(5): 392-9
• Lee MH, Bull TM. The role of pulmonary arterial hypertension-targeted therapy in systemic sclerosis. F1000Res. 2019;8. PubMed PMID: 32025283
• Bull, TM. Groves, B. Badesch DM. Cardiac Catheterization of Patients with Pulmonary Hypertension. Pulmonary Circulation, 4th edition.
• Bull, TM. CT angiography and the diagnosis of pulmonary hypertension. The Color Atlas of Pulmonary Hypertension, 1st edition.
• Marron RM, Rali P, Hountras P, Bull TM. Inferior Vena Cava Filters: Past, Present, and Future. Chest. 2020 Dec;158(6):2579-2589. PubMed PMID: 32795479
• Hountras P, Bull TM. Advanced therapies for pulmonary embolism. Curr Opin Pulm Med. 2020 Sep;26(5):397-405. PubMed PMID: 32740381
• Al-Naamani N, Krowka MJ, Forde KA, Krok KL, Feng R, Heresi GA, Dweik RA, Bartolome S, Bull TM, Roberts KE, Austin ED, Hemnes AR, Patel MJ, Oh JK, Lin G, Doyle MF, Denver N, Andrew R, MacLean MR, Fallon MB, Kawut SM. Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2). Hepatology. 2020 May 14. [Epub ahead of print] PubMed PMID: 32407592
• Rochon ER, Krowka MJ, Bartolome S, Heresi GA, Bull T, Roberts K, Hemnes A, Forde KA, Krok KL, Patel M, Lin G, McNeil M, Al-Naamani N, Roman BL, Yu PB, Fallon MB, Gladwin MT, Kawut SM. BMP9/10 in Pulmonary Vascular Complications of Liver Disease. Am J Respir Crit Care Med. 2020 Jun 15;201(12):1575-1578. PubMed PMID: 32083953
• Koff PB, Min SJ, Freitag TJ, Diaz DLP, James SS, Voelkel NF, Linderman DJ, Diaz Del Valle F, Zakrajsek JK, Albert RK, Bull TM, Beck A, Stelzner TJ, Ritzwoller DP, Kveton CM, Carwin S, Ghosh M, Keith RL, Westfall JM, Vandivier RW. Impact of Proactive Integrated Care on Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2021 Jan;8(1). PubMed PMID: 33238087
• Purohit SN, Lee PJ, Strobel AL, Desai AA, Marsala MT, Bull TM, Brieke A, Vargas D, Kay JD, Altman NL. Unusual Case of Acquired Hypoxemia Following Left Ventricular Assist Device Implantation. Circ Heart Fail. 2020 Jan;13(1):e006394. PubMed PMID: 31896269
• Risbano, MG, Meadows, CM. Tuder, RM. Bull TM. Growth Differentiation Factor-15 in Scleroderma Associated Pulmonary Hypertension. Presented at ATS, San Diego, May 2009
• Risbano, MG, Meadows, CM, Coldren, CD, Dysilva, W. Geraci, MW. Bull, TM. Gene Expression Analysis of Peripheral Blood Cells in Scleroderma Associated Pulmonary Hypertension. Presented at ATS, San Diego, May 2009
• PAH Diagnosis: Patient Presentations from the Pulmonary Hypertension Assoication.
• Genomics of pulmonary arterial hypertension: implications for therapy. Geraci MW, Bull TM, Tuder RM. Heart Fail Clin. 2010 Jan;6(1):101-14. Review. PMID:19945066[PubMed - indexed for MEDLINE
• Borgese M, Badesch D, Bull T, Chakinala M, DeMarco T, Feldman J, Ford HJ, Grinnan D, Klinger JR, Bolivar L, Shlobin OA, Frantz RP, Sager JS, Mathai SC, Kawut S, Leary P, Gray MP, Popat RA, Zamanian RT. EmPHasis-10 as a Measure of Health-Related Quality of Life in Pulmonary Arterial Hypertension: data from PHAR. Eur Respir J. 2020 Nov 26. [Epub ahead of print] PubMed PMID: 33243844
• Fakhri S, Hannon K, Moulden K, Peterson R, Hountras P, Bull T, Maloney J, De Marco T, Ivy D, Thenappan T, Sager JS, Ryan JJ, Mazimba S, Hirsch R, Chakinala M, Shlobin O, Lammi M, Zwicke D, Robinson J, Benza RL, Klinger J, Grinnan D, Mathai S, Badesch D. Residence at moderately high altitude and its relationship with WHO Group 1 pulmonary arterial hypertension symptom severity and clinical characteristics: the Pulmonary Hypertension Association Registry. Pulm Circ. 2020 Oct-Dec;10(4):2045894020964342. PubMed PMID: 33240488
• Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury. Bull TM, Clark B, McFann K, Moss M; National Institutes of Health/National Heart, Lung, and Blood Institute ARDS Network. Am J Respir Crit Care Med. 2010 Nov 1;182(9):1123-8. Epub 2010 Jun 17. PMID:20558628[PubMed - indexed for MEDLINE
• Increased Expression of Growth Differentiation Factor-15 in Scleroderma-Associated Pulmonary Arterial Hypertension. Meadows CA, Risbano MG, Zhang L, Geraci MW, Tuder RM, Collier DH, Bull TM. Chest. 2010 Sep 9. [Epub ahead of print] PMID:20829333
• Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension. Risbano MG, Meadows CA, Coldren CD, Jenkins TJ, Edwards MG, Collier D, Huber W, Mack DG, Fontenot AP, Geraci MW, Bull TM. Clin Transl Sci. 2010 Oct;3(5):210-8. doi: 10.1111/j.1752-8062.2010.00218.x. Erratum in: Clin Transl Sci. 2010 Dec;3(6):340
• Viral infection and pulmonary hypertension: is there an association? Cool CD, Voelkel NF, Bull T. Expert Rev Respir Med. 2011 Apr;5(2):207-16. PMID:21510731[PubMed - in process
• Ethical Discussion of Clinical Trials in Pulmoanry Hypertension. Badesch, D, Bull TM.
• Lashari BH, Kumaran M, Aneja A, Bull T, Rali P. BEYOND CLOTS IN THE PULMONARY CIRCULATION; PULMONARY ARTERY TUMORS MIMICKING PULMONARY EMBOLISM. Chest. 2022 Jan 15. [Epub ahead of print] PubMed PMID: 35041833
• GDF-15 is a Marker for Survival in Scleroderma Related Pulmonary Arterial Hypertension M.G. Risbano1, C. Meadows1, L. Zhang, R. Tuder, M. Geraci, T.M. Bull
• Cool CD, Voelkel NF, Bull T. Viral infection and pulmonary hypertension: Is there an association? Expert Rev Respir Med 2011 Apr;5(2): 207-16.
• Leung AN, Bull TM, Jaeschke R, Lockwood CJ. James AH, McCullough LB, Tuttle BD. An Official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1200-8. PMID 22086989.
• Lee MH, Graham BB, Bull TM. Double Trouble: Airflow and Pulmonary Vascular Obstruction. Am J Respir Crit Care Med. 2021 Dec 15;204(12):1365-1367. PubMed PMID: 34644521
• American Thoracic Society documents: an official American Thoracic Society/Society of Thoracic Radiology Clinical Practice Guideline--Evaluation of Suspected Pulmonary Embolism in Pregnancy Leung AN, Bull TM, Jaeschke R, Lockwood CJ, Boiselle PM, Hurwitz LM, James AH, McCullough LB, Menda Y, Paidas MJ, Royal HD, Tapson VF, Winer-Muram HT, Chervenak FA, Cody DD, McNitt-Gray MF, Stave CD, Tuttle BD; ATS/STR Committee on Pulmonary Embolism in Pregnancy. Radiology. 2012 Feb;262(2):635-46. PMID: 22282185 [PubMed]
• Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension. Maloney JP, Stearman RS, Bull TM, Calabrese DW, Tripp-Addison ML, Wick MJ, Broeckel U, Robbins IM, Wheeler LA, Cogan JD, Loyd JE. Am J Physiol Lung Cell Mol Physiol. 2012 Mar;302(6):L541-54. Epub 2011 Dec 23. PMID: 22198906 [PubMed - in process]
• Practical approach to screening for scleroderma-associated pulmonary arterial hypertension. Fischer A, Bull TM, Steen VD. Arthritis Care Res (Hoboken). 2012 Mar;64(3):303-10. doi: 10.1002/acr.20693. No abstract available. PMID: 22076819 [PubMed - in process]
• Clinical review of pulmonary embolism: diagnosis, prognosis, and treatment. Hunt JM, Bull TM. Med Clin North Am. 2011 Nov;95(6):1203-22. Epub 2011 Sep 22. Review. PMID: 22032435 [PubMed - indexed for MEDLINE]
• Barrett CD, Moore HB, Moore EE, Wang DJ, Hajizadeh N, Biffl WL, Lottenberg L, Patel PR, Truitt MS, McIntyre R, Bull TM, Ammons LA, Ghasabyan A, Chandler J, Douglas I, Schmidt E, Moore PK, Wright FL, Ramdeo R, Borrego R, Rueda M, Dhupa A, McCaul DS, Dandan T, Sarkar PK, Khan B, Sreevidya C, McDaniel C, Grossman Verner HM, Pearcy C, Anez-Bustillos L, Baedorf-Kassis EN, Jhunjhunwala R, Shaefi S, Capers K, Banner-Goodspeed V, Talmor DS, Sauaia A, Yaffe MB. Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial. Chest. 2021 Sep 27. [Epub ahead of print] PubMed PMID: 34592318
• Pulmonary Embolism: Clinical Respiratory Medicine. Pending
• Outcome of non-cardiac, non-obstetric surgery in patients with pulmonary arterial hypertension: results from an international prospective survey. Meyer S, McLaughlin VV, Seyfarth HJ, Bull TM, Vizza CD, Gomberg-Maitland M, Preston IR, Barberà JA, Hassoun PM, Halank M, Jaïs X, Nickel N, Hoeper MM, Humbert M.
• Ther Adv Respir Dis. 2012 Oct;6(5):269-76. Epub 2012 Aug 6. Experiences with treprostinil in the treatment of pulmonary arterial hypertension. Stream AR, Bull TM.
• Minhas J, Shou H, Hershman S, Zamanian R, Ventetuolo CE, Bull T, Hemnes A, Chakinala MM, Mathai S, Al-Naamani N, Ellenberg S, Matura LA, Kawut SM, Shcherbina A. Physical Activity and Its Association with Traditional Outcome Measures in Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2021 Sep 2. [Epub ahead of print] PubMed PMID: 34473938
• COPD. 2012 Jun;9(3):211-2. doi: 10.3109/15412555.2012.683966. Sildenafil for COPD: a randomized crossover trial. Bull T, Badesch DB.
• Send to: Radiology. 2012 Feb;262(2):635-46. doi: 10.1148/radiol.11114045. American Thoracic Society documents: an official American Thoracic Society/Society of Thoracic Radiology Clinical Practice Guideline--Evaluation of Suspected Pulmonary Embolism in Pregnancy. Leung AN, Bull TM, Jaeschke R, Lockwood CJ, Boiselle PM, Hurwitz LM, James AH, McCullough LB, Menda Y, Paidas MJ, Royal HD, Tapson VF, Winer-Muram HT, Chervenak FA, Cody DD, McNitt-Gray MF, Stave CD, Tuttle BD; ATS/STR Committee on Pulmonary Embolism in Pregnancy
• Send to: Am J Respir Crit Care Med. 2011 Nov 15;184(10):1200-8. doi: 10.1164/rccm.201108-1575ST. An official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy. Leung AN, Bull TM, Jaeschke R, Lockwood CJ, Boiselle PM, Hurwitz LM, James AH, McCullough LB, Menda Y, Paidas MJ, Royal HD, Tapson VF, Winer-Muram HT, Chervenak FA, Cody DD, McNitt-Gray MF, Stave CD, Tuttle BD; ATS/STR Committee on Pulmonary Embolism in Pregnancy
• Arthritis Care Res (Hoboken). 2012 Mar;64(3):303-10. doi: 10.1002/acr.20693. Practical approach to screening for scleroderma-associated pulmonary arterial hypertension. Fischer A, Bull TM, Steen VD. Source National Jewish Health and University of Colorado, Denver, USA. fischera@njhealth.org
• Lee MH, Doran J, Bang TJ, Hohsfield R, Hountras P, Boddie G, Wagh MS, Badesch D, Bull TM. Pulmonary Arterial Hypertension and Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Novel Association?. Chest. 2021 Dec;160(6):2260-2265. PubMed PMID: 34284002
• DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ. Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry. Pulm Circ. 2021 Jul-Sep;11(3):20458940211020913. PubMed PMID: 34158918
• Bull TM. Clotting and COVID-19. Chest. 2021 Jun;159(6):2151-2152. PubMed PMID: 34099126
• Bradley M, Bull T, Hountras P, MacLaren R. Pragmatic Use of Catheter-Directed Thrombolysis in Venous Thromboembolism and a Comparative Evaluation With Traditional Therapies in Submassive Pulmonary Embolism. J Pharm Pract. 2021 Apr 7;:8971900211004833. [Epub ahead of print] PubMed PMID: 33823705
• Borgese M, Badesch D, Bull T, Chakinala M, DeMarco T, Feldman J, Ford HJ, Grinnan D, Klinger JR, Bolivar L, Shlobin OA, Frantz RP, Sager JS, Mathai SC, Kawut S, Leary PJ, Gray MP, Popat RA, Zamanian RT. EmPHasis-10 as a measure of health-related quality of life in pulmonary arterial hypertension: data from PHAR. Eur Respir J. 2021 Feb;57(2). PubMed PMID: 33243844
• Al-Naamani N, Krowka MJ, Forde KA, Krok KL, Feng R, Heresi GA, Dweik RA, Bartolome S, Bull TM, Roberts KE, Austin ED, Hemnes AR, Patel MJ, Oh JK, Lin G, Doyle MF, Denver N, Andrew R, MacLean MR, Fallon MB, Kawut SM. Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2). Hepatology. 2021 Feb;73(2):726-737. PubMed PMID: 32407592
• Koff PB, Min SJ, Freitag TJ, Diaz DLP, James SS, Voelkel NF, Linderman DJ, Diaz Del Valle F, Zakrajsek JK, Albert RK, Bull TM, Beck A, Stelzner TJ, Ritzwoller DP, Kveton CM, Carwin S, Ghosh M, Keith RL, Westfall JM, Vandivier RW. Impact of Proactive Integrated Care on Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2021 Jan;8(1). PubMed PMID: 33238087
• DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ. Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry. Pulm Circ. 2022 Oct;12(4):e12172. PubMed PMID: 36540874
• Garry JD, Kolaitis NA, Kronmal R, Thenappan T, Hemnes A, Grinnan D, Bull T, Chakinala MM, Horn E, Simon MA, De Marco T. Anticoagulation in pulmonary arterial hypertension - association with mortality, healthcare utilization, and quality of life: The Pulmonary Hypertension Association Registry (PHAR). J Heart Lung Transplant. 2022 Dec;41(12):1808-1818. PubMed PMID: 36150996
• Hill NS, Feldman JP, Sahay S, Benza RL, Preston IR, Badesch D, Frantz RP, Patel S, Galloway A, Bull TM. INSPIRE: Safety and tolerability of inhaled Yutrepia (treprostinil) in pulmonary arterial hypertension (PAH). Pulm Circ. 2022 Jul;12(3):e12119. PubMed PMID: 36034402
• Grinnan D, Kang L, DeWilde C, Badesch D, Benza R, Bull T, Chakinala M, DeMarco T, Feldman J, Ford HJ, Klinger J, McConnell J, Rosenzweig EB, Sager J, Shlobin O, Zamanian R. Prediction of patient outcomes through social determinants of health: The Pulmonary Hypertension Association Registry (PHAR) evaluation. Pulm Circ. 2022 Jul;12(3):e12120. PubMed PMID: 35911181
• Minhas J, Narasimmal SP, Bull TM, De Marco T, Mc Connell JW, Lammi MR, Thenappan T, Feldman JP, Sager JS, Badesch DB, Ryan JJ, Grinnan DC, Zwicke D, Horn EM, Elwing JM, Moss JE, Eggert M, Shlobin OA, Frantz RP, Bartolome SD, Mathai SC, Mazimba S, Pugliese SC, Al-Naamani N. Corrigendum for health-related quality of life and hospitalizations in chronic thromboembolic pulmonary hypertension versus idiopathic pulmonary arterial hypertension: And analysis from the Pulmonary Hypertension Association Registry. Pulm Circ. 2022 Apr;12(2):e12085. PubMed PMID: 35783032
• Mickael C, Kheyfets VO, Langouët-Astrié C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. Am J Respir Cell Mol Biol. 2022 May;66(5):580-581. PubMed PMID: 35486078
• Chang KY, Duval S, Badesch DB, Bull TM, Chakinala MM, De Marco T, Frantz RP, Hemnes A, Mathai SC, Rosenzweig EB, Ryan JJ, Thenappan T. Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry. J Am Heart Assoc. 2022 May 3;11(9):e024969. PubMed PMID: 35475351
• Bradley M, Bull T, Hountras P, MacLaren R. Pragmatic Use of Catheter-Directed Thrombolysis in Venous Thromboembolism and a Comparative Evaluation With Traditional Therapies in Submassive Pulmonary Embolism. J Pharm Pract. 2022 Oct;35(5):738-746. PubMed PMID: 33823705
• Cain MT, Schäfer M, Ross LK, Ivy DD, Mitchell MB, Fenster BE, Bull TM, Barker AJ, Vargas D, Hoffman JRH. 4D-Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension. Pulm Circ. 2023 Oct;13(4):e12307. PubMed PMID: 37941938
• Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2023 Oct 30. [Epub ahead of print] PubMed PMID: 37902921
• Minhas J, Shou H, Hershman S, Zamanian R, Ventetuolo CE, Bull TM, Hemnes A, Chakinala MM, Mathai S, Al-Naamani N, Ellenberg S, Matura LA, Kawut SM, Shcherbina A. Physical Activity and Its Association with Traditional Outcome Measures in Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2022 Apr;19(4):572-582. PubMed PMID: 34473938
• Forbes LM, Bull TM, Lahm T, Lawley JS, Hunter K, Levine BD, Lovering A, Roach RC, Subudhi AW, Cornwell WK 3rd. Right Ventricular Response to Acute Hypoxia among Healthy Humans. Am J Respir Crit Care Med. 2023 Aug 1;208(3):333-336. PubMed PMID: 37311248
• Mayer M, Badesch DB, Nielsen KH, Kawut S, Bull T, Ryan JJ, Sager J, Mazimba S, Hemnes A, Klinger J, Runo J, McConnell JW, De Marco T, Chakinala MM, Yung D, Elwing J, Kaplan A, Argula R, Pomponio R, Peterson R, Hountras P. Impact of the COVID-19 pandemic on chronic disease management and patient reported outcomes in patients with pulmonary hypertension: The Pulmonary Hypertension Association Registry. Pulm Circ. 2023 Apr;13(2):e12233. PubMed PMID: 37159803
• Barrett CD, Moore HB, Moore EE, Wang J, Hajizadeh N, Biffl WL, Lottenberg L, Patel PR, Truitt MS, McIntyre RC Jr, Bull TM, Ammons LA, Ghasabyan A, Chandler J, Douglas IS, Schmidt EP, Moore PK, Wright FL, Ramdeo R, Borrego R, Rueda M, Dhupa A, McCaul DS, Dandan T, Sarkar PK, Khan B, Sreevidya C, McDaniel C, Grossman Verner HM, Pearcy C, Anez-Bustillos L, Baedorf-Kassis EN, Jhunjhunwala R, Shaefi S, Capers K, Banner-Goodspeed V, Talmor DS, Sauaia A, Yaffe MB. Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial. Chest. 2022 Mar;161(3):710-727. PubMed PMID: 34592318
• Piazza G, Spyropoulos AC, Hsia J, Goldin M, Towner WJ, Go AS, Bull TM, Weng S, Lipardi C, Barnathan ES, Bonaca MP. Rivaroxaban for Prevention of Thrombotic Events, Hospitalization, and Death in Outpatients With COVID-19: A Randomized Clinical Trial. Circulation. 2023 Jun 20;147(25):1891-1901. PubMed PMID: 37154020
• Forbes LM, Bull TM, Lahm T, Make BJ, Cornwell WK 3rd. Exercise Testing in the Risk Assessment of Pulmonary Hypertension. Chest. 2023 Sep;164(3):736-746. PubMed PMID: 37061028
• Zhang H, D'Alessandro A, Li M, Reisz JA, Riddle S, Muralidhar A, Bull T, Zhao L, Gerasimovskaya E, Stenmark KR. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension. Vascul Pharmacol. 2023 Apr;149:107157. PubMed PMID: 36849042
• McCormick A, Krishnan A, Badesch D, Benza RL, Bull TM, De Marco T, Feldman J, Hemnes AR, Hirsch R, Horn E, Kennedy J, Mathai SC, McConnell W, Pugliese SC, Sager JS, Shlobin OA, Simon MA, Lammi MR. Pulmonary artery compliance in different forms of pulmonary hypertension. Heart. 2023 Jun 26;109(14):1098-1105. PubMed PMID: 36787969
• Lashari BH, Kumaran M, Aneja A, Bull T, Rali P. Beyond Clots in the Pulmonary Circulation: Pulmonary Artery Tumors Mimicking Pulmonary Embolism. Chest. 2022 Jun;161(6):1642-1650. PubMed PMID: 35041833
• Winters R, Forbes LM, Ivy D, Cool C, Park BD, Hountras P, Badesch D, Gu S, Spiekerkoetter E, Zamanian R, LeierGluck S, Bull TM. Case report: A finding of PVOD and PAH in first degree relatives suggests shared heritable risk and overlapping features of both pulmonary vascular diseases. Respirol Case Rep. 2024 Nov;12(11):e70064. PubMed PMID: 39588328
• Nathan SD, Lacasse V, Bell H, Sista P, Di Marino M, Bull T, Tapson V, Waxman A. COPD associated pulmonary hypertension: A post hoc analysis of the PERFECT study. Pulm Circ. 2024 Oct;14(4):e12430. PubMed PMID: 39364449
• Nathan SD, Argula R, Trivieri MG, Aziz S, Gay E, Medarov B, Parambil J, Raina A, Risbano MG, Thenappan T, Soto JS, Bell H, Lacasse V, Sista P, Di Marino M, Smart A, Hawkes B, Nelson E, Bull T, Tapson V, Waxman A. Inhaled treprostinil in pulmonary hypertension associated with COPD: PERFECT study results. Eur Respir J. 2024 Jun;63(6). PubMed PMID: 38811045
• Kawut SM, Feng R, Ellenberg SS, Zamanian R, Bull T, Chakinala M, Mathai SC, Hemnes A, Lin G, Doyle M, Andrew R, MacLean M, Stasinopoulos I, Austin E, DeMichele A, Shou H, Minhas J, Song N, Moutchia J, Ventetuolo CE. Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double-Blind, Placebo-Controlled Trial. Am J Respir Crit Care Med. 2024 Nov 1;210(9):1143-1151. PubMed PMID: 38747680
• Rockstrom MD, Jin Y, Peterson RA, Hountras P, Badesch D, Gu S, Park B, Messenger J, Forbes LM, Cornwell WK 3rd, Bull TM. The effects of oxygenation on acute vasodilator challenge in pulmonary arterial hypertension. Pulm Circ. 2024 Apr;14(2):e12375. PubMed PMID: 38736893
• Gardner TA, Fuher A, Longino A, Sink EM, Jurica J, Park B, Lindquist J, Bull TM, Hountras P. Reduced mortality associated with pulmonary embolism response team consultation for intermediate and high-risk pulmonary embolism: a retrospective cohort study. Thromb J. 2024 Apr 19;22(1):38. PubMed PMID: 38641802
• Forbes LM, Bull TM, Lahm T, Sisson T, O'Gean K, Lawley JS, Hunter K, Levine BD, Lovering A, Roach RC, Subudhi AW, Cornwell WK 3rd. Right ventricular performance during acute hypoxic exercise. J Physiol. 2024 Nov;602(21):5523-5537. PubMed PMID: 38409819
• Cain MT, Schäfer M, Ross LK, Ivy DD, Mitchell MB, Fenster BE, Bull TM, Barker AJ, Vargas D, Hoffman JRH. 4D-Flow MRI intracardiac flow analysis considering different subtypes of pulmonary hypertension. Pulm Circ. 2023 Oct;13(4):e12307. PubMed PMID: 37941938
• Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2024 Feb;40(2):425-439. PubMed PMID: 37902921
• Forbes LM, Bull TM, Lahm T, Lawley JS, Hunter K, Levine BD, Lovering A, Roach RC, Subudhi AW, Cornwell WK 3rd. Right Ventricular Response to Acute Hypoxia among Healthy Humans. Am J Respir Crit Care Med. 2023 Aug 1;208(3):333-336. PubMed PMID: 37311248
• Mayer M, Badesch DB, Nielsen KH, Kawut S, Bull T, Ryan JJ, Sager J, Mazimba S, Hemnes A, Klinger J, Runo J, McConnell JW, De Marco T, Chakinala MM, Yung D, Elwing J, Kaplan A, Argula R, Pomponio R, Peterson R, Hountras P. Impact of the COVID-19 pandemic on chronic disease management and patient reported outcomes in patients with pulmonary hypertension: The Pulmonary Hypertension Association Registry. Pulm Circ. 2023 Apr;13(2):e12233. PubMed PMID: 37159803
• Piazza G, Spyropoulos AC, Hsia J, Goldin M, Towner WJ, Go AS, Bull TM, Weng S, Lipardi C, Barnathan ES, Bonaca MP. Rivaroxaban for Prevention of Thrombotic Events, Hospitalization, and Death in Outpatients With COVID-19: A Randomized Clinical Trial. Circulation. 2023 Jun 20;147(25):1891-1901. PubMed PMID: 37154020
• Forbes LM, Bull TM, Lahm T, Make BJ, Cornwell WK 3rd. Exercise Testing in the Risk Assessment of Pulmonary Hypertension. Chest. 2023 Sep;164(3):736-746. PubMed PMID: 37061028
• Zhang H, D'Alessandro A, Li M, Reisz JA, Riddle S, Muralidhar A, Bull T, Zhao L, Gerasimovskaya E, Stenmark KR. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension. Vascul Pharmacol. 2023 Apr;149:107157. PubMed PMID: 36849042
• McCormick A, Krishnan A, Badesch D, Benza RL, Bull TM, De Marco T, Feldman J, Hemnes AR, Hirsch R, Horn E, Kennedy J, Mathai SC, McConnell W, Pugliese SC, Sager JS, Shlobin OA, Simon MA, Lammi MR. Pulmonary artery compliance in different forms of pulmonary hypertension. Heart. 2023 Jun 26;109(14):1098-1105. PubMed PMID: 36787969
• Bernardo RJ, Lu D, Ramirez RL 3rd, Hedlin H, Kawut SM, Bull T, De Marco T, Ford HJ, Grinnan D, Klinger JR, McConnell JW, Berman-Rosenzweig E, Shlobin OA, Zamanian RT, de Jesus Perez VA. Hispanic Ethnicity and Social Determinants of Health in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry. Ann Am Thorac Soc. 2022 Sep;19(9):1459-1468. PubMed PMID: 35239467
• Barrett CD, Moore HB, Moore EE, Benjamin Christie D 3rd, Orfanos S, Anez-Bustillos L, Jhunjhunwala R, Hussain S, Shaefi S, Wang J, Hajizadeh N, Baedorf-Kassis EN, Al-Shammaa A, Capers K, Banner-Goodspeed V, Wright FL, Bull T, Moore PK, Nemec H, Thomas Buchanan J, Nonnemacher C, Rajcooar N, Ramdeo R, Yacoub M, Guevara A, Espinal A, Hattar L, Moraco A, McIntyre R, Talmor DS, Sauaia A, Yaffe MB. MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID-19 severe respiratory failure (MUST COVID): A retrospective cohort study. Res Pract Thromb Haemost. 2022 Feb;6(2):e12669. PubMed PMID: 35341072

Practice Locations

• University of Colorado Hospital

• Comprehensive Lungs and Breathing Program

Specialty Information

• Internal Medicine, Board Certification (1997)
• Pulmonary Disease and Critical Care Medicine, Board Certification (2001)
• Critical Care Medicine, Board Certification (1992)

• Lungs and Breathing - Pulmonary Hypertension
• Critical Care
• Lungs and Breathing - Pulmonary Embolism
• Lungs and Breathing
• Lungs and Breathing - Chronic Thromboembolic Pulmonary Hypertension (CTEPH)